Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.
T Kayo, A Koizumi
T Kayo, A Koizumi
Published May 15, 1998
Citation Information: J Clin Invest. 1998;101(10):2112-2118. https://doi.org/10.1172/JCI1842.
View: Text | PDF
Research Article

Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.

  • Text
  • PDF
Abstract

Mutation of the murine maturity-onset diabetes mellitus of the young (Mody) locus induces diabetes, but the effects of its homozygosity on the pancreas remain unknown. F2 mice were obtained by F1 (diabetic C57BL6 x normal Mus musculus castaneus) crosses. About 20% of the F2 progeny developed diabetes by 2 wk of age, 50% of the progeny were normal at 2 wk and developed diabetes between 5 and 8 wk of age, and the remaining 30% did not develop diabetes. Quantitative trait locus analysis using blood glucose levels of 118 F2 mice at 2 wk of age and 5-8 wk of age located Mody within 3 cM of D7Mit258. Histopathological investigation revealed hypoplastic islets (approximately 33% of that of wild-type mice) and a lower density of beta cells (approximately 20% of wild-type) with a reciprocal dominance of alpha cells (four times that of wild-type) in Mody homozygotes. Electron microscopic observations revealed a specific decrease in the number of insulin secretory granules and a lower density of beta cells. Ratios of insulin to glucagon contents confirmed specific decreases in insulin content: 0.01 for homozygotes, 0.54 for heterozygotes, and 1.11 for wild-type mice on day 14. These results suggest that Mody is involved in both islet growth and beta cell function.

Authors

T Kayo, A Koizumi

×

Total citations by year

Year: 2025 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2000 1999 Total
Citations: 1 2 2 7 1 6 4 2 3 1 4 10 8 6 5 3 7 2 1 4 3 4 1 1 88
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (88)

