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Citations to this article

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
José M. Fernández-Fernández, … , Jaume Marrugat, Miguel A. Valverde
José M. Fernández-Fernández, … , Jaume Marrugat, Miguel A. Valverde
Published April 1, 2004
Citation Information: J Clin Invest. 2004;113(7):1032-1039. https://doi.org/10.1172/JCI20347.
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Article Cardiology

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension

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Abstract

Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca2+-dependent K+ (BK) channel. The BK channel in vascular smooth muscle is formed by an ion-conducting α subunit and a regulatory β1 subunit, which couples local increases in intracellular Ca2+ to augmented channel activity and vascular relaxation. Our large population-based genetic epidemiological study has identified a new single-nucleotide substitution (G352A) in the β1 gene (KCNMB1), corresponding to an E65K mutation in the protein. This mutation results in a gain of function of the channel and is associated with low prevalence of moderate and severe diastolic hypertension. BK-β1E65K channels showed increased Ca2+ sensitivity, compared with wild-type channels, without changes in channel kinetics. In conclusion, the BK-β1E65K channel might offer a more efficient negative-feedback effect on vascular smooth muscle contractility, consistent with a protective effect of the K allele against the severity of diastolic hypertension.

Authors

José M. Fernández-Fernández, Marta Tomás, Esther Vázquez, Patricio Orio, Ramón Latorre, Mariano Sentí, Jaume Marrugat, Miguel A. Valverde

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 2 2 2 3 1 5 5 5 4 5 6 9 7 3 8 9 3 4 4 2 2 91
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (9)

Title and authors Publication Year
Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches
BK Joseph, KM Thakali, CL Moore, SW Rhee
Pharmacological Research 2013
DiBAC₄(3) hits a "sweet spot" for the activation of arterial large-conductance Ca²⁺-activated potassium channels independently of the β₁-subunit
FS Scornik, RS Bucciero, Y Wu, E Selga, CB Calero, R Brugada, GJ Pérez
American journal of physiology. Heart and circulatory physiology 2013
BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating
AI Fernández-Mariño, MA Valverde, JM Fernández-Fernández
Pflügers Archiv - European Journal of Physiology 2013
Keeping you healthy: BK channel activation by omega-3 fatty acids
R Latorre, G Contreras
The Journal of General Physiology 2013
Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels
X Niu, G Liu, RS Wu, N Chudasama, SI Zakharov, A Karlin, SO Marx
PloS one 2013
Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel
RS Wu, G Liu, SI Zakharov, N Chudasama, H Motoike, A Karlin, SO Marx
The Journal of General Physiology 2013
Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies
O Carreño, R Corominas, SA Serra, C Sintas, N Fernández-Castillo, M Vila-Pueyo, C Toma, GG Gené, R Pons, M Llaneza, MJ Sobrido, D Grinberg, MÁ Valverde, JM Fernández-Fernández, A Macaya, B Cormand
Molecular Genetics & Genomic Medicine 2013
A BK (Slo1) channel journey from molecule to physiology
GF Contreras, K Castillo, N Enrique, W Carrasquel-Ursulaez, JP Castillo, V Milesi, A Neely, O Alvarez, G Ferreira, C González, R Latorre
Channels (Austin, Tex.) 2013
Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β 1-Subunit by a Novel Nonsteroidal Agent
AN Bukiya, JE McMillan, AL Fedinec, SA Patil, DD Miller, CW Leffler, AL Parrill, AM Dopico
Molecular pharmacology 2013

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