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Evidence for a bone-kidney axis regulating phosphate homeostasis
L. Darryl Quarles
L. Darryl Quarles
Published September 1, 2003
Citation Information: J Clin Invest. 2003;112(5):642-646. https://doi.org/10.1172/JCI19687.
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Evidence for a bone-kidney axis regulating phosphate homeostasis

Abstract

A novel circulation phosphaturic hormone is postulated to regulate systemic phosphate homeostasis. Two new studies reveal that the phosphaturic factor FGF-23 is increased in hypophosphatemic subjects with McCune-Albright syndrome and that secreted frizzled-related protein-4 (sFRP-4), a factor produced by tumors derived from subjects with tumor-induced osteomalacia, also has phosphaturic activity. It remains to be established whether FGF-23 and sFRP-4 represent two distinct phosphatonins or are somehow integrated in a novel phosphate-regulating bone-kidney axis.

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L. Darryl Quarles

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Citations to this article (49)

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