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Citations to this article

Multiple sclerosis
David A. Hafler
David A. Hafler
Published March 15, 2004
Citation Information: J Clin Invest. 2004;113(6):788-794. https://doi.org/10.1172/JCI21357.
View: Text | PDF | Erratum
Science in Medicine Article has an altmetric score of 23

Multiple sclerosis

  • Text
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Abstract

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.

Authors

David A. Hafler

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Natural triterpenes modulate immune-inflammatory markers of experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis
R Martín, M Hernández, C Córdova, ML Nieto
British Journal of Pharmacology 2012
Molecular Mechanisms of Oligodendrocyte Injury in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
J Patel, R Balabanov
International journal of molecular sciences 2012
Decreased serum levels of nucleolin protein fragment, as analyzed by bead-based proteomic technology, in multiple sclerosis patients compared to controls
J Liu, L Yin, H Dong, E Xu, L Zhang, Y Qiao, Y Liu, L Li, J Jia
Journal of Neuroimmunology 2012
Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease
L Codarri, M Greter, B Becher
Trends in Immunology 2012
PLAUSIBLE BINDING MODE OF THE ACTIVE α4β1 ANTAGONIST, MK-0617, DETERMINED BY DOCKING AND FREE ENERGY CALCULATIONS
CM Carlevaro, JH Martins-Da-Silva, W Savino, ER Caffarena
Journal of Theoretical and Computational Chemistry 2012
Adhesion and hemifusion of cytoplasmic myelin lipid membranes are highly dependent on the lipid composition
X Banquy, K Kristiansen, DW Lee, JN Israelachvili
Biochimica et Biophysica Acta (BBA) - Biomembranes 2012
Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients
R Natarajan, E Einarsdottir, A Riutta, S Hagman, M Raunio, N Mononen, T Lehtimäki, I Elovaara
Journal of Neuroimmunology 2012
Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis
T Petersen, A Møller-Larsen, S Ellermann-Eriksen, S Thiel, T Christensen
Journal of Neuroimmunology 2012
Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model
L Weiss, R Or, RC Jones, R Amunugama, L JeBailey, S Ramu, SA Bernstein, Z Yekhtin, O Almogi-Hazan, R Shainer, I Reibstein, AO Vortmeyer, MJ Paidas, M Zeira, S Slavin, ER Barnea
Journal of the Neurological Sciences 2012
Pregnancy and Multiple Sclerosis (MS): A Beneficial Association. Possible therapeutic application of embryo-specific Pre-implantation Factor (PIF*)
MJ Paidas, J Annunziato, M Romano, L Weiss, R Or, ER Barnea
American Journal of Reproductive Immunology 2012
Autologous hematopoietic stem cell transplantation with reduced-intensity conditioning in multiple sclerosis
JL Shevchenko, AN Kuznetsov, TI Ionova, VY Melnichenko, DA Fedorenko, AV Kartashov, KA Kurbatova, GI Gorodokin, AA Novik
Experimental Hematology 2012
Prevalence of atopic disorders in rheumatic diseases
S Karatay, K Yildirim, M Ugur, K Senel, A Erdal, B Durmus, O Baysal, Z Altay, AJ Sarac, A Gur, O Ardicoglu, A Kamanli, R Cevik, A Kaya, Y Ersoy, K Nas, S Ozgocmen
Modern Rheumatology 2012
IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination
M Zandian, KR Mott, SJ Allen, S Chen, M Arditi, H Ghiasi
PloS one 2011
The Role of Kinin Receptors in Preventing Neuroinflammation and Its Clinical Severity during Experimental Autoimmune Encephalomyelitis in Mice
RC Dutra, DF Leite, AF Bento, MN Manjavachi, ES Patrício, CP Figueiredo, JB Pesquero, JB Calixto
PloS one 2011
Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases
P Manikwar, P Kiptoo, AH Badawi, B Büyüktimkin, TJ Siahaan
Medicinal Research Reviews 2011
Radical changes in multiple sclerosis pathogenesis
J Horssen, ME Witte, G Schreibelt, HE de Vries
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2011
Regulatory role of resveratrol on Th17 in autoimmune disease
TM Petro
International Immunopharmacology 2011
Neuroprotective action of lithium in disorders of the central nervous system
CT Chiu, DM Chuang
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2011
Relating domain size distribution to line tension and molecular dipole density in model cytoplasmic myelin lipid monolayers
DW Lee, Y Min, P Dhar, A Ramachandran, JN Israelachvili, JA Zasadzinski
Proceedings of the National Academy of Sciences 2011
Euphol prevents experimental autoimmune encephalomyelitis in mice: evidence for the underlying mechanisms
