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Birgit Liliensiek, … , Peter P. Nawroth, Bernd Arnold
Published June 1, 2004
Citation Information: J Clin Invest. 2004;113(11):1641-1650. https://doi.org/10.1172/JCI18704.
Citation Information: J Clin Invest. 2004;113(11):1641-1650. https://doi.org/10.1172/JCI18704.
Abstract
While the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced glycation end products (RAGE), a transmembrane receptor of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture. Such protection is reversed by reconstitution of RAGE in endothelial and hematopoietic cells. These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.
Authors
Birgit Liliensiek, Markus A. Weigand, Angelika Bierhaus, Werner Nicklas, Michael Kasper, Stefan Hofer, Jens Plachky, Herman-Josef Gröne, Florian C. Kurschus, Ann Marie Schmidt, Shi Du Yan, Eike Martin, Erwin Schleicher, David M. Stern, Günter J. Hämmerling, Peter P. Nawroth, Bernd Arnold
Total citations by year
Citation information
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Expert Review of Proteomics | 2016 |
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The Course of Skin and Serum Biomarkers of Advanced Glycation Endproducts and Its Association with Oxidative Stress, Inflammation, Disease Severity, and Mortality during ICU Admission in Critically Ill Patients: Results from a Prospective Pilot Study
JH Meertens, HL Nienhuis, JD Lefrandt, CG Schalkwijk, K Nyyssönen, JJ Ligtenberg, AJ Smit, JG Zijlstra, DJ Mulder, R Nagaraj |
PloS one | 2016 |
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High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway
D Shang, T Peng, S Gou, Y Li, H Wu, C Wang, Z Yang |
Scientific Reports | 2016 |
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The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation
W Wan, L Cao, R Khanabdali, B Kalionis, X Tai, S Xia |
Journal of Immunology Research | 2016 |
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The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis
R Kang, R Chen, M Xie, L Cao, MT Lotze, D Tang, HJ Zeh |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
|
The diagnostic utility and tendency of the soluble receptor for advanced glycation end products (sRAGE) in exudative pleural effusion
YS Sim, DG Kim, TR Shin |
Journal of Thoracic Disease | 2016 |
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The Mouse-Specific Splice Variant mRAGE_v4 Encodes a Membrane-Bound RAGE That Is Resistant to Shedding and Does Not Contribute to the Production of Soluble RAGE
SD Maggio, E Gatti, J Liu, M Bertolotti, G Fritz, ME Bianchi, A Raucci, T Fukai |
PloS one | 2016 |
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RAGE Deficiency Impairs Bacterial Clearance in Murine Staphylococcal Sepsis, but Has No Significant Impact on Staphylococcal Septic Arthritis
M Mohammad, M Na, A Welin, MN Svensson, A Ali, T Jin, R Pullerits, R Kang |
PloS one | 2016 |
|
C1q and HMGB1 reciprocally regulate human macrophage polarization
M Son, A Porat, M He, J Suurmond, F Santiago-Schwarz, U Andersson, TR Coleman, BT Volpe, KJ Tracey, Y Al-Abed, B Diamond |
Blood | 2016 |
|
Pathophysiology of Neonatal Sepsis
Wynn JL, Wong HR |
Fetal and Neonatal Physiology | 2016 |
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Phagocytosis of apoptotic cells in homeostasis
S Arandjelovic, KS Ravichandran |
Nature Immunology | 2015 |
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DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury
A Liesz, A Dalpke, E Mracsko, DJ Antoine, S Roth, W Zhou, H Yang, SY Na, M Akhisaroglu, T Fleming, T Eigenbrod, PP Nawroth, KJ Tracey, R Veltkamp |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2015 |
|
Xuebijing Ameliorates Sepsis-Induced Lung Injury by Downregulating HMGB1 and RAGE Expressions in Mice
Q Wang, X Wu, X Tong, Z Zhang, B Xu, W Zhou |
Evidence-Based Complementary and Alternative Medicine | 2015 |
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Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma
L Zeng, J Du, W Gu, A Zhang, H Wang, D Wen, L Qiu, X Yang, J Sun, M Zhang, J Hao, J Jiang |
Critical Care | 2015 |
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Inorganic polyphosphate elicits pro-inflammatory responses through activation of the mammalian target of rapamycin complexes 1 and 2 in vascular endothelial cells
SM Hassanian, P Dinarvand, SA Smith, AR Rezaie |
Journal of Thrombosis and Haemostasis | 2015 |
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Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells
EA Oczypok, PS Milutinovic, JF Alcorn, A Khare, LT Crum, ML Manni, MW Epperly, AM Pawluk, A Ray, TD Oury |
Journal of Allergy and Clinical Immunology | 2015 |
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Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?
