Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting, we produced double mutant mice homozygous for both Agtr1a and Agtr1b null mutation (Agtr1a-/-; Agtr1b-/-) by mating the single gene mutants. Agtr1a-/-, Agtr1b-/- mice are characterized by normal in utero survival but decreased ex utero survival rate. After birth they are characterized by low body weight gain, marked hypotension, and abnormal kidney morphology including delayed maturity in glomerular growth, hypoplastic papilla, and renal arterial hypertrophy. These abnormal phenotypes are quantitatively similar to those found in mutant mice homozygous for the angiotensinogen gene (Agt-/-), indicating that major biological functions of endogenous Ang elucidated by the abnormal phenotypes of Agt-/- are mediated by the AT1 receptors. Infusion of Ang II, AT1 blockers, or an AT2 blocker was without effect on blood pressure in Agtr1a-/-; Agtr1b-/- mice, indicating that AT2 receptor does not exert acute depressor effects in these mice lacking AT1 receptors. Also, unlike Agt-/- mice, some Agtr1a-/-; Agtr1b-/- mice have a large ventricular septum defect, suggesting that another receptor such as AT2 is functionally activated in Agtr1a-/-, Agtr1b-/- mice.
S Tsuchida, T Matsusaka, X Chen, S Okubo, F Niimura, H Nishimura, A Fogo, H Utsunomiya, T Inagami, I Ichikawa
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Nephron progenitor fate is modulated by angiotensin type 1 receptor signaling in human kidney organoids
Chung H, Rahmani W, Sinha S, Imanzadeh A, Pun A, Arora R, Jaffer A, Biernaskie J, Chun J |
Stem Cells | 2025 |
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International journal of molecular sciences | 2024 |
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American Journal of Physiology - Renal Physiology | 2024 |
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Scientific Reports | 2022 |
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Hirofumi Watanabe, Alexandre G. Martini, Evan Brown, Xiuyin Liang, Silvia Medrano, Shin Goto, Ichiei Narita, Lois J. Arend, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez |
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Targeting the Renin–Angiotensin–Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins
CN Hsu, YL Tain |
International journal of molecular sciences | 2021 |
Advances in use of mouse models to study the renin-angiotensin system
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Circulation research | 2021 |
Advances in use of mouse models to study the renin-angiotensin system
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Molecular and Cellular Endocrinology | 2021 |
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IV Yosypiv |
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Hypertension | 2020 |
Sequence variants in the renin–angiotensin system genes are associated with isolated multicystic dysplastic kidney in children
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Reproductive sciences (Thousand Oaks, Calif.) | 2020 |
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The Journal of Physiological Sciences | 2019 |
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American journal of physiology. Renal physiology | 2019 |
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COX-2-derived PGE2 triggers hyperplastic renin expression and hyperreninemia in aldosterone synthase-deficient mice
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Pediatric Hypertension
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Pediatric Hypertension | 2017 |
Chronic Stimulation of Renin Cells Leads to Vascular PathologyNovelty and Significance
M Oka, S Medrano, ML Sequeira-Lόpez, RA Gómez |
Hypertension | 2017 |
Fate of Renin Cells During Development and Disease
RA Gomez |
Hypertension | 2017 |
Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes
T Kamo, H Akazawa, J Suzuki, I Komuro |
Inflammation and Regeneration | 2016 |
Kidney Development, Disease, Repair and Regeneration
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Pediatric Kidney Disease
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International Heart Journal | 2015 |
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Scientific Reports | 2015 |
A role for the extracellular matrix component hyaluronan in kidney dysfunction during ACE-inhibitor fetopathy
P Hansell, F Palm |
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LC Matavelli, HM Siragy |
Journal of Cardiovascular Pharmacology | 2015 |
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XC Li, JL Zhuo |
Colloquium Series on Integrated Systems Physiology From Molecule to Function | 2015 |
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RA Gomez, ML Sequeira-Lopez |
Physiology (Bethesda, Md.) | 2015 |
Comprehensive Physiology
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Comprehensive Physiology | 2014 |
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DJ Campbell |
Frontiers in Endocrinology | 2014 |
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S Hibino, H Sasaki, Y Abe, A Hojo, M Uematsu, T Sekine, K Itabashi |
Pediatric Nephrology | 2014 |
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HM Rasouly, W Lu |
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IV Yosypiv |
Pediatric Nephrology | 2013 |
Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme
RA Gonzalez-Villalobos, XZ Shen, EA Bernstein, T Janjulia, B Taylor, JF Giani, WL Blackwell, KH Shah, PD Shi, S Fuchs, KE Bernstein |
Journal of Molecular Medicine | 2013 |
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich |
Seldin and Giebisch's The Kidney | 2013 |
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K Madsen, AR Tinning, N Marcussen, BL Jensen |
Acta Physiologica | 2013 |
Frontiers in Neuroscience: Transduction and Integration
D Daniels |
Frontiers in neuroscience | 2013 |
Fate and plasticity of renin precursors in development and disease
RA Gomez, B Belyea, S Medrano, ES Pentz, ML Sequeira-Lopez |
Pediatric Nephrology | 2013 |
Chronic unilateral ureteral obstruction in the neonatal mouse delays maturation of both kidneys and leads to late formation of atubular glomeruli
MS Forbes, BA Thornhill, CI Galarreta, JJ Minor, KA Gordon, RL Chevalier |
American journal of physiology. Renal physiology | 2013 |
A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists
MC Michel, C Foster, HR Brunner, L Liu, DM Perez |
Pharmacological reviews | 2013 |
A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme
KE Bernstein, FS Ong, WL Blackwell, KH Shah, JF Giani, RA Gonzalez-Villalobos, XZ Shen, S Fuchs, RM Touyz |
Pharmacological reviews | 2012 |
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R Song, IV Yosypiv |
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R Song, G Preston, A Khalili, SS El-Dahr, IV Yosypiv |
American journal of physiology. Renal physiology | 2012 |
Long-term blood pressure control: is there a set-point in the brain?
