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Citations to this article

Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
S Tsuchida, … , T Inagami, I Ichikawa
S Tsuchida, … , T Inagami, I Ichikawa
Published February 15, 1998
Citation Information: J Clin Invest. 1998;101(4):755-760. https://doi.org/10.1172/JCI1899.
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Research Article

Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

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Abstract

Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting, we produced double mutant mice homozygous for both Agtr1a and Agtr1b null mutation (Agtr1a-/-; Agtr1b-/-) by mating the single gene mutants. Agtr1a-/-, Agtr1b-/- mice are characterized by normal in utero survival but decreased ex utero survival rate. After birth they are characterized by low body weight gain, marked hypotension, and abnormal kidney morphology including delayed maturity in glomerular growth, hypoplastic papilla, and renal arterial hypertrophy. These abnormal phenotypes are quantitatively similar to those found in mutant mice homozygous for the angiotensinogen gene (Agt-/-), indicating that major biological functions of endogenous Ang elucidated by the abnormal phenotypes of Agt-/- are mediated by the AT1 receptors. Infusion of Ang II, AT1 blockers, or an AT2 blocker was without effect on blood pressure in Agtr1a-/-; Agtr1b-/- mice, indicating that AT2 receptor does not exert acute depressor effects in these mice lacking AT1 receptors. Also, unlike Agt-/- mice, some Agtr1a-/-; Agtr1b-/- mice have a large ventricular septum defect, suggesting that another receptor such as AT2 is functionally activated in Agtr1a-/-, Agtr1b-/- mice.

Authors

S Tsuchida, T Matsusaka, X Chen, S Okubo, F Niimura, H Nishimura, A Fogo, H Utsunomiya, T Inagami, I Ichikawa

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Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
Y Huang, S Wongamorntham, J Kasting, D McQuillan, RT Owens, L Yu, NA Noble, W Border
Kidney International 2006
The renin???angiotensin system in the development of the congenital anomalies of the kidney and urinary tract
F Niimura, V Kon, I Ichikawa
Current Opinion in Pediatrics 2006
Foetal kidney maldevelopment in maternal use of angiotensin II type I receptor antagonists
F Daïkha-Dahmane, E Levy-Beff, M Jugie, R Lenclen
Pediatric Nephrology 2006
Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors
WO Cooper, S Hernandez-Diaz, PG Arbogast, JA Dudley, S Dyer, PS Gideon, K Hall, WA Ray
New England Journal of Medicine 2006
The renin???angiotensin system in the development of the congenital anomalies of the kidney and urinary tract:
F Niimura, V Kon, I Ichikawa
Current Opinion in Pediatrics 2006
Molecular Mechanisms in Hypertension: focus on transgenic animal models
N Alenina, O Baltatu, M Bader
Molecular Mechanisms in Hypertension: paracrine regulator of salt sensitivity and blood pressure 2006
Efferent arterioles exclusively express the subtype 1A angiotensin receptor: functional insights from genetic mouse models
LM Harrison-Bernard, CJ Monjure, BJ Bivona
American journal of physiology. Renal physiology 2006
The Vascular Endothelium I
S Moncada, A Higgs
2006
Foetal kidney maldevelopment in maternal use of angiotensin II type I receptor antagonists
F Daïkha-Dahmane, E Levy-Beff, M Jugie, R Lenclen
Pediatric Nephrology 2006
Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells
Y Maeshima
Clinical and Experimental Nephrology 2005
Gene expression in pediatric heart disease with emphasis on conotruncal defects
DC Bittel, N Kibiryeva, JE O'Brien, GK Lofland, MG Butler
Progress in Pediatric Cardiology 2005
Role of the renin-angiotensin system in the development of the ureteric bud and renal collecting system
IV Yosypiv, SS El-Dahr
Pediatric Nephrology 2005
Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors
Y Takazawa, Y Maeshima, H Kitayama, Y Yamamoto, H Kawachi, F Shimizu, H Matsui, H Sugiyama, Y Yamasaki, H Makino
Kidney International 2005
LOW RENIN-ANGIOTENSIN SYSTEM ACTIVITY GENE POLYMORPHISM AND DYSPLASIA ASSOCIATED WITH POSTERIOR URETHRAL VALVES
L Peruzzi, F Lombardo, A Amore, E Merlini, G Restagno, L Silvestro, T Papalia, R Coppo
The Journal of Urology 2005
Physiological regulation of brain angiotensin receptor mRNA in AT1a deficient mice
MJ Rocha, Y Chen, GR Oliveira, M Morris
Experimental Neurology 2005
Animal models of hypertension: An overview
LO Lerman, AR Chade, V Sica, C Napoli