RC Dutra, PR de de Souza, AF Bento, R Marcon, MA Bicca, LF Pianowski, JB Calixto
Biochemical Pharmacology 2011
Cytokine gene polymorphisms in multiple sclerosis: a meta-analysis of 45 studies including 7379 cases and 8131 controls: Cytokine gene polymorphisms and multiple sclerosis
GK Nikolopoulos, A Masgala, C Tsiara, OK Limitsiou, AC Karnaouri, NL Dimou, PG Bagos
European Journal of Neurology 2011
Charcot–Marie–Tooth disease associated with recurrent optic neuritis
BR Wakerley, FE Harman, DM Altmann, O Malik
Journal of Clinical Neuroscience 2011
Immunological consequences of ischemic stroke: Immunosuppression and autoimmunity
A Vogelgesang, A Dressel
Journal of Neuroimmunology 2011
Autoantibodies with enzymatic properties in human autoimmune diseases
B Wootla, S Lacroix-Desmazes, AE Warrington, AJ Bieber, SV Kaveri, M Rodriguez
Journal of Autoimmunity 2011
Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions
MM Wilhelmus, SM van der Pol, Q Jansen, ME Witte, P der Valk, AJ Rozemuller, B Drukarch, HE de Vries, JV Horssen
Free radical biology & medicine 2011
Critical and Off-Critical Miscibility Transitions in Model Extracellular and Cytoplasmic Myelin Lipid Monolayers
Y Min, TF Alig, DW Lee, JM Boggs, JN Israelachvili, JA Zasadzinski
Biophysical Journal 2011
Multiple sclerosis in Caucasians and Latino Americans
L Aguirre-Cruz, J Flores-Rivera, DL de la Cruz-Aguilera, E Rangel-López, T Corona
Autoimmunity 2011
Morphological and functional characterization of leech circulating blood cells: role in immunity and neural repair
C Boidin-Wichlacz, D Vergote, C Slomianny, N Jouy, M Salzet, A Tasiemski
Cellular and Molecular Life Sciences 2011
Health-related quality of life and its promotion among multiple sclerosis patients in Finland: Quality of life: multiple sclerosis patients
S Heiskanen, B Vickrey, AM Pietilä
International Journal of Nursing Practice 2011
HLA allele frequencies in Iranian opticospinal multiple sclerosis patients<br>——HLA in Opticospinal MS
H Kalanie, M Kamgooyan, Y Kholghie, AA Harandi, Z Hosseinzadeh
Journal of Biomedical Science and Engineering 2011
Interleukin 2 Receptor α Gene Polymorphism and Risk of Multiple Sclerosis: A Meta-Analysis
LM Wang, DM Zhang, YM Xu, SL Sun
J INT MED RES 2011
Just in Time: An Update on Continuum Neurogenetics:
NS Rost
CONTINUUM: Lifelong Learning in Neurology 2011
Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite
CR Strader, CJ Pearce, NH Oberlies
Journal of Natural Products 2011
Methylxanthines
BB Fredholm
Methylxanthines 2010
Methylxanthines
BB Fredholm
Methylxanthines 2010
Methylxanthines
BB Fredholm
Methylxanthines 2010
Methylxanthines
BB Fredholm
Methylxanthines 2010
Methylxanthines
BB Fredholm
Methylxanthines 2010
Methylxanthines
BB Fredholm
Methylxanthines 2010
Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2
JW Leavenworth, C Schellack, HJ Kim, L Lu, P Spee, H Cantor
Proceedings of the National Academy of Sciences 2010
IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE)
A Rynda, M Maddaloni, J Ochoa-Repáraz, G Callis, DW Pascual
PloS one 2010
Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine
X Qin, BT Guo, B Wan, L Fang, L Lu, L Wu, YQ Zang, JZ Zhang
Journal of immunology (Baltimore, Md. : 1950) 2010
Loss of epidermal growth factor regulation by cobalamin in multiple sclerosis
G Scalabrino, D Galimberti, E Mutti, D Scalabrini, D Veber, MD Riz, F Bamonti, E Capello, GL Mancardi, E Scarpini
Brain Research 2010
Increased cerebrospinal fluid chitotriosidase index in patients with multiple sclerosis
MM Verbeek, EA Notting, B Faas, R Claessens-Linskens, PJ Jongen
Acta Neurologica Scandinavica 2010
Interferon beta inhibits the Th17 cell-mediated autoimmune response in patients with relapsing–remitting multiple sclerosis
X Zhang, S Markovic-Plese
Clinical Neurology and Neurosurgery 2010
Novel sinomenine derivative 1032 improves immune suppression in experimental autoimmune encephalomyelitis
LC Yan, EG Bi, YT Lou, XD Wu, ZD Liu, J Zhou, Y Wang, Z Ma, GM Lin, SH Sun, C Bian, AZ Chen, ZJ Yao, B Sun
Biochemical and Biophysical Research Communications 2010
New hypotheses on sunlight and the geographic variability of multiple sclerosis prevalence
BK Mehta
Journal of the Neurological Sciences 2010
HERVs in Neuropathogenesis
T Christensen
Journal of Neuroimmune Pharmacology 2010
Janus head: the dual role of HLA-G in CNS immunity
YH Huang, L Airas, N Schwab, H Wiendl
Cellular and Molecular Life Sciences 2010
