Usage Information

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
Mitsuhiro Watanabe, … , David D. Moore, Johan Auwerx
Mitsuhiro Watanabe, … , David D. Moore, Johan Auwerx
Published May 15, 2004
Citation Information: J Clin Invest. 2004;113(10):1408-1418. https://doi.org/10.1172/JCI21025.
View: Text | PDF
Article Metabolism

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Abstract

We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDL secretion, and elevated serum TG in mouse models of hypertriglyceridemia. At the molecular level, CA decreases hepatic expression of SREBP-1c and its lipogenic target genes. Through the use of mouse mutants for the short heterodimer partner (SHP) and liver X receptor (LXR) α and β, we demonstrate the critical dependence of the reduction of SREBP-1c expression by either natural or synthetic farnesoid X receptor (FXR) agonists on both SHP and LXRα and LXRβ. These results suggest that strategies aimed at increasing FXR activity and the repressive effects of SHP should be explored to correct hypertriglyceridemia.

Authors

Mitsuhiro Watanabe, Sander M. Houten, Li Wang, Antonio Moschetta, David J. Mangelsdorf, Richard A. Heyman, David D. Moore, Johan Auwerx

×

Usage data is cumulative from November 2023 through November 2024.

Usage JCI PMC
Text version 1,974 733
PDF 240 146
Figure 496 15
Table 104 0
Citation downloads 105 0
Totals 2,919 894
Total Views 3,813
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement