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Research LetterIn-Press PreviewEndocrinologyInfectious disease
Open Access | 
10.1172/JCI182550
Leptin signaling maintains autonomic stability during severe influenza infection in mice
Andrés R. Muñoz-Rojas,1 Adam C. Wang,2 Lisa E. Pomeranz,2 Elizabeth L. Reizis,2 Heather W. Stout-Delgado,3 Ileana C. Miranda,4 Krishnan Rajagopalan,5 Tadiwanashe Gwatiringa,5 Roger R. Fan,5 Ahmad A. Huda,2 Neha Maskey,2 Roseline P. Olumuyide,2 Aryan S. Patel,5 Jeffrey M. Friedman,2 Diane Mathis,1 and Kartik N. Rajagopalan5
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Rajagopalan, K. in: JCI | PubMed | Google Scholar
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Gwatiringa, T. in: JCI | PubMed | Google Scholar
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Fan, R. in: JCI | PubMed | Google Scholar
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Maskey, N. in: JCI | PubMed | Google Scholar
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Patel, A. in: JCI | PubMed | Google Scholar
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Friedman, J. in: JCI | PubMed | Google Scholar
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Mathis, D. in: JCI | PubMed | Google Scholar
1Department of Immunology, Harvard Medical School, Boston, United States of America
2Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, United States of America
3Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, United States of America
4Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Rajagopalan, K. in: JCI | PubMed | Google Scholar
Published October 31, 2024 - More info
Copyright © 2024, Muñoz-Rojas et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2024 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)