Pathophysiology of multiple sclerosis and the place of teriflunomide: MS pathophysiology and the place of teriflunomide
R Gold, JS Wolinsky
Acta Neurologica Scandinavica 2010
The sad plight of multiple sclerosis research (low on fact, high on fiction): critical data to support it being a neurocristopathy
PO Behan, A Chaudhuri
Inflammopharmacology 2010
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
CT Chiu, DM Chuang
Pharmacology & Therapeutics 2010
Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration
B Barrette, E Calvo, N Vallières, S Lacroix
Brain, Behavior, and Immunity 2010
Oxidative Stress and Free Radical Damage in Neurology
N Gadoth, HH Göbel
2010
Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis
YH Huang, AL Zozulya, C Weidenfeller, I Metz, D Buck, KV Toyka, W Brück, H Wiendl
Annals of Neurology 2009
Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production
S Tzima, P Victoratos, K Kranidioti, M Alexiou, G Kollias
Journal of Experimental Medicine 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Molecular Basis of Multiple Sclerosis
R Martin, A Lutterotti
2009
Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain
SN Willis, C Stadelmann, SJ Rodig, T Caron, S Gattenloehner, SS Mallozzi, JE Roughan, SE Almendinger, MM Blewett, W Brück, DA Hafler, KC O'Connor
Brain : a journal of neurology 2009
The role of the CD58 locus in multiple sclerosis
PL de Jager, C Baecher-Allan, LM Maier, AT Arthur, L Ottoboni, L Barcellos, JL McCauley, S Sawcer, A Goris, J Saarela, R Yelensky, A Price, V Leppa, N Patterson, PI de Bakker, D Tran, C Aubin, S Pobywajlo, E Rossin, X Hu, CW Ashley, E Choy, JD Rioux, MA Pericak-Vance, A Ivinson, DR Booth, GJ Stewart, A Palotie, L Peltonen, B Dubois, JL Haines, HL Weiner, A Compston, SL Hauser, MJ Daly, D Reich, JR Oksenberg, DA Hafler
Proceedings of the National Academy of Sciences 2009
Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosis
T Petersen, A Møller-Larsen, S Thiel, T Brudek, TK Hansen, T Christensen
Journal of Neuroimmunology 2009
Interaction forces and adhesion of supported myelin lipid bilayers modulated by myelin basic protein
Y Min, K Kristiansen, JM Boggs, C Husted, JA Zasadzinski, J Israelachvili
Proceedings of the National Academy of Sciences 2009
The T-cell pool is anergized in patients with multiple sclerosis in remission
ME Fransson, LS Liljenfeldt, J Fagius, TH Tötterman, AS Loskog
Immunology 2009
Update on Inflammation, Neurodegeneration, and Immunoregulation in Multiple Sclerosis
JL Bennett, O Stüve
Clinical Neuropharmacology 2009
Brazilian experience with two conditioning regimens in patients with multiple sclerosis: BEAM/horse ATG and CY/rabbit ATG
N Hamerschlak, M Rodrigues, DA Moraes, MC Oliveira, AB Stracieri, F Pieroni, GM Barros, MI Madeira, BP Simões, AA Barreira, DG Brum, AA Ribeiro, JM Kutner, CP Tylberi, PP Porto, CL Santana, JZ Neto, JC Barros, AT Paes, RK Burt, EA Oliveira, AP Mastropietro, AC Santos, JC Voltarelli
Bone Marrow Transplantation 2009
Netter's Internal Medicine
DS Rubenstein, LA Diaz
Netter's Internal Medicine 2009
Clinical response to interferon-β-1a may be linked to low baseline circulating BDCA1 myeloid dendritic cells
C Andrés, C Aristimuño, M Bartolomé, V las Heras, ML Martínez-Ginés, R Arroyo, E Fernández-Cruz, S Sánchez-Ramón
Journal of Neuroimmunology 2009
Hematopoietic stem cell transplantation in multiple sclerosis
C Rogojan, JL Frederiksen
Acta Neurologica Scandinavica 2009
Stammzelltherapie bei multipler Sklerose: Eine Bilanz aus klinischer Sicht
S Schippling, R Martin
Zeitschrift für Rheumatologie 2009
Quantitative proteomic analysis of the cerebrospinal fluid of patients with multiple sclerosis
S Liu, S Bai, Z Qin, Y Yang, Y Cui, Y Qin
Journal of Cellular and Molecular Medicine 2009
Psychosocial support as a counselling in improving health-related quality of life in patients with recent multiple sclerosis in Finland
S Heiskanen, AM Pietilä
Journal of Nursing and Healthcare of Chronic Illness 2009
Degenerate T-Cell Receptor Recognition, Autoreactive Cells, and the Autoimmune Response in Multiple Sclerosis
S Markovic-Plese
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2009
Mechanical hypernociception in experimental autoimmune encephalomyelitis
DH Rodrigues, D Sachs, AL Teixeira
Arquivos de Neuro-Psiquiatria 2009
Oral Administration of 1,4-Aryl-2-mercaptoimidazole Inhibits T-Cell Proliferation and Reduces Clinical Severity in the Murine Experimental Autoimmune Encephalomyelitis Model
