Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery
Shimon Sakaguchi
Shimon Sakaguchi
Published November 1, 2003
Citation Information: J Clin Invest. 2003;112(9):1310-1312. https://doi.org/10.1172/JCI20274.
View: Text | PDF
Commentary

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery

  • Text
  • PDF
Abstract

Naturally arising CD4+ regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to determine their origin and developmental pathway .

Authors

Shimon Sakaguchi

×

Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 2 2 2 1 6 2 6 1 3 4 6 4 5 1 7 5 4 4 6 1 72
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (72)

Title and authors Publication Year
Too much of a good thing: a review of primary immune regulatory disorders
Tsilifis C, Slatter MA, Gennery AR
Frontiers in immunology 2023
Impact of Chlorogenic Acid on Peripheral Blood Mononuclear Cell Proliferation, Oxidative Stress, and Inflammatory Responses in Racehorses during Exercise.
Dąbrowska I, Grzędzicka J, Niedzielska A, Witkowska-Piłaszewicz O
2023
Regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function.
Negera E, Bobosha K, Aseffa A, Dockrell HM, Lockwood DNJ, Walker SL
PLoS neglected tropical diseases 2022
SPRC Suppresses Experimental Periodontitis by Modulating Th17/Treg Imbalance.
Peng Q, Zhao B, Lin J, Liu H, Zhou R, Lan D, Yao C, Cong S, Tao S, Zhu Y, Wang R, Qi S
Frontiers in Bioengineering and Biotechnology 2022
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy
V Salemme, G Centonze, F Cavallo, P Defilippi, L Conti
Frontiers in Oncology 2021
Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity.
Song D, Liu X, Dong C, Wang Q, Sha C, Liu C, Ning Z, Han J, Liu H, Zong M, Zhao Y, Li Y, Liu G, Shao X, Dou C
Scientific Reports 2021
A Nutritional Supplement (DìLsh(TM)) Improves the Inflammatory Cytokines Response, Oxidative Stress Markers and Clinical Signs in Dogs Naturally Infected by Leishmania infantum.
Mastellone V, Musco N, Vassalotti G, Piantedosi D, Vastolo A, Cutrignelli MI, Britti D, Cortese L, Lombardi P
2020
FoxP3 in T reg cell biology: a molecular and structural perspective
G Deng, X Song, MI Greene
Clinical & Experimental Immunology 2019
Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa
P Pandiyan, N Bhaskaran, M Zou, E Schneider, S Jayaraman, J Huehn
Frontiers in immunology 2019
Leptin and Immunological Profile in Obesity and Its Associated Diseases in Dogs
L Cortese, G Terrazzano, A Pelagalli
International journal of molecular sciences 2019
Screening of the growth of thymus of human fetuses
Asghar A, Asad MR, Naaz S, Rani M
Anatomy & cell biology 2019
Clinical and Immunological Response in Dogs Naturally Infected by L. infantum Treated with a Nutritional Supplement
Lombardi P, Palatucci AT, Giovazzino A, Mastellone V, Ruggiero G, Rubino V, Musco N, Crupi R, Cutrignelli MI, Britti D, Vassalotti G, Terrazzano G, Cortese L
2019
The Pungent and Hot Chinese Herbs Cause Heat Syndrome in Rats by Affecting the Regulatory T Cells
Wu DH, Xu L, Xie GQ, Fan YS, Zhou J
Evidence-based complementary and alternative medicine : eCAM 2019
Regulatory T Cells for More Targeted Immunosuppressive Therapies
H Allos, BS Dulaijan, J Choi, J Azzi
Clinics in Laboratory Medicine 2018
Molecular Mechanisms Involved in HCC Recurrence after Direct-Acting Antiviral Therapy
R Villani, G Vendemiale, G Serviddio
International journal of molecular sciences 2018
Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis
LM Pereira, ST Gomes, R Ishak, AC Vallinoto
Frontiers in immunology 2017
T-cell regulation in Erythema Nodosum Leprosum
E Negera, SL Walker, K Bobosha, R Howe, A Aseffa, HM Dokrell, DN Lockwood, PL Small
PLoS neglected tropical diseases 2017
Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision
PR Adair, YC Kim, AH Zhang, J Yoon, DW Scott
Frontiers in immunology 2017
Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60
F Wang, L Wang, J Wu, I Sokirniy, P Nguyen, T Bregnard, J Weinstock, M Mattern, I Bezsonova, WW Hancock, S Kumar, KH Baek
PloS one 2017
The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
A Bajnok, M Ivanova, J Rigó, G Toldi
Mediators of Inflammation 2017
Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome
Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez SF, Zoukhri D
Stem Cells International 2017
Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica
K Nakada-Tsukui, T Nozaki
Frontiers in immunology 2016
Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity
A Chruscinski, H Sadozai, V Rojas-Luengas, A Bartczak, R Khattar, N Selzner, GA Levy
Rambam Maimonides Medical Journal 2015
Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
AI Loewendorf, M Csete, A Flake
Frontiers in pharmacology 2015
Evaluation of transcription factor that regulates T helper 17 and regulatory T cells function in periodontal health and disease
Karthikeyan B, Talwar, Arun KV, Kalaivani S
Journal of Pharmacy & Bioallied Sciences 2015
Harnessing FOXP3 regulatory T-cells for transplantation tolerance
Herman Waldmann, Robert Hilbrands, Duncan Howie, Stephen Cobbold
Journal of Clinical Investigation 2014
Tumour Immunogenicity, Antigen Presentation, and Immunological Barriers in Cancer Immunotherapy
D Escors
New Journal of Science 2014
Prognostic value of peripheral and local forkhead box P3+ regulatory T cells in patients with non-small-cell lung cancer
HASEGAWA T, SUZUKI H, YAMAURA T, MUTO S, OKABE N, OSUGI J, HOSHINO M, HIGUCHI M, ISE K, GOTOH M
Molecular and Clinical Oncology 2014
Normal Human Pregnancy Results in Maternal Immune Activation in the Periphery and at the Uteroplacental Interface
Loewendorf AI, Nguyen TA, Yesayan MN, Kahn DA
PloS one 2014
Changes in natural Foxp3(+)Treg but not mucosally-imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the circulation of celiac disease patients
MA van Leeuwen, MF du Pré, RL van Wanrooij, LF de Ruiter, HR Raatgeep, DJ Lindenbergh-Kortleve, CJ Mulder, L Ridder, JC Escher, JN Samsom
PloS one 2013
Do Natural T Regulatory Cells become Activated to Antigen Specific T Regulatory Cells in Transplantation and in Autoimmunity?
BM Hall, GT Tran, ND Verma, KM Plain, CM Robinson, M Nomura, SJ Hodgkinson
Frontiers in immunology 2013
Regulation of intestinal homeostasis by innate immune cells
H Kayama, J Nishimura, K Takeda
Immune Network 2013
B cell-regulated immune responses in tumor models and cancer patients
C Fremd, F Schuetz, C Sohn, P Beckhove, C Domschke
OncoImmunology 2013
Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma
Dannenmann SR, Thielicke J, Stöckli M, Matter C, von Boehmer L, Cecconi V, Hermanns T, Hefermehl L, Schraml P, Moch H, Knuth A, van den Broek M
OncoImmunology 2013
FOXP3 expression and nodal metastasis of breast cancer.
Gökmen-Polar Y, Thorat MA, Sojitra P, Saxena R, Badve S
Cellular oncology (Dordrecht) 2013
IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival
DA Wainwright, IV Balyasnikova, AL Chang, AU Ahmed, KS Moon, B Auffinger, AL Tobias, Y Han, MS Lesniak
Clinical cancer research 2012
Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant
Z McIver, JJ Melenhorst, C Wu, A Grim, S Ito, I Cho, N Hensel, M Battiwalla, AJ Barrett
Haematologica 2012
Anti-CD25 Treatment Depletes Treg Cells and Decreases Disease Severity in Susceptible and Resistant Mice Infected with Paracoccidioides brasiliensis
Felonato M, Pina A, de Araujo EF, Loures FV, Bazan SB, Feriotti C, Calich VL
PloS one 2012
Proteomics plus genomics approaches in primary immunodeficiency: the case of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome
Zennaro D, Scala E, Pomponi D, Caprini E, Arcelli D, Gambineri E, Russo G, Mari A
Clinical & Experimental Immunology 2012
NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti-CD3 antibody
V Ablamunits, O Henegariu, P Preston-Hurlburt, KC Herold
European Journal of Immunology 2011
Foxp3+ Inducible Regulatory T cells Suppress Endothelial Activation and Leukocyte Recruitment1
E Maganto-García, D Bu, ML Tarrio, P Alcaide, G Newton, GK Griffin, KJ Croce, FW Luscinskas, AH Lichtman, N Grabie
Journal of immunology (Baltimore, Md. : 1950) 2011
Helios Expression Is a Marker of T Cell Activation and Proliferation
Akimova T, Beier UH, Wang L, Levine MH, Hancock WW
PloS one 2011
The concept of "compartment allergy": prilocaine injected into different skin layers
Wobser M, Gaigl Z, Trautmann A
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2011
The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation.
Jin D, Duan K, Zhang L, Peng J, Zhao Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011
Teplizumab therapy for type 1 diabetes
UB Masharani, J Becker
Expert Opinion on Biological Therapy 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma
HS McGee, DK Agrawal
American journal of respiratory and critical care medicine 2009
Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumour immunity
S Homma, S Koido, Y Sagawa, H Suzuki, H Komita, E Nagasaki, A Takahara, J Horiguchi-Yamada, H Tajiri, DC Zeldin, T Obata
Clinical & Experimental Immunology 2009