D Kojic |
World Journal of Experimental Medicine | 2015 |
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Soluble RAGEs — Prospects for treating & tracking metabolic and inflammatory disease
AM Schmidt |
Vascular Pharmacology | 2015 |
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The Receptor for Advanced Glycation Endproducts Does Not Contribute to Pathology in a Mouse Mesenteric Ischemia/Reperfusion-Induced Injury Model
MC Wu, TD Gilmour, S Mantovani, TM Woodruff |
Frontiers in immunology | 2015 |
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RAGE Controls Activation and Anti-Inflammatory Signalling of Protein C
N Braach, D Frommhold, K Buschmann, J Pflaum, L Koch, H Hudalla, K Staudacher, H Wang, B Isermann, P Nawroth, J Poeschl, C Schulz |
PloS one | 2014 |
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Tissue advanced glycation end products (AGEs), measured by skin autofluorescence, predict mortality in peritoneal dialysis
D Siriopol, S Hogas, G Veisa, I Mititiuc, C Volovat, M Apetrii, M Onofriescu, I Busila, M Oleniuc, A Covic |
International Urology and Nephrology | 2014 |
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The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma
EM Akirav, O Henegariu, P Preston-Hurlburt, AM Schmidt, R Clynes, KC Herold, M Moser |
PloS one | 2014 |
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Vessel Ultrasound Sonographic Assessment of Soluble Receptor for Advanced Glycation End Products Efficacy in a Rat Balloon Injury Model
HJ Tae, N Petrashevskaya, I Ahmet, S Park, MI Talan, EG Lakatta, L Lin |
Current Therapeutic Research | 2014 |
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The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation
DJ Weber, AS Gracon, MS Ripsch, AJ Fisher, BM Cheon, PH Pandya, R Vittal, ML Capitano, Y Kim, YM Allette, AA Riley, BP McCarthy, PR Territo, GD Hutchins, HE Broxmeyer, GE Sandusky, FA White, DS Wilkes |
Science Translational Medicine | 2014 |
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Role of advanced glycation end products in cellular signaling
C Ott, K Jacobs, E Haucke, AN Santos, T Grune, A Simm |
Redox Biology | 2014 |
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Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome
DG Craig, P Lee, EA Pryde, E Hidalgo, PC Hayes, SJ Wigmore, SJ Forbes, KJ Simpson |
Case Reports in Transplantation | 2014 |
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RAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population
ZT Wang, JJ Hu, R Fan, J Zhou, J Zhong |
World journal of gastroenterology : WJG | 2014 |
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Anti-Inflammatory Functions of Protein C Require RAGE and ICAM-1 in a Stimulus-Dependent Manner
N Braach, K Buschmann, J Pflaum, H Hudalla, L Koch, E Ryschich, J Poeschl, D Frommhold |
Mediators of Inflammation | 2014 |
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Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes
G Tesch, KC Sourris, SA Summers, D McCarthy, MS Ward, DJ Borg, LA Gallo, AK Fotheringham, AR Pettit, FY Yap, BE Harcourt, AL Tan, JY Kausman, D Nikolic-Paterson, AR Kitching, JM Forbes |
Diabetologia | 2014 |
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HMGB1-DNA Complex-induced Autophagy Limits AIM2 Inflammasome Activation through RAGE
L Liu, M Yang, R Kang, Y Yu, Y Dai, F Gao, H Wang, X Sun, X Li, J Li, H Wang, L Cao, D Tang |
Biochemical and Biophysical Research Communications | 2014 |
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The receptor for advanced glycation end products in ventilator-induced lung injury
MT Kuipers, H Aslami, P Tuinman, AM Boer, G Jongsma, KF van der Sluijs, G Choi, EK Wolthuis, J Roelofs, P Bresser, MJ Schultz, T der Poll, CW Wieland |
Intensive Care Medicine Experimental | 2014 |
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HMGB1 in health and disease
R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao, J Huang, Y Yu, X Fan, Z Yan, X Sun, H Wang, Q Wang, A Tsung, TR Billiar, HJ Zeh, MT Lotze, D Tang |
Molecular Aspects of Medicine | 2014 |
|
Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function
X Zhu, Y Yao, L Zhang, N Dong, Y Yu, Z Sheng |
Acta Pharmacologica Sinica | 2014 |
|
RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer
R Kang, W Hou, Q Zhang, R Chen, YJ Lee, DL Bartlett, MT Lotze, D Tang, HJ Zeh |
Cell Death and Disease | 2014 |
|
RAGE controls leukocyte adhesion in preterm and term infants
K Buschmann, R Tschada, MS Metzger, N Braach, N Kuss, H Hudalla, J Poeschl, D Frommhold |
BMC Immunology | 2014 |
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The Receptor for Advanced Glycation End-Products (RAGE) Is Only Present in Mammals, and Belongs to a Family of Cell Adhesion Molecules (CAMs)
L Sessa, E Gatti, F Zeni, A Antonelli, A Catucci, M Koch, G Pompilio, G Fritz, A Raucci, ME Bianchi, BI Hudson |
PloS one | 2014 |
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Modulation of cell proliferation, survival and gene expression by RAGE and TLR signaling in cells of the innate and adaptive immune response: role of p38 MAPK and NF-KB.
