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The enigma of sepsis

Niels C. Riedemann, … , Ren-Feng Guo, Peter A. Ward

Niels C. Riedemann, … , Ren-Feng Guo, Peter A. Ward

Published August 15, 2003
Citation Information: J Clin Invest. 2003;112(4):460-467. https://doi.org/10.1172/JCI19523.

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Citations to this article (230)

Title and authors	Publication	Year
Endothelial GSDMD Underlies Lipopolysaccharide-induced Systemic Vascular Injury and Lethality Enyong Su, Xiaoyue Song, Lili Wei, Junqiang Xue, Xuelin Cheng, Shiyao Xie, Hong Jiang, Ming Liu	JCI Insight	2025
Sepsis: the evolution of molecular pathogenesis concepts and clinical management Feng Z, Wang L, Yang J, Li T, Liao X, Kang Y, Xiao F, Zhang W	MedComm	2025
Computational Design and In Vitro and In Vivo Characterization of an ApoE-Based Synthetic High-Density Lipoprotein for Sepsis Therapy Guo L, Yuan Y, Zheng F, Zhan C, Li X	Biomolecules	2025
Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia Olney KC, de Ávila C, Todd KT, Tallant LE, Barnett JH, Gibson KA, Hota P, Pandiane AS, Durgun PC, Serhan M, Wang R, Lind ML, Forzani E, Gades NM, Thomas LF, Fryer JD	Journal of Neuroinflammation	2024
Preliminary study on the protective effect of remazolam against sepsis-induced acute respiratory distress syndrome (ARDS) Gao X, Zhang R, Wang Z, Chen Q, Lei Z, Yang Y, Tian J	PeerJ	2024
Correlation Analyses Between Serum Interleukin-7, Interleukin-15 and Lactate Provide Insights Into Their Potential Roles in the Regulation of Inflammation in Elderly Septic Patients Zhao J, Zhang Y, Wang JY, Wei B, Liu YG	Biomarker Insights	2024
Oncostatin M Receptor Type II Knockout Mitigates Inflammation and Improves Survival from Sepsis in Mice Salim SY, AlMalki N, Macala KF, Wiedemeyer A, Mueller TF, Churchill TA, Bourque SL, Khadaroo RG	Biomedicines	2023
Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling Kelestemur T, Németh ZH, Pacher P, Beesley J, Robson SC, Eltzschig HK, Haskó G	Respiratory Research	2023
Systems immunology of regulatory T cells: Can one circuit explain it all? Tripathi S, Tsang JS, Park K	Trends in Immunology	2023
Identifying Molecular Phenotypes in Sepsis: A Prospective Analysis of Two Observational Cohorts and Secondary Analysis of Two Randomised Controlled Trials Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek M, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS	The lancet. Respiratory medicine	2023
Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis Guo R, Wang J, Tang W, Xiao D	ESC Heart Failure	2023
Acute kidney injury in burns in the intensive care unit: A retrospective research Yoldaş TK, Atalay A, Balcı C, Demirağ K, Uyar M, Çankayalı İ		2023
A prognostic assessment predicated by blood culture-based bacteria clustering from real-world evidence: Novel strategies and perspectives on prevention and management of sepsis Xu S, Cai J, Doomi A, Shi J	Frontiers in Molecular Biosciences	2023
Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats Prado Y, Echeverría C, Feijóo CG, Riedel CA, Cabello-Verrugio C, Santibanez JF, Simon F	Antioxidants	2023
Endotoxin in Sepsis: Methods for LPS Detection and the Use of Omics Techniques Virzì GM, Mattiotti M, de Cal M, Ronco C, Zanella M, De Rosa S	Diagnostics	2022
Cortistatin-14 Exerts Neuroprotective Effect Against Microglial Activation, Blood-brain Barrier Disruption, and Cognitive Impairment in Sepsis-associated Encephalopathy Wen Q, Ding Q, Wang J, Yin Y, Xu S, Ju Y, Ji H, Liu B	Journal of Immunology Research	2022
Paeoniflorin Attenuated TREM-1-Mediated Inflammation in THP-1 Cells Cao L, Yang K	Journal of Healthcare Engineering	2022
Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis. Adams R, Henry KE, Sridharan A, Soleimani H, Zhan A, Rawat N, Johnson L, Hager DN, Cosgrove SE, Markowski A, Klein EY, Chen ES, Saheed MO, Henley M, Miranda S, Houston K, Linton RC, Ahluwalia AR, Wu AW, Saria S	Nature Medicine	2022
Glycosaminoglycans: Methods and Protocols K Balagurunathan, H Nakato, U Desai, Y Saijoh		2021
Molecular Mechanisms of Muscle Fatigue D Constantin-Teodosiu, D Constantin	International journal of molecular sciences	2021
Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes N Liu, C Jiang, P Cai, Z Shen, W Sun, H Xu, M Fang, X Yao, L Zhu, X Gao, J Fang, J Lin, C Guo, K Qu	Cell Reports	2021
Tong‑fu‑li‑fei decoction attenuates immunosuppression to protect the intestinal‑mucosal barrier in sepsis by inhibiting the PD‑1/PD‑L1 signaling pathway L Chen, L Li, S Zou, Q Liao, B Lv	Molecular medicine reports	2021
Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis O Sommerfeld, A Medyukhina, S Neugebauer, M Ghait, S Ulferts, A Lupp, R König, R Wetzker, S Schulz, MT Figge, M Bauer, AT Press	Molecular Therapy	2020
Extracellular DNA—A Danger Signal Triggering Immunothrombosis C Shi, L Yang, A Braun, HJ Anders	Frontiers in immunology	2020
Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways P Vinay, C Karen, K Balamurugan, KE Rajan	Journal of Molecular Neuroscience	2020
CD14 inhibition improves survival and attenuates thrombo‐inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis RS Keshari, R Silasi, NI Popescu, G Regmi, H Chaaban, JD Lambris, C Lupu, TE Mollnes, F Lupu	Journal of Thrombosis and Haemostasis	2020