Y Nishida, M Tandai-Hiruma, T Kemuriyama, K Hagisawa |
The Journal of Physiological Sciences | 2012 |
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D Fournier, FC Luft, M Bader, D Ganten, MA Andrade-Navarro |
Journal of Molecular Medicine | 2012 |
Brenner and Rector's The Kidney
C Brugnara, KU Eckardt |
Brenner and Rector's The Kidney | 2012 |
AT1a receptor signaling is required for basal and water deprivation-induced urine concentration in AT1a receptor-deficient mice
XC Li, Y Shao, JL Zhuo |
American journal of physiology. Renal physiology | 2012 |
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J Gao, J Chao, KJ Parbhu, L Yu, L Xiao, F Gao, L Gao |
Journal of the renin-angiotensin-aldosterone system : JRAAS | 2012 |
Ontogeny of angiotensin type 2 and type 1 receptor expression in mice
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Angiotensin II regulates growth of the developing papillas ex vivo
R Song, G Preston, A Khalili, SS El-Dahr, IV Yosypiv |
American journal of physiology. Renal physiology | 2012 |
Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice
F Yiannikouris, M Karounos, R Charnigo, VL English, DL Rateri, A Daugherty, LA Cassis |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2012 |
AT 1a receptor signaling is required for basal and water deprivation-induced urine concentration in AT 1a receptor-deficient mice
XC Li, Y Shao, JL Zhuo |
American journal of physiology. Renal physiology | 2012 |
Cardiac Adaptations: Molecular Mechanisms
B Ostadal, NS Dhalla |
2012 | |
Angiotensin II Type 1 Receptor Signaling Regulates Feeding Behavior through Anorexigenic Corticotropin-releasing Hormone in Hypothalamus*
R Yamamoto, H Akazawa, H Fujihara, Y Ozasa, N Yasuda, K Ito, Y Kudo, Y Qin, Y Ueta, I Komuro |
The Journal of biological chemistry | 2011 |
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ML Lopez, RA Gomez |
Journal of the American Society of Nephrology : JASN | 2011 |
(Pro)renin Receptor in Kidney Development and Disease
R Song, IV Yosypiv |
International Journal of Nephrology | 2011 |
Wnt signaling and renal medulla formation
J Yu |
Pediatric Nephrology | 2011 |
Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice
F Yiannikouris, M Karounos, R Charnigo, VL English, DL Rateri, A Daugherty, LA Cassis |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2011 |
Renin–angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms
IV Yosypiv |
Pediatric Nephrology | 2011 |
Blood pressure and renal hemodynamic effects of angiotensin fragments
R Yang, I Smolders, AG Dupont |
Hypertension Research | 2011 |
Renin–angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms
IV Yosypiv |
Pediatric Nephrology | 2011 |
Genetic polymorphisms of the renin-angiotensin system and obesity-related metabolic changes in response to low-energy diets in obese women
T Hamada, K Kotani, N Nagai, K Tsuzaki, Y Sano, Y Matsuoka, M Fujibayashi, N Kiyohara, S Tanaka, M Yoshimura, K Egawa, Y Kitagawa, Y Kiso, T Moritani, N Sakane |
Nutrition | 2011 |
Endothelial cell-specific aryl hydrocarbon receptor knockout mice exhibit hypotension mediated, in part, by an attenuated angiotensin II responsiveness
LN Agbor, KM Elased, MK Walker |
Biochemical Pharmacology | 2011 |
Protein kinase C inhibitor prevents renal apoptotic and fibrotic changes in response to partial ureteric obstruction : PKC INHIBITOR TREATMENT IN OBSTRUCTIVE NEPHROPATHY
YS Juan, SM Chuang, CY Long, RJ Lin, KM Liu, WJ Wu, CH Huang |
BJU International | 2011 |
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis
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Human Mutation | 2011 |
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani |
Fetal and Neonatal Physiology | 2011 |
Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review
C Wu, H Lu, LA Cassis, A Daugherty |
North American journal of medicine & science | 2011 |
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C Comiter |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2011 |
The renin angiotensin system and the metabolic syndrome
CH Wang, F Li, N Takahashi |
The open hypertension journal | 2010 |
The renin phenotype: roles and regulation in the kidney
ML Lopez, RA Gomez |
Current Opinion in Nephrology and Hypertension | 2010 |
The MicroRNA-Processing Enzyme Dicer Maintains Juxtaglomerular Cells
ML Sequeira-Lopez, ET Weatherford, GR Borges, MC Monteagudo, ES Pentz, BD Harfe, O Carretero, CD Sigmund, RA Gomez |
Journal of the American Society of Nephrology : JASN | 2010 |
Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis
M Sata, D Fukuda |
The Journal of Medical Investigation | 2010 |
Histone Deacetylases Are Critical Regulators of the Renin-Angiotensin System During Ureteric Bud Branching Morphogenesis
R Song, TV Buren, IV Yosypiv |
Pediatric Research | 2010 |
Angiotensin II-induced activation of c-Ret signaling is critical in ureteric bud branching morphogenesis
R Song, M Spera, C Garrett, IV Yosypiv |