Medeiros MC, Frasnelli SC, Bastos Ade S, Orrico SR, Rossa C Jr |
Journal of applied oral science : revista FOB | 2014 |
|
Sepsis
Wynn JL, Hazelzet JA, Shanley TP, Wong HR, Wheeler DS |
Pediatric Critical Care Medicine | 2014 |
|
The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics
R Kang, D Tang, NE Schapiro, T Loux, KM Livesey, TR Billiar, H Wang, BV Houten, MT Lotze, HJ Zeh |
Oncogene | 2013 |
|
Specific siRNA Targeting Receptor for Advanced Glycation End Products (RAGE) Decreases Proliferation in Human Breast Cancer Cell Lines
AM Radia, AM Yaser, X Ma, J Zhang, C Yang, Q Dong, P Rong, B Ye, S Liu, W Wang |
International journal of molecular sciences | 2013 |
|
Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
YK Chuah, R Basir, H Talib, TH Tie, N Nordin |
International Journal of Inflammation | 2013 |
|
Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction
D Xu, JH Young, JM Krahn, D Song, KD Corbett, WJ Chazin, LC Pedersen, JD Esko |
ACS chemical biology | 2013 |
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Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor
P Dinarvand, SM Hassanian, SH Qureshi, C Manithody, JC Eissenberg, L Yang, AR Rezaie |
Blood | 2013 |
|
Soluble receptor for advanced glycation end products predicts 28-day mortality in critically ill patients with sepsis
H Brodska, K Malickova, J Valenta, A Fabio, T Drabek |
Scandinavian Journal of Clinical & Laboratory Investigation | 2013 |
|
High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products
Y Nadatani, T Watanabe, T Tanigawa, F Ohkawa, S Takeda, A Higashimori, M Sogawa, H Yamagami, M Shiba, K Watanabe, K Tominaga, Y Fujiwara, K Takeuchi, T Arakawa |
PloS one | 2013 |
|
HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4
JM Tadie, HB Bae, S Jiang, DW Park, CP Bell, H Yang, JF Pittet, K Tracey, VJ Thannickal, E Abraham, JW Zmijewski |
American journal of physiology. Lung cellular and molecular physiology | 2013 |
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Early Plasma Soluble Receptor for Advanced Glycation End-Product Levels Are Associated With Bronchiolitis Obliterans Syndrome: Plasma sRAGE Is Associated With BOS
RJ Shah, SL Bellamy, JC Lee, E Cantu, JM Diamond, N Mangalmurti, SM Kawut, LB Ware, JD Christie |
American Journal of Transplantation | 2013 |
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The Effect of Soluble RAGE on Inhibition of Angiotensin II-Mediated Atherosclerosis in Apolipoprotein E Deficient Mice
D Lee, KH Lee, H Park, SH Kim, T Jin, S Cho, JH Chung, S Lim, S Park, O Kocher |
PloS one | 2013 |
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Combinatorial Library of Improved Peptide Aptamers, CLIPs to Inhibit RAGE Signal Transduction in Mammalian Cells
S Reverdatto, V Rai, J Xue, DS Burz, AM Schmidt, A Shekhtman, C Verma |
PloS one | 2013 |
|
Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
R Chen, W Hou, Q Zhang, R Kang, XG Fan, D Tang |
Molecular Medicine | 2013 |
|
CD166/ALCAM Mediates Proinflammatory Effects of S100B in Delayed Type Hypersensitivity
R von Bauer, D Oikonomou, A Sulaj, S Mohammed, A Hotz-Wagenblatt, HJ Gröne, B Arnold, C Falk, D Luethje, A Erhardt, DM Stern, A Bierhaus, PP Nawroth |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia.