Protocatechuic aldehyde from Salvia miltiorrhiza exhibits an anti-inflammatory effect through inhibiting MAPK signalling pathway Wu S, Wang Q, Wang J, Duan B, Tang Q, Sun Z, Han J, Shan C, Wang Z, Hao Z		2020
Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis Wang B, Bellot GL, Iskandar K, Chong TW, Goh FY, Tai JJ, Schwarz H, Wong SC, Pervaiz S	Scientific Reports	2020
The predisposing factors of AKI for prophylactic strategies in burn care Tsai SY, Lio CF, Shih SC, Lin CJ, Chen YT, Yu CM, Sun FJ, Kuo CF, Jia X	PeerJ	2020
Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance Alford MA, Baquir B, Santana FL, Haney EF, Hancock RE	Frontiers in microbiology	2020
Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance Ayoub Moubareck C	Membranes	2020
Defective Neutrophil Function in Patients with Sepsis Is Mostly Restored by ex vivo Ascorbate Incubation Sae-khow K, Tachaboon S, Wright HL, Edwards SW, Srisawat N, Leelahavanichkul A, Chiewchengchol D	Journal of inflammation research	2020
Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression Georgescu AM, Banescu C, Azamfirei R, Hutanu A, Moldovan V, Badea I, Voidazan S, Dobreanu M, Chirtes IR, Azamfirei L	BMC Infectious Diseases	2020
Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality G Zhao, Y Zhong, W Su, S Liu, X Song, T Hou, X Mu, MC Gong, Z Guo	Molecular and cellular biology	2019
Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis in Mice Model Y Wang, Q Liu, Q Zheng, T Liu, , X Liu, W Gao, X Bai, Z Li	Inflammation	2019
HSP-Target of Therapeutic Agents in Sepsis Treatment A Vulczak, CH Catalão, LA de Freitas, MJ Rocha	International journal of molecular sciences	2019
The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients Hasan MJ, Rabbani R, Huq SM	The Journal of Critical Care Medicine	2019
Renal Tubular Glucagon-Like Peptide-1 Receptor Expression Is Increased in Early Sepsis but Reduced in Chronic Kidney Disease and Sepsis-Induced Kidney Injury Choi JH, Kim SJ, Kwon SK, Kim HY, Jeon H	International journal of molecular sciences	2019
Anti-inflammatory, anti-oxidative stress effect of Phascolosoma esculenta oligosaccharides on Escherichia coli-induced sepsis mice Yang Z, Pan Y, Chen J, Zhang H, Wei H, Wu Z, Liu L	Food Science and Biotechnology	2019
Treatment with Recombinant Interleukin-15 (IL-15) Increases the Number of T Cells and Natural Killer (NK) Cells and Levels of Interferon-γ (IFN-γ) in a Rat Model of Sepsis Zhao X, Qi H, Zhou J, Xu S, Gao Y	Medical science monitor : international medical journal of experimental and clinical research	2019
An Aspirin a Day Keeps the Intensivist Away? Turnbull IR, Hotchkiss RS	Critical Care Medicine	2019
Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation Shi Y, Hua Q, Li N, Zhao M, Cui Y	Evidence-based complementary and alternative medicine : eCAM	2019
miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years Tacke F, Spehlmann ME, Vucur M, Benz F, Luedde M, Cardenas DV, Roy S, Loosen S, Hippe HJ, Frey N, Trautwein C, Koch A, Roderburg C, Luedde T	Mediators of Inflammation	2019
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia. Gatica S, Villegas V, Vallejos A, Olivares P, Aballai V, Lagos-Meza F, Echeverria C, Cabello-Verrugio C, Varela D, Simon F	Laboratory Investigation	2019
Macrophage P2X4 receptors augment bacterial killing and protect against sepsis Balazs Csoka, Zoltan Nemeth, Ildiko Szabo, Daryl L. Davies, Zoltan V. Varga, Janos Paloczi, Simonetta Falzoni, Francesco Di Virgilio, Rieko Muramatsu, Toshihide Yamashita, Pal Pacher, György Haskó	JCI Insight	2018
Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival A Vallejos, P Olivares, D Varela, C Echeverria, C Cabello-Verrugio, C Pérez-Leighton, F Simon	Frontiers in physiology	2018
2′-Fluoro-Pyrimidine-Modified RNA Aptamers Specific for Lipopolysaccharide Binding Protein (LBP) Aldag J, Persson T, Hartmann RK	International journal of molecular sciences	2018
Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages Sulistyowati E, Lee MY, Wu LC, Hsu JH, Dai ZK, Wu BN, Lin MC, Yeh JL		2018
Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides Saravanan R, Holdbrook DA, Petrlova J, Singh S, Berglund NA, Choong YK, Kjellström S, Bond PJ, Malmsten M, Schmidtchen A	Nature Communications	2018
Plasminogen Activator Inhibitor 1 for Predicting Sepsis Severity and Mortality Outcomes: A Systematic Review and Meta-Analysis Tipoe TL, Wu WK, Chung L, Gong M, Dong M, Liu T, Roever L, Ho J, Wong MC, Chan MT, Tse G, Wu JC, Wong SH	Frontiers in immunology	2018
Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function Leroy Joseph, Dimitra Kokkinaki, Mesele-Christina Valenti, Grace Kim, Emanuele Barca, Dhanendra Tomar, Nicholas Hoffman, Prakash Subramanyam, Henry Colecraft, Michio Hirano, Adam J. Ratner, Muniswamy Madesh, Konstantinos Drosatos, John Morrow	JCI Insight	2017
Lipocalin-2 protects the brain during inflammatory conditions SS Kang, Y Ren, CC Liu, A Kurti, KE Baker, G Bu, Y Asmann, JD Fryer	Molecular Psychiatry	2017
Impact of thrombosis on pulmonary endothelial injury and repair following sepsis CE Evans, YY Zhao	American journal of physiology. Lung cellular and molecular physiology	2017
Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database X Lu, L Xue, W Sun, J Ye, Z Zhu, H Mei	Molecular medicine reports	2017
Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients? A Dewitte, S Lepreux, J Villeneuve, C Rigothier, C Combe, A Ouattara, J Ripoche	Annals of Intensive Care	2017
白介素17对急性肺损伤时肺水肿液清除的影响		2017
The Role of Endotoxin in the Setting of Cardiorenal Syndrome Type 5 Clementi A, Virzì GM, Brocca A, Ronco C	Cardiorenal Medicine	2017
Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance Itakura J, Sato M, Ito T, Mino M, Fushimi S, Takahashi S, Yoshimura T, Matsukawa A	Scientific Reports	2017
Interleukin-17A Aggravates Middle Ear Injury Induced by Streptococcus pneumoniae through the p38 Mitogen-Activated Protein Kinase Signaling Pathway Wang W, Liu W, Liu J, Wang Z, Fan F, Ma Y, Jin C, Xiang Y, Huang Y, Zhang X, Xu W, Yin Y, He Y	Infection and immunity	2017
Disorders of nutritional status in sepsis – facts and myths Kosałka K, Wachowska E, Słotwiński R		2017
Concise Review: Mesenchymal Stromal Cell‐Based Approaches for the Treatment of Acute Respiratory Distress and Sepsis Syndromes Johnson CL, Soeder Y, Dahlke MH	Stem Cells Translational Medicine	2017
The alpha-lipoic acid derivative DHLHZn: a new therapeutic agent for acute lung injury in vivo. Shoji Y, Takeuchi H, Fukuda K, Fukunaga K, Nakamura R, Takahashi T, Wada N, Kawakubo H, Miyasho T, Hiratsuka T, Inomata M, Betsuyaku T, Kitagawa Y	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2017
Bakuchiol Protects Against Acute Lung Injury in Septic Mice. Zhang X, Chang N, Zhang Y, Ye M, Han Z, Li J, Zhang J	Inflammation	2017
Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice M Doerflinger, J Glab, C Nedeva, I Jose, A Lin, L OReilly, C Allison, M Pellegrini, RS Hotchkiss, H Puthalakath	Scientific Reports	2016
Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells M Elfeky, R Kaede, Y Okamatsu-Ogura, K Kimura	Mediators of Inflammation	2016
Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli Y Ren, L Hua, X Meng, Y Xiao, X Hao, S Guo, P Zhao, L Wang, B Dong, Y Yu, L Wang	Mediators of Inflammation	2016
Cytoplasmic translocation of high-mobility group box-1 protein is induced by diabetes and high glucose in retinal pericytes Kim J, Kim CS, Sohn E, Kim JS	Molecular medicine reports	2016
Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2 Zhang Z, Deng W, Kang R, Xie M, Billiar T, Wang H, Cao L, Tang D	Molecular Medicine	2016
Sepsis induces incomplete M2 phenotype polarization in peritoneal exudate cells in mice Watanabe N, Suzuki Y, Inokuchi S, Inoue S	Journal of Intensive Care	2016
Monitoring Sepsis Using Electrical Cell Profiling Prieto JL, Su HW, Hou HW, Vera MP, Levy BD, Baron RM, Han J, Voldman J	Lab on a Chip	2016
Cortisol Response to Low-dose (1 µg) ACTH Stimulation for the Prediction of Outcome in Patients with Systemic Inflammatory Response Syndrome Bjekić-Macut J, Radosavljević V, Andrić Z, Ilić D, Stanojlović O, Milutinović DV, Antić IB, Zdravković M, Hinić S, Macut D, Žarković M	Journal of Medical Biochemistry	2016
Adrenergic Effect on Cytokine Release After Ex Vivo Healthy Volunteers' Whole Blood LPS Stimulation. Papandreou V, Kavrochorianou N, Katsoulas T, Myrianthefs P, Venetsanou K, Baltopoulos G	Inflammation	2016
Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing B Csoka, ZH Nemeth, G Toro, M Idzko, A Zech, B Koscso, Z Spolarics, L Antonioli, K Cseri, K Erdelyi, P Pacher, G Hasko	The FASEB Journal	2015
HDL in sepsis – risk factor and therapeutic approach EE Morin, L Guo, A Schwendeman, XA Li	Frontiers in pharmacology	2015
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice R Thoonen, A Cauwels, K Decaluwe, S Geschka, RE Tainsh, J Delanghe, T Hochepied, LD Cauwer, E Rogge, S Voet, P Sips, RH Karas, KD Bloch, M Vuylsteke, JP Stasch, JV de Voorde, ES Buys, P Brouckaert	Nature Communications	2015
Tubular cross talk in acute kidney injury: a story of sense and sensibility TM El-Achkar, PC Dagher	American journal of physiology. Renal physiology	2015
Involvement of Hypoxia-Inducible Factors in the Dysregulation of Oxygen Homeostasis in Sepsis Hirota K	Cardiovascular & hematological disorders drug targets	2015
Peritoneal wash contents used to predict mortality in a murine sepsis model Kuethe JW, Midura EF, Rice TC, Caldwell CC	The Journal of surgical research	2015
Methylprednisolone Protects Cardiac Pumping Mechanics from Deteriorating in Lipopolysaccharide-Treated Rats Ko YH, Tsai MS, Chang RW, Chang CY, Wang CH, Wu MS, Liang JT, Chang KC	Frontiers in physiology	2015
Innate immunity gene expression changes in critically ill patients with sepsis and disease-related malnutrition Słotwiński R, Sarnecka A, Dąbrowska A, Kosałka K, Wachowska E, Bałan BJ, Jankowska M, Korta T, Niewiński G, Kański A, Mikaszewska-Sokolewicz M, Omidi M, Majewska K, Słotwińska SM		2015
Current views on the mechanisms of immune responses to trauma and infection Binkowska AM, Michalak G, Słotwiński R		2015
Pentoxifylline immunomodulation in the treatment of experimental chronic pulmonary paracoccidioidomycosis Lopera DE, Naranjo TW, Hidalgo JM, Echeverri L, Patiño JH, Moreno ÁR, Lenzi HL, Cano LE	Fibrogenesis & Tissue Repair	2015