Mechanisms of Development | 2010 |
An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice
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Biochemical Pharmacology | 2010 |
Histone deacetylases are critical regulators of the renin-angiotensin system during ureteric bud branching morphogenesis
R Song, TV Buren, IV Yosypiv |
Pediatric Research | 2010 |
Pediatric Urology
C Bouvattier |
Pediatric Urology | 2010 |
Angiotensin II AT 2 receptor regulates ureteric bud morphogenesis
R Song, M Spera, C Garrett, SS El-Dahr, IV Yosypiv |
American journal of physiology. Renal physiology | 2010 |
Comparative effect of direct renin inhibition and AT 1 R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat
A Whaley-Connell, R Nistala, J Habibi, MR Hayden, RI Schneider, MS Johnson, R Tilmon, N Rehmer, CM Ferrario, JR Sowers |
American journal of physiology. Renal physiology | 2010 |
Targeted Inactivation of EGF Receptor Inhibits Renal Collecting Duct Development and Function
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Journal of the American Society of Nephrology : JASN | 2010 |
Angiotensin II Promotes Development of the Renal Microcirculation through AT 1 Receptors
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A Whaley-Connell, R Nistala, J Habibi, MR Hayden, RI Schneider, MS Johnson, R Tilmon, N Rehmer, CM Ferrario, JR Sowers |
American journal of physiology. Renal physiology | 2009 |
Mutations des gènes du SRA et anomalies du développement rénal
MC Gubler, O Gribouval, V Morinière, A Pawtowski, C Antignac |
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MC Gubler, C Antignac |
Kidney International | 2009 |
Angiotensin II AT2 receptor regulates ureteric bud morphogenesis
R Song, M Spera, C Garrett, SS El-Dahr, IV Yosypiv |
American journal of physiology. Renal physiology | 2009 |
Children’s toxicology from bench to bed - Drug-induced Renal Injury (1): The toxic effects of ARB/ACEI on fetal kidney development
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The Journal of Toxicological Sciences | 2009 |
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American journal of physiology. Renal physiology | 2009 |
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AJP Gastrointestinal and Liver Physiology | 2009 |
Placental Insufficiency Associated with Loss of Cited1 Causes Renal Medullary Dysplasia
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Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis
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American journal of physiology. Gastrointestinal and liver physiology | 2008 |
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Pharmacology & Therapeutics | 2008 |
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IV Yosypiv |
Pediatric Nephrology | 2008 |
A New Role for the Renin-angiotensin System in the Development of the Ureteric Bud and Renal Collecting System
IV Yosypiv |
The Keio Journal of Medicine | 2008 |
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Respiratory Research | 2008 |
Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
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Kidney International | 2008 |
A new role for the renin-angiotensin system in the development of the ureteric bud and renal collecting system
IV Yosypiv |
The Keio Journal of Medicine | 2008 |
Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade
S Chen, Y Ge, J Si, A Rifai, LD Dworkin, R Gong |
Kidney International | 2008 |
The Kidney in Congenital Ureteropelvic Junction Obstruction: A Spectrum From Normal to Nephrectomy
S Rosen, CA Peters, RL Chevalier, WY Huang |
The Journal of Urology | 2008 |
Developmental biology of the human kidney
ND Rosenblum |
Seminars in Fetal and Neonatal Medicine | 2008 |
Inhibition of Angiotensin II receptors during pregnancy induces malformations in developing rat kidney
SI Sánchez, AM Seltzer, LB Fuentes, ML Forneris, GM Ciuffo |
European Journal of Pharmacology | 2008 |
Comprehensive Pediatric Nephrology
R Gbadegesin, WE Smoyer |
Comprehensive Pediatric Nephrology | 2008 |
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EF Nogueira, WB Bollag, WE Rainey |
Molecular and Cellular Endocrinology | 2008 |
Augmented Renal Vascular nNOS and Renin Protein Expression in Angiotensin Type 1 Receptor Null Mice
S Park, LM Harrison-Bernard |
Journal of Histochemistry & Cytochemistry | 2008 |
Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria
L Kota, H Schulz, S Falak, N Hübner, M Osborne-Pellegrin |
Physiological genomics | 2008 |
Maternal Diabetes Modulates Renal Morphogenesis in Offspring
S Tran, YW Chen, I Chenier, JS Chan, S Quaggin, MJ Hébert, JR Ingelfinger, SL Zhang |
Journal of the American Society of Nephrology : JASN | 2008 |
Frontiers in Research of the Renin-Angiotensin System on Human Disease
PS Leung |
2008 | |
Local Angiotensin Generation and AT2 Receptor Activation
Esch JH, Danser AH |
2007 | |
Functional renin receptors in renal mesangial cells.