Achouiti A, de Vos AF, de Beer R, Florquin S, van 't Veer C, van der Poll T |
Journal of Innate Immunity | 2013 |
|
Alarmins: Awaiting a Clinical Response
James Chan, Johannes Roth, Joost J. Oppenheim, Kevin J. Tracey, Thomas Vogl, Marc Feldmann, Nicole Horwood, Jagdeep Nanchahal |
Journal of Clinical Investigation | 2012 |
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Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4
R Allam, CR Scherbaum, MN Darisipudi, SR Mulay, H Hägele, J Lichtnekert, JH Hagemann, KV Rupanagudi, M Ryu, C Schwarzenberger, B Hohenstein, C Hugo, B Uhl, CA Reichel, F Krombach, M Monestier, H Liapis, K Moreth, L Schaefer, HJ Anders |
Journal of the American Society of Nephrology : JASN | 2012 |
|
The Formin mDia1 Mediates Vascular Remodeling via Integration of Oxidative & Signal Transduction Pathways
F Touré, G Fritz, Q Li, V Rai, G Daffu, YS Zou, R Rosario, R Ramasamy, AS Alberts, SF Yan, AM Schmidt |
Circulation research | 2012 |
|
Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice
AM Watson, SP Gray, L Jiaze, A Soro-Paavonen, B Wong, ME Cooper, A Bierhaus, R Pickering, C Tikellis, D Tsorotes, MC Thomas, KA Jandeleit-Dahm |
Diabetes | 2012 |
|
Role of advanced glycation end products in cardiovascular disease
Z Hegab, S Gibbons, L Neyses, MA Mamas |
World journal of cardiology | 2012 |
|
RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses
EM Akirav, P Preston-Hurlburt, J Garyu, O Henegariu, R Clynes, AM Schmidt, KC Herold |
PloS one | 2012 |
|
S100B Engages RAGE or bFGF/FGFR1 in Myoblasts Depending on Its Own Concentration and Myoblast Density. Implications for Muscle Regeneration
F Riuzzi, G Sorci, S Beccafico, R Donato |
PloS one | 2012 |
|
S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis
T Arumugam, V Ramachandran, SB Gomez, AM Schmidt, CD Logsdon |
Clinical cancer research | 2012 |
|
Plasma sRAGE enables prediction of acute lung injury after cardiac surgery in children
X Liu, Q Chen, S Shi, Z Shi, R Lin, L Tan, J Yu, Q Shu, X Fang |
Critical Care | 2012 |
|
The effect of sRAGE-Fc fusion protein attenuates inflammation and decreases mortality in a murine cecal ligation and puncture model
SJ Jeong, BJ Lim, S Park, D Choi, HW Kim, NS Ku, SH Han, CO Kim, JY Choi, YG Song, JM Kim |
Inflammation Research | 2012 |
|
Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE
R Romero, T Chaiworapongsa, ZA Savasan, Y Hussein, Z Dong, JP Kusanovic, CJ Kim, SS Hassan |
Journal of Maternal-Fetal and Neonatal Medicine | 2012 |
|
RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity
W Yu, R Liu-Bryan, S Stevens, JK Damanahalli, R Terkeltaub |
Atherosclerosis | 2012 |
|
RAGE Does Not Contribute to Renal Injury and Damage upon Ischemia/Reperfusion-Induced Injury
MC Dessing, WP Pulskens, GJ Teske, LM Butter, T der Poll, H Yang, KJ Tracey, PP Nawroth, A Bierhaus, S Florquin, JC Leemans |
Journal of Innate Immunity | 2012 |
|
Opposing Roles of Membrane and Soluble Forms of the Receptor for Advanced Glycation End Products in Primary Respiratory Syncytial Virus Infection
AL Miller, GP Sims, YA Brewah, MC Rebelatto, J Kearley, E Benjamin, AE Keller, P Brohawn, R Herbst, AJ Coyle, AA Humbles, R Kolbeck |
The Journal of Infectious Diseases | 2012 |
|
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
M Schiraldi, A Raucci, LM Muñoz, E Livoti, B Celona, E Venereau, T Apuzzo, FD Marchis, M Pedotti, A Bachi, M Thelen, L Varani, M Mellado, A Proudfoot, ME Bianchi, M Uguccioni |
Journal of Experimental Medicine | 2012 |
|
Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis
RM Narvaez-Rivera, A Rendon, MC Salinas-Carmona, AG Rosas-Taraco |
BMC Infectious Diseases | 2012 |
|
An advanced glycation end product (AGE)-receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein function
CY Chen, AM Abell, YS Moon, KH Kim |
The Journal of biological chemistry | 2012 |
|
Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis
W Wei, L Lampe, S Park, BS Vangara, GS Waldo, S Cabantous, SS Subaran, D Yang, EG Lakatta, L Lin |
PloS one | 2012 |
|
Identification of haplotype tag single nucleotide polymorphisms within the receptor for advanced glycation end products gene and their clinical relevance in patients with major trauma
L Zeng, AQ Zhang, W Gu, J Zhou, LY Zhang, DY Du, M Zhang, HY Wang, J Yan, C Yang, JX Jiang |
Critical Care | 2012 |
|
RAGE influences obesity in mice: Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet
B Leuner, M Max, K Thamm, C Kausler, Y Yakobus, A Bierhaus, S Sel, B Hofmann, RE Silber, A Simm, N Nass |
Zeitschrift für Gerontologie und Geriatrie | 2012 |
|