EJ Jung, M Hur, YL Kim, GH Lee, J Kim, I Kim, MW Lee, HK Han, MS Kim, S Hwang, S Kim, AM Woo, Y Yoon, HJ Park, J Won
The Journal of pharmacology and experimental therapeutics 2009
Sequelae and Long-Term Consequences of Infectious Diseases
PM Fratamico, JL Smith, KA Brogden
2009
EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2
JD Lünemann, I Jelcić, S Roberts, A Lutterotti, B Tackenberg, R Martin, C Münz
Journal of Experimental Medicine 2008
Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt
MP Quinones, Y Kalkonde, CA Estrada, F Jimenez, R Ramirez, L Mahimainathan, S Mummidi, GG Choudhury, H Martinez, L Adams, M Mack, RL Reddick, S Maffi, S Haralambous, L Probert, SK Ahuja, SS Ahuja
Molecular and cellular neurosciences 2008
Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair
S Markovic-Plese, AK Singh, I Singh
Future Neurology 2008
Statins’ immunomodulatory potential against Th17 cell-mediated autoimmune response
X Zhang, S Markovic-Plese
Immunologic Research 2008
GM-CSF-induced autoimmune gastritis in interferon α receptor deficient mice
J Field, F Alderuccio, P Hertzog, BH Toh
Journal of Autoimmunity 2008
The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature
RL Rabin, AI Levinson
Clinical & Experimental Immunology 2008
Microarray analysis in B cells among siblings with/without MS - role for transcription factor TCF2
JR Avasarala, SV Chittur, AD George, JA Tine
BMC Medical Genomics 2008
Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis
AS Paintlia, MK Paintlia, I Singh, AK Singh
Experimental Neurology 2008
Regulation of different inflammatory diseases by impacting the mevalonate pathway
R Zeiser, K Maas, S Youssef, C Dürr, L Steinman, RS Negrin
Immunology 2008
Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis
P Casaccia-Bonnefil, G Pandozy, F Mastronardi
Progress in Neurobiology 2008
Recognition and Degradation of Myelin Basic Protein Peptides by Serum Autoantibodies: Novel Biomarker for Multiple Sclerosis
AA Belogurov, IN Kurkova, A Friboulet, D Thomas, VK Misikov, MY Zakharova, SV Suchkov, SV Kotov, AI Alehin, B Avalle, EA Souslova, HC Morse, AG Gabibov, NA Ponomarenko
Journal of immunology (Baltimore, Md. : 1950) 2008
IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier
J Niemelä, I Ifergan, GG Yegutkin, S Jalkanen, A Prat, L Airas
European Journal of Immunology 2008
Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis
S Kuerten, S Javeri, M Tary-Lehmann, PV Lehmann, DN Angelov
Clinical Immunology 2008
Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease
PA Carpentier, MT Getts, SD Miller
Virology 2008
HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility
MJ Chao, MC Barnardo, MR Lincoln, SV Ramagopalan, BM Herrera, DA Dyment, A Montpetit, AD Sadovnick, JC Knight, GC Ebers
Proceedings of the National Academy of Sciences 2008
The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation
AL Zozulya, H Wiendl
Human Immunology 2008
Can the immune system be harnessed to repair the CNS?
PG Popovich, EE Longbrake
Nature Reviews Neuroscience 2008
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes
X Zhang, J Jin, X Peng, VS Ramgolam, S Markovic-Plese
Journal of immunology (Baltimore, Md. : 1950) 2008
Development of laquinimod for relapsing–remitting multiple sclerosis
DR Jeffery
Future Neurology 2008
Stem cell transplantation in multiple sclerosis
S Schippling, C Heesen, A Zander, R Martin
Journal of Neurology 2008
Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression
J Horssen, G Schreibelt, J Drexhage, T Hazes, CD Dijkstra, P der Valk, HE Vries
Free radical biology & medicine 2008
Dendritic cells loaded with apoptotic oligodendrocytes as a source of myelin T-cell epitopes in multiple sclerosis
F Meloni, D Accapezzato, C Agresti, F Aloisi, G Ristori, M Salvetti, R Furlan, G Martino, V Barnaba, M Paroli
Clinical Immunology 2008
Coagulation status and biochemical and inflammatory markers in multiple sclerosis
FB Aksungar, AE Topkaya, Z Yildiz, S Sahin, U Turk
Journal of Clinical Neuroscience 2008
Variants of ST8SIA1 Are Associated with Risk of Developing Multiple Sclerosis
S Husain, C Yildirim-Toruner, JP Rubio, J Field, M Schwalb, S Cook, M Devoto, E Vitale, PH Reitsma
PloS one 2008
Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis
PD Sarno, RC Axtell, C Raman, KA Roth, DR Alessi, RS Jope
Journal of immunology (Baltimore, Md. : 1950) 2008
Variants of ST8SIA1 are associated with risk of developing multiple sclerosis.