Huang Y, Border WA, Noble NA |
Current Hypertension Reports | 2007 |
Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker
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Journal of Hypertension | 2007 |
Regulation of expression and functional activity of G-protein-coupled receptors. Alterations of these processes in diseases
PV Avdonin, LM Kozhevnikova |
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology | 2007 |
Functional renin receptors in renal mesangial cells
Y Huang, WA Border, NA Noble |
Current Hypertension Reports | 2007 |
Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice
XC Li, LG Navar, Y Shao, JL Zhuo |
American journal of physiology. Renal physiology | 2007 |
Adverse effects of angiotensin-converting enzyme inhibitors and Angiotensin-II receptor blockers in pregnancy
RL Branch, U Martin |
Adverse Drug Reaction Bulletin | 2007 |
Mouse Models and the Urinary Concentrating Mechanism in the New Millennium
RA Fenton, MA Knepper |
Physiological reviews | 2007 |
Compromised renal microvascular reactivity of angiotensin type 1 double null mice
S Park, BJ Bivona, LM Harrison-Bernard |
American journal of physiology. Renal physiology | 2007 |
Genetic deletion of AT 1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT 1a receptor-deficient mice
XC Li, LG Navar, Y Shao, JL Zhuo |
American journal of physiology. Renal physiology | 2007 |
Loss of ACE2 leads to a late development of angiotensin II dependent glomerulosclerosis and compartmentalization of renal injury
Gavin Y. Oudit, Andrew M. Herzenberg, Zamaneh Kassiri, Mark C. Chappell, Heather Reich, Rama Khokha, Michael A. Crackower, Peter H. Backx, Josef M. Penninger, James W. Scholey |
The American Journal of Pathology | 2006 |
Hypertension, kidney, and transgenics: a fresh perspective
LJ Mullins, MA Bailey, JJ Mullins |
Physiological reviews | 2006 |
Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene
H Castrop, M Oppermann, Y Weiss, Y Huang, D Mizel, H Lu, S Germain, F Schweda, F Theilig, S Bachmann, J Briggs, A Kurtz, J Schnermann |
Physiological genomics | 2006 |
Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
Y Huang, S Wongamorntham, J Kasting, D McQuillan, RT Owens, L Yu, NA Noble, W Border |
Kidney International | 2006 |
The renin???angiotensin system in the development of the congenital anomalies of the kidney and urinary tract
F Niimura, V Kon, I Ichikawa |
Current Opinion in Pediatrics | 2006 |
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F Daïkha-Dahmane, E Levy-Beff, M Jugie, R Lenclen |
Pediatric Nephrology | 2006 |
Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors
WO Cooper, S Hernandez-Diaz, PG Arbogast, JA Dudley, S Dyer, PS Gideon, K Hall, WA Ray |
New England Journal of Medicine | 2006 |
The renin???angiotensin system in the development of the congenital anomalies of the kidney and urinary tract:
F Niimura, V Kon, I Ichikawa |
Current Opinion in Pediatrics | 2006 |
Molecular Mechanisms in Hypertension: focus on transgenic animal models
N Alenina, O Baltatu, M Bader |
Molecular Mechanisms in Hypertension: paracrine regulator of salt sensitivity and blood pressure | 2006 |
Efferent arterioles exclusively express the subtype 1A angiotensin receptor: functional insights from genetic mouse models
LM Harrison-Bernard, CJ Monjure, BJ Bivona |
American journal of physiology. Renal physiology | 2006 |
The Vascular Endothelium I
S Moncada, A Higgs |
2006 | |
Foetal kidney maldevelopment in maternal use of angiotensin II type I receptor antagonists
F Daïkha-Dahmane, E Levy-Beff, M Jugie, R Lenclen |
Pediatric Nephrology | 2006 |
Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells
Y Maeshima |
Clinical and Experimental Nephrology | 2005 |
Gene expression in pediatric heart disease with emphasis on conotruncal defects
DC Bittel, N Kibiryeva, JE O'Brien, GK Lofland, MG Butler |
Progress in Pediatric Cardiology | 2005 |
Role of the renin-angiotensin system in the development of the ureteric bud and renal collecting system
IV Yosypiv, SS El-Dahr |
Pediatric Nephrology | 2005 |
Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors
Y Takazawa, Y Maeshima, H Kitayama, Y Yamamoto, H Kawachi, F Shimizu, H Matsui, H Sugiyama, Y Yamasaki, H Makino |
Kidney International | 2005 |
LOW RENIN-ANGIOTENSIN SYSTEM ACTIVITY GENE POLYMORPHISM AND DYSPLASIA ASSOCIATED WITH POSTERIOR URETHRAL VALVES
L Peruzzi, F Lombardo, A Amore, E Merlini, G Restagno, L Silvestro, T Papalia, R Coppo |
The Journal of Urology | 2005 |
Physiological regulation of brain angiotensin receptor mRNA in AT1a deficient mice
MJ Rocha, Y Chen, GR Oliveira, M Morris |
Experimental Neurology | 2005 |
Animal models of hypertension: An overview
LO Lerman, AR Chade, V Sica, C Napoli |
Journal of Laboratory and Clinical Medicine | 2005 |
Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice
X Ouyang |
AJP Renal Physiology | 2005 |
Angiotensin II receptor blockade and ventricular remodelling
NS Anavekar, SD Solomon |
Journal of Renin-Angiotensin-Aldosterone System | 2005 |
Altered renin–angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia
B Chertin, N Nakazawa, S Montedonico, H Shima, P Puri |
Pediatric Surgery International | 2005 |
Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans
Y Aoki, S Mori, K Kitajima, O Yokoyama, H Kanamaru, K Okada, Y Yokota |
Genes to Cells | 2004 |
Exploring type I angiotensin (AT1) receptor functions through gene targeting
SD Crowley, PL Tharaux, LP Audoly, TM Coffman |
Acta Physiologica Scandinavica | 2004 |
The renin-angiotensin system in kidney development
Y Chen, D Lasaitiene, P Friberg |
Acta Physiologica Scandinavica | 2004 |
The role of the RAS in programming of adult hypertension
R Rasch, E Skriver, LL Woods |
Acta Physiologica Scandinavica | 2004 |
The role of the renin–angiotensin system in malignant vascular injury affecting the systemic and cerebral circulations
TA Collidge, GA Lammie, S Fleming, JJ Mullins |
Progress in Biophysics and Molecular Biology | 2004 |
Vasoactive Peptides, their Receptors and Drug Development
H Kusserow, T Unger |
Pharmacology and Toxicology | 2004 |
Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension
S Racasan, B Hahnel, DM van der Giezen, EL Blezer, R Goldschmeding, B Braam, W Kriz, HA Koomans, JA Joles |
Kidney International | 2004 |
DNAzyme for TGF-β suppressed extracellular matrix accumulation in experimental glomerulonephritis
Y Isaka, H Nakamura, M Mizui, Y Takabatake, M Horio, H Kawachi, F Shimizu, E Imai, M Hori |
Kidney International | 2004 |
AT1 and AT2 receptor in the kidney: role in health and disease
HM Siragy |
Seminars in Nephrology | 2004 |
The role of angiotensin II in kidney embryogenesis and kidney abnormalities
ML Lopez, RA Gomez |
Current Opinion in Nephrology and Hypertension | 2004 |
Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype
ES Pentz, MA Moyano, BA Thornhill, ML Lopez, RA Gomez |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
Dissecting the JGA: new functions for JG cells?
PB Freeburg, DR Abrahamson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
A γGT-AT 1A receptor transgene protects renal cortical structure in AT 1 receptor-deficient mice
TH Le, MI Oliverio, HS Kim, H Salzler, RC Dash, DN Howell, O Smithies, S Bronson, TM Coffman |
Physiological genomics | 2004 |
Kidney angiotensin and angiotensin receptor expression in prenatally programmed hypertension
VM Vehaskari, T Stewart, D Lafont, C Soyez, D Seth, J Manning |
American journal of physiology. Renal physiology | 2004 |
Angiotensin Vol. II
T Unger, BA Schölkens |
2004 | |
Angiotensin Vol. I
T Unger, BA Schölkens |
2004 | |
Loss-of-Function Polymorphic Variants of the Human Angiotensin II Type 1 Receptor
JL Hansen, S Haunsø, MR Brann, SP Sheikh, DM Weiner |
Molecular pharmacology | 2004 |
Pericyte‐specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation
H Cho, T Kozasa, C Bondjers, C Betsholtz, JH Kehrl |
The FASEB Journal | 2003 |
The renin receptor: the facts, the promise and the hope
G Nguyen, C Burckle, JD Sraer |
Current Opinion in Nephrology and Hypertension | 2003 |
The renin–angiotensin and the kallikrein–kinin systems
DJ Campbell |
The International Journal of Biochemistry & Cell Biology | 2003 |
Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice
T Mitsui, S Nomura, M Okada, Y Ohno, H Kobayashi, Y Nakashima, Y Murata, M Takeuchi, N Kuno, T Nagasaka, J O-Wang, MD Cooper, S Mizutani |
Molecular Medicine | 2003 |
Association of Angiotensin II Type 2 Receptor Gene Variant with Hypertension
JJ JIN, J NAKURA, Z WU, M YAMAMOTO, M ABE, Y CHEN, Y TABARA, Y YAMAMOTO, M IGASE, X BO, K KOHARA, T MIKI |
Hypertension Research | 2003 |
Lack of Association between Angiotensin II Type 1 Receptor Gene Polymorphism and Hypertension in Japanese
K ONO, T MANNAMI, S BABA, N YASUI, T OGIHARA, N IWAI |
Hypertension Research | 2003 |
Perturbed medullary tubulogenesis in neonatal rat exposed to renin-angiotensin system inhibition
D Lasaitiene, Y Chen, G Guron, N Marcussen, A Tarkowski, E Telemo, P Friberg |
Nephrology Dialysis Transplantation | 2003 |
The Kidney
LM Satlin, CB Woda, GJ Schwartz |
The Kidney | 2003 |
Sex and the Renin Angiotensin System: Implications for Gender Differences in the Progression of Kidney Disease
K Sandberg, H Ji |
Advances in renal replacement therapy | 2003 |
Maintenance of Normal Blood Pressure and Renal Functions Are Independent Effects of Angiotensin-converting Enzyme