HMGB1 is an independent predictor of death and heart transplantation in heart failure
HC Volz, D Laohachewin, D Schellberg, AR Wienbrandt, M Nelles, C Zugck, Z Kaya, HA Katus, M Andrassy |
Clinical Research in Cardiology | 2012 |
|
The Receptor for Advanced Glycation End Products Promotes Pancreatic Carcinogenesis and Accumulation of Myeloid-Derived Suppressor Cells
PJ Vernon, TJ Loux, NE Schapiro, R Kang, R Muthuswamy, P Kalinski, D Tang, MT Lotze, HJ Zeh |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
|
High Mobility Group Box 1 Contributes to the Pathogenesis of Experimental Pulmonary Hypertension via Activation of Toll-like Receptor 4
EM Bauer, R Shapiro, H Zheng, F Ahmad, D Ishizawar, SA Comhair, SC Erzurum, TR Billiar, PM Bauer |
Molecular Medicine | 2012 |
|
HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption
RK Wolfson, ET Chiang, JG Garcia |
Microvascular Research | 2011 |
|
Special issues in the management and selection of the donor for lung transplantation
PM Naik, LF Angel |
Seminars in Immunopathology | 2011 |
|
sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy
YM Arabi, M Dehbi, AH Rishu, E Baturcam, SH Kahoul, RJ Brits, B Naidu, A Bouchama |
Critical Care | 2011 |
|
The role of receptor for advanced glycation endproducts (RAGE) in infection
MA van Zoelen, A Achouiti, T der Poll |
Critical Care | 2011 |
|
Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing
JM Tadié, HB Bae, S Banerjee, JW Zmijewski, E Abraham |
American journal of physiology. Cell physiology | 2011 |
|
High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products
A Mazarati, M Maroso, V Iori, A Vezzani, M Carli |
Experimental Neurology | 2011 |
|
Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes
Y Tekabe, X Shen, J Luma, D Weisenberger, SF Yan, R Haubner, AM Schmidt, L Johnson |
EJNMMI Research | 2011 |
|
Matrix metalloproteinases: all the RAGE in the acute respiratory distress syndrome
AH Hergrueter, K Nguyen, CA Owen |
AJP Lung Cellular and Molecular Physiology | 2011 |
|
RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
D Frommhold, A Kamphues, S Dannenberg, K Buschmann, V Zablotskaya, R Tschada, B Lange-Sperandio, PP Nawroth, J Poeschl, A Bierhaus, M Sperandio |
BMC Immunology | 2011 |
|
The Receptor for Advanced Glycation End-Products (RAGE) Protects Pancreatic Tumor Cells Against Oxidative Injury
R Kang, D Tang, KM Livesey, NE Schapiro, MT Lotze, HJ Zeh |
Antioxidants & Redox Signaling | 2011 |
|
Lack of the Receptor for Advanced Glycation End-Products Attenuates E. coli Pneumonia in Mice
L Ramsgaard, JM Englert, ML Manni, PS Milutinovic, J Gefter, J Tobolewski, L Crum, GM Coudriet, J Piganelli, R Zamora, Y Vodovotz, JJ Enghild, TD Oury, UA Maus |
PloS one | 2011 |
|
Participation of the Receptor for Advanced Glycation End Products in Efferocytosis
A Friggeri, S Banerjee, S Biswas, A de Freitas, G Liu, A Bierhaus, E Abraham |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
The Role of Receptor for Advanced Glycation Endproducts (RAGE) in Infection
van Zoelen MA, Achouiti A, van der Poll T |
2011 | |
|
sRAGE induces human monocyte survival and differentiation
Y Wang, H Wang, MG Piper, S McMaken, X Mo, J Opalek, AM Schmidt, CB Marsh |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
|
Pathophysiology and treatment of septic shock in neonates
JL Wynn, HR Wong |
Clinics in Perinatology | 2010 |
|
Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction
H Zong, A Madden, M Ward, MH Mooney, CT Elliott, AW Stitt |
The Journal of biological chemistry | 2010 |
|
Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE -/- mice
Y Vugmeyster, D DeFranco, DD Pittman, X Xu |
mAbs | 2010 |
|
Soluble RAGE: therapy and biomarker in unraveling the RAGE axis in chronic disease and aging
SF Yan, R Ramasamy, AM Schmidt |
Biochemical Pharmacology | 2010 |
|
The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature
SF Yan, R Ramasamy, AM Schmidt |
Circulation research | 2010 |
|
HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
D Tang, R Kang, CW Cheh, KM Livesey, X Liang, NE Schapiro, R Benschop, LJ Sparvero, AA Amoscato, KJ Tracey, HJ Zeh, MT Lotze |
Oncogene | 2010 |
|
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
H Yang, HS Hreggvidsdottir, K Palmblad, H Wang, M Ochani, J Li, B Lu, S Chavan, M Rosas-Ballina, Y Al-Abed, S Akira, A Bierhaus, H Erlandsson-Harris, U Andersson, KJ Tracey |
Proceedings of the National Academy of Sciences | 2010 |
|
High-mobility group box 1 and cancer
D Tang, R Kang, HJ 3rd, MT Lotze |
Biochimica et Biophysica Acta | 2010 |
|
The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?
