Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.
Guido Silvestri, Mark B. Feinberg
Title and authors | Publication | Year |
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Immune Activation and Collateral Damage in AIDS Pathogenesis
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Frontiers in immunology | 2013 |
Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions
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Genetic variation and HIV-associated neurologic disease
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Molecular Neurobiology | 2013 |
Candida colonisation in asymptomatic HIV patients attending a tertiary hospital in Benin City, Nigeria.
Esebelahie NO, Enweani IB, Omoregie R |
The Libyan journal of medicine | 2013 |