Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target
Roger S. Smith, Barbara H. Iglewski
Roger S. Smith, Barbara H. Iglewski
Published November 15, 2003
Citation Information: J Clin Invest. 2003;112(10):1460-1465. https://doi.org/10.1172/JCI20364.
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Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target

Abstract

Pseudomonas aeruginosa has two complete quorum-sensing systems. Both of these systems have been shown to be important for Pseudomonas virulence in multiple models of infection. Thus, these systems provide unique targets for novel antimicrobial drugs.

Authors

Roger S. Smith, Barbara H. Iglewski

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Analyses of the QS-regulated transcriptome of P. aeruginosa. A compariso...
Analyses of the QS-regulated transcriptome of P. aeruginosa. A comparison of QS-induced genes from microarray experiments performed by three different research groups is shown. The data reported by Hentzer et al. (13) represent only those genes that were induced fivefold or more. The studies by Wagner et al. (11) and Schuster et al. (12) include all induced genes. A total of 97 QS-regulated genes were common to all three studies.