BC Creagh-Brown, GJ Quinlan, TW Evans, A Burke-Gaffney |
Intensive Care Medicine | 2010 |
|
Urosepsis und Therapie
FM Wagenlehner, C Lichtenstern, MA Weigand, W Weidner |
Der Urologe, Ausgabe A | 2010 |
|
Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis*:
MA van Zoelen, A Achouiti, AM Schmidt, H Yang, S Florquin, KJ Tracey, T der Poll |
Critical Care Medicine | 2010 |
|
The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis
S Banerjee, A Friggeri, G Liu, E Abraham |
Journal of leukocyte biology | 2010 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
Anti-Receptor for Advanced Glycation End Products Therapies as Novel Treatment for Abdominal Aortic Aneurysm
F Zhang, KC Kent, D Yamanouchi, Y Zhang, K Kato, S Tsai, R Nowygrod, AM Schmidt, B Liu |
Transactions of the ... Meeting of the American Surgical Association | 2009 |
|
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
A Bierhaus, PP Nawroth |
Diabetologia | 2009 |
|
Receptor for AGE (RAGE) and its ligands—cast into leading roles in diabetes and the inflammatory response
SF Yan, R Ramasamy, AM Schmidt |
Journal of Molecular Medicine | 2009 |
|
AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis
PM Humpert, IK Lukic, SR Thorpe, S Hofer, EM Awad, M Andrassy, EK Deemer, M Kasper, E Schleicher, M Schwaninger, MA Weigand, PP Nawroth, A Bierhaus |
Journal of leukocyte biology | 2009 |
|
The receptor RAGE: Bridging inflammation and cancer
A Riehl, J Németh, P Angel, J Hess |
Cell communication and signaling : CCS | 2009 |
|
RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
LJ Sparvero, D Asafu-Adjei, R Kang, D Tang, N Amin, J Im, R Rutledge, B Lin, AA Amoscato, HJ Zeh, MT Lotze |
Journal of Translational Medicine | 2009 |
|
Advanced glycation end products and C-peptide—modulators in diabetic vasculopathy and atherogenesis
D Walcher, N Marx |
Seminars in Immunopathology | 2009 |
|
Tempering the wrath of RAGE: an emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation
SF Yan, SD Yan, R Ramasamy, AM Schmidt |
Annals of Medicine | 2009 |
|
Diabetes, insulin, and development of acute lung injury
S Honiden, MN Gong |
Critical Care Medicine | 2009 |
|
Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis
YS Chen, W Yan, CL Geczy, MA Brown, R Thomas |
Arthritis Research & Therapy | 2009 |
|
Central sympatholytics prolong survival in experimental sepsis
S Hofer, J Steppan, T Wagner, B Funke, C Lichtenstern, E Martin, BM Graf, A Bierhaus, MA Weigand |
Critical Care | 2009 |
|
High-mobility group protein box-1 and its relevance to cerebral ischemia
Q Yang, JZ Wang, JC Li, Y Zhou, Q Zhong, FL Lu, J Xiang |
Journal of Cerebral Blood Flow & Metabolism | 2009 |
|
Immunostimulatory activity of haptenated proteins
NW Palm, R Medzhitov |
Proceedings of the National Academy of Sciences | 2009 |
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The Receptor for Advanced Glycation End-products (RAGE) Sustains Autophagy and Limits Apoptosis, Promoting Pancreatic Tumor Cell Survival
R Kang, D Tang, NE Schapiro, KM Livesey, A Farkas, P Loughran, A Bierhaus, MT Lotze, HJ Zeh |
Cell Death and Differentiation | 2009 |
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ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO:
MA van Zoelen, H Yang, S Florquin, JC Meijers, S Akira, B Arnold, PP Nawroth, A Bierhaus, KJ Tracey, T der Poll |
Shock | 2009 |
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Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia
MA van Zoelen, KF van der Sluijs, A Achouiti, S Florquin, JM Braun-Pater, H Yang, PP Nawroth, KJ Tracey, A Bierhaus, T der Poll |
Virology | 2009 |
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The Pattern Recognition Receptor CD36 Is a Chondrocyte Hypertrophy Marker Associated with Suppression of Catabolic Responses and Promotion of Repair Responses to Inflammatory Stimuli
DL Cecil, CT Appleton, MD Polewski, JS Mort, AM Schmidt, A Bendele, F Beier, R Terkeltaub |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
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RAGE signaling in inflammation and arterial aging.