SP Kessler, PS Senanayake, TS Scheidemantel, JB Gomos, TM Rowe, GC Sen |
The Journal of biological chemistry | 2003 |
Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats
J Stubbe, BL Jensen, S Bachmann, P Morsing, O Skøtt |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2003 |
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity
DL Brutsaert |
Physiological reviews | 2003 |
Role of bradykinin in angiotensin-converting enzyme knockout mice
HD Xiao, S Fuchs, JM Cole, KM Disher, RL Sutliff, KE Bernstein |
American journal of physiology. Heart and circulatory physiology | 2003 |
New approaches to genetic manipulation of mice: tissue-specific expression of ACE
JM Cole, H Xiao, JW Adams, KM Disher, H Zhao, KE Bernstein |
American journal of physiology. Renal physiology | 2003 |
ACE inhibition modulates transforming growth factor-? receptors in the young rat
HE Yim, IS Bae, JH Choi, BM Choi, KH Yoo, YS Hong, JW Lee, SK Kim, NS Kang |
Pediatric Nephrology | 2003 |
The receptor of renin and prorenin plays a pivotal role in cell-surface generation of angiotensin II and mediates cellular effects of renin
Genevieve Nguyen, Françoise Delarue, Celine Burckle, Latifa Bouzhir, Thomas Giller, Jean-Daniel Sraer |
Journal of Clinical Investigation | 2002 |
Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure
Justin Cole, Du Le Quach, Karthik Sundaram, Pierre Corvol, Mario R Capecchi, Kenneth E Bernstein |
Circulation research | 2002 |
Renin-angiotensin system inhibition: how much is too much of a good thing?
DJ Campbell |
Internal Medicine Journal | 2002 |
Gene-targeting Studies of the Renin-Angiotensin System: Mechanisms of Hypertension and Cardiovascular Disease
S Gurley, T Le, T Coffman |
Cold Spring Harbor Symposia on Quantitative Biology | 2002 |
Toward an etiological classification of developmental disorders of the kidney and upper urinary tract
M Pohl, V Bhatnagar, SA Mendoza, SK Nigam |
Kidney International | 2002 |
The renin angiotensin system and kidney development
T Matsusaka, Y Miyazaki, I Ichikawa |
Annual Review of Physiology | 2002 |
Effects of AT 1A receptor deletion on blood pressure and sodium excretion during altered dietary salt intake
AJ Mangrum, RA Gomez, VF Norwood |
American journal of physiology. Renal physiology | 2002 |
The New Angiotherapy
TP Fan, EC Kohn |
2002 | |
Biphasic Regulation of Na + -HCO 3− Cotransporter by Angiotensin II Type 1A Receptor
S Horita, Y Zheng, C Hara, H Yamada, M Kunimi, S Taniguchi, S Uwatoko, T Sugaya, A Goto, T Fujita, G Seki |
Hypertension | 2002 |
Mouse models of blood pressure regulation and hypertension
F Sugiyama, K Yagami, B Paigen |
Current Hypertension Reports | 2001 |
Knockout of renin-angiotensin system genes: Effects on vascular development
D Methot, TL Reudelhuber |
Current Hypertension Reports | 2001 |
Hyperplastic vascular smooth muscle cells of the intrarenal arteries in angiotensin II type 1a receptor null mutant mice
S Inokuchi, K Kimura, T Sugaya, K Inokuchi, K Murakami, T Sakai |
Kidney International | 2001 |
Genetic manipulation of the renin-angiotensin system in the kidney
CD Sigmund |
Acta Physiologica Scandinavica | 2001 |
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract
Y Miyazaki |
Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology | 2001 |
Genetic manipulation of the renin-angiotensin system
TN Doan, N Gletsu, J Cole, KE Bernstein |
Current Opinion in Nephrology and Hypertension | 2001 |
Transgenic mouse models of angiotensin receptor subtype function in the cardiovascular system
M Brede, L Hein |
Regulatory Peptides | 2001 |
Maternal Protein Restriction Suppresses the Newborn Renin-Angiotensin System and Programs Adult Hypertension in Rats
LL Woods, JR Ingelfinger, JR Nyengaard, R Rasch |
Pediatric Research | 2001 |
Review: Lessons on renal function from transgenic mice lacking different angiotensin II receptors
WJ Arendshorst |
Journal of Renin-Angiotensin-Aldosterone System | 2001 |
Review: Gene targeting studies of angiotensin II type 1 (AT1) receptors
TM Coffman, LP Audoly, MI Oliverio |
Journal of Renin-Angiotensin-Aldosterone System | 2001 |
Physiological and Enzymatic Properties of the Ram Epididymal Soluble Form of Germinal Angiotensin I-Converting Enzyme1
S Métayer, F Dacheux, Y Guérin, JL Dacheux, JL Gatti |
Biology of reproduction | 2001 |
Role of the renin-angiotensin system during alterations of sodium intake in conscious mice
BC Cholewa, DL Mattson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2001 |
Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control
E Féraille, A Doucet |
Physiological reviews | 2001 |
Ureteric bud derivatives express angiotensinogen and AT 1 receptors
M Prieto, S Dipp, S Meleg-Smith, SS El-Dahr |