Husain S, Yildirim-Toruner C, Rubio JP, Field J, Schwalb M, Cook S, Devoto M, Vitale E
PloS one 2008
Heme Oxygenase-1 and Carbon Monoxide Suppress Autoimmune Neuroinflammation
Ângelo A. Chora, Paulo Fontoura, Andreia Cunha, Teresa F. Pais, Sílvia Cardoso, Peggy P Ho, Lowen Y Lee, Raymond A. Sobel, Lawrence Steinman and Miguel P. Soares
Journal of Clinical Investigation 2007
Identification of short-term pharmacodynamic effects of interferon-beta-1a in multiple sclerosis subjects with broad- based phenotypic profiling
AB Kantor, J Deng, E Waubant, H Lin, CH Becker, JR Lacy, AM Perrone, D Bennett, SE Goelz
Journal of Neuroimmunology 2007
Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system
BR Lawson, Y Manenkova, J Ahamed, X Chen, JP Zou, R Baccala, AN Theofilopoulos, C Yuan
Journal of immunology (Baltimore, Md. : 1950) 2007
Epstein-Barr Virus: Environmental Trigger of Multiple Sclerosis?
JD Lünemann, T Kamradt, R Martin, C Münz
Journal of virology 2007
Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis
Z Wang, J Qiu, TB Guo, A Liu, Y Wang, Y Li, JZ Zhang
Journal of immunology (Baltimore, Md. : 1950) 2007
CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions
M Krumbholz, D Theil, F Steinmeyer, S Cepok, B Hemmer, M Hofbauer, C Farina, T Derfuss, A Junker, T Arzberger, I Sinicina, C Hartle, J Newcombe, R Hohlfeld, E Meinl
Journal of Neuroimmunology 2007
TWEAK and the Central Nervous System
M Yepes
Molecular Neurobiology 2007
Glucocorticoids in the control of neuroinflammation
D Tischner, HM Reichardt
Molecular and Cellular Endocrinology 2007
Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis
LS Harbige, MK Sharief
British Journal of Nutrition 2007
Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
D Rossum, S Hilbert, S Straßenburg, U Hanisch, W Brück
Glia 2007
The role of dendritic cells in multiple sclerosis
GF Wu, TM Laufer
Current Neurology and Neuroscience Reports 2007
Substrate specificity of catalytic autoantibodies in neurodegenerative processes
AA Belogurov, IN Kurkova, VK Misikov, SV Suchkov, GB Telegin, AI Alekhin, NG Goncharov, VD Knorre, AG Gabibov, NA Ponomarenko
Doklady Biochemistry and Biophysics 2007
CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases
X Valencia, PE Lipsky
Nature Clinical Practice Rheumatology 2007
The kaleidoscope of autoimmunity: multiple autoimmune syndromes and familial autoimmunity
JM Anaya, R Corena, J Castiblanco, A Rojas-Villarraga, Y Shoenfeld
Expert Review of Clinical Immunology 2007
Health-related quality of life ? testing the reliability of the MSQOL-54 instrument among MS patients
S Heiskanen, P Meriläinen, AM Pietilä
Scandinavian Journal of Caring Sciences 2007
Natalizumab for Multiple Sclerosis
RM Ransohoff
New England Journal of Medicine 2007
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
V Preller, A Gerber, S Wrenger, M Togni, D Marguet, J Tadje, U Lendeckel, C Röcken, J Faust, K Neubert, B Schraven, R Martin, S Ansorge, S Brocke, D Reinhold
Journal of immunology (Baltimore, Md. : 1950) 2007
The complex etiology of multiple sclerosis
RJ Winquist, A Kwong, R Ramachandran, J Jain
Biochemical Pharmacology 2007
Gene–environment interactions in multiple sclerosis: Innate and adaptive immune responses to human endogenous retrovirus and herpesvirus antigens and the lectin complement activation pathway
T Christensen, T Petersen, S Thiel, T Brudek, S Ellermann-Eriksen, A Møller-Larsen
Journal of Neuroimmunology 2007
Expression of IL-27 p28 by Theiler's virus-infected macrophages depends on TLR3 and TLR7 activation of JNK-MAP-kinases
L Hause, FM Al-Salleeh, TM Petro
Antiviral Research 2007
Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis
FM Martín-Saavedra, N Flores, B Dorado, C Eguiluz, B Bravo, A García-Merino, S Ballester
Molecular Immunology 2007
Assimilation of omega 3 and omega 6 fatty acids and removing of cholesterol from environment by Saccharomyces cerevisiae and Saccharomyces boulardii strains
A Krasowska, A Kubik, A Prescha, M Lukaszewicz
Journal of Biotechnology 2007
Handbook of Neurochemistry and Molecular Neurobiology
VH Routh, JJ McArdle, NM Sanders, Z Song, R Wang
Handbook of Neurochemistry and Molecular Neurobiology 2007
A thermodynamic study of β-N-acetylhexosaminidase enzyme heterogeneity in cerebrospinal fluid from patients with multiple sclerosis
LF Perez, JM Prieto, JC Tutor
Upsala Journal of Medical Sciences 2007
The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes: a pilot study
RK Zabad, LM Metz, TR Todoruk, Y Zhang, JR Mitchell, M Yeung, DG Patry, RB Bell, VW Yong
Multiple sclerosis (Houndmills, Basingstoke, England) 2007
Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis
T Quirico-Santos, V Suppiah, S Heggarty, R Caetano, S Alves-Leon, K Vandenbroeck
Arquivos de Neuro-Psiquiatria 2007
Biologics in General Medicine
WH Boehncke, HH Radeke
2007
Immune Regulation and Immunotherapy in Autoimmune Disease
J Zhang
2007
Should We Inhibit Type I Interferons in Sepsis?