Lin L, Park S, Lakatta EG |
2009 | |
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Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE
V Urbonaviciute, BG Fürnrohr, S Meister, L Munoz, P Heyder, FD Marchis, ME Bianchi, C Kirschning, H Wagner, AA Manfredi, JR Kalden, G Schett, P Rovere-Querini, M Herrmann, RE Voll |
Journal of Experimental Medicine | 2008 |
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Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
A Soro-Paavonen, AM Watson, J Li, K Paavonen, A Koitka, AC Calkin, D Barit, MT Coughlan, BG Drew, GI Lancaster, M Thomas, JM Forbes, PP Nawroth, A Bierhaus, ME Cooper, KA Jandeleit-Dahm |
Diabetes | 2008 |
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A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis
JM Englert, LE Hanford, N Kaminski, JM Tobolewski, RJ Tan, CL Fattman, L Ramsgaard, TJ Richards, I Loutaev, PP Nawroth, M Kasper, A Bierhaus, TD Oury |
The American Journal of Pathology | 2008 |
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Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and inflammation
R Romero, J Espinoza, S Hassan, F Gotsch, JP Kusanovic, C Avila, O Erez, S Edwin, AM Schmidt |
Journal of Perinatal Medicine | 2008 |
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RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
O Turovskaya, D Foell, P Sinha, T Vogl, R Newlin, J Nayak, M Nguyen, A Olsson, PP Nawroth, A Bierhaus, N Varki, M Kronenberg, HH Freeze, G Srikrishna |
Carcinogenesis | 2008 |
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RAGE signaling sustains inflammation and promotes tumor development
C Gebhardt, A Riehl, M Durchdewald, J Németh, G Fürstenberger, K Müller-Decker, A Enk, B Arnold, A Bierhaus, PP Nawroth, J Hess, P Angel |
Journal of Experimental Medicine | 2008 |
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Feeding our immune system: impact on metabolism
I Wolowczuk, C Verwaerde, O Viltart, A Delanoye, M Delacre, B Pot, C Grangette |
Clinical & developmental immunology | 2008 |
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Harmful molecular mechanisms in sepsis
D Rittirsch, MA Flierl, PA Ward |
Nature reviews. Immunology | 2008 |
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The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation
N Kayhan, B Funke, LO Conzelmann, H Winkler, S Hofer, J Steppan, H Schmidt, H Bardenheuer, CF Vahl, MA Weigand |
Critical Care | 2008 |
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Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis
C Bopp, A Bierhaus, S Hofer, A Bouchon, PP Nawroth, E Martin, MA Weigand |
Critical Care | 2008 |
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Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs
C Tikellis, MC Thomas, BE Harcourt, MT Coughlan, J Pete, K Bialkowski, A Tan, A Bierhaus, ME Cooper, JM Forbes |
American journal of physiology. Endocrinology and metabolism | 2008 |
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Targeting RAGE in sepsis
MA van Zoelen, T der Poll |
Critical Care | 2008 |
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Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury
Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA |
Thorax | 2008 |
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RAGE ligation affects T cell activation and controls T cell differentiation.
Chen Y, Akirav EM, Chen W, Henegariu O, Moser B, Desai D, Shen JM, Webster JC, Andrews RC, Mjalli AM, Rothlein R, Schmidt AM, Clynes R, Herold KC |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
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A novel function of the receptor for advanced glycation end-products (RAGE) in association with tumorigenesis and tumor differentiation of HCC
K Hiwatashi, S Ueno, K Abeyama, F Kubo, M Sakoda, I Maruyama, M Hamanoue, S Natsugoe, T Aikou |
Annals of Surgical Oncology | 2007 |
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The biology of RAGE and its ligands: Uncovering mechanisms at the heart of diabetes and its complications
SF Yan, GR Barile, V DAgati, SD Yan, R Ramasamy, AM Schmidt |
Current Diabetes Reports | 2007 |
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A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
VV Orlova, EY Choi, C Xie, E Chavakis, A Bierhaus, E Ihanus, CM Ballantyne, CG Gahmberg, ME Bianchi, PP Nawroth, T Chavakis |
The EMBO Journal | 2007 |
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Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
EC Lutterloh, SM Opal, DD Pittman, JC Keith, XY Tan, BM Clancy, H Palmer, K Milarski, Y Sun, JE Palardy, NA Parejo, N Kessimian |
Critical Care | 2007 |
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Plasma Receptor for Advanced Glycation End-products Predicts Duration of ICU Stay and Mechanical Ventilation in Patients After Lung Transplantation
CS Calfee, MM Budev, MA Matthay, G Church, S Brady, T Uchida, A Ishizaka, A Lara, JL Ranes, MM deCamp, AC Arroliga |
The Journal of Heart and Lung Transplantation | 2007 |
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Peripheral, but not central nervous system, type I interferon expression in mice in response to intranasal vesicular stomatitis virus infection
MD Trottier, DS Lyles, CS Reiss |
Journal of Neurovirology | 2007 |
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RAGE: exacting a toll on the host in response to polymicrobial sepsis and Listeria monocytogenes
R Clynes, K Herold, AM Schmidt |
Critical Care | 2007 |
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Chronic sepsis mortality characterized by an individualized inflammatory response.