Title and authors Publication Year
Phosphoinositide 3-Kinase Enhancer Protein: Insights into Its Expression and Functions in Retinal Cells.
Rajala A, Rajala RVS
Advances in experimental medicine and biology 2025
Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy.
Hagmann H, Khayyat NH, Matin M, Oezel C, Chen H, Schauss A, Schell C, Benzing T, Dryer S, Brinkkoetter PT
Cells 2023
Contribution of animal models to diabetes research: Its history, significance, and translation to humans
Yagihashi S
Journal of Diabetes Investigation 2023
Type 1 diabetic Akita mice have low bone mass and impaired fracture healing
P Hu, JA McKenzie, EG Buettmann, N Migotsky, MJ Gardner, MJ Silva
Bone 2021
Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes
T Ali, X Lei, SE Barbour, A Koizumi, CE Chalfant, S Ramanadham
Molecules (Basel, Switzerland) 2021
Animal Models of Diabetes: Methods and Protocols
AJ King
2020
Animal Models of Diabetes: Methods and Protocols
AJ King
2020
Animal Models of Diabetes: Methods and Protocols
AJ King
2020
Animal Models of Diabetes: Methods and Protocols
AJ King
2020
Animal Models of Diabetes: Methods and Protocols
AJ King
2020
Inhibition of protein kinase C beta phosphorylation activates nuclear factor-kappa B and improves postischemic recovery in type 1 diabetes
S Alleboina, T Wong, MV Singh, AO Dokun
Experimental biology and medicine (Maywood, N.J.) 2020
A Low-Carbohydrate Diet Improves Glucose Metabolism in Lean Insulinopenic Akita Mice Along With Sodium-Glucose Cotransporter 2 Inhibitor
Y Fujita, KK Atageldiyeva, Y Takeda, T Yanagimachi, Y Makino, M Haneda
Frontiers in Endocrinology 2020
In utero exposure to maternal diabetes impairs nephron progenitor differentiation
DM Cerqueira, SL Hemker, AJ Bodnar, DM Ortiz, FO Oladipupo, E Mukherjee, Z Gong, C Appolonia, R Muzumdar, S Sims-Lucas, J Ho
American journal of physiology. Renal physiology 2019
Biosynthesis, structure, and folding of the insulin precursor protein
M Liu, MA Weiss, A Arunagiri, J Yong, N Rege, J Sun, L Haataja, RJ Kaufman, P Arvan
Diabetes, obesity & metabolism 2018
Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse
Y Riahi, T Israeli, R Yeroslaviz, S Chimenez, D Avrahami, M Stolovich-Rain, I Alter, M Sebag, N Polin, E Bernal-Mizrachi, Y Dor, E Cerasi, G Leibowitz
eLife 2018
Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes
D Balboa, J Saarimäki-Vire, D Borshagovski, M Survila, P Lindholm, E Galli, S Eurola, J Ustinov, H Grym, H Huopio, J Partanen, K Wartiovaara, T Otonkoski
eLife 2018
β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice
J Choi, H Kobayashi, H Okuda, KH Harada, M Takeda, H Fujimoto, S Yamane, D Tanaka, S Youssefian, N Inagaki, A Koizumi, V Sánchez-Margalet
PloS one 2018
Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes: Diabetogenic misfolding of proinsulin
A Arunagiri, L Haataja, CN Cunningham, N Shrestha, B Tsai, L Qi, M Liu, P Arvan
Annals of the New York Academy of Sciences 2018
Pulmonary Vein Ganglia Are Remodeled in the Diabetic Heart
G Bassil, M Chang, A Pauza, JD Vera, A Tsalatsanis, BG Lindsey, SF Noujaim
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2018
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
M Cnop, S Toivonen, M Igoillo-Esteve, P Salpea
Molecular Metabolism 2017
Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung
C Grasemann, R Herrmann, J Starschinova, M Gertsen, MR Palmert, H Grasemann
Nutrition and Diabetes 2017
QRS/T-Wave and Calcium Alternans in a Type I Diabetic Mouse Model for Spontaneous Post Myocardial Infarction Ventricular Tachycardia: A Mechanism for the Antiarrhythmic Effect of Statins
H Jin, CM Welzig, M Aronovitz, F Noubary, R Blanton, B Wang, M Rajab, A Albano, MS Link, SF Noujaim, HJ Park, JB Galper
Heart Rhythm 2017
“Statins Protect Against Arrhythmogenic Calcium Alternans in the Post-MI Diabetic Heart: Pleiotropy on Steroids”
RL Verrier
Heart Rhythm 2017
Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?
F Barbetti, C Colombo, L Haataja, C Cras-Méneur, S Bernardini, P Arvan