T Mahieu, C Libert
Infection and immunity 2007
Tolerance in the Absence of Autoantigen
Pascual DW, Ochoa-Repáraz J, Rynda A, Yang X
Endocrine, metabolic & immune disorders drug targets 2007
Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis
X Peng, J Jin, S Giri, M Montes, D Sujkowski, Y Tang, J Smrtka, T Vollmer, I Singh, S Markovic-Plese
Journal of Neuroimmunology 2006
Dysregulated T cell expression of TIM3 in multiple sclerosis
K Koguchi, DE Anderson, L Yang, KC O'Connor, VK Kuchroo, DA Hafler
Journal of Experimental Medicine 2006
CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system
RC Axtell, L Xu, SR Barnum, C Raman
Journal of immunology (Baltimore, Md. : 1950) 2006
Virus-mediated autoimmunity in Multiple Sclerosis
N Grigoriadis, GM Hadjigeorgiou
Journal of autoimmune diseases 2006
Human regulatory T cells and their role in autoimmune disease
C Baecher-Allan, DA Hafler
Immunological Reviews 2006
Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat
K Zerria, E Jerbi, S Hammami, A Maaroufi, S Boubaker, JP Xiong, MA Arnaout, DM Fathallah
Immunology 2006
Contribution of peptides to multiple sclerosis research
MC Alcaro, AM Papini
Biopolymers 2006
The role of SAP and the SLAM family in autoimmunity
AY Chan, JM Westcott, JM Mooney, EK Wakeland, JD Schatzle
Current Opinion in Immunology 2006
Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
G Loo, RD Lorenzi, H Schmidt, M Huth, A Mildner, M Schmidt-Supprian, H Lassmann, MR Prinz, M Pasparakis
Nature Immunology 2006
Glatiramer acetate-specific human CD8+ T cells: Increased IL-4 production in multiple sclerosis is reduced by glatiramer acetate treatment
A Dressel, A Vogelgesang, H Brinkmeier, M Mäder, F Weber
Journal of Neuroimmunology 2006
Effect of the treatment with methylprednisolone on the cerebrospinal fluid and serum levels of CCL2 and CXCL10 chemokines in patients with active multiple sclerosis
MA Moreira, CP Tilbery, LP Monteiro, MM Teixeira, AL Teixeira
Acta Neurologica Scandinavica 2006
FTY720 in multiple sclerosis: the emerging evidence of its therapeutic value
A Thomson
Core evidence 2006
The Autoimmune Diseases
I Kang, J Craft
The Autoimmune Diseases 2006
Catalytic autoantibodies in clinical autoimmunity and modern medicine
AG Gabibov, NA Ponomarenko, EB Tretyak, MA Paltsev, SV Suchkov
Autoimmunity Reviews 2006
Extensive extracellular matrix depositions in active multiple sclerosis lesions
J Horssen, L Bö, CD Dijkstra, HE de Vries
Neurobiology of Disease 2006
Neuroinflammation in multiple sclerosis: Evidence for autoimmune dysregulation, not simple autoimmune reaction
N Grigoriadis, S Grigoriadis, E Polyzoidou, I Milonas, D Karussis
Clinical Neurology and Neurosurgery 2006
Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis
KS Shindler, Y Guan, E Ventura, J Bennett, A Rostami
Multiple sclerosis (Houndmills, Basingstoke, England) 2006
Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis
MA Moreira, AL Souza, MA Lana-Peixoto, MM Teixeira, AL Teixeira
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2006
Multiple sclerosis: living the reality
TN Fawcett, M Lucas
British Journal of Nursing 2006
A subtype of multiple sclerosis defined by an activated immune defense program
LG van Baarsen, TC van der Pouw Kraan, JJ Kragt, JM Baggen, F Rustenburg, T Hooper, JF Meilof, MJ Fero, CD Dijkstra, CH Polman, CL Verweij