Journal of Laboratory and Clinical Medicine 2005
Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice
X Ouyang
AJP Renal Physiology 2005
Angiotensin II receptor blockade and ventricular remodelling
NS Anavekar, SD Solomon
Journal of Renin-Angiotensin-Aldosterone System 2005
Altered renin–angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia
B Chertin, N Nakazawa, S Montedonico, H Shima, P Puri
Pediatric Surgery International 2005
Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans
Y Aoki, S Mori, K Kitajima, O Yokoyama, H Kanamaru, K Okada, Y Yokota
Genes to Cells 2004
Exploring type I angiotensin (AT1) receptor functions through gene targeting
SD Crowley, PL Tharaux, LP Audoly, TM Coffman
Acta Physiologica Scandinavica 2004
The renin-angiotensin system in kidney development
Y Chen, D Lasaitiene, P Friberg
Acta Physiologica Scandinavica 2004
The role of the RAS in programming of adult hypertension
R Rasch, E Skriver, LL Woods
Acta Physiologica Scandinavica 2004
The role of the renin–angiotensin system in malignant vascular injury affecting the systemic and cerebral circulations
TA Collidge, GA Lammie, S Fleming, JJ Mullins
Progress in Biophysics and Molecular Biology 2004
Vasoactive Peptides, their Receptors and Drug Development
H Kusserow, T Unger
Pharmacology and Toxicology 2004
Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension
S Racasan, B Hahnel, DM van der Giezen, EL Blezer, R Goldschmeding, B Braam, W Kriz, HA Koomans, JA Joles
Kidney International 2004
DNAzyme for TGF-β suppressed extracellular matrix accumulation in experimental glomerulonephritis
Y Isaka, H Nakamura, M Mizui, Y Takabatake, M Horio, H Kawachi, F Shimizu, E Imai, M Hori
Kidney International 2004
AT1 and AT2 receptor in the kidney: role in health and disease
HM Siragy
Seminars in Nephrology 2004
The role of angiotensin II in kidney embryogenesis and kidney abnormalities
ML Lopez, RA Gomez
Current Opinion in Nephrology and Hypertension 2004
Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype
ES Pentz, MA Moyano, BA Thornhill, ML Lopez, RA Gomez
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2004
Dissecting the JGA: new functions for JG cells?
PB Freeburg, DR Abrahamson
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2004
A γGT-AT 1A receptor transgene protects renal cortical structure in AT 1 receptor-deficient mice
TH Le, MI Oliverio, HS Kim, H Salzler, RC Dash, DN Howell, O Smithies, S Bronson, TM Coffman
Physiological genomics 2004
Kidney angiotensin and angiotensin receptor expression in prenatally programmed hypertension
VM Vehaskari, T Stewart, D Lafont, C Soyez, D Seth, J Manning
American journal of physiology. Renal physiology 2004
Angiotensin Vol. II
T Unger, BA Schölkens
2004
Angiotensin Vol. I
T Unger, BA Schölkens
2004
Loss-of-Function Polymorphic Variants of the Human Angiotensin II Type 1 Receptor
JL Hansen, S Haunsø, MR Brann, SP Sheikh, DM Weiner
Molecular pharmacology 2004
Pericyte‐specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation
H Cho, T Kozasa, C Bondjers, C Betsholtz, JH Kehrl
The FASEB Journal 2003
The renin receptor: the facts, the promise and the hope
G Nguyen, C Burckle, JD Sraer
Current Opinion in Nephrology and Hypertension 2003
The renin–angiotensin and the kallikrein–kinin systems
DJ Campbell
The International Journal of Biochemistry & Cell Biology 2003
Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice
T Mitsui, S Nomura, M Okada, Y Ohno, H Kobayashi, Y Nakashima, Y Murata, M Takeuchi, N Kuno, T Nagasaka, J O-Wang, MD Cooper, S Mizutani
Molecular Medicine 2003
Association of Angiotensin II Type 2 Receptor Gene Variant with Hypertension
JJ JIN, J NAKURA, Z WU, M YAMAMOTO, M ABE, Y CHEN, Y TABARA, Y YAMAMOTO, M IGASE, X BO, K KOHARA, T MIKI
Hypertension Research 2003
Lack of Association between Angiotensin II Type 1 Receptor Gene Polymorphism and Hypertension in Japanese
K ONO, T MANNAMI, S BABA, N YASUI, T OGIHARA, N IWAI
Hypertension Research 2003
Perturbed medullary tubulogenesis in neonatal rat exposed to renin-angiotensin system inhibition
D Lasaitiene, Y Chen, G Guron, N Marcussen, A Tarkowski, E Telemo, P Friberg
Nephrology Dialysis Transplantation 2003
The Kidney
LM Satlin, CB Woda, GJ Schwartz
The Kidney 2003
Sex and the Renin Angiotensin System: Implications for Gender Differences in the Progression of Kidney Disease
K Sandberg, H Ji
Advances in renal replacement therapy 2003
Maintenance of Normal Blood Pressure and Renal Functions Are Independent Effects of Angiotensin-converting Enzyme
