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Citations to this article

Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines.
L B Margolis, … , J C Grivel, P M Murphy
L B Margolis, … , J C Grivel, P M Murphy
Published May 1, 1998
Citation Information: J Clin Invest. 1998;101(9):1876-1880. https://doi.org/10.1172/JCI2015.
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Research Article Article has an altmetric score of 3

Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines.

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Abstract

The CC chemokines MIP-1alpha, MIP-1beta, and RANTES suppress replication of certain HIV-1 strains in cultured PBMC and T cell lines by blocking interaction of gp120 with CC chemokine receptor 5 (CCR5). However, the same chemokines can enhance HIV-1 replication in cultured macrophages. The net effect of chemokines on HIV-1 infection in intact lymphoid tissue, the major reservoir of HIV-1 in vivo, is unknown and unpredictable since the tissue contains both T lymphocytes and macrophages. Here we show that exogenous MIP-1alpha, MIP-1beta, and RANTES markedly suppressed replication of CCR5-tropic HIV-1 strains in blocks of human lymphoid tissue infected ex vivo. Moreover, endogenous MIP-1alpha, MIP-1beta, and RANTES were upregulated in tissues infected ex vivo with CXC chemokine receptor 4-tropic but not CCR5-tropic HIV-1. Such an upregulation may contribute to the virus phenotype shift in the course of HIV disease in vivo.

Authors

L B Margolis, S Glushakova, J C Grivel, P M Murphy

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Total citations by year

Year: 2024 2017 2011 2010 2009 2007 2005 2004 2003 2002 2001 2000 1999 1998 Total
Citations: 1 1 1 1 2 1 3 2 3 3 5 4 11 1 39
Citation information
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Citations to this article in year 2011 (1)

Title and authors Publication Year
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné
Advances in Immunology Volume 110 2011

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Referenced in 2 patents
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