JCI - Citations to Central role of the P2Y12 receptor in platelet activation

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Central role of the P2Y₁₂ receptor in platelet activation

Robert T. Dorsam, Satya P. Kunapuli

Robert T. Dorsam, Satya P. Kunapuli

Published February 1, 2004
Citation Information: J Clin Invest. 2004;113(3):340-345. https://doi.org/10.1172/JCI20986.

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Citations to this article (181)

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Functional dynamics of G protein coupled receptors reveal new routes for drug discovery Conflitti P, Lyman E, Sansom MS, Hildebrand P, Gutiérrez-de-Terán H, Carloni P, Ansell TB, Shuguang Y, Barth P, Robinson AS, Tate CG, Gloriam D, Grzesiek S, Eddy MT, Prosser S, Limongelli V	Nature reviews. Drug discovery	2025
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Inhibitory Effect of Clopidogrel, a P2Y(12) Receptor Antagonist, on Hematogenic Metastasis in B16-BL6 Mouse Melanoma Cells. Yoshikawa N, Xia M, Nakamura K	In vivo (Athens, Greece)	2025
Blood oxygen regulation via P2Y12R expressed in the carotid body Iring A, Baranyi M, Iring-Varga B, Mut-Arbona P, Gál ZT, Nagy D, Hricisák L, Varga J, Benyó Z, Sperlágh B	Respiratory Research	2024
Mechanisms of HIV-mediated blood-brain barrier compromise and leukocyte transmigration under the current antiretroviral era. Hernandez C, Gorska AM, Eugenin E	iScience	2024
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Outcome of tailored antiplatelet therapy in carotid stenting: a retrospective comparative study. Vigláš P, Smolka V, Raupach J, Hejčl A, Černík D, Cihlář F	CVIR endovascular	2024
Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses Sowa MA, Sun H, Wang TT, Virginio VW, Schlamp F, El Bannoudi H, Cornwell M, Bash H, Izmirly PM, Belmont HM, Ruggles KV, Buyon JP, Voora D, Barrett TJ, Berger JS	JACC: Basic to Translational Science	2024
Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion Tao Z, Wang S, Liu J, Zhu T, Jiang J, Liu S, Ma X	Advanced Science	2024
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How to Solve the Conundrum of Heparin-Induced Thrombocytopenia during Cardiopulmonary Bypass Revelly E, Scala E, Rosner L, Rancati V, Gunga Z, Kirsch M, Ltaief Z, Rusca M, Bechtold X, Alberio L, Marcucci C	Journal of Clinical Medicine	2023
Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation Su C, Zhang Z, Chen J, Tian M, Wu C, Zhang T	BMC Cardiovascular Disorders	2023
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Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets R Aiolfi, G Sitia, M Iannacone, I Brunetta, L Guidotti, Z Ruggeri	Science signaling	2022
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Targeting Platelet Activation in Abdominal Aortic Aneurysm: Current Knowledge and Perspectives. Sun W, Zheng J, Gao Y	Biomolecules	2022
Tumor Cell-Induced Platelet Aggregation as an Emerging Therapeutic Target for Cancer Therapy Strasenburg W, Jóźwicki J, Durślewicz J, Kuffel B, Kulczyk MP, Kowalewski A, Grzanka D, Drewa T, Adamowicz J	Frontiers in Oncology	2022
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Immunothrombosis and the Role of Platelets in Venous Thromboembolic Diseases Heestermans M, Poenou G, Duchez AC, Hamzeh-Cognasse H, Bertoletti L, Cognasse F	International journal of molecular sciences	2022
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Response to clopidogrel in patients undergoing lower extremity revascularization Tawil M, Maldonado TS, Xia Y, Berland T, Cayne N, Jacobowitz G, Lugo J, Lamparello P, Sadek M, Rockman C, Berger JS	Vascular	2022
The profile of inflammatory extracellular vesicles in intracerebral hemorrhage patients Sawant H, Bihl T, Nguyen D, Iwuchukwu I, Bihl J	Frontiers in stroke	2022
The Molecular Aspects of Disturbed Platelet Activation through ADP/P2Y12 Pathway in Multiple Sclerosis A Dziedzic, E Miller, J Saluk-Bijak, M Niwald, M Bijak	International journal of molecular sciences	2021
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The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO Z Chen, A Haider, J Chen, Z Xiao, L Gobbi, M Honer, U Grether, S Arnold, L Josephson, S Liang	Journal of Medicinal Chemistry	2021
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Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches Han D, Zhang J, Griffith BP, Wu ZJ	Journal of Biomechanical Engineering	2021
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Potential antiviral properties of antiplatelet agents against SARS-CoV-2 infection: an in silico perspective Abosheasha MA, El-Gowily AH, Elfiky AA	Journal of Thrombosis and Thrombolysis	2021
Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives Đukanović N, Obradović S, Zdravković M, Đurašević S, Stojković M, Tosti T, Jasnić N, Đorđević J, Todorović Z	International journal of molecular sciences	2021
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The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System G Daryabor, MR Atashzar, D Kabelitz, S Meri, K Kalantar	Frontiers in immunology	2020
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Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells Elaskalani O, Domenchini A, Abdol Razak NB, E. Dye D, Falasca M, Metharom P	Cancers	2020
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Assessment of a flow cytometry technique for studying signaling pathways in platelets: Monitoring of VASP phosphorylation in clinical samples Mallouk N, Varvat J, Berger A, Epinat M, Accassat S, Garcin A, Montmartin A, Li G, Garnier P, Mismetti P, Lambert C	Practical Laboratory Medicine	2018
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Association of polymorphisms of platelet receptors GPIa (807C>T), GPVI (13254T>C), and P2Y12 (34C>T and H1/H2 haplotype) with increased risk of periprocedural bleeding in patients undergoing coronary angiography/percutaneous coronary intervention M Sionova, P Blasko, S Jirous, D Vindis, R Rokyta, Z Motovska	POSTEP KARDIOL INTER	2017
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The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance Elaskalani O, Falasca M, Moran N, Berndt MC, Metharom P	Cancers	2017
Panax notoginseng Saponins for Treating Coronary Artery Disease: A Functional and Mechanistic Overview Duan L, Xiong X, Hu J, Liu Y, Li J, Wang J	Frontiers in pharmacology	2017
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Antiplatelet and anti-proliferative action of disintegrin from Echis multisquamatis snake venom Chernyshenko V, Petruk N, Korolova D, Kasatkina L, Gornytska O, Platonova T, Chernyshenko T, Rebriev A, Dzhus O, Garmanchuk L, Lugovskoy E	Croatian medical journal	2017
Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients Yi X, Wang C, Zhou Q, Lin J	BMC neurology	2017
Platelet receptor Gene (P2Y12, P2Y1) and platelet glycoprotein Gene (GPIIIa) polymorphisms are associated with antiplatelet drug responsiveness and clinical outcomes after acute minor ischemic stroke. Yi X, Zhou Q, Wang C, Lin J, Liu P, Fu C	European Journal of Clinical Pharmacology	2017
Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders: A Lecchi, EA Femia, S Paoletta, A Dupuis, P Ohlmann, C Gachet, KA Jacobson, K Machura, GM Podda, B Zieger, M Cattaneo	Hämostaseologie	2016
Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier N Lou, T Takano, Y Pei, AL Xavier, SA Goldman, M Nedergaard	Proceedings of the National Academy of Sciences	2016
Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on HemostasisHighlights R Piatt, DS Paul, RH Lee, SE McKenzie, LV Parise, DO Cowley, BC Cooley, W Bergmeier	Arteriosclerosis, thrombosis, and vascular biology	2016
Platelet-cytokine Complex Suppresses Tumour Growth by Exploiting Intratumoural Thrombin-dependent Platelet Aggregation YT Li, T Nishikawa, Y Kaneda	Scientific Reports	2016
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ABCC4, a plasma membrane transporter modulating platelet aggregation SB Cheepala, A Pitre, Y Fukuda, K Takenaka, Y Zhang, Y Wang, S Frase, T Pestina, TK Gartner, C Jackson, JD Schuetz	Blood	2015
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Current status of high on-treatment platelet reactivity in patients with coronary or peripheral arterial disease: Mechanisms, evaluation and clinical implications S Spiliopoulos	World journal of cardiology	2015
Personalized antiplatelet therapy with P2Y12 receptor inhibitors: benefits and pitfalls Winter MP, Koziński M, Kubica J, Aradi D, Siller-Matula JM		2015
Supportive or detrimental roles of P2Y receptors in brain pathology?—The two faces of P2Y receptors in stroke and neurodegeneration detected in neural cell and in animal model studies Förster D, Reiser G	Purinergic Signalling	2015
A New Reversible and Potent P2Y12 Receptor Antagonist (ACT-246475): Tolerability, Pharmacokinetics, and Pharmacodynamics in a First-in-Man Trial D Baldoni, S Bruderer, A Krause, M Gutierrez, P Gueret, B Astruc, J Dingemanse	Clinical Drug Investigation	2014
C-type lectin like-receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets Manne BK, Badolia R, Dangelmaier CA, Kunapuli SP	Biochemical Pharmacology	2014
P2Y Receptors in Alzheimer’s Disease Erb L, Cao C, Ajit D, Weisman GA	Biology of the cell / under the auspices of the European Cell Biology Organization	2014
Another “String to the Bow” of PJ34, a Potent Poly(ADP-Ribose)Polymerase Inhibitor: An Antiplatelet Effect through P2Y12 Antagonism? Lechaftois M, Dreano E, Palmier B, Margaill I, Marchand-Leroux C, Bachelot-Loza C, Lerouet D	PloS one	2014
Distribution of ABCB1, CYP3A5, CYP2C19, and P2RY12 gene polymorphisms in a Mexican Mestizos population. Vargas-Alarcón G, Ramírez-Bello J, de la Peña A, Calderón-Cruz B, Peña-Duque MA, Martínez-Ríos MA, Ramírez-Fuentes S, Pérez-Méndez O, Fragoso JM	Molecular Biology Reports	2014
Signaling pathways mediating adhesion and spreading through extracellular ADP and the P2Y12 receptor: Presented by Maria P. Abbracchio B Fuss	Purinergic Signalling	2013
Platelet P2Y12 is involved in murine pulmonary metastasis Y Wang, Y Sun, D Li, L Zhang, K Wang, Y Zuo, TK Gartner, J Liu	PloS one	2013
Platelet P2Y12 receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng Gao B, Huang L, Liu H, Wu H, Zhang E, Yang L, Wu X, Wang Z	British Journal of Pharmacology	2013
CYP-mediated pharmacologic interference with optimal platelet inhibition. Cuisset T, Quilici J	Journal of Cardiovascular Translational Research	2013
The ADP receptor P2Y12 regulates osteoclast function and pathologic bone remodeling Xinming Su, Desiree Floyd, Alun Hughes, Jingyu Xiang, Jochen Schneider, Ozge Uluckan, Emanuela Heller, Hongju Deng, Wei Zou, Clarissa Craft, Kaiming Wu, Angela Hirbe, Dorota Grabowska, Mark Eagleton, Sarah Townsley, Lynne Collins, David Piwnica-Worms, Thomas Steinberg, Deborah Novack, Pamela Conley, Michelle Hurchla, Michael J. Rogers, katherine weilbaecher	Journal of Clinical Investigation	2012
Increased CD39 Nucleotidase Activity on Microparticles from Patients with Idiopathic Pulmonary Arterial Hypertension SH Visovatti, MC Hyman, D Bouis, R Neubig, VV McLaughlin, DJ Pinsky	PloS one	2012
P2Y12 receptor: platelet thrombus formation and medical interventions F Moheimani, DE Jackson	International Journal of Hematology	2012
The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism B Xiang, G Zhang, H Ren, M Sunkara, AJ Morris, TK Gartner, SS Smyth, Z Li	PloS one	2012
Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12 Y Zhang, J Ye, L Hu, S Zhang, SH Zhang, Y Li, SP Kunapuli, Z Ding	Journal of Thrombosis and Haemostasis	2012
Mechanisms of Platelet Activation and Integrin αIIβ3 SJ Joo	Korean Circulation Journal	2012
Aspirin: Pharmacology and Clinical Applications EV Espinosa, JP Murad, FT Khasawneh	Thrombosis	2012
The Evolution of Antiplatelet Therapy in the Treatment of Acute Coronary Syndromes: From Aspirin to the Present Day DJ Angiolillo	Drugs	2012
Abnormal whole blood thrombi in humans with inherited platelet receptor defects FJ Castellino, Z Liang, PK Davis, RD Balsara, H Musunuru, DL Donahue, DL Smith, MJ Sandoval-Cooper, VA Ploplis, M Walsh	PloS one	2012
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects MT Holmberg, A Tornio, L Joutsi-Korhonen, M Neuvonen, PJ Neuvonen, R Lassila, M Niemi, JT Backman	British Journal of Clinical Pharmacology	2012
Coupling of P2Y receptors to G proteins and other signaling pathways Erb L, Weisman GA	Wiley interdisciplinary reviews. Membrane transport and signaling	2012
P2Y Receptors in the Mammalian Nervous System: Pharmacology, Ligands and Therapeutic Potential Weisman GA, Woods LT, Erb L, Seye CI	CNS & neurological disorders drug targets	2012
Appropriate Anti-Thrombotic/Anti-Thrombin Therapy for Thrombotic Lesions Iqbal Z, Rana G, Cohen M	Current cardiology reviews	2012
Pistacia chinensis Methanolic Extract Attenuated MAPK and Akt Phosphorylations in ADP Stimulated Rat Platelets In Vitro Park JY, Hong M, Jia Q, Lee YC, Yayeh T, Hyun E, Kwak DM, Cho JY, Rhee MH	Evidence-based complementary and alternative medicine : eCAM	2012
Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease Masud R, Shameer K, Dhar A, Ding K, Kullo IJ	Journal of Clinical Bioinformatics	2012
Comparative pharmacokinetics and pharmacodynamics of platelet adenosine diphosphate receptor antagonists and their clinical implications. Floyd CN, Passacquale G, Ferro A	Clinical Pharmacokinetics	2012
Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation S Jones, RJ Evans, MP Mahaut-Smith	British Journal of Haematology	2011
Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation H Akbar, X Shang, R Perveen, M Berryman, K Funk, JF Johnson, NN Tandon, Y Zheng	PloS one	2011
A Novel Small Molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose Mimics the Antiplatelet Actions of Insulin R Perveen, K Funk, J Thuma, SW Ridge, Y Cao, JW Akkerman, X Chen, H Akbar	PloS one	2011
Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia B Nagy, J Jin, B Ashby, MP Reilly, SP Kunapuli	Journal of Thrombosis and Haemostasis	2011
Purinergic receptors expressed in human skeletal muscle fibres Bornø A, Ploug T, Bune LT, Rosenmeier JB, Thaning P	Purinergic Signalling	2011
P2Y12 platelet inhibition in clinical practice Damman P, Woudstra P, Kuijt WJ, de Winter RJ, James SK	Journal of Thrombosis and Thrombolysis	2011
Comparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor Deflorian F, Jacobson KA	Journal of Computer-Aided Molecular Design	2011
G12/13 Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets Bhavaraju K, Lakhani PR, Dorsam RT, Jin J, Hitchcock IS, Sanjay A, Kunapuli SP	PloS one	2011
Recent advances in the pharmacogenetics of clopidogrel. Cuisset T, Morange PE, Alessi MC	Human Genetics	2011
Genotypic and phenotypic assessment of platelet function and response to P2Y12 antagonists. de Labriolle A, Doazan JP, Lemesle G, Bonello L	Current Cardiology Reports	2011
2009 World Congress on the Insulin Resistance Syndrome: Cardiovascular Disease Concepts ZT Bloomgarden	Diabetes care	2010
Deadly allies: the fatal interplay between platelets and metastasizing cancer cells L Erpenbeck, MP Schön	Blood	2010
Preinterventional Clopidogrel Response Variability for Coil Embolization of Intracranial Aneurysms: Clinical Implications Kang HS, Kwon BJ, Kim JE, Han MH		2010
Clopidogrel: A Pharmacogenomic Perspective on its Use in Coronary Artery Disease Terpening C	Clinical Medicine Insights. Cardiology	2010
Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP J Yu, N Sheung, EM Soliman, C Spirli, JA Dranoff	American journal of physiology. Gastrointestinal and liver physiology	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels S Srinivasan, F Mir, JS Huang, FT Khasawneh, SC Lam, GC le Breton	The Journal of biological chemistry	2009
Coagulation dysregulation as a barrier to xenotransplantation in the primate CC Lin, DK Cooper, A Dorling	Transplant Immunology	2009
Mechanism of activation and functional role of protein kinase Ceta in human platelets YS Bynagari, B Nagy, F Tuluc, K Bhavaraju, S Kim, KV Vijayan, SP Kunapuli	The Journal of biological chemistry	2009
Raloxifene enhances spontaneous microaggregation of platelets through upregulation of p44/p42 MAP kinase: a case report. Tokuda H, Harada A, Adachi S, Matsushima-Nishiwaki R, Natsume H, Minamitani C, Mizutani J, Otsuka T, Kozawa O	Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA	2009
The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets GF Guidetti, P Lova, B Bernardi, F Campus, G Baldanzi, A Graziani, C Balduini, M Torti	The Journal of biological chemistry	2008
CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets SM Cifuni, DD Wagner, W Bergmeier	Blood	2008
The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism G Beldi, K Enjyoji, Y Wu, L Miller, Y Banz, X Sun, SC Robson	Frontiers in bioscience : a journal and virtual library	2008
Antiplatelet drugs in cardiological practice: Established strategies and new developments Krötz F, Sohn HY, Klauss V	Vascular Health and Risk Management	2008
Rab27b regulates number and secretion of platelet dense granules T Tolmachova, M Abrink, CE Futter, KS Authi, MC Seabra	Proceedings of the National Academy of Sciences	2007
The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts P Savi, JL Zachayus, N Delesque-Touchard, C Labouret, C Hervé, MF Uzabiaga, JM Pereillo, JM Culouscou, F Bono, P Ferrara, JM Herbert	Proceedings of the National Academy of Sciences	2006
A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans JA Jakubowski, N Matsushima, F Asai, H Naganuma, JT Brandt, T Hirota, S Freestone, KJ Winters	British Journal of Clinical Pharmacology	2006
Modulation of purinergic signaling by NPP-type ectophosphodiesterases C Stefan, S Jansen, M Bollen	Purinergic Signalling	2006
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation M Holinstat, B Voss, ML Bilodeau, JN McLaughlin, J Cleator, HE Hamm	The Journal of biological chemistry	2006
P2 receptors and neuronal injury H Franke, U Krügel, P Illes	Pflügers Archiv - European Journal of Physiology	2006
Antiplatelet Drug Resistance and Drug-Drug Interactions: Role of Cytochrome P450 3A4 WC Lau, PA Gurbel	Pharmaceutical Research	2006
Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors Mamedova LK, Gao ZG, Jacobson KA	Biochemical Pharmacology	2006
Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets Minuz P, Fumagalli L, Gaino S, Tommasoli RM, Degan M, Cavallini C, Lecchi A, Cattaneo M, Lechi Santonastaso C, Berton G	Biochemical Journal	2006
S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner T Kokkola, JR Savinainen, KS Mönkkönen, MD Retamal, JT Laitinen	BMC cell biology	2005

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