Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
The addicted human brain: insights from imaging studies
Nora D. Volkow, … , Joanna S. Fowler, Gene-Jack Wang
Nora D. Volkow, … , Joanna S. Fowler, Gene-Jack Wang
Published May 15, 2003
Citation Information: J Clin Invest. 2003;111(10):1444-1451. https://doi.org/10.1172/JCI18533.
View: Text | PDF
Perspective

The addicted human brain: insights from imaging studies

  • Text
  • PDF
Abstract

Authors

Nora D. Volkow, Joanna S. Fowler, Gene-Jack Wang

×

Figure 4

Options: View larger image (or click on image) Download as PowerPoint
Images of axial sections obtained with PET, showing DA D2 receptors in n...
Images of axial sections obtained with PET, showing DA D2 receptors in nonhuman primates that were initially tested while housed in separate cages and then retested after being housed in a group. Animals that became dominant when placed in a group (a) showed increased numbers of DA D2 receptors in striatum, whereas subordinate animals (b) did not. (c) The levels of cocaine administration in the subordinate and the dominant animals. Note the much lower intake of cocaine by dominant animals which possessed higher numbers of DA D2 receptors. The temperature scale was used to code the PET images; radiotracer concentration is displayed from higher to lower as yellow > red. Asterisks indicate significant differences in drug intake between groups. Adapted with permission from ref. 11.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts