Citations to this article

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas
David H. Viskochil
David H. Viskochil
Published December 15, 2003
Citation Information: J Clin Invest. 2003;112(12):1791-1793. https://doi.org/10.1172/JCI20503.
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Commentary

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas

Abstract

Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could influence the multicellular microenvironment of neurofibromas to inhibit the development and/or progression of these tumors in human NF

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David H. Viskochil

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Citations to this article (13)

Title and authors Publication Year
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An Unusual Intraosseous Swelling of the Jaw: Two Rare Case Reports.
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