Genes and Immunity 2006
Design, Synthesis, and Biological Evaluation of Semicarbazide-Sensitive Amine Oxidase (SSAO) Inhibitors with Anti-inflammatory Activity
EY Wang, H Gao, L Salter-Cid, J Zhang, L Huang, EM Podar, A Miller, J Zhao, A O'Rourk, MD Linnik
Journal of Medicinal Chemistry 2006
Differences in Susceptibility of MBP Charge Isomers to Digestion by Stromelysin-1 (MMP-3) and Release of an Immunodominant Epitope
CA DSouza, MA Moscarello
Neurochemical Research 2006
Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen
NA Ponomarenko, OM Durova, II Vorobiev, AA Belogurov, IN Kurkova, AG Petrenko, GB Telegin, SV Suchkov, SL Kiselev, MA Lagarkova, VM Govorun, MV Serebryakova, B Avalle, P Tornatore, A Karavanov, HC 3rd, D Thomas, A Friboulet, AG Gabibov
Proceedings of the National Academy of Sciences 2005
A glycosylated synthetic probe to detect disease-specific autoantibodies, biomarkers of Multiple Sclerosis
Francesco Lolli, Barbara Mulinacci, Alfonso Carotenuto, Bruno Bonetti, Anna M. D’Ursi, Ettore Novellino, Giuseppina Sabatino, Benedetta Mazzanti, Marta Pazzagli, Laura Lovato, Maria C. Alcaro, Elisa Peroni, Maria C. Pozo-Carrero, Francesca Nuti, Luca Battistini, Giovanna Borsellino, Mario Chelli, Paolo Rovero, and Anna M. Papini*
Proceedings of the National Academy of Sciences 2005
Adenosine Deaminase and 5′Nucleotidase Activities in Peripheral Blood T Cells of Multiple Sclerosis Patients
S Vivekanandhan, CC Soundararajan, M Tripathi, MC Maheshwari
Neurochemical Research 2005
Frequency of blood CX 3 CR1‐positive natural killer cells correlates with disease activity in multiple sclerosis patients
C InfanteDuarte, A Weber, J Krätzschmar, T Prozorovski, S Pikol, I Hamann, J BellmannStrobl, O Aktas, J Dörr, J Wuerfel, CS Stürzebecher, F Zipp
The FASEB Journal 2005
Target Identification and Validation in Systemic Autoimmunity
SL Peng
Immunologic Research 2005
Immunology of multiple sclerosis
M Sospedra, R Martin
Annual Review of Immunology 2005
Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis
CE Smith, TN Eagar, JL Strominger, SD Miller
Proceedings of the National Academy of Sciences 2005
The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain
H Rus, CA Pardo, L Hu, E Darrah, C Cudrici, T Niculescu, F Niculescu, KM Mullen, R Allie, L Guo, H Wulff, C Beeton, SI Judge, DA Kerr, HG Knaus, KG Chandy, PA Calabresi
Proceedings of the National Academy of Sciences 2005
Basement Membrane Proteins in Multiple Sclerosis-Associated Inflammatory Cuffs: Potential Role in Influx and Transport of Leukocytes
J Horssen, L Bö, CM Vos, I Virtanen, HE de Vries
Journal of Neuropathology and Experimental Neurology 2005
Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis
TM Kauppinen, SW Suh, CP Genain, RA Swanson
Journal of Neuroscience Research 2005
Interferons as pathogenic effectors in autoimmunity
R Baccala, DH Kono, AN Theofilopoulos
Immunological Reviews 2005
Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
PA Muraro, DC Douek, A Packer, K Chung, FJ Guenaga, R Cassiani-Ingoni, C Campbell, S Memon, JW Nagle, FT Hakim, RE Gress, HF McFarland, RK Burt, R Martin
Journal of Experimental Medicine 2005
Can blood gene expression predict which patients with multiple sclerosis will respond to interferon?
