The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia . Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.
Michael J. Owen, Nigel M. Williams, Michael C. O’Donovan
Title and authors | Publication | Year |
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Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus
Bhardwaj SK, Nath M, Wong TP, Srivastava LK |
Scientific Reports | 2024 |
Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice.
Borlepawar A, Schmiedel N, Eden M, Christen L, Rosskopf A, Frank D, Lüllmann-Rauch R, Frey N, Rangrez AY |
Cells | 2020 |
Dysbindin-1 Involvement in the Etiology of Schizophrenia
H Wang, J Xu, P Lazarovici, W Zheng |
International journal of molecular sciences | 2017 |
TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels
A Borlepawar, AY Rangrez, A Bernt, L Christen, S Sossalla, D Frank, N Frey |
The Journal of biological chemistry | 2017 |
Genetic association of single nucleotide polymorphisms in dystrobrevin binding protein 1 gene with schizophrenia in a Malaysian population
GK Tan, SF Tee, PY Tang |
Genetics and molecular biology | 2015 |
The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans
S Trost, B Platz, J Usher, H Scherk, T Wobrock, S Ekawardhani, J Meyer, W Reith, P Falkai, O Gruber |
European Archives of Psychiatry and Clinical Neuroscience | 2012 |
Contribution of nonprimate animal models in understanding the etiology of schizophrenia.
Lazar NL, Neufeld RW, Cain DP |
Journal of psychiatry & neuroscience : JPN | 2011 |
Nucleocytoplasmic Shuttling of Dysbindin-1, a Schizophrenia-related Protein, Regulates Synapsin I Expression*
E Fei, X Ma, C Zhu, T Xue, J Yan, Y Xu, J Zhou, G Wang |
The Journal of biological chemistry | 2010 |
The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions
M Baharnoori, C Bartholomeusz, AA Boucher, L Buchy, C Chaddock, B Chiliza, M Föcking, A Fornito, JA Gallego, H Hori, G Huf, GA Jabbar, SH Kang, YE Kissi, J Merchán-Naranjo, G Modinos, NA Abdel-Fadeel, AK Neubeck, HP Ng, G Novak, OO Owolabi, DP Prata, NP Rao, I Riecansky, DC Smith, RP Souza, R Thienel, HD Trotman, H Uchida, KA Woodberry, A O'Shea, LE DeLisi |
Schizophrenia Research | 2010 |
The effects of a DTNBP1 gene variant on attention networks: an fMRI study.
Thimm M, Krug A, Kellermann T, Markov V, Krach S, Jansen A, Zerres K, Eggermann T, Stöcker T, Shah NJ, Nöthen MM, Rietschel M, Kircher T |
Behavioral and brain functions : BBF | 2010 |
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
Chen X, Lee G, Maher BS, Fanous AH, Chen J, Zhao Z, Guo A, van den Oord E, Sullivan PF, Shi J, Levinson DF, Gejman PV, Sanders A, Duan J, Owen MJ, Craddock NJ, O'Donovan MC, Blackman J, Lewis D, Kirov GK, Qin W, Schwab S, Wildenauer D, Chowdari K, Nimgaonkar V, Straub RE, Weinberger DR, O'Neill FA, Walsh D, Bronstein M, Darvasi A, Lencz T, Malhotra AK, Rujescu D, Giegling I, Werge T, Hansen T, Ingason A, Nöethen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Cantor RM, Ophoff R, Corvin A, Morris DW, Gill M, Pato CN, Pato MT, Macedo A, Gurling HM, McQuillin A, Pimm J, Hultman C, Lichtenstein P, Sklar P, Purcell SM, Scolnick E, St Clair D, Blackwood DH, Kendler KS |
Molecular Psychiatry | 2010 |
Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals.
Markov V, Krug A, Krach S, Jansen A, Eggermann T, Zerres K, Stöcker T, Shah NJ, Nöthen MM, Treutlein J, Rietschel M, Kircher T |
Human Brain Mapping | 2010 |
The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval.
Thimm M, Krug A, Markov V, Krach S, Jansen A, Zerres K, Eggermann T, Stöcker T, Shah NJ, Nöthen MM, Rietschel M, Kircher T |
Human Brain Mapping | 2010 |
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
DK Dickman, GW Davis |
Science (New York, N.Y.) | 2009 |
Dysbindin gene (DTNBP1) and schizophrenia in Korean population.
Pae CU, Mandelli L, De Ronchi D, Kim JJ, Jun TY, Patkar AA, Serretti A |
European Archives of Psychiatry and Clinical Neuroscience | 2009 |
Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
SR Datta, A McQuillin, V Puri, K Choudhury, S Thirumalai, J Lawrence, J Pimm, N Bass, G Lamb, H Moorey, J Morgan, B Punukollu, G Kandasami, S Kirwin, A Sule, D Quested, D Curtis, HughGurling |
Behavioral and Brain Functions | 2007 |
DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene.
Duan J, Martinez M, Sanders AR, Hou C, Burrell GJ, Krasner AJ, Schwartz DB, Gejman PV |
Human Heredity | 2007 |
Schizophrenia: an update and review.
Austin J |
Journal of Genetic Counseling | 2005 |