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Abstract
Aging negatively affects the capacity of muscle stem cells (MuSCs) to regenerate muscle. In this issue of the JCI, Ancel, Michaud, and colleagues used a high-content imaging screen to identify nicotinamide and pyridoxine as promoters of MuSC function. The combination of the two compounds promoted MuSC function in vivo in aged mice and in primary cells isolated from older individuals. Furthermore, the two compounds were lower in the circulation of older men, paralleling decreases in lean mass and gait speed. These results advance the translational perspective of rejuvenating MuSC function through nutraceuticals.
Authors
Taylor Peach, Mattia Quattrocelli
Figure 1
Nicotinamide and pyridoxine converge to rejuvenate aging MuSCs.
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Ancel et al. (3 ) used mouse models, human myogenic progenitor cells, and data from the Bushehr Elderly Health cohort to demonstrate the involvement of nicotinamide and pyridoxine with MuSCs. The two nutraceuticals enhanced the regenerative capacity in aging muscle through parallel pathways: nicotinamide stimulated MuSC proliferation via CK1α inhibition, thereby promoting β-catenin transcriptional outputs, and pyridoxine promoted AKT phosphorylation to enhance MuSC differentiation. In aged mice, the treatment combination rescued muscle repair.
Copyright © 2024 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)