SP Kessler, PS Senanayake, TS Scheidemantel, JB Gomos, TM Rowe, GC Sen
The Journal of biological chemistry 2003
Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats
J Stubbe, BL Jensen, S Bachmann, P Morsing, O Skøtt
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity
DL Brutsaert
Physiological reviews 2003
Role of bradykinin in angiotensin-converting enzyme knockout mice
HD Xiao, S Fuchs, JM Cole, KM Disher, RL Sutliff, KE Bernstein
American journal of physiology. Heart and circulatory physiology 2003
New approaches to genetic manipulation of mice: tissue-specific expression of ACE
JM Cole, H Xiao, JW Adams, KM Disher, H Zhao, KE Bernstein
American journal of physiology. Renal physiology 2003
ACE inhibition modulates transforming growth factor-? receptors in the young rat
HE Yim, IS Bae, JH Choi, BM Choi, KH Yoo, YS Hong, JW Lee, SK Kim, NS Kang
Pediatric Nephrology 2003
The receptor of renin and prorenin plays a pivotal role in cell-surface generation of angiotensin II and mediates cellular effects of renin
Genevieve Nguyen, Françoise Delarue, Celine Burckle, Latifa Bouzhir, Thomas Giller, Jean-Daniel Sraer
Journal of Clinical Investigation 2002
Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure
Justin Cole, Du Le Quach, Karthik Sundaram, Pierre Corvol, Mario R Capecchi, Kenneth E Bernstein
Circulation research 2002
Renin-angiotensin system inhibition: how much is too much of a good thing?
DJ Campbell
Internal Medicine Journal 2002
Gene-targeting Studies of the Renin-Angiotensin System: Mechanisms of Hypertension and Cardiovascular Disease
S Gurley, T Le, T Coffman
Cold Spring Harbor Symposia on Quantitative Biology 2002
Toward an etiological classification of developmental disorders of the kidney and upper urinary tract
M Pohl, V Bhatnagar, SA Mendoza, SK Nigam
Kidney International 2002
The renin angiotensin system and kidney development
T Matsusaka, Y Miyazaki, I Ichikawa
Annual Review of Physiology 2002
Effects of AT 1A receptor deletion on blood pressure and sodium excretion during altered dietary salt intake
AJ Mangrum, RA Gomez, VF Norwood
American journal of physiology. Renal physiology 2002
The New Angiotherapy
TP Fan, EC Kohn
2002
Biphasic Regulation of Na + -HCO 3− Cotransporter by Angiotensin II Type 1A Receptor
S Horita, Y Zheng, C Hara, H Yamada, M Kunimi, S Taniguchi, S Uwatoko, T Sugaya, A Goto, T Fujita, G Seki
Hypertension 2002
Mouse models of blood pressure regulation and hypertension
F Sugiyama, K Yagami, B Paigen
Current Hypertension Reports 2001
Knockout of renin-angiotensin system genes: Effects on vascular development
D Methot, TL Reudelhuber
Current Hypertension Reports 2001
Hyperplastic vascular smooth muscle cells of the intrarenal arteries in angiotensin II type 1a receptor null mutant mice
S Inokuchi, K Kimura, T Sugaya, K Inokuchi, K Murakami, T Sakai
Kidney International 2001
Genetic manipulation of the renin-angiotensin system in the kidney
CD Sigmund
Acta Physiologica Scandinavica 2001
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract
Y Miyazaki
Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology 2001
Genetic manipulation of the renin-angiotensin system
TN Doan, N Gletsu, J Cole, KE Bernstein
Current Opinion in Nephrology and Hypertension 2001
Transgenic mouse models of angiotensin receptor subtype function in the cardiovascular system
M Brede, L Hein
Regulatory Peptides 2001
Maternal Protein Restriction Suppresses the Newborn Renin-Angiotensin System and Programs Adult Hypertension in Rats
LL Woods, JR Ingelfinger, JR Nyengaard, R Rasch
Pediatric Research 2001
Review: Lessons on renal function from transgenic mice lacking different angiotensin II receptors
WJ Arendshorst
Journal of Renin-Angiotensin-Aldosterone System 2001
Review: Gene targeting studies of angiotensin II type 1 (AT1) receptors
TM Coffman, LP Audoly, MI Oliverio
Journal of Renin-Angiotensin-Aldosterone System 2001
Physiological and Enzymatic Properties of the Ram Epididymal Soluble Form of Germinal Angiotensin I-Converting Enzyme1
S Métayer, F Dacheux, Y Guérin, JL Dacheux, JL Gatti
Biology of reproduction 2001
Role of the renin-angiotensin system during alterations of sodium intake in conscious mice
BC Cholewa, DL Mattson
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2001
Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control
E Féraille, A Doucet
Physiological reviews 2001
Ureteric bud derivatives express angiotensinogen and AT 1 receptors
M Prieto, S Dipp, S Meleg-Smith, SS El-Dahr