Isolation of Highly Active Monoclonal Antibodies against Multiresistant Gram-Positive Bacteria Rossmann FS, Laverde D, Kropec A, Romero-Saavedra F, Meyer-Buehn M, Huebner J	PloS one	2015
Interleukin-1 Gene Cluster Polymorphisms and its Haplotypes may Predict the Risk to Develop Cervical Cancer in Tunisia. Zidi S, Sghaier I, Zouidi F, Benahmed A, Stayoussef M, Kochkar R, Gazouani E, Mezlini A, Yacoubi-Loueslati B	Pathology oncology research : POR	2015
CD39 improves survival in microbial sepsis by attenuating systemic inflammation B Csoka, ZH Nemeth, G Toro, B Koscso, E Kokai, SC Robson, K Enjyoji, RH Rolandelli, K Erdelyi, P Pacher, G Hasko	The FASEB Journal	2014
Hepatic Scavenger Receptor BI Protects Against Polymicrobial-induced Sepsis through Promoting LPS Clearance in Mice L Guo, Z Zheng, J Ai, B Huang, XA Li	The Journal of biological chemistry	2014
Erworbene Muskelschwäche des kritisch Kranken: Pathogenese, Behandlung, Rehabilitation, Outcome M Ponfick, K Bösl, J Lüdemann-Podubecka, G Neumann, M Pohl, DA Nowak, HJ Gdynia	Der Nervenarzt	2014
Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis R Gawish, R Martins, B Bohm, T Wimberger, O Sharif, K Lakovits, M Schmidt, S Knapp	The FASEB Journal	2014
The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy F Schmidt, M Kny, X Zhu, T Wollersheim, K Persicke, C Langhans, D Lodka, C Kleber, S Weber-Carstens, J Fielitz	Critical Care	2014
Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis MC Exline, S Justiniano, JL Hollyfield, F Berhe, BY Besecker, S Das, MD Wewers, A Sarkar	PloS one	2014
Paeoniflorin reduced BLP-induced inflammatory response by inhibiting the NF-κB signal transduction in pathway THP-1 cells Zhang Q, Zhou J, Huang M, Bi L, Zhou S		2014
Is nosocomial infection really the major cause of death in sepsis? Goldenberg NM, Leligdowicz A, Slutsky AS, Friedrich JO, Lee WL	Critical Care	2014
Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy Fernandez R, Nardocci G, Navarro C, Reyes EP, Acuña-Castillo C, Cortes PP	Frontiers in physiology	2014
Therapeutic interventions in sepsis: current and anticipated pharmacological agents Shukla P, Rao GM, Pandey G, Sharma S, Mittapelly N, Shegokar R, Mishra PR	British Journal of Pharmacology	2014
Anthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock Prasad KD, Trinath J, Biswas A, Sekar K, Balaji KN, Guru Row TN	Scientific Reports	2014
Persistent inflammation and T cell exhaustion in severe sepsis in the elderly Inoue S, Suzuki K, Komori Y, Morishita Y, Suzuki-Utsunomiya K, Hozumi K, Inokuchi S, Sato T	Critical Care	2014
Editorial: The intricacy of choice: can bacteria decide what type of myeloid cells to stimulate? Gabrilovich DI	Journal of leukocyte biology	2014
Toxic Shock Syndrome Toxin-1-Mediated Toxicity Inhibited by Neutralizing Antibodies Late in the Course of Continual in Vivo and in Vitro Exposure Stich N, Model N, Samstag A, Gruener CS, Wolf HM, Eibl MM	Toxins	2014
Endotoxin Induces Fibrosis in Vascular Endothelial Cells through a Mechanism Dependent on Transient Receptor Protein Melastatin 7 Activity Echeverría C, Montorfano I, Hermosilla T, Armisén R, Velásquez LA, Cabello-Verrugio C, Varela D, Simon F	PloS one	2014
Remote ischemic preconditioning prevents lipopolysaccharide-induced liver injury through inhibition of NF-κB activation in mice. Shin HJ, Won NH, Lee HW	Journal of Anesthesia	2014
Scavenger receptor class B type I and immune dysfunctions Zheng Z, Ai J, Li XA	Current opinion in endocrinology, diabetes, and obesity	2014
WAVE-1 mediates suppression of phagocytosis by phospholipid-derived DAMPs Ulrich Matt, Omar Sharif, Rui Martins, Tanja Furtner, Lorene Langeberg, Riem Gawish, Immanuel Elbau, Ana Zivkovic, Karin Lakovits, Olga Oskolkova, Bianca Doninger, Andreas Vychytil, Thomas Perkmann, Gernot Schabbauer, Christoph Binder, Valery Bochkov, John D. Scott, Sylvia Knapp	Journal of Clinical Investigation	2013
Fibrin Facilitates Both Innate and T Cell–Mediated Defense against Yersinia pestis D Luo, , MA Parent, I Mullarky-Kanevsky, FM Szaba, LW Kummer, DK Duso, M Tighe, J Hill, A Gruber, N Mackman, D Gailani, ST Smiley	Journal of immunology (Baltimore, Md. : 1950)	2013
Effect of carbon monoxide-releasing molecules II-liberated CO on suppressing inflammatory response in sepsis by interfering with nuclear factor kappa B activation W Qin, J Zhang, W Lv, X Wang, B Sun	PloS one	2013
Insulin hypersensitivity induced by hepatic PTEN gene ablation protects from murine endotoxemia PM Guenzl, R Raim, J Kral, J Brunner, E Sahin, G Schabbauer	PloS one	2013
High density lipoprotein protects against polymicrobe-induced sepsis in mice L Guo, J Ai, Z Zheng, DA Howatt, A Daugherty, B Huang, XA Li	The Journal of biological chemistry	2013
The therapeutic potential and mechanisms of action of quercetin in relation to lipopolysaccharide-induced sepsis in vitro and in vivo YC Chang, MH Tsai, WH Sheu, SC Hsieh, AN Chiang	PloS one	2013
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells C Echeverría, I Montorfano, D Sarmiento, A Becerra, F Nuñez-Villena, XF Figueroa, C Cabello-Verrugio, AA Elorza, C Riedel, F Simon	Journal of Cellular and Molecular Medicine	2013
Host innate immune responses to sepsis WJ Wiersinga, SJ Leopold, DR Cranendonk, T der Poll	Virulence	2013
Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia. Achouiti A, de Vos AF, de Beer R, Florquin S, van 't Veer C, van der Poll T	Journal of Innate Immunity	2013
IL6 trans-signaling promotes functional recovery of hypofunctional phagocytes through STAT3 activation during peritonitis T Onogawa, T Saito-Taki, H Yamamoto, T Wada	Inflammation Research	2013
Towards Clinical Applications of Anti-endotoxin Antibodies; A Re-appraisal of the Disconnect J Hurley	Toxins	2013
Sepsis Induced by Cecal Ligation and Puncture Wen H	Methods in molecular biology (Clifton, N.J.)	2013
The TFPI-2 Derived Peptide EDC34 Improves Outcome of Gram-Negative Sepsis Papareddy P, Kalle M, Sørensen OE, Malmsten M, Mörgelin M, Schmidtchen A	PLoS pathogens	2013
Chloroquine Inhibits HMGB1 Inflammatory Signaling and Protects Mice from Lethal Sepsis Yang M, Cao L, Xie M, Yu Y, Kang R, Yang L, Zhao M, Tang D	Biochemical Pharmacology	2013
The Innate Immune Response in HIV/AIDS Septic Shock Patients: A Comparative Study Amancio RT, Japiassu AM, Gomes RN, Mesquita EC, Assis EF, Medeiros DM, Grinsztejn B, Bozza PT, Castro-Faria HC Neto, Bozza FA	PloS one	2013
Autocrine Regulation of Macrophage Activation via Exocytosis of ATP and Activation of P2Y11 Receptor Sakaki H, Tsukimoto M, Harada H, Moriyama Y, Kojima S	PloS one	2013
Comparative Analysis of Hepatic CD14 Expression between Two Different Endotoxin Shock Model Mice: Relation between Hepatic Injury and CD14 Expression Hozumi H, Tada R, Murakami T, Adachi Y, Ohno N	PloS one	2013
Angiopoietin-2 may contribute to multi-organ dysfunction and death in sepsis S David, A Mukherjee, CC Ghosh, M Yano, EV Khankin, JB Wenger, SA Karumanchi, NI Shapiro, SM Parikh	Critical Care Medicine	2012
Anti-Inflammatory Activity of a Novel Family of Aryl Ureas Compounds in an Endotoxin-Induced Airway Epithelial Cell Injury Model NE Cabrera-Benitez, E Pérez-Roth, M Casula, Á Ramos-Nuez, C Ríos-Luci, C Rodríguez-Gallego, I Sologuren, V Jakubkiene, AS Slutsky, JM Padrón, J Villar, RE Morty	PloS one	2012
The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice H Miyazaki, J Morishita, M Ueki, K Nishina, S Shiozawa, N Maekawa	BMC Nephrology	2012
The Chymase Mouse Mast Cell Protease 4 Degrades TNF, Limits Inflammation, and Promotes Survival in a Model of Sepsis AM Piliponsky, CC Chen, EJ Rios, PM Treuting, A Lahiri, M Abrink, G Pejler, M Tsai, SJ Galli	The American Journal of Pathology	2012
CHOP deficiency results in elevated lipopolysaccharide-induced inflammation and kidney injury V Esposito, F Grosjean, J Tan, L Huang, L Zhu, J Chen, H Xiong, GE Striker, F Zheng	American journal of physiology. Renal physiology	2012
Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat K Takahashi, H Mizukami, K Kamata, W Inaba, N Kato, C Hibi, S Yagihashi	PloS one	2012
Fueling the flame: bioenergy couples metabolism and inflammation TF Liu, CM Brown, ME Gazzar, L McPhail, P Millet, A Rao, VT Vachharajani, BK Yoza, CE McCall	Journal of leukocyte biology	2012
Identification of sepsis subtypes in critically ill adults using gene expression profiling Maslove DM, Tang BM, McLean AS	Critical Care	2012
Chlorogenic Acid Attenuates High Mobility Group Box 1 (HMGB1) and Enhances Host Defense Mechanisms in Murine Sepsis Lee CH, Yoon SJ, Lee SM	Molecular Medicine	2012
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes Martin GS	Expert Review of Anti-infective Therapy	2012
Neutralisation of Peritoneal IL-17A Markedly Improves the Prognosis of Severe Septic Mice by Decreasing Neutrophil Infiltration and Proinflammatory Cytokines Li J, Zhang Y, Lou J, Zhu J, He M, Deng X, Cai Z	PloS one	2012
Protection from Inflammatory Organ Damage in a Murine Model of Hemophagocytic Lymphohistiocytosis Using Treatment with IL-18 Binding Protein Chiossone L, Audonnet S, Chetaille B, Chasson L, Farnarier C, Berda-Haddad Y, Jordan S, Koszinowski UH, Dalod M, Mazodier K, Novick D, Dinarello CA, Vivier E, Kaplanski G	Frontiers in immunology	2012
The birth pangs of monoclonal antibody therapeutics: The failure and legacy of Centoxin Marks L	mAbs	2012
The new vitamin E derivative, ETS-GS, protects against cecal ligation and puncture-induced systemic inflammation in rats. Koga H, Hagiwara S, Inomata M, Kono Y, Oyama Y, Kai S, Nishida T, Noguchi T	Inflammation	2012
Ecto-5′-Nucleotidase (CD73) Decreases Mortality and Organ Injury in Sepsis G Haskó, B Csóka, B Koscsó, R Chandra, P Pacher, LF Thompson, EA Deitch, Z Spolarics, L Virág, P Gergely, RH Rolandelli, ZH Németh	Journal of immunology (Baltimore, Md. : 1950)	2011
Pathophysiology of ischemic acute kidney injury AA Sharfuddin, BA Molitoris	Nature Reviews Nephrology	2011
Advances in the management of sepsis and the understanding of key immunologic defects LP Skrupky, PW Kerby, RS Hotchkiss	Anesthesiology	2011
Cecal ligation puncture procedure MG Toscano, D Ganea, AM Gamero	Journal of visualized experiments : JoVE	2011
Chronic kidney disease-induced HMGB1 elevation worsens sepsis and sepsis-induced acute kidney injury A Leelahavanichkul, Y Huang, X Hu, H Zhou, T Tsuji, R Chen, JB Kopp, J Schnermann, PS Yuen, RA Star	Kidney International	2011
