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Citations to this article

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR
Wendong Huang, … , Jun Zhang, David D. Moore
Wendong Huang, … , Jun Zhang, David D. Moore
Published January 1, 2004
Citation Information: J Clin Invest. 2004;113(1):137-143. https://doi.org/10.1172/JCI18385.
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Article Hepatology

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR

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Abstract

Yin Zhi Huang, a decoction of Yin Chin (Artemisia capillaris) and three other herbs, is widely used in Asia to prevent and treat neonatal jaundice. We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver. Here we show that treatment of WT and humanized CAR transgenic mice with Yin Zhi Huang for 3 days accelerates the clearance of intravenously infused bilirubin. This effect is absent in CAR knockout animals. Expression of bilirubin glucuronyl transferase and other components of the bilirubin metabolism pathway is induced by Yin Zhi Huang treatment of WT mice or mice expressing only human CAR, but not CAR knockout animals. 6,7-Dimethylesculetin, a compound present in Yin Chin, activates CAR in primary hepatocytes from both WT and humanized CAR mice and accelerates bilirubin clearance in vivo. We conclude that CAR mediates the effects of Yin Zhi Huang on bilirubin clearance and that 6,7-dimethylesculetin is an active component of this herbal medicine. CAR is a potential target for the development of new drugs to treat neonatal, genetic, or acquired forms of jaundice.

Authors

Wendong Huang, Jun Zhang, David D. Moore

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Total citations by year

Year: 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 1 5 3 5 3 2 6 5 2 2 10 3 3 4 6 5 2 5 2 2 76
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (5)

Title and authors Publication Year
YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α
Y Zhao, L Xu, Z Qiao, L Gao, S Ding, X Ying, Y Su, N Lin, B He, J Pu
Scientific Reports 2016
Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?
S Rudraiah, X Zhang, L Wang
Annual Review of Pharmacology and Toxicology 2016
Dimethylesculetin ameliorates maternal glucose intolerance and fetal overgrowth in high-fat diet-fed pregnant mice via constitutive androstane receptor
H Masuyama, T Mitsui, J Maki, K Tani, K Nakamura, Y Hiramatsu
Molecular and Cellular Biochemistry 2016
Cotoneaster: A Safe and Easy Way to Reduce Neonatal Jaundice
M Rafieian-kopaei
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2016
Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndrome
H Fang, A Zhang, J Yu, L Wang, C Liu, X Zhou, H Sun, Q Song, X Wang
Scientific Reports 2016

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