CD8+CD28− cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients
B Karagöz, O Bilgi, M Gümüs, AA Erikçi, Ö Sayan, O Türken, EG Kandemir, A Öztürk, M Yaylacı
Medical Oncology 2009
Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs
L Kolte, JC Gaardbo, K Skogstrand, LP Ryder, AK Ersbøll, SD Nielsen
Clinical & Experimental Immunology 2009
Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects
SA Long, MR Walker, M Rieck, E James, WW Kwok, S Sanda, C Pihoker, C Greenbaum, GT Nepom, JH Buckner
European Journal of Immunology 2009
Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation
Wang Q, Liu C, Zhu F, Liu F, Zhang P, Guo C, Wang X, Li H, Ma C, Sun W, Zhang Y, Chen W, Zhang L
Molecular Immunology 2009
Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
JM Lee, J Yanagawa, KA Peebles, S Sharma, JT Mao, SM Dubinett
Critical Reviews in Oncology/Hematology 2008
Induction of mucosal tolerance in SLE: A sniff or a sip away from ameliorating lupus?
HY Wu
Clinical Immunology 2008
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion
B Kavanagh, S O'Brien, D Lee, Y Hou, V Weinberg, B Rini, JP Allison, EJ Small, L Fong
Blood 2008
Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis
DE Kaplan, F Ikeda, Y Li, N Nakamoto, S Ganesan, ME Valiga, FA Nunes, KR Reddy, KM Chang
Journal of Hepatology 2008
[Active immunotherapy of urologic malignancies and tumor-mediated immunosuppression].
Kübler H, Gschwend JE
Der Urologe A 2008
Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease
S Mielke, K Rezvani, BN Savani, R Nunes, AS Yong, J Schindler, R Kurlander, V Ghetie, EJ Read, SR Solomon, ES Vitetta, AJ Barrett
Blood 2007
Adult Autoimmune Enteropathy: Mayo Clinic Rochester Experience
Akram S, Murray JA, Pardi DS, Alexander GL, Schaffner JA, Russo PA, Abraham SC
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007
Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Rαhigh cell population in solid organ transplant recipients
Codarri L, Vallotton L, Ciuffreda D, Venetz JP, Garcia M, Hadaya K, Buhler L, Rotman S, Pascual M, Pantaleo G
Journal of Experimental Medicine 2007
The different effects of indirubin on effector and CD4+CD25+ regulatory T cells in mice: potential implication for the treatment of autoimmune diseases.
Zhang A, Qu Y, Zhang B, Zhang L, Zeng C, Peng J, Ji X, Hou M, Zhao Y
Journal of Molecular Medicine 2007
Role of Gamma-Interferon in Induction of Foxp3 and Conversion of CD4+CD25- T cells to CD4+ Regulatory T Cells
Zhaojun Wang, Jian Hong, Wei Sun, Guangwu Xu, Ningli Li, Xi Chen, Ailian Liu, Lingyun Xu, Bing Sun, Jingwu Z Zhang
Journal of Clinical Investigation 2006
Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications
L Li, VA Boussiotis
Journal of Molecular Medicine 2006
Modulation of T cell function by combination of epitope specific and low dose anticytokine therapy controls autoimmune arthritis
ST Roord, E Zonneveld-Huijssoon, T Le, GP Yung, E Koffeman, A Ronaghy, N Ghahramani, P Lanza, R Billetta, BJ Prakken, S Albani
PloS one 2006
Foxp3-Expressing CD103+ Regulatory T Cells Accumulate in Dendritic Cell Aggregates of the Colonic Mucosa in Murine Transfer Colitis
Leithäuser F, Meinhardt-Krajina T, Fink K, Wotschke B, Möller P, Reimann J
The American Journal of Pathology 2006
AIRE deficiency in thymus of two patients with omenn syndrome
Patrizia Cavadini, William Vermi, Fabio Facchetti, Stefania Fontana, Seiho Nagafuchi, Evelina Mazzolari, Anna Sediva, Veronica Marrella, Anna Villa, Alain Fischer, Luigi D Notarangelo, Raffaele Badolato
Journal of Clinical Investigation 2005
Human T cell receptor signaling with modified anti-CD3 monoclonal antibody expands CD8+ T cells and induces regulatory CD8+CD25+ cells
Brygida Bisikirska, John Colgan, Jeremy Luban, Jeffrey A. Bluestone, Kevan C. Herold
Journal of Clinical Investigation 2005
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
E Bettelli, M Dastrange, M Oukka
Proceedings of the National Academy of Sciences 2005
Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor
I Bellinghausen, B König, I Böttcher, J Knop, J Saloga
Immunology 2005
CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
M Möttönen, J Heikkinen, L Mustonen, P Isomäki, R Luukkainen, O Lassila
Clinical & Experimental Immunology 2005
Regulatory T cells and type 1 diabetes.
Bisikirska BC, Herold KC
Current Diabetes Reports 2005
Tregs and transplantation tolerance
PT Walsh, DK Taylor, LA Turka
Journal of Clinical Investigation 2004

← Previous 1 2 3 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts