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Human African trypanosomiasis of the CNS: current issues and challenges

Peter G.E. Kennedy

Peter G.E. Kennedy

Published February 15, 2004
Citation Information: J Clin Invest. 2004;113(4):496-504. https://doi.org/10.1172/JCI21052.

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Citations to this article (117)

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Generation of neuroinflammation in human African trypanosomiasis J Rodgers, I Steiner, PG Kennedy	Neurology: Neuroimmunology & Neuroinflammation	2019
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Human African Trypanosomiasis Encephalitis in the United States: Serial Magnetic Resonance Imaging Denny MC, Lai LL, Laureno R	The Neurohospitalist	2016
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Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Thuita JK, Wolf KK, Murilla GA, Bridges AS, Boykin DW, Mutuku JN, Liu Q, Jones SK, Gem CO, Ching S, Tidwell RR, Wang MZ, Paine MF, Brun R	PLoS neglected tropical diseases	2015
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Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro. Werbovetz KA, Riccio ES, Furimsky A, Richard JV, He S, Iyer L, Mirsalis J	International Journal of Toxicology	2014
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IL-6 is upregulated in late-stage disease in monkeys experimentally infected with Trypanosoma brucei rhodesiense. Nyawira Maranga D, Kagira JM, Kinyanjui CK, Muturi Karanja S, Wangari Maina N, Ngotho M	Clinical & developmental immunology	2013
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Early Invasion of Brain Parenchyma by African Trypanosomes U Frevert, A Movila, OV Nikolskaia, J Raper, ZB Mackey, M Abdulla, J McKerrow, DJ Grab	PloS one	2012
Infektionen Schwab S, Schellinger P, Werner C, Unterberg A, Hacke W	NeuroIntensiv	2012
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Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis J Rodgers, C McCabe, G Gettinby, B Bradley, B Condon, PG Kennedy	The American journal of tropical medicine and hygiene	2011
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Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. Rodgers J, Jones A, Gibaud S, Bradley B, McCabe C, Barrett MP, Gettinby G, Kennedy PG	PLoS neglected tropical diseases	2011
Using detergent to enhance detection sensitivity of African trypanosomes in human CSF and blood by loop-mediated isothermal amplification (LAMP). Grab DJ, Nikolskaia OV, Inoue N, Thekisoe OM, Morrison LJ, Gibson W, Dumler JS	PLoS neglected tropical diseases	2011
High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei. Mackey ZB, Koupparis K, Nishino M, McKerrow JH	Chemical Biology & Drug Design	2011
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Importance of Nonenteric Protozoan Infections in Immunocompromised People JL Barratt, J Harkness, D Marriott, JT Ellis, D Stark	Clinical microbiology reviews	2010
Partial biochemical characterization of a metalloproteinase from the bloodstream forms of Trypanosoma brucei brucei parasites. de Sousa KP, Atouguia J, Silva MS	The Protein Journal	2010
Immunobiology of African trypanosomes: need of alternative interventions TN Baral	Journal of biomedicine & biotechnology	2010
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Focus-specific clinical profiles in human African Trypanosomiasis caused by Trypanosoma brucei rhodesiense. MacLean LM, Odiit M, Chisi JE, Kennedy PG, Sternberg JM	PLoS neglected tropical diseases	2010
Discovery and verification of osteopontin and Beta-2-microglobulin as promising markers for staging human African trypanosomiasis. Tiberti N, Hainard A, Lejon V, Robin X, Ngoyi DM, Turck N, Matovu E, Enyaru J, Ndung'u JM, Scherl A, Dayon L, Sanchez JC	Molecular & cellular proteomics : MCP	2010
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis. Nare B, Wring S, Bacchi C, Beaudet B, Bowling T, Brun R, Chen D, Ding C, Freund Y, Gaukel E, Hussain A, Jarnagin K, Jenks M, Kaiser M, Mercer L, Mejia E, Noe A, Orr M, Parham R, Plattner J, Randolph R, Rattendi D, Rewerts C, Sligar J, Yarlett N, Don R, Jacobs R	Antimicrobial agents and chemotherapy	2010
Novel biomarkers for late-stage human African trypanosomiasis--the search goes on. Kennedy PG	The American journal of tropical medicine and hygiene	2010
Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei. Worthen C, Jensen BC, Parsons M	PLoS neglected tropical diseases	2010
[Parasitic diseases of the central nervous system]. Schmutzhard E	Der Nervenarzt	2010
Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells DJ Grab, JC Garcia-Garcia, OV Nikolskaia, YV Kim, A Brown, CA Pardo, Y Zhang, KG Becker, BA Wilson, AP de Lima, J Scharfstein, JS Dumler	PLoS neglected tropical diseases	2009
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Rodgers J, Stone TW, Barrett MP, Bradley B, Kennedy PG	Brain : a journal of neurology	2009
Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture. Kitani H, Naessens J, Kubo M, Nakamura Y, Iraqi F, Gibson J, Yamakawa M	Parasitology Research	2009
Infectious diseases of the nervous system and their impact in developing countries. Bruzzone R, Dubois-Dalcq M, Grau GE, Griffin DE, Kristensson K	PLoS pathogens	2009
The Fatal Sleep: Africa’s killer disease that went undiscovered for centuries Linda G. Donelson and John E. Donelson	Journal of Clinical Investigation	2008
The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain L Sanderson, M Dogruel, J Rodgers, B Bradley, SA Thomas	Journal of Neurochemistry	2008
Traversal of human and animal trypanosomes across the blood-brain barrier. Grab DJ, Kennedy PG	Journal of Neurovirology	2008
Infektionen Pfister HW, Klein M, Schmutzhard E, Meyding-Lamadé U, Sellner J, Menon S, Martinez-Torres F, Helbok R, Pfausler B, Grabowski A, Kress B	NeuroIntensiv	2008
Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis. Thuita JK, Kagira JM, Mwangangi D, Matovu E, Turner CM, Masiga D	PLoS neglected tropical diseases	2008
Assembly of the Trypanosoma brucei 60S ribosomal subunit nuclear export complex requires trypanosome-specific proteins P34 and P37. Prohaska K, Williams N	Eukaryotic cell	2008
Global metabolic responses of mice to Trypanosoma brucei brucei infection. Wang Y, Utzinger J, Saric J, Li JV, Burckhardt J, Dirnhofer S, Nicholson JK, Singer BH, Brun R, Holmes E	Proceedings of the National Academy of Sciences	2008
Eliminating human African trypanosomiasis: where do we stand and what comes next? Simarro PP, Jannin J, Cattand P	PLoS Medicine	2008
Spatially and genetically distinct African Trypanosome virulence variants defined by host interferon-gamma response L Maclean, M Odiit, A Macleod, L Morrison, L Sweeney, A Cooper, PG Kennedy, JM Sternberg	The Journal of Infectious Diseases	2007
African trypanosomiasis: Sensitive and rapid detection of the sub-genus Trypanozoon by loop-mediated isothermal amplification (LAMP) of parasite DNA Njiru ZK, Mikosza AS, Matovu E, Enyaru JC, Ouma JO, Kibona SN, Thompson RC, Ndung\u2019u JM	International Journal for Parasitology	2007
Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathway. Hellman K, Prohaska K, Williams N	Eukaryotic cell	2007
Antiproliferative effect of dihydroxyacetone on Trypanosoma brucei bloodstream forms: cell cycle progression, subcellular alterations, and cell death. Uzcátegui NL, Carmona-Gutiérrez D, Denninger V, Schoenfeld C, Lang F, Figarella K, Duszenko M	Antimicrobial agents and chemotherapy	2007
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease Olga V. Nikolskaia, Ana Paula C. de A. Lima, Yuri V. Kim, John D. Lonsdale-Eccles, Toshihide Fukuma, Julio Scharfstein and Dennis J. Grab	Journal of Clinical Investigation	2006
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Prathalingham SR, Wilkinson SR, Horn D, Kelly JM	Antimicrobial agents and chemotherapy	2006
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Tasdemir D, Kaiser M, Brun R, Yardley V, Schmidt TJ, Tosun F, Rüedi P	Antimicrobial agents and chemotherapy	2006
Human African trypanosomiasis-neurological aspects. Kennedy PG	Journal of Neurology	2006
Options for field diagnosis of human african trypanosomiasis F Chappuis, L Loutan, P Simarro, V Lejon, P Büscher	Clinical microbiology reviews	2005
Parasitic central nervous system infections in immunocompromised hosts: malaria, microsporidiosis, leishmaniasis, and African trypanosomiasis. Walker M, Kublin JG, Zunt JR	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America	2005
African Trypanosomiasis: Changing Epidemiology and Consequences. Chretien JP, Smoak BL	Current Infectious Disease Reports	2005

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