Physiological genomics 2001
Desensitization of Type 1 Angiotensin II Receptor Subtypes in the Rat Kidney
A Hus-Citharel, N Bouby, J Marchetti, D Chansel, D Goidin, D Gourdji, P Corvol, C Llorens-Cortes
Endocrinology 2001
Characterization of Signal Transduction Pathway in Neurotropic Action of Angiotensin II in Brain Neurons
H Yang, X Wang, MK Raizada
Endocrinology 2001
Insights into the Functions of Type 1 (AT1) Angiotensin II Receptors Provided by Gene Targeting
LP Audoly, MI Oliverio, TM Coffman
Trends in Endocrinology & Metabolism 2000
What can knockout mice contribute to an understanding of hypertension?
LP Audoly, TH Le, TM Coffman
Current Hypertension Reports 2000
An intact renin – angiotensin system is a prerequisite for normal renal development
G Guron, P Friberg
Journal of Hypertension 2000
Salutary role for angiotensin in partial urinary tract obstruction
H Fujinaka, Y Miyazaki, T Matsusaka, H Yoshida, AB Fogo, T Inagami, I Ichikawa
Kidney International 2000
A molecular and genetic view of human renal and urinary tract malformations
AS Woolf
Kidney International 2000
Understanding hypertension through genetic manipulation in mice
B Cvetkovic, CD Sigmund
Kidney International 2000
Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways
KD Lake-Bruse, CD Sigmund
Current Hypertension Reports 2000
The cardiac renin–angiotensin system: novel signaling mechanisms related to cardiac growth and function
DE Dostal
Regulatory Peptides 2000
Insights derived from ACE knockout mice
J Cole, D Ertoy, KE Bernstein
Journal of Renin-Angiotensin-Aldosterone System 2000
Genetic Evidence That Lethality in Angiotensinogen-deficient Mice Is Due to Loss of Systemic but Not Renal Angiotensinogen
Y Ding, DE Stec, CD Sigmund
The Journal of biological chemistry 2000
Angiotensin II Receptor Physiology Using Gene Targeting
MI Oliverio, TM Coffman
Physiology (Bethesda, Md.) 2000
Novel expression and regulation of the renin-angiotensin system in metanephric organ culture
VF Norwood, M Garmey, J Wolford, RM Carey, RA Gomez
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2000
IGF-I treatment attenuates renal abnormalities induced by neonatal ACE inhibition
AB Nilsson, N Nitescu, Y Chen, GS Guron, N Marcussen, GL Matejka, P Friberg
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2000
Regulation of Sodium Balance and Blood Pressure by the AT 1A Receptor for Angiotensin II
MI Oliverio, CF Best, O Smithies, TM Coffman
Hypertension 2000
Comparative Roles of the Renal Apical Sodium Transport Systems in Blood Pressure Control
P Meneton
Journal of the American Society of Nephrology : JASN 2000
Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells
J S Chan, T T Wang, S L Zhang, X Chen, S Carrière
Molecular and Cellular Biochemistry 2000
Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor
A R Brasier, M Jamaluddin, Y Han, C Patterson, M S Runge
Molecular and Cellular Biochemistry 2000
Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
HF Cheng, JL Wang, MZ Zhang, Y Miyazaki, I Ichikawa, JA McKanna, RC Harris
Journal of Clinical Investigation 1999
THE MOLECULAR BASIS OF HYPERTENSION
DL Garbers, SK Dubois
Annual Review of Biochemistry 1999
Genetic manipulation of the renin - angiotensin system
TH Le, TM Coffman
Current Opinion in Nephrology and Hypertension 1999
New insights into the renin-angiotensin system and hypertensive renal disease
AB Fogo
Current Hypertension Reports 1999
Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature
S Tsuchida, Y Miyazaki, T Matsusaka, TE Hunley, T Inagami, A Fogo, I Ichikawa
Kidney International 1999
The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy
Y Miyazaki, S Tsuchida, A Fogo, I Ichikawa
Kidney International 1999
Mechanisms of impaired urinary concentrating ability in adult rats treated neonatally with enalapril
GURON, NILSSON, NITESCU, NIELSEN, SUNDELIN, FROKIAER, FRIBERG
Acta Physiologica Scandinavica 1999
Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions
L Cervenka, KD Mitchell, MI Oliverio, TM Coffman, LG Navar
Kidney International 1999
Renal renin-angiotensin system dysregulation caused by partial bladder outlet obstruction in fetal sheep
R Gobet, JM Park, HT Nguyen, B Chang, LJ Cisek, CA Peters
Kidney International 1999
Transgenic and knockout models in renin–angiotensin system
K Murakami, A Fukamizu
Immunopharmacology 1999
Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and disease
BH Lorell
The American Journal of Cardiology 1999
The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function?
