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Abstract
Intestinal colonic crypts are derived from a stem cell population located at the base of each crypt. A new analysis of mitochondrial function and of the rates of mitochondrial DNA (mtDNA) mutation in individual crypts shows that mtDNA mutations arise in stem cells — and at a surprisingly high frequency. Because crypts turn over extremely rapidly (about once per week), somatic mtDNA mutations can “take over the system” and even become homoplasmic, in a manner similar to what has been shown to occur in tumors.
Authors
Eric A. Schon
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Citations to this article (1)
| Title and authors | Publication | Year |
|---|---|---|
|
Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates
Y Kirita, D Kami, R Ishida, T Adachi, K Tamagaki, S Matoba, T Kusaba, S Gojo |
Scientific Reports | 2016 |
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