G1 cell cycle arrest signaling in hepatic injury after intraperitoneal sepsis in rats Q Yang, D Liu, X Wang, R Yang, Y Shi, Y Long, H Liu, H He, X Zhou, B Tang	Inflammation Research	2011
Factor XI-Deficient Mice Display Reduced Inflammation, Coagulopathy, and Bacterial Growth during Listeriosis D Luo, FM Szaba, LW Kummer, LL Johnson, EI Tucker, A Gruber, D Gailani, ST Smiley, RP Morrison	Infection and immunity	2011
Influence of the recombinant human 70-kDa heat-shock protein on simulation of gram-positive sepsis in rats VF Ostrov, MB Evgenev, AN Murashev	Doklady Biological Sciences	2011
Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury GUO Y, YAN KP	Experimental and therapeutic medicine	2011
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients Zhang Y, Li J, Lou J, Zhou Y, Bo L, Zhu J, Zhu K, Wan X, Cai Z, Deng X	Critical Care	2011
Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection Martin-Loeches I, Papiol E, Rodríguez A, Diaz E, Zaragoza R, Granada RM, Socias L, Bonastre J, Valverdú M, Pozo JC, Luque P, Juliá-Narvaéz JA, Cordero L, Albaya A, Serón D, Rello J	Critical Care	2011
Therapeutic potential of plasma gelsolin administration in a rat model of sepsis Cohen TS, Bucki R, Byfield FJ, Ciccarelli NJ, Rosenberg B, DiNubile MJ, Janmey PA, Margulies SS	Cytokine	2011
Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice Tsoyi K, Jang HJ, Nizamutdinova IT, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC	British Journal of Pharmacology	2011
High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy Y Oyama, T Hashiguchi, N Taniguchi, S Tancharoen, T Uchimura, KK Biswas, KI Kawahara, T Nitanda, Y Umekita, M Lotz, I Maruyama	Laboratory Investigation	2010
The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth KA Cavassani, WF 4th, AP Moreira, H Wen, MA Schaller, M Ishii, DM Lindell, Y Dou, NW Lukacs, VG Keshamouni, CM Hogaboam, SL Kunkel	Blood	2010
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis J Unsinger, M McGlynn, KR Kasten, AS Hoekzema, E Watanabe, JT Muenzer, JS McDonough, J Tschoep, TA Ferguson, JE McDunn, M Morre, DA Hildeman, CC Caldwell, RS Hotchkiss	Journal of immunology (Baltimore, Md. : 1950)	2010
Cultured alveolar epithelial cells from septic rats mimic in vivo septic lung TS Cohen, GG Lawrence, SS Margulies	PloS one	2010
Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds GD Amatngalim, A Nijnik, PS Hiemstra, RE Hancock	Inflammation	2010
Gene-specific epigenetic regulation in serious infections with systemic inflammation CE McCall, B Yoza, T Liu, ME Gazzar	Journal of Innate Immunity	2010
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction Y Zhang, Y Zhou, J Lou, J Li, L Bo, K Zhu, X Wan, X Deng, Z Cai	Critical Care	2010
Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis LM Ocuin, ZM Bamboat, VP Balachandran, MJ Cavnar, H Obaid, G Plitas, RP DeMatteo	Journal of leukocyte biology	2010
Toll-Like Receptor 2 Deficiency Results in Impaired Antibody Responses and Septic Shock during Borrelia hermsii Infection GS Dickinson, H Piccone, G Sun, E Lien, L Gatto, KR Alugupalli	Infection and immunity	2010
Suppressive action of resolvin D1 on the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice MURAKAMI T, SUZUKI K, TAMURA H, NAGAOKA I	Experimental and therapeutic medicine	2010
Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis Feng H, Guo L, Song Z, Gao H, Wang D, Fu W, Han J, Li Z, Huang B, Li XA	The Journal of biological chemistry	2010
CD11c+ Cells Are Required to Prevent Progression from Local Acute Lung Injury to Multiple Organ Failure and Death Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW, Toews GB, Huffnagle GB, Olszewski MA	The American Journal of Pathology	2010
Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice. Chen Z, Zhang X, Chu X, Zhang X, Song K, Jiang Y, Yu L, Deng X	Inflammation	2010
Animal models of sepsis and sepsis-induced kidney injury Kent Doi, Asada Leelahavanichkul, Peter Yuen, Robert Star	Journal of Clinical Investigation	2009
Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response L Guo, Z Song, M Li, Q Wu, D Wang, H Feng, P Bernard, A Daugherty, B Huang, XA Li	The Journal of biological chemistry	2009
VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis P Weber, P Wang, S Maddens, PS Wang, R Wu, M Miksa, W Dong, M Mortimore, JM Golec, P Charlton	Critical Care	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
A Pivotal Role of Endothelial-Specific NF-κB Signaling in the Pathogenesis of Septic Shock and Septic Vascular Dysfunction J Ding, D Song, X Ye, SF Liu	Journal of immunology (Baltimore, Md. : 1950)	2009
New Concepts and Emerging Issues in Sepsis		2009
Quercetin Prevents LPS-Induced High-Mobility Group Box 1 Release and Proinflammatory Function D Tang, R Kang, W Xiao, H Zhang, MT Lotze, H Wang, X Xiao	American journal of respiratory cell and molecular biology	2009
Scientific and Clinical Challenges in Sepsis Ulloa L, Brunner M, Ramos L, Deitch EA	Current pharmaceutical design	2009
The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance Chen X, El Gazzar M, Yoza BK, McCall CE	The Journal of biological chemistry	2009
Toll-Like Receptor 4 Decoy, TOY, Attenuates Gram-Negative Bacterial Sepsis Jung K, Lee JE, Kim HZ, Kim HM, Park BS, Hwang SI, Lee JO, Kim SC, Koh GY	PloS one	2009
Lethal pulmonary infection with Francisella novicida is associated with severe sepsis Sharma J, Li Q, Mishra BB, Pena C, Teale JM	Journal of leukocyte biology	2009
The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes Martin G, Brunkhorst FM, Janes JM, Reinhart K, Sundin DP, Garnett K, Beale R	Critical Care	2009
Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury Gupta A, Gerlitz B, Richardson MA, Bull C, Berg DT, Syed S, Galbreath EJ, Swanson BA, Jones BE, Grinnell BW	Journal of the American Society of Nephrology : JASN	2009
Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats. Hagiwara S, Iwasaka H, Hidaka S, Hasegawa A, Koga H, Noguchi T	Intensive Care Medicine	2009
C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC	PloS one	2009
Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome K Doi, A Leelahavanichkul, X Hu, KL Sidransky, H Zhou, Y Qin, C Eisner, J Schnermann, PS Yuen, RA Star	Kidney International	2008
Functions of the complement components C3 and C5 during sepsis MA Flierl, D Rittirsch, BA Nadeau, DE Day, FS Zetoune, JV Sarma, MS Huber-Lang, PA Ward	The FASEB Journal	2008
The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis MA Flierl, D Rittirsch, AJ Chen, BA Nadeau, DE Day, JV Sarma, MS Huber-Lang, PA Ward	PloS one	2008
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis AM Piliponsky, CC Chen, T Nishimura, M Metz, EJ Rios, PR Dobner, E Wada, K Wada, S Zacharias, UM Mohanasundaram, JD Faix, M Abrink, G Pejler, RG Pearl, M Tsai, SJ Galli	Nature Medicine	2008
Crossroads in Sepsis Research Review Series: The alternative complement pathway revisited M Harboe, TE Mollnes	Journal of Cellular and Molecular Medicine	2008
Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis X Ye, J Ding, X Zhou, G Chen, SF Liu	Journal of Experimental Medicine	2008
Sepsis: Links between Pathogen Sensing and Organ Damage Crouser E, Exline M, Knoell D, Wewers MD	Current pharmaceutical design	2008
“Crossroads in Sepsis Research” Review Series Overview of the pathophysiology of sepsis Lupu F	Journal of Cellular and Molecular Medicine	2008
Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression. Yue G, Shi G, Azaro MA, Yang Q, Hu G, Luo M, Yin K, Nagele RG, Fine DH, Yang JM, Li H	BMC Genomics	2008
Inflammatory response in microvascular endothelium in sepsis: role of oxidants. Cepinskas G, Wilson JX	Journal of Clinical Biochemistry and Nutrition	2008
Mitochondrial mechanisms of sepsis-induced organ failure. Exline MC, Crouser ED	Frontiers in bioscience : a journal and virtual library	2008
Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis. Plitas G, Burt BM, Nguyen HM, Bamboat ZM, DeMatteo RP	Journal of Experimental Medicine	2008
Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1. Chorny A, Delgado M	The American Journal of Pathology	2008
Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis H Zhu, Y Tang, L Ivanciu, M Centola, C Lupu, FB Taylor, F Lupu	BMC Genomics	2007
Role of A2A adenosine receptors in regulation of opsonized E. coli-induced macrophage function B Csóka, ZH Németh, Z Selmeczy, B Koscsó, P Pacher, ES Vizi, EA Deitch, G Haskó	Purinergic Signalling	2007
Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction HF Brooks, CK Osabutey, RF Moss, PL Andrews, DC Davies	Metabolic Brain Disease	2007
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis FA Bozza, JI Salluh, AM Japiassu, M Soares, EF Assis, RN Gomes, MT Bozza, HC Castro-Faria-Neto, PT Bozza	Critical Care	2007
Sepsis JM O’Brien, NA Ali, SK Aberegg, E Abraham	The American Journal of Medicine	2007
Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Wen H, Dou Y, Hogaboam CM, Kunkel SL	Blood	2007
A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. Li W, Ashok M, Li J, Yang H, Sama AE, Wang H	PloS one	2007
Benefit-risk assessment of drotrecogin alfa (activated) in the treatment of sepsis. De Backer D	Drug Safety	2007
Functional significance of gene polymorphisms in the promoter of myeloid differentiation-2. Gu W, Shan YA, Zhou J, Jiang DP, Zhang L, Du DY, Wang ZG, Jiang JX	Annals of Surgery	2007
Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Gao L, Flores C, Fan-Ma S, Miller EJ, Moitra J, Moreno L, Wadgaonkar R, Simon B, Brower R, Sevransky J, Tuder RM, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Ye SQ, Barnes KC, Garcia JG	Translational research : the journal of laboratory and clinical medicine	2007
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL	Journal of Experimental Medicine	2007
Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury. Hagiwara S, Iwasaka H, Noguchi T	Journal of Anesthesia	2007
High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei. Wiersinga WJ, Dessing MC, Kager PA, Cheng AC, Limmathurotsakul D, Day NP, Dondorp AM, van der Poll T, Peacock SJ	Infection and immunity	2007
Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis ZH Németh, B Csóka, J Wilmanski, D Xu, Q Lu, C Ledent, EA Deitch, P Pacher, Z Spolarics, G Haskó	Journal of immunology (Baltimore, Md. : 1950)	2006
Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis DJ Schaer, CA Schaer, G Schoedon, A Imhof, MO Kurrer	European Journal of Haematology	2006
Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome L Fialkow, LF Filho, MC Bozzetti, AR Milani, EM Filho, RM Ladniuk, P Pierozan, RM de Moura, JC Prolla, E Vachon, GP Downey	Critical Care	2006
Lipoproteins in inflammation and sepsis. I. Basic science O Murch, M Collin, CJ Hinds, C Thiemermann	Intensive Care Medicine	2006
Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile H Wen, CM Hogaboam, J Gauldie, SL Kunkel	The American Journal of Pathology	2006
Protective effect of exogenous 70-kDa heat shock protein during endotoxic shock (sepsis). Kustanova GA, Murashev AN, Guzhova IV, Margulis BA, Prokhorenko IR, Grachev SV, Evgen'ev MB		2006
IL-1 resets glucose homeostasis at central levels. Del Rey A, Roggero E, Randolf A, Mahuad C, McCann S, Rettori V, Besedovsky HO	Proceedings of the National Academy of Sciences	2006
Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats. Kustanova GA, Murashev AN, Karpov VL, Margulis BA, Guzhova IV, Prokhorenko IR, Grachev SV, Evgen'ev MB	Cell Stress & Chaperones	2006
Modulation of inflammatory response in sepsis by proteasome inhibition. Safránek R, Ishibashi N, Oka Y, Ozasa H, Shirouzu K, Holecek M	International Journal of Experimental Pathology	2006
[Sepsis. Update on pathophysiology, diagnostics and therapy]. Bauer M, Brunkhorst F, Welte T, Gerlach H, Reinhart K	Der Anaesthesist	2006
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Conte D, Holcik M, Lefebvre CA, Lacasse E, Picketts DJ, Wright KE, Korneluk RG	Molecular and cellular biology	2006
The N-terminal Domain of Thrombomodulin Sequesters HMGB1: A Novel Anti-inflammatory Mechanism Kazuhiro Abeyama, David M. Stern, Yuji Ito, Ko-ichi Kawahara1, Yasushi Yoshimoto, Motoyuki Tanaka, Tomonori Uchimura, Nobuo Ida, Yoshiaki Yamazaki, Shingo Yamada, Yasuhiko Yamamoto, Hiroshi Yamamoto, Satoshi Iino, Noboru Taniguchi, Ikuro Maruyama	Journal of Clinical Investigation	2005
Role of Thromboxane A 2 in the Induction of Apoptosis of Immature Thymocytes by Lipopolysaccharide PN Rocha, TJ Plumb, LA Robinson, R Spurney, D Pisetsky, BH Koller, TM Coffman	Clinical and vaccine immunology : CVI	2005
Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS) RF Chen, JC Chang, WT Yeh, CH Lee, JW Liu, HL Eng, KD Yang	Microbes and infection / Institut Pasteur	2005
Induction of the Heat Shock Response In Vivo Inhibits NF-κB Activity and Protects Murine Liver from Endotoxemia-Induced Injury D Chen, J Pan, B Du, D Sun	Journal of Clinical Immunology	2005
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock Q Zhao, X Wang, LD Nelin, Y Yao, R Matta, ME Manson, RS Baliga, X Meng, CV Smith, JA Bauer, CH Chang, Y Liu	Journal of Experimental Medicine	2005
Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country TANRIOVER MD, GUVEN GS, SEN D, UNAL S, UZUN O	Epidemiology and Infection	2005
Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models. Corral J, Yélamos J, Hernández-Espinosa D, Monreal Y, Mota R, Arcas I, Miñano A, Parrilla P, Vicente V	The American Journal of Pathology	2005
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis Song Hui Jia, Yue Li, Jean Parodo, Andras Kapus, Lingzhi Fan, Ori D. Rotstein, John C. Marshall	Journal of Clinical Investigation	2004
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells Vishwa Deep Dixit, Eric M Schaffer, Robert S Pyle, Gary D Collins, Senthil K Sakthivel, Ravichandran Palaniappan, James W Lillard, Dennis D Taub	Journal of Clinical Investigation	2004
Reversal of long-term sepsis-induced immunosuppression by dendritic cells CF Benjamim, SK Lundy, NW Lukacs, CM Hogaboam, SL Kunkel	Blood	2004
Sepsis: avoiding its deadly toll T Decker	Journal of Clinical Investigation	2004
Progress in the Understanding of the Protein C Anticoagulant Pathway B Dahlbäck	International Journal of Hematology	2004
Necrotizing pancreatitis: a surgical approach independent of documented infection. Harris HW, Barcia A, Schell MT, Thoeni RF, Schecter WP	HPB : the official journal of the International Hepato Pancreato Biliary Association	2004
Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study. Morgenthaler NG, Struck J, Christ-Crain M, Bergmann A, Müller B	Critical Care	2004
A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Ganopolsky JG, Castellino FJ	The American Journal of Pathology	2004
Toll-like Receptors and Sepsis. Ishii KJ, Akira S	Current Infectious Disease Reports	2004
Comparative effects of ciprofloxacin and ceftazidime on cytokine production in patients with severe sepsis caused by gram-negative bacteria. Gogos CA, Skoutelis A, Lekkou A, Drosou E, Starakis I, Marangos MN, Bassaris HP	Antimicrobial agents and chemotherapy	2004
Bench-to-bedside review: understanding genetic predisposition to sepsis. Villar J, Maca-Meyer N, Pérez-Méndez L, Flores C	Critical Care	2004
Is there a place for N-acetylcysteine in the treatment of septic shock? Del Sorbo L, Zhang H	Critical Care	2004
Septic Encephalopathy J Maher, GB Young	Journal of Intensive Care Medicine	1993

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