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Citations to this article

Impaired pancreatic growth, β cell mass, and β cell function in E2F1 –/– mice
Lluis Fajas, … , Mitsuhiro Watanabe, Johan Auwerx
Lluis Fajas, … , Mitsuhiro Watanabe, Johan Auwerx
Published May 1, 2004
Citation Information: J Clin Invest. 2004;113(9):1288-1295. https://doi.org/10.1172/JCI18555.
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Article Metabolism

Impaired pancreatic growth, β cell mass, and β cell function in E2F1 –/– mice

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Abstract

We evaluated the effects of E2F1 on glucose homeostasis using E2F1–/– mice. E2F1–/– mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth. Furthermore, these animals have dysfunctional β cells, linked to impaired PDX-1 activity. Because of the disproportionate small pancreas and dysfunctional islets, E2F1–/– mice secrete insufficient amounts of insulin in response to a glucose load, resulting in glucose intolerance. Despite this glucose intolerance, E2F1–/– mice do not develop overt diabetes mellitus because they have insulin hypersensitivity, which is secondary to a diminished adipose tissue mass and altered adipocytokine levels, which compensates for the defect in insulin secretion. These data demonstrate that factors controlling cell proliferation, such as E2F1, determine pancreatic growth and function, subsequently affecting metabolic homeostasis.

Authors

Lluis Fajas, Jean-Sébastien Annicotte, Stéphanie Miard, David Sarruf, Mitsuhiro Watanabe, Johan Auwerx

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Total citations by year

Year: 2025 2022 2021 2020 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 1 9 4 4 3 2 2 3 6 2 2 5 4 1 1 2 1 1 53
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2007 (1)

Title and authors Publication Year
Mechanisms of action of glucagon-like peptide 1 in the pancreas
ME Doyle, JM Egan
Pharmacology & Therapeutics 2007

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