Clinical Diabetes and Endocrinology 2016
A prominent role of PDIA6 in processing of misfolded proinsulin
DG Gorasia, NL Dudek, H Safavi-Hemami, RA Perez, RB Schittenhelm, PM Saunders, S Wee, JE Mangum, MJ Hubbard, AW Purcell
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 2016
Insulin demand regulates beta cell proliferation via the UPR
Rohit Sharma, Amy O'Donnell, Rachel Stamateris, Binh Ha, Karen McCloskey, Paul Reynolds, Peter Arvan, Laura Alonso
Journal of Clinical Investigation 2015
Group VIA Phospholipase A 2 (iPLA 2 β) Modulates Bcl-x 5′-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells
SE Barbour, PT Nguyen, M Park, B Emani, X Lei, M Kambalapalli, JC Shultz, D Wijesinghe, CE Chalfant, S Ramanadham
The Journal of biological chemistry 2015
Altered parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice
PS Krishnaswamy, EE Egom, M Moghtadaei, HJ Jansen, J Azer, O Bogachev, M Mackasey, C Robbins, RA Rose
Journal of Molecular and Cellular Cardiology 2015
Glycogen Synthase Kinase-3  Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice
Y Zhang, CM Welzig, KL Picard, C Du, B Wang, JQ Pan, JM Kyriakis, MJ Aronovitz, WC Claycomb, RM Blanton, HJ Park, JB Galper
Diabetes 2014
Interactive network analysis of the plasma amino acids profile in a mouse model of hyperglycemia
T Tanaka, T Mochida, Y Maki, Y Shiraki, H Mori, S Matsumoto, K Shimbo, T Ando, K Nakamura, F Endo, M Okamoto
SpringerPlus 2013
Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin
SY Park, MZ Ludwig, NA Tamarina, BZ He, SH Carl, DA Dickerson, L Barse, B Arun, CL Williams, CM Miles, LH Philipson, DF Steiner, GI Bell, M Kreitman
Genetics 2013
Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin
M Rajab, H Jin, CM Welzig, A Albano, M Aronovitz, Y Zhang, HJ Park, MS Link, SF Noujaim, JB Galper
American journal of physiology. Heart and circulatory physiology 2013
Involvement of ASK1–p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion
K Yamaguchi, K Takeda, H Kadowaki, I Ueda, Y Namba, Y Ouchi, H Nishitoh, H Ichijo
Biochimica et Biophysica Acta (BBA) - General Subjects 2013
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance
M Maris, L Overbergh, C Gysemans, A Waget, AK Cardozo, E Verdrengh, JP Cunha, T Gotoh, M Cnop, DL Eizirik, R Burcelin, C Mathieu
Diabetologia 2012
Transgenic zebrafish model of the C43G human insulin gene mutation
SC Eames, MD Kinkel, S Rajan, VE Prince, LH Philipson
Journal of Diabetes Investigation 2012
Proinsulin Atypical Maturation and Disposal Induces Extensive Defects in Mouse Ins2+/Akita β-Cells
Q Yuan, W Tang, X Zhang, JA Hinson, C Liu, K Osei, J Wang, M Gasset
PloS one 2012
Loss of TIMP3 selectively exacerbates diabetic nephropathy
R Basu, J Lee, Z Wang, VB Patel, D Fan, SK Das, GC Liu, R John, JW Scholey, GY Oudit, Z Kassiri
American journal of physiology. Renal physiology 2012
Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice
CK Yeh, SE Harris, S Mohan, D Horn, R Fajardo, YH Chun, J Jorgensen, M MacDougall, S Abboud-Werner
Laboratory Investigation 2012
Diabetic modifier QTL, Dbm4, affecting elevated fasting blood glucose concentrations in congenic mice
S Takeshita, S Kitayama, T Suzuki, M Moritani, H Inoue, M Itakura
Genes & Genetic Systems 2012
Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring
C Grasemann, MJ Devlin, PA Rzeczkowska, R Herrmann, B Horsthemke, BP Hauffa, M Grynpas, C Alm, ML Bouxsein, MR Palmert
PloS one 2012
Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation
S Takeshita, T Suzuki, S Kitayama, M Moritani, H Inoue, M Itakura
Genes & Genetic Systems 2012
Parental Diabetes: The Akita Mouse as a Model of the Effects of Maternal and Paternal Hyperglycemia in Wildtype Offspring
C Grasemann, MJ Devlin, PA Rzeczkowska, R Herrmann, B Horsthemke, BP Hauffa, M Grynpas, C Alm, ML Bouxsein, MR Palmert, AE Toland
PloS one 2012
Loss of TIMP3 selectively exacerbates diabetic nephropathy
R Basu, J Lee, Z Wang, VB Patel, D Fan, SK Das, GC Liu, R John, JW Scholey, GY Oudit, Z Kassiri
American journal of physiology. Renal physiology 2012
Insulin gene mutations and diabetes
M Nishi, K Nanjo
Journal of Diabetes Investigation 2011
Hyperglycemic Ins2AkitaLdlr−/− mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease[S]
C Zhou, B Pridgen, N King, J Xu, JL Breslow
Journal of lipid research 2011
Endoplasmic reticulum stress and pancreatic beta cell death
SG Fonseca, J Gromada, F Urano
Trends in endocrinology and metabolism: TEM 2011
Time-dependent changes in the plasma amino acid concentration in diabetes mellitus
T Mochida, T Tanaka, Y Shiraki, H Tajiri, S Matsumoto, K Shimbo, T Ando, K Nakamura, M Okamoto, F Endo
Molecular Genetics and Metabolism 2011
A Model of Threshold Behavior Reveals Rescue Mechanisms of Bystander Proteins in Conformational Diseases
CI Sandefur, S Schnell
Biophysical Journal 2011
Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice
H Chen, C Zheng, X Zhang, J Li, J Li, L Zheng, K Huang
Peptides 2011
Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2
Y Gu, Y Mao, H Li, S Zhao, Y Yang, H Gao, J Yu, X Zhang, DM Irwin, G Niu, H Tan
Translational Research 2011
Hyperglycemic Ins2 Akita Ldlr −/− mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease
C Zhou, B Pridgen, N King, J Xu, JL Breslow
Journal of lipid research 2011
Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport
M Liu, L Haataja, J Wright, NP Wickramasinghe, QX Hua, NF Phillips, F Barbetti, MA Weiss, P Arvan
PloS one 2010
A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β)
X Lei, S Zhang, B Emani, SE Barbour, S Ramanadham
Diabetes, Obesity and Metabolism 2010
Proinsulin misfolding and diabetes: Mutant INS gene-induced Diabetes of Youth
M Liu, I Hodish, L Haataja, R Lara-Lemus, G Rajpal, J Wright, P Arvan
Trends in endocrinology and metabolism: TEM 2010
The binary switch that controls the life and death decisions of ER stressed beta cells
CM Oslowski, F Urano
Current Opinion in Cell Biology 2010
Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death
X Lei, SE Barbour, S Ramanadham
Biochimie 2010
Toward a More Rational Field-Genetic Epidemiology
A KOIZUMI
Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 2010
Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice
HJ Park, Y Zhang, C Du, CM Welzig, C Madias, MJ Aronovitz, SP Georgescu, I Naggar, B Wang, YB Kim, RO Blaustein, RH Karas, R Liao, CE Mathews, JB Galper
Circulation research 2009
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
I Hodish, M Liu, G Rajpal, D Larkin, RW Holz, A Adams, L Liu, P Arvan
The Journal of biological chemistry 2009
Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1
X Lei, S Zhang, SE Barbour, A Bohrer, EL Ford, A Koizumi, FR Papa, S Ramanadham
The Journal of biological chemistry 2009
Use of erythrocyte adhesion assay to predict the risk of diabetic complications
Y Isaji, M Okochi, F Horio, H Honda
Biochemical Engineering Journal 2009
Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A 2 Expression: A ROLE FOR REGULATION BY SREBP-1
X Lei, S Zhang, SE Barbour, A Bohrer, EL Ford, A Koizumi, FR Papa, S Ramanadham
The Journal of biological chemistry 2009
A new immunodeficient hyperglycaemic mouse model based on the Ins2 Akita mutation for analyses of human islet and beta stem and progenitor cell function
T Pearson, LD Shultz, J Lief, L Burzenski, B Gott, T Chase, O Foreman, AA Rossini, R Bottino, M Trucco, DL Greiner
Diabetologia 2008
Ablation of estrogen receptor alpha (ERα) prevents upregulation of POMC by leptin and insulin
M Hirosawa, M Minata, KH Harada, T Hitomi, A Krust, A Koizumi
Biochemical and Biophysical Research Communications 2008
Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects
B Aigner, B Rathkolb, N Herbach, MH de Angelis, R Wanke, E Wolf
American journal of physiology. Endocrinology and metabolism 2008
Diabetes Induces Rapid Suppression of Adaptive Immunity Followed by Homeostatic T-cell Proliferation
B Luo, WF Chan, SJ Lord, SA Nanji, RV Rajotte, AM Shapiro, CC Anderson
Scandinavian Journal of Immunology 2007