N Kaminski, A Achiron
PLoS Medicine 2005
Association of human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses
T Christensen
Reviews in Medical Virology 2005
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
AN Theofilopoulos, R Baccala, B Beutler, DH Kono
Annual Review of Immunology 2005
Catalytic autoantibodies in multiple sclerosis: Pathogenetic and clinical aspects
VK Misikov, MV Kimova, OM Durova, AG Gabibov, SV Suchkov, II Vorob’ev, NA Ponomarenko
Bulletin of Experimental Biology and Medicine 2005
Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis
OA Bizzozero, G DeJesus, K Callahan, A Pastuszyn
Journal of Neuroscience Research 2005
Normal bone marrow hematopoietic stem cell reserves and normal stromal cell function support the use of autologous stem cell transplantation in patients with multiple sclerosis
HA Papadaki, M Tsagournisakis, V Mastorodemos, C Pontikoglou, A Damianaki, K Pyrovolaki, K Stamatopoulos, A Fassas, A Plaitakis, GD Eliopoulos
Bone Marrow Transplantation 2005
Clinical Add-on: Multiple sclerosis – clinical picture and therapeutic strategies
H Lins
Signal Transduction 2005
Causes of Unexpected Death in Patients With Multiple Sclerosis: A Forensic Study of 50 Cases
MA Riudavets, C Colegial, A Rubio, D Fowler, C Pardo, JC Troncoso
The American Journal of Forensic Medicine and Pathology 2005
Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats
M Moriya, Y Nakatsuji, T Okuno, T Hamasaki, M Sawada, S Sakoda
Journal of Neuroimmunology 2005
Downregulation of VLA-4 on T cells as a marker of long term treatment response to interferon beta-1a in MS
M Soilu-Hänninen, M Laaksonen, A Hänninen, JP Erälinna, M Panelius
Journal of Neuroimmunology 2005
Pregnancy-induced expansion of regulatory T-lymphocytes may mediate protection to multiple sclerosis activity
S Sánchez-Ramón, J Navarro, C Aristimuño, M Rodríguez-Mahou, JM Bellón, E Fernández-Cruz, C Andrés
Immunology Letters 2005
Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments
E Nizri, R Adani, H Meshulam, G Amitai, T Brenner
Neuroscience Letters 2005
Why we should offer routine vitamin D supplementation in pregnancy and childhood to prevent multiple sclerosis
A Chaudhuri
Medical Hypotheses 2005
A possible link between multiple sclerosis and Creutzfeldt–Jakob disease based on clinical, genetic, pathological and immunological evidence involving Acinetobacter bacteria
A Ebringer, T Rashid, C Wilson, R Boden, E Thompson
Medical Hypotheses 2005
MPTP and SNpc DA neuronal vulnerability: Role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview
V Jackson-Lewis, RJ Smeyne
Neurotoxicity Research 2005
Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes
LA Criswell, KA Pfeiffer, RF Lum, B Gonzales, J Novitzke, M Kern, KL Moser, AB Begovich, VE Carlton, W Li, AT Lee, W Ortmann, TW Behrens, PK Gregersen
The American Journal of Human Genetics 2005
Spread of T Lymphocyte Immune Responses to Myelin Epitopes With Duration of Multiple Sclerosis
S Davies, T Nicholson, M Laura, G Giovannoni, DM Altmann
Journal of Neuropathology and Experimental Neurology 2005
Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
PA Muraro, DC Douek, A Packer, K Chung, FJ Guenaga, R Cassiani-Ingoni, C Campbell, S Memon, JW Nagle, FT Hakim, RE Gress, HF McFarland, RK Burt, R Martin
Journal of Experimental Medicine 2005
Cannabinoids as Therapeutics
R Mechoulam
2005
Autocatalytic Cleavage of Myelin Basic Protein: An Alternative to Molecular Mimicry
CA D'Souza, DD Wood, YM She, MA Moscarello
Biochemistry 2005
MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview.
Jackson-Lewis V, Smeyne RJ
Neurotoxicity Research 2005
Suppressor T cells in human diseases
C Baecher-Allan, DA Hafler
Journal of Experimental Medicine 2004
Multiple sclerosis
A Fassas, R Nash
Best Practice & Research Clinical Haematology 2004
SH2D1A regulates T-dependent humoral autoimmunity
JD Hron, L Caplan, AJ Gerth, PL Schwartzberg, SL Peng
Journal of Experimental Medicine 2004
Fas Ligand as a Tool for Immunosuppression and Generation of Immune Tolerance
O Bohana-Kashtan, CI Civin
Stem Cells 2004
Multiple Sclerosis, Sporadic Creutzfeldt–Jakob Disease and Bovine Spongiform Encephalopathy: Are they Autoimmune Diseases Evoked by Acinetobacter Microbes Showing Molecular Mimicry to Brain Antigens?
A Ebringer, T Rashid, C Wilson, H Tiwana, AJ Green, EJ Thompson, V Chamoun, JR Croker, A Binder
Journal of nutritional & environmental medicine 2004
Models of multiple sclerosis
DM Altmann, RJ Boyton
Drug Discovery Today: Disease Models 2004
Suppressor T Cells in Human Diseases
C Baecher-Allan, DA Hafler
Journal of Experimental Medicine 2004
Targeting leukocyte integrins in human diseases
K Yonekawa, JM Harlan
Journal of leukocyte biology 2004
Development of a web-based DICOM-SR viewer for CAD data of multiple sclerosis lesions in an imaging informatics-based efolder
MY Law, TS Cook, K Ma, J Wong, M Zhong, J Zhang, B Liu
SPIE Medical Imaging
miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40
MP Mycko, M Cichalewska, H Cwiklinska, KW Selmaj
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis
G Berencsi
2012
Neuroinflammation and Peripheral Immune Infiltration in Parkinson's Disease: An Autoimmune Hypothesis
AJ Monahan, M Warren, PM Carvey
Cell Transplantation 2008
Big data in multiple sclerosis: development of a web-based longitudinal study viewer in an imaging informatics-based eFolder system for complex data analysis and management
TS Cook, J Zhang, K Ma, X Wang, A Lerner, M Shiroishi, L Amezcua, B Liu
SPIE Medical Imaging
Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?
ME Witte, JJ Geurts, HE de Vries, P van der Valk, J van Horssen
Mitochondrion 2010
Adhesion Molecules: Function and Inhibition
K Ley
2007

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