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ResearchIn-Press PreviewDermatologyInflammation Open Access | 10.1172/JCI183219

Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease

Kavita Vats,1 Hua Tian,2 Kunal Singh,1 Yulia Y. Tyurina,2 Louis J. Sparvero,2 Vladimir A. Tyurin,2 Oleg Kruglov,1 Alexander Chang,3 Jiefei Wang,3 Felicia Green,4 Svetlana N. Samovich,2 Jiying Zhang,1 Ansuman Chattopadhyay,5 Natalie Murray,1 Vrusha K. Shah,6 Alicia R. Mathers,1 Uma R. Chandran,7 Joseph M. Pilewski,8 John A. Kellum,9 Sally E. Wenzel,2 Hülya Bayir,10 Valerian E. Kagan,2 and Yuri L. Bunimovich1

1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

Find articles by Vats, K. in: JCI | PubMed | Google Scholar

1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

Find articles by Tian, H. in: JCI | PubMed | Google Scholar

1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

Find articles by Singh, K. in: JCI | PubMed | Google Scholar

1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

Find articles by Tyurin, V. in: JCI | PubMed | Google Scholar |

1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

Find articles by Chang, A. in: JCI | PubMed | Google Scholar |

1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

Find articles by Zhang, J. in: JCI | PubMed | Google Scholar

1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

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1Department of Dermatology, University of Pittsburgh, Pittsburgh, United States of America

2Center for Free Radical and Antioxidant Health, Department of Environmental, University of Pittsburgh, Pittsburgh, United States of America

3Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States of America

4Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom

5Molecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, United States of America

6School of Medicine, University of Pittsburgh, Pittsburgh, United States of America

7Department of Biomedical Informatics, University of PIttsburgh, Pittsburgh, United States of America

8Department of Medicine, University of Pittsburgh, Pittsburgh, United States of America

9Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States of America

10Department of Pediatrics, Columbia University Irving Medical Center, New York, United States of America

Find articles by Bunimovich, Y. in: JCI | PubMed | Google Scholar

Published November 21, 2024 - More info

J Clin Invest. https://doi.org/10.1172/JCI183219.
Copyright © 2024, Vats et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published November 21, 2024 - Version history
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Abstract

Dysregulations of epithelial-immune interactions frequently culminate in chronic inflammatory diseases of the skin, lungs, kidneys, and gastrointestinal tract. Yet, the intraepithelial processes which initiate and perpetuate inflammation in these organs are poorly understood. Here, by utilizing redox lipidomics we identified ferroptosis-associated peroxidation of polyunsaturated phosphatidylethanolamines in the epithelia of patients with asthma, cystic fibrosis, psoriasis and renal failure. Focusing on psoriasis as a disease model, we used high-resolution mass spectrometry imaging and identified keratin 14 (K14)-expressing keratinocytes executing a ferroptotic death program in human psoriatic skin. Psoriatic phenotype with characteristic Th1/Th17 skin and extracutaneous immune responses was initiated and maintained in a murine model designed to actuate ferroptosis in a fraction of K14+ glutathione peroxidase 4 (Gpx4)-deficient epidermal keratinocytes. Importantly, an anti-ferroptotic agent, Liproxstatin-1, was as effective as clinically relevant biologic IL-12/IL-23/TNFα-targeting therapies or the depletion of T cells in completely abrogating molecular, biochemical and morphologic features of psoriasis. As ferroptosis in select epidermal keratinocytes triggers and sustains a pathologic psoriatic multi-organ inflammatory circuit, we suggest that strategies targeting ferroptosis, or its causes, may be effective in preventing or ameliorating a variety of chronic inflammatory diseases.

Graphical Abstract
graphical abstract
Supplemental material

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View Table S1: Content of PE and oxPE in psoriatic vs. perilesional skin.

View Table S2: RNAseq human psoriasis lesional vs. perilesional skin (DEGs).

View Table S3: RNAseq human prosiasis lesional vs. perilesional skin (IPA pathways).

View Table S4: LC-MS oxPE+2O in mouse epidermis after topical induction of ferroptosis

View Table S5: LC-MS PE and oxPE content in K14_Gpx4 vs Cre- control epidermis.

View Table S6: RNAseq K14/Gpx4 lesional skin vs. K14-Cre- control skin (DEGs).

View Table S7: RNAseq K14/Gpx4 lesional skin vs. K14-Cre- control skin (IPA pathways).

View Table S8: RNAseq K14/Gpx4 lesional skin vs. K14-Cre- control skin (GO analysis).

View Table S9: Meta analysis K14/Gpx4 vs. human psoriasis and other mouse models (IPA pathways).

View Table S10: Meta analysis K14/Gpx4 vs. human psoriasis and other mouse models (Correlation Engine).

View Table S11: RNAseq K14/Gpx4 vs. K14-Cre- epidermis only (DEGs and IPA pathways).

Version history
  • Version 1 (November 21, 2024): In-Press Preview
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