Originating in the thyroid, the prohormone thyroxine is converted to triiodothyronine, which is essential in brain development, growth, and metabolism. A study in this issue reveals a novel mechanism for controlling triiodothyronine production that provides the first example of enzyme activity being restored by deubiquitination.
Ronald J. Koenig
Title and authors | Publication | Year |
---|---|---|
Increased Sensitivity of Thyroid Hormone-mediated Signaling Despite Prolonged Fasting
B Martinez, M Scheibner, JG Soñanez-Organis, JT Jaques, DE Crocker, RM Ortiz |
General and Comparative Endocrinology | 2017 |