Proinsulin maturation, misfolding, and proteotoxicity
M Liu, I Hodish, CJ Rhodes, P Arvan
Proceedings of the National Academy of Sciences 2007
Expression of mutant Ins2C96Y results in enhanced tubule formation causing enlargement of pre-Golgi intermediates of CHO cells
JY Fan, J Roth, C Zuber
Histochemistry and Cell Biology 2007
Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice
N Herbach, B Rathkolb, E Kemter, L Pichl, M Klaften, MH de Angelis, PA Halban, E Wolf, B Aigner, R Wanke
Diabetes 2007
Endoplasmic Reticulum Stress Signaling in Pancreaticβ-Cells
SG Fonseca, KL Lipson, F Urano
Antioxidants & Redox Signaling 2007
Dimorphic gene expression patterns of anorexigenic and orexigenic peptides in hypothalamus account male and female hyperphagia in Akita type 1 diabetic mice
M Toyoshima, A Asakawa, M Fujimiya, K Inoue, S Inoue, M Kinboshi, A Koizumi
Biochemical and Biophysical Research Communications 2007
Endoplasmic Reticulum Stress Signaling in Pancreatic β -Cells
SG Fonseca, KL Lipson, F Urano
Antioxidants & Redox Signaling 2007
Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice
S Takeshita, M Moritani, K Kunika, H Inoue, M Itakura
Mammalian Genome 2006
Endoplasmic Reticulum Stress Increases Glucose-6-Phosphatase and Glucose Cycling in Liver Cells
D Wang, Y Wei, D Schmoll, KN Maclean, MJ Pagliassotti
Endocrinology 2006
Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita, tends to aggregate due to the exposed hydrophobic surface
T Yoshinaga, K Nakatome, J Nozaki, M Naitoh, J Hoseki, H Kubota, K Nagata, A Koizumi
Biological Chemistry 2005
Roles of CHOP/GADD153 in endoplasmic reticulum stress
S Oyadomari, M Mori
Cell Death and Differentiation 2004
Misfolded proinsulin accumulates in expanded pre‐Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice
C Zuber, JY Fan, B Guhl, J Roth
The FASEB Journal 2004
High ER stress in β-cells stimulates intracellular degradation of misfolded insulin
JR Allen, LX Nguyen, KE Sargent, KL Lipson, A Hackett, F Urano
Biochemical and Biophysical Research Communications 2004
Genetic Dissection of the Familial Cerebral Arteriovenous Malformation
K Takenaka, J Moroi, S Yamada, H Yamakawa, M Abe, K Tabuchi, A Koizumi
Japanese Journal of Neurosurgery 2004
Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells
AY Savinov, FS Wong, AC Stonebraker, AV Chervonsky
Journal of Experimental Medicine 2003
Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8 + T Cells
AY Savinov, FS Wong, AC Stonebraker, AV Chervonsky
Journal of Experimental Medicine 2003
Impact of Endoplasmic Reticulum Stress Pathway on Pancreatic β-Cells and Diabetes Mellitus
E Araki, S Oyadomari, M Mori
Experimental biology and medicine (Maywood, N.J.) 2003
Targeted disruption of the CHOP gene delays the onset of endoplasmic reticulum stress-mediated diabetes in Akita mice
Seiichi Oyadomari, Akio Koizumi, Kiyoshi Takeda, Tomomi Gotoh, Shizuo Akira, Eiichi Araki, Masataka Mori
Journal of Clinical Investigation 2002
Increase in Oxidative Stress in Kidneys of Diabetic Akita Mice
Y UENO, F HORIO, K UCHIDA, M NAITO, H NOMURA, Y KATO, T TSUDA, S TOYOKUNI, T OSAWA
Bioscience, Biotechnology, and Biochemistry 2002
Complications of IgA Nephropathy in a Non-Insulin-Dependent Diabetes Model, the Akita Mouse
T Haseyama, T Fujita, F Hirasawa, M Tsukada, H Wakui, A Komatsuda, H Ohtani, AB Miura, H Imai, A Koizumi
The Tohoku Journal of Experimental Medicine 2002
New mouse model to study islet transplantation in insulin-dependent diabetes mellitus:
CE Mathews, SH Langley, EH Leiter
Transplantation 2002
Developing a New Model for Non-Insulin Dependent Diabetes Mellitus (NIDDM) by Using the Philippine Wild Mouse, Mus musculus castaneus
RV ANUNCIADO, T IMAMURA, T OHNO, F HORIO, T NAMIKAWA
Experimental Animals 2000
A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse
J Wang, T Takeuchi, S Tanaka, SK Kubo, T Kayo, D Lu, K Takata, A Koizumi, T Izumi
Journal of Clinical Investigation 1999

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts