Antigen-specific lymphocytes are involved in synovial proliferation within inflamed joints. Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL). A new study demonstrates that DCs pulsed with collagen and transduced with an adenovirus-based vector able to express TRAIL limit the incidence of arthritis in a model of collagen-induced arthritis and joint inflammation. These results suggest that gene-modified cell therapy represents a therapeutic option for systemic rheumatic diseases.
George C. Tsokos, Maria Tsokos
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Defective T-Cell Apoptosis and T-Regulatory Cell Dysfunction in Rheumatoid Arthritis.
Malemud CJ |
Cells | 2018 |
Soluble trail as a marker of efficacy of allergen-specific immunotherapy in patients with allergic rhinoconjunctivitis.
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Medical science monitor : international medical journal of experimental and clinical research | 2012 |
Apigenin enhances the cytotoxic effects of tumor necrosis factor-related apoptosis-inducing ligand in human rheumatoid arthritis fibroblast-like synoviocytes
Q Sun, S Jiang, K Yang, J Zheng, L Zhang, W Xu |
Molecular Biology Reports | 2011 |
TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis
A Bisgin, E Terzioglu, C Aydin, B Yoldas, V Yazisiz, N Balci, H Bagci, RM Gorczynski, CA Akdis, S Sanlioglu |
BMC musculoskeletal disorders | 2010 |