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Citations to this article

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
Robert E. Hunger, … , Steven A. Porcelli, Robert L. Modlin
Robert E. Hunger, … , Steven A. Porcelli, Robert L. Modlin
Published March 1, 2004
Citation Information: J Clin Invest. 2004;113(5):701-708. https://doi.org/10.1172/JCI19655.
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Article Dermatology

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

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Abstract

Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.

Authors

Robert E. Hunger, Peter A. Sieling, Maria Teresa Ochoa, Makoto Sugaya, Anne E. Burdick, Thomas H. Rea, Patrick J. Brennan, John T. Belisle, Andrew Blauvelt, Steven A. Porcelli, Robert L. Modlin

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Journal of Experimental Medicine 2005
Spinal cord compression as a result of Rosai-Dorfman disease of the upper cervical spine in a child.
Tubbs RS, Kelly DR, Mroczek-Musulman EC, Hammers YA, Berkow RL, Oakes WJ, Grabb PA
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2005
CD1a and langerin: acting as more than Langerhans cell markers
N Mizumoto, A Takashima
Journal of Clinical Investigation 2004

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