Physiological genomics | 2001 |
Desensitization of Type 1 Angiotensin II Receptor Subtypes in the Rat Kidney
A Hus-Citharel, N Bouby, J Marchetti, D Chansel, D Goidin, D Gourdji, P Corvol, C Llorens-Cortes |
Endocrinology | 2001 |
Characterization of Signal Transduction Pathway in Neurotropic Action of Angiotensin II in Brain Neurons
H Yang, X Wang, MK Raizada |
Endocrinology | 2001 |
Insights into the Functions of Type 1 (AT1) Angiotensin II Receptors Provided by Gene Targeting
LP Audoly, MI Oliverio, TM Coffman |
Trends in Endocrinology & Metabolism | 2000 |
What can knockout mice contribute to an understanding of hypertension?
LP Audoly, TH Le, TM Coffman |
Current Hypertension Reports | 2000 |
An intact renin – angiotensin system is a prerequisite for normal renal development
G Guron, P Friberg |
Journal of Hypertension | 2000 |
Salutary role for angiotensin in partial urinary tract obstruction
H Fujinaka, Y Miyazaki, T Matsusaka, H Yoshida, AB Fogo, T Inagami, I Ichikawa |
Kidney International | 2000 |
A molecular and genetic view of human renal and urinary tract malformations
AS Woolf |
Kidney International | 2000 |
Understanding hypertension through genetic manipulation in mice
B Cvetkovic, CD Sigmund |
Kidney International | 2000 |
Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways
KD Lake-Bruse, CD Sigmund |
Current Hypertension Reports | 2000 |
The cardiac renin–angiotensin system: novel signaling mechanisms related to cardiac growth and function
DE Dostal |
Regulatory Peptides | 2000 |
Insights derived from ACE knockout mice
J Cole, D Ertoy, KE Bernstein |
Journal of Renin-Angiotensin-Aldosterone System | 2000 |
Genetic Evidence That Lethality in Angiotensinogen-deficient Mice Is Due to Loss of Systemic but Not Renal Angiotensinogen
Y Ding, DE Stec, CD Sigmund |
The Journal of biological chemistry | 2000 |
Angiotensin II Receptor Physiology Using Gene Targeting
MI Oliverio, TM Coffman |
Physiology (Bethesda, Md.) | 2000 |
Novel expression and regulation of the renin-angiotensin system in metanephric organ culture
VF Norwood, M Garmey, J Wolford, RM Carey, RA Gomez |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
IGF-I treatment attenuates renal abnormalities induced by neonatal ACE inhibition
AB Nilsson, N Nitescu, Y Chen, GS Guron, N Marcussen, GL Matejka, P Friberg |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
Regulation of Sodium Balance and Blood Pressure by the AT 1A Receptor for Angiotensin II
MI Oliverio, CF Best, O Smithies, TM Coffman |
Hypertension | 2000 |
Comparative Roles of the Renal Apical Sodium Transport Systems in Blood Pressure Control
P Meneton |
Journal of the American Society of Nephrology : JASN | 2000 |
Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells
J S Chan, T T Wang, S L Zhang, X Chen, S Carrière |
Molecular and Cellular Biochemistry | 2000 |
Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor
A R Brasier, M Jamaluddin, Y Han, C Patterson, M S Runge |
Molecular and Cellular Biochemistry | 2000 |
Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
HF Cheng, JL Wang, MZ Zhang, Y Miyazaki, I Ichikawa, JA McKanna, RC Harris |
Journal of Clinical Investigation | 1999 |
THE MOLECULAR BASIS OF HYPERTENSION
DL Garbers, SK Dubois |
Annual Review of Biochemistry | 1999 |
Genetic manipulation of the renin - angiotensin system
TH Le, TM Coffman |
Current Opinion in Nephrology and Hypertension | 1999 |
New insights into the renin-angiotensin system and hypertensive renal disease
AB Fogo |
Current Hypertension Reports | 1999 |
Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature
S Tsuchida, Y Miyazaki, T Matsusaka, TE Hunley, T Inagami, A Fogo, I Ichikawa |
Kidney International | 1999 |
The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy
Y Miyazaki, S Tsuchida, A Fogo, I Ichikawa |
Kidney International | 1999 |
Mechanisms of impaired urinary concentrating ability in adult rats treated neonatally with enalapril
GURON, NILSSON, NITESCU, NIELSEN, SUNDELIN, FROKIAER, FRIBERG |
Acta Physiologica Scandinavica | 1999 |
Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions
L Cervenka, KD Mitchell, MI Oliverio, TM Coffman, LG Navar |
Kidney International | 1999 |
Renal renin-angiotensin system dysregulation caused by partial bladder outlet obstruction in fetal sheep
R Gobet, JM Park, HT Nguyen, B Chang, LJ Cisek, CA Peters |
Kidney International | 1999 |
Transgenic and knockout models in renin–angiotensin system
K Murakami, A Fukamizu |
Immunopharmacology | 1999 |
Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and disease
BH Lorell |
The American Journal of Cardiology | 1999 |
The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function?
