Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Androgens stimulate early stages of follicular growth in the primate ovary.
K A Vendola, … , S J Weil, C A Bondy
K A Vendola, … , S J Weil, C A Bondy
Published June 15, 1998
Citation Information: J Clin Invest. 1998;101(12):2622-2629. https://doi.org/10.1172/JCI2081.
View: Text | PDF
Research Article Article has an altmetric score of 3

Androgens stimulate early stages of follicular growth in the primate ovary.

  • Text
  • PDF
Abstract

The concept that androgens are atretogenic, derived from murine ovary studies, is difficult to reconcile with the fact that hyperandrogenic women have more developing follicles than normal-cycling women. To evaluate androgen's effects on primate follicular growth and survival, normal-cycling rhesus monkeys were treated with placebo-, testosterone-(T), or dihydrotestosterone-sustained release implants, and ovaries were taken for histological analysis after 3-10 d of treatment. Growing preantral and small antral follicles up to 1 mm in diameter were significantly and progressively increased in number and thecal layer thickness in T-treated monkeys from 3-10 d. Granulosa and thecal cell proliferation, as determined by immunodetection of the Ki67 antigen, were significantly increased in these follicles. Preovulatory follicles (> 1 mm), however, were not increased in number in androgen-treated animals. Follicular atresia was not increased and there were actually significantly fewer apoptotic granulosa cells in the T-treated groups. Dihydrotestosterone treatment had identical effects, indicating that these growth-promoting actions are mediated by the androgen receptor. These findings show that, over the short term at least, androgens are not atretogenic and actually enhance follicular growth and survival in the primate. These new data provide a plausible explanation for the pathogenesis of "polycystic" ovaries in hyperandrogenism.

Authors

K A Vendola, J Zhou, O O Adesanya, S J Weil, C A Bondy

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1970 Total
Citations: 3 6 6 10 31 20 22 27 43 22 46 29 32 34 25 14 25 21 22 20 22 9 10 6 4 3 5 1 518
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2008 (21)

Title and authors Publication Year
Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review
S Palomba, A Falbo, F Zullo, F Orio
Endocrine reviews 2008
Testosterone selectively increases primary follicles in ovarian cortex grafted onto embryonic chick membranes: relevance to polycystic ovaries
AI Qureshi, SS Nussey, G Bano, P Musonda, SA Whitehead, HD Mason
Reproduction (Cambridge, England) 2008
Implications of polycystic ovary syndrome on oocyte development
DA Dumesic, DH Abbott
Seminars in reproductive medicine 2008
Polycystic ovary syndrome and oocyte developmental competence
DA Dumesic, V Padmanabhan, DH Abbott
Obstetrical & Gynecological Survey 2008
Insulin resistance and fertility in polycystic ovary syndrome
S Fica, A Albu, M Constantin, GA Dobri
Journal of medicine and life 2008
Polycystic ovary syndrome (PCOS) trilogy: a translational and clinical review
H Mason, A Colao, U Blume-Peytavi, S Rice, A Qureshi, L Pellatt, F Orio, SL Atkin
Clinical Endocrinology 2008
Changes in germ cells population and in vitro oocyte maturation in female mice with imperforated vagina
M Lenartowicz, B Brzęk, Z Polański, A Sierpniowska, J Galas, B Bilińska
Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 2008
The relationship between anti-Mullerian hormone, androgen and insulin resistance on the number of antral follicles in women with polycystic ovary syndrome
MJ Chen, WS Yang, CL Chen, MY Wu, YS Yang, HN Ho
Human Reproduction 2008
Anti-Mullerian hormone is increased in follicular fluid from unstimulated ovaries in women with polycystic ovary syndrome
M Das, DJ Gillott, E Saridogan, O Djahanbakhch
Human Reproduction 2008
Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial
K Lossl, CY Andersen, A Loft, NL Freiesleben, S Bangsboll, AN Andersen
Human Reproduction 2008
Mild ovarian stimulation for IVF
MF Verberg, NS Macklon, G Nargund, R Frydman, P Devroey, FJ Broekmans, BC Fauser
Human Reproduction Update 2008
Reply: Androgen priming before ovarian stimulation for IVF
K Lossl, CY Andersen, A Loft, AN Andersen
Human Reproduction 2008
Metformin use in infertile patients with polycystic ovary syndrome: an evidence-based overview
S Palomba, R Oppedisano, A Tolino, F Orio, F Zullo
Reproductive BioMedicine Online 2008
Puberty and Its Disorders in the Female
RL Rosenfield, DW Cooke, S Radovick
Pediatric Endocrinology 2008
Genomic approach in evaluating the role of androgens on the growth of Atlantic cod (Gadus morhua) previtellogenic oocytes
TM Kortner, E Rocha, P Silva, LF Castro, A Arukwe
Comparative Biochemistry and Physiology Part D Genomics and Proteomics 2008
Méthodes d'exploration de la fonction ovarienne
L Maitrot, S Christin-Maitre
EMC - Endocrinologie - Nutrition 2008
Androgen Actions and the Ovary
KA Walters, CM Allan, DJ Handelsman
Biology of reproduction 2008
The Macaque Ovary, with Special Reference to the Cynomolgus Macaque (Macaca fascicularis)
E Buse, M Zöller, EV Esch
Toxicologic pathology 2008
Androgens and Insulin – Two Key Players in Polycystic Ovary Syndrome
AN Schüring, N Schulte, B Sonntag, L Kiesel
Gynäkologisch-geburtshilfliche Rundschau 2008
Granulosa Cell Survival and Proliferation Are Altered in Polycystic Ovary Syndrome
M Das, O Djahanbakhch, B Hacihanefioglu, E Saridogan, M Ikram, L Ghali, M Raveendran, A Storey
The Journal of clinical endocrinology and metabolism 2008
Use of letrozole in assisted reproduction: a systematic review and meta-analysis.
Requena A, Herrero J, Landeras J, Navarro E, Neyro JL, Salvador C, Tur R, Callejo J, Checa MA, Farré M, Espinós JJ, Fábregues F, Graña-Barcia M
Human Reproduction Update 2008

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 3 patents
156 readers on Mendeley
See more details