Osuchowski MF, Welch K, Yang H, Siddiqui J, Remick DG |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
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Regulation of osteoclast function and bone mass by RAGE
Z Zhou, D Immel, CX Xi, A Bierhaus, X Feng, L Mei, P Nawroth, DM Stern, WC Xiong |
Journal of Experimental Medicine | 2006 |
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Receptor for Advanced Glycation End-Products Is a Marker of Type I Cell Injury in Acute Lung Injury
T Uchida, M Shirasawa, LB Ware, K Kojima, Y Hata, K Makita, G Mednick, ZA Matthay, MA Matthay |
American journal of respiratory and critical care medicine | 2006 |
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The ligand/RAGE axis: Lighting the fuse and igniting vascular stress
SF Yan, Y Naka, BI Hudson, K Herold, SD Yan, R Ramasamy, AM Schmidt |
Current Atherosclerosis Reports | 2006 |
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Posttranslationally modified proteins as mediators of sustained intestinal inflammation
M Andrassy, J Igwe, F Autschbach, C Volz, A Remppis, MF Neurath, E Schleicher, PM Humpert, T Wendt, B Liliensiek, M Morcos, S Schiekofer, K Thiele, J Chen, R Kientsch-Engel, AM Schmidt, W Stremmel, DM Stern, HA Katus, PP Nawroth, A Bierhaus |
The American Journal of Pathology | 2006 |
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Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis.
Sawa H, Ueda T, Takeyama Y, Yasuda T, Shinzeki M, Nakajima T, Kuroda Y |
World Journal of Gastroenterology | 2006 |
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The N-terminal Domain of Thrombomodulin Sequesters HMGB1: A Novel Anti-inflammatory Mechanism
Kazuhiro Abeyama, David M. Stern, Yuji Ito, Ko-ichi Kawahara1, Yasushi Yoshimoto, Motoyuki Tanaka, Tomonori Uchimura, Nobuo Ida, Yoshiaki Yamazaki, Shingo Yamada, Yasuhiko Yamamoto, Hiroshi Yamamoto, Satoshi Iino, Noboru Taniguchi, Ikuro Maruyama |
Journal of Clinical Investigation | 2005 |
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Understanding RAGE, the receptor for advanced glycation end products
A Bierhaus, PM Humpert, M Morcos, T Wendt, T Chavakis, B Arnold, DM Stern, PP Nawroth |
Journal of Molecular Medicine | 2005 |
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Atherosclerosis and restenosis: Is there a role for rage?
P Nawroth, A Bierhaus, M Marrero, H Yamamoto, DM Stern |
Current Diabetes Reports | 2005 |
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Loss of pain perception in diabetes is dependent on a receptor of the immunglobulin superfamily
Angelika Bierhaus, Karl-Matthias Haselbeck, Per M. Humpert, Birgit Liliensiek, Thomas Dehmer, Michael Morcos, Ahmed A. R. Sayed, Martin Andrassy, Stephan Schiekofer, Jochen G. Schneider, Joerg B. Schulz, Dieter Heuss, Bernhard Neundoerfer, Stefan Dierl, Jochen Huber, Hans Tritschler, Ann-Marie Schmidt, Markus Schwaninger, Hans-Ulrich Haering, Erwin Schleicher, Michael Kasper, David M. Stern, Bernd Arnold, Peter P. Nawroth |
Journal of Clinical Investigation | 2004 |
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A new rat type I-like alveolar epithelial cell line R3/1: bleomycin effects on caveolin expression
R Koslowski, K Barth, A Augstein, T Tschernig, G Bargsten, M Aufderheide, M Kasper |
Histochemistry and Cell Biology | 2004 |
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