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Citations to this article

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
Karen M. Dwyer, … , Peter J. Cowan, Anthony J.F. d’Apice
Karen M. Dwyer, … , Peter J. Cowan, Anthony J.F. d’Apice
Published May 15, 2004
Citation Information: J Clin Invest. 2004;113(10):1440-1446. https://doi.org/10.1172/JCI19560.
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Article

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

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Abstract

Extracellular nucleotides play an important role in thrombosis and inflammation, triggering a range of effects such as platelet activation and recruitment, endothelial cell activation, and vasoconstriction. CD39, the major vascular nucleoside triphosphate diphosphohydrolase (NTPDase), converts ATP and ADP to AMP, which is further degraded to the antithrombotic and anti-inflammatory mediator adenosine. Deletion of CD39 renders mice exquisitely sensitive to vascular injury, and CD39-null cardiac xenografts show reduced survival. Conversely, upregulation of CD39 by somatic gene transfer or administration of soluble NTPDases has major benefits in models of transplantation and inflammation. In this study we examined the consequences of transgenic expression of human CD39 (hCD39) in mice. Importantly, these mice displayed no overt spontaneous bleeding tendency under normal circumstances. The hCD39 transgenic mice did, however, exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. Donor hearts transgenic for hCD39 were substantially protected from thrombosis and survived longer in a mouse cardiac transplant model of vascular rejection. These thromboregulatory manifestations in hCD39 transgenic mice suggest important therapeutic potential in clinical vascular disease and in the control of serious thrombotic events that compromise the survival of porcine xenografts in primates.

Authors

Karen M. Dwyer, Simon C. Robson, Harshal H. Nandurkar, Duncan J. Campbell, Hilton Gock, Lisa J. Murray-Segal, Nella Fisicaro, Tharun B. Mysore, Elzbieta Kaczmarek, Peter J. Cowan, Anthony J.F. d’Apice

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 3 7 1 4 2 1 6 4 5 5 8 12 7 7 9 3 4 3 1 92
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2008 (3)

Title and authors Publication Year
CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation
Y Banz, G Beldi, Y Wu, B Atkinson, A Usheva, SC Robson
British Journal of Haematology 2008
Update: cardiac xenotransplantation:
B Ekser, DK Cooper
Current Opinion in Organ Transplantation 2008
Disordered Pancreatic Inflammatory Responses and Inhibition of Fibrosis in CD39-Null Mice
BM Künzli, P Nuhn, K Enjyoji, Y Banz, RN Smith, E Csizmadia, D Schuppan, PO Berberat, H Friess, SC Robson
Gastroenterology 2008

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ISSN: 0021-9738 (print), 1558-8238 (online)

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