DE Dostal, KM Baker |
Circulation research | 1999 |
Angiotensin II induces alpha3(IV) collagen expression in cultured murine proximal tubular cells
G Wolf, R Kalluri, F N Ziyadeh, E G Neilson, R A Stahl |
Proceedings of The Association of American Physicians | 1999 |
Role of AT 1 receptors and autonomic nervous system in mediating acute pressor responses to ANG II in anesthetized mice
TJ Bivalacqua, A Dalal, HC Champion, PJ Kadowitz |
American journal of physiology. Endocrinology and metabolism | 1999 |
Surviving Infarction One Gene at a Time: Decreased Remodeling and Mortality in Engineered Mice Lacking the Angiotensin II Type 1A Receptor
V Gaussin, MD Schneider |
Circulation | 1999 |
Effects of Mineralocorticoid Receptor Gene Disruption on the Components of the Renin-Angiotensin System in 8-Day-Old Mice
C Hubert, JM Gasc, S Berger, G Schütz, P Corvol |
Molecular Endocrinology | 1999 |
Renal Vascular Reactivity in Mice: AngII-Induced Vasoconstriction in AT 1A Receptor Null Mice
XI Ruan, MI OLIVERIO, TM Coffman, WJ Arendshorst |
Journal of the American Society of Nephrology : JASN | 1999 |
Postnatal Time Frame for Renal Vulnerability to Enalapril in Rats
G Guron, N Marcussen, A Nilsson, B Sundelin, P Friberg |
Journal of the American Society of Nephrology : JASN | 1999 |
Gene Targeting Approaches to Analyzing Hypertension
N Takahashi, OL Smithies |
Journal of the American Society of Nephrology : JASN | 1999 |
Renal Function in Mice: Effects of Volume Expansion and Angiotensin II
L Cervenka, KD Mitchell, LG Navar |
Journal of the American Society of Nephrology : JASN | 1999 |
Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse
LD Asico, C Ladines, S Fuchs, D Accili, RM Carey, C Semeraro, F Pocchiari, RA Felder, GM Eisner, PA Jose |
Journal of Clinical Investigation | 1998 |
Angiotensin induces the urinary peristaltic machinery during the perinatal period
Y Miyazaki, S Tsuchida, H Nishimura, JC 4th, RC Harris, JM McKanna, T Inagami, BL Hogan, A Fogo, I Ichikawa |
Journal of Clinical Investigation | 1998 |
ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN DISORDERS OF THE URINARY TRACT
JW Brock, TE Hunley, MC Adams, V Kon |
The Journal of Urology | 1998 |
Role of angiotensin in renal vascular development
RA Gomez |
Kidney International | 1998 |
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II
MI Oliverio, HS Kim, M Ito, T Le, L Audoly, CF Best, S Hiller, K Kluckman, N Maeda, O Smithies, TM Coffman |
Proceedings of the National Academy of Sciences | 1998 |
Rescue of Angiotensinogen-Knockout Mice
J Ishida, F Sugiyama, K Tanimoto, K Taniguchi, M Syouji, E Takimoto, H Horiguchi, K Murakami, K Yagami, A Fukamizu |
Biochemical and Biophysical Research Communications | 1998 |
THE RENIN-ANGIOTENSIN SYSTEM AND THE DEVELOPMENT OF THE KIDNEY AND ADRENAL IN SHEEP
EM Wintour, D Alcorn, A Albiston, WC Boon, A Butkus, L Earnest, K Moritz, L Shandley |
Clinical and Experimental Pharmacology and Physiology | 1998 |
Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse
LD Asico, C Ladines, S Fuchs, D Accili, RM Carey, C Semeraro, F Pocchiari, RA Felder, GM Eisner, PA Jose |
Journal of Clinical Investigation | 1998 |
A Memorial to Robert Tiegerstedt: The Centennial of Renin Discovery
T Inagami |
Hypertension | 1998 |
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler |
1998 |