DE Dostal, KM Baker
Circulation research 1999
Angiotensin II induces alpha3(IV) collagen expression in cultured murine proximal tubular cells
G Wolf, R Kalluri, F N Ziyadeh, E G Neilson, R A Stahl
Proceedings of The Association of American Physicians 1999
Role of AT 1 receptors and autonomic nervous system in mediating acute pressor responses to ANG II in anesthetized mice
TJ Bivalacqua, A Dalal, HC Champion, PJ Kadowitz
American journal of physiology. Endocrinology and metabolism 1999
Surviving Infarction One Gene at a Time: Decreased Remodeling and Mortality in Engineered Mice Lacking the Angiotensin II Type 1A Receptor
V Gaussin, MD Schneider
Circulation 1999
Effects of Mineralocorticoid Receptor Gene Disruption on the Components of the Renin-Angiotensin System in 8-Day-Old Mice
C Hubert, JM Gasc, S Berger, G Schütz, P Corvol
Molecular Endocrinology 1999
Renal Vascular Reactivity in Mice: AngII-Induced Vasoconstriction in AT 1A Receptor Null Mice
XI Ruan, MI OLIVERIO, TM Coffman, WJ Arendshorst
Journal of the American Society of Nephrology : JASN 1999
Postnatal Time Frame for Renal Vulnerability to Enalapril in Rats
G Guron, N Marcussen, A Nilsson, B Sundelin, P Friberg
Journal of the American Society of Nephrology : JASN 1999
Gene Targeting Approaches to Analyzing Hypertension
N Takahashi, OL Smithies
Journal of the American Society of Nephrology : JASN 1999
Renal Function in Mice: Effects of Volume Expansion and Angiotensin II
L Cervenka, KD Mitchell, LG Navar
Journal of the American Society of Nephrology : JASN 1999
Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse
LD Asico, C Ladines, S Fuchs, D Accili, RM Carey, C Semeraro, F Pocchiari, RA Felder, GM Eisner, PA Jose
Journal of Clinical Investigation 1998
Angiotensin induces the urinary peristaltic machinery during the perinatal period
Y Miyazaki, S Tsuchida, H Nishimura, JC 4th, RC Harris, JM McKanna, T Inagami, BL Hogan, A Fogo, I Ichikawa
Journal of Clinical Investigation 1998
ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN DISORDERS OF THE URINARY TRACT
JW Brock, TE Hunley, MC Adams, V Kon
The Journal of Urology 1998
Role of angiotensin in renal vascular development
RA Gomez
Kidney International 1998
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II
MI Oliverio, HS Kim, M Ito, T Le, L Audoly, CF Best, S Hiller, K Kluckman, N Maeda, O Smithies, TM Coffman
Proceedings of the National Academy of Sciences 1998
Rescue of Angiotensinogen-Knockout Mice
J Ishida, F Sugiyama, K Tanimoto, K Taniguchi, M Syouji, E Takimoto, H Horiguchi, K Murakami, K Yagami, A Fukamizu
Biochemical and Biophysical Research Communications 1998
THE RENIN-ANGIOTENSIN SYSTEM AND THE DEVELOPMENT OF THE KIDNEY AND ADRENAL IN SHEEP
EM Wintour, D Alcorn, A Albiston, WC Boon, A Butkus, L Earnest, K Moritz, L Shandley
Clinical and Experimental Pharmacology and Physiology 1998
Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse
LD Asico, C Ladines, S Fuchs, D Accili, RM Carey, C Semeraro, F Pocchiari, RA Felder, GM Eisner, PA Jose
Journal of Clinical Investigation 1998
A Memorial to Robert Tiegerstedt: The Centennial of Renin Discovery
T Inagami
Hypertension 1998
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler
1998

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