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Michal Safran, William G. Kaelin Jr.
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Citations to this article (264)
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Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation
J Moehlenbrink, N Bitomsky, TG Hofmann |
Cancer Letters | 2010 |
|
An integrative model for vascular endothelial growth factor A as a tumour biomarker
AM Latham, C Molina-París, S Homer-Vanniasinkam, S Ponnambalam |
Integrative Biology | 2010 |
|
Progress in Molecular Biology and Translational Science
CJ Galbán, S Galbán, ME van Dort, GD Luker, MS Bhojani, A Rehemtulla, BD Ross |
Progress in molecular biology and translational science | 2010 |
|
Analysis of a Mathematical Model of Ischemic Cutaneous Wounds
A Friedman, B Hu, C Xue |
SIAM Journal on Mathematical Analysis | 2010 |
|
Fibulin-5 Is Up-regulated by Hypoxia in Endothelial Cells through a Hypoxia-inducible Factor-1 (HIF-1α)-dependent Mechanism
A Guadall, M Orriols, R Rodríguez-Calvo, O Calvayrac, J Crespo, R Aledo, J Martínez-González, C Rodríguez |
The Journal of biological chemistry | 2010 |
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Mass Spectrometry-Based Characterization of New Drugs and Methods of Performance Manipulation in Doping Control Analysis
M Thevis, A Thomas, M Kohler, S Beuck, I Möller, M Schäfer, G Rodchenkov, S Yin, JA Loo, H Geyer, W Schänzer |
European journal of mass spectrometry (Chichester, England) | 2010 |
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The Tumor Microenvironment
RG Bagley |
The Tumor Microenvironment | 2010 |
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The Hypoxia-Inducible Factor 1/NOR-1 Axis Regulates the Survival Response of Endothelial Cells to Hypoxia
L Martorell, M Gentile, J Rius, C Rodríguez, J Crespo, L Badimon, J Martínez-González |
Molecular and cellular biology | 2009 |
|
Mitochondrial Glutathione, a Key Survival Antioxidant
M Marí, A Morales, A Colell, C García-Ruiz, JC Fernández-Checa |
Antioxidants & Redox Signaling | 2009 |
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Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy
KG Pringle, KL Kind, AN Sferruzzi-Perri, JG Thompson, CT Roberts |
Human Reproduction Update | 2009 |
|
Oxygen Sensors at the Crossroad of Metabolism
J Aragonés, P Fraisl, M Baes, P Carmeliet |
Cell Metabolism | 2009 |
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Emerging drugs: mechanism of action, mass spectrometry and doping control analysis
M Thevis, A Thomas, M Kohler, S Beuck, W Schänzer |
Journal of Mass Spectrometry | 2009 |
|
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase
ES Ehrlich, T Wang, K Luo, Z Xiao, AM Niewiadomska, T Martinez, W Xu, L Neckers, XF Yu |
Proceedings of the National Academy of Sciences | 2009 |
|
A mathematical model of ischemic cutaneous wounds
C Xue, A Friedman, CK Sen |
Proceedings of the National Academy of Sciences | 2009 |
|
Potent antitumor activity of double-regulated oncolytic adenovirus-mediated ST13 for colorectal cancer
DB Yu, SY Zhong, M Yang, YG Wang, QJ Qian, S Zheng, XY Liu |
Cancer Science | 2009 |
|
Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas
ML Wong, A Prawira, AH Kaye, CM Hovens |
Journal of Clinical Neuroscience | 2009 |
|
Oncology of Infancy and Childhood
MJ O'Sullivan, JA Fletcher, CA Felix |
Oncology of Infancy and Childhood | 2009 |
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Métabolisme du glucose en situation pathologique aiguë
MR Losser, C Damoisel, D Payen |
Annales Françaises d'Anesthésie et de Réanimation | 2009 |
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Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia
M Fähling |
Acta physiologica (Oxford, England) | 2009 |
|
From Local Invasion to Metastatic Cancer
SP Leong |
2009 | |
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Potent antitumor activity of double‐regulated oncolytic adenovirus‐mediated ST13 for colorectal cancer
Yu DB, Zhong SY, Yang M, Wang YG, Qian QJ, Zheng S, Liu XY |
Cancer Science | 2009 |
|
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
L Lei, S Mason, D Liu, Y Huang, C Marks, R Hickey, IS Jovin, M Pypaert, RS Johnson, FJ Giordano |
Molecular and cellular biology | 2008 |
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Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11
KL He, AB Deora, H Xiong, Q Ling, BB Weksler, R Niesvizky, KA Hajjar |
The Journal of biological chemistry | 2008 |
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The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration
S Grisanti, O Tatar |
Progress in Retinal and Eye Research | 2008 |
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Renal hypoxia and dysoxia after reperfusion of the ischemic kidney
M Legrand, EG Mik, T Johannes, D Payen, C Ince |
Molecular Medicine | 2008 |
|
PET and SPECT Imaging of Tumor Biology: New Approaches towards Oncology Drug Discovery and Development
ME van Dort, A Rehemtulla, BD Ross |
Current computer-aided drug design | 2008 |
|
Wound angiogenesis as a function of tissue oxygen tension: a mathematical model
RC Schugart, A Friedman, R Zhao, CK Sen |
Proceedings of the National Academy of Sciences | 2008 |
|
Illicit organogenesis: Methods and substances of doping and manipulation
M Thevis, W Schänzer |
Organogenesis | 2008 |
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VEGF inhibition: insights from preclinical and clinical studies
Y Crawford, N Ferrara |
Cell and Tissue Research | 2008 |
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How cells switch HIPK2 on and off
D Sombroek, TG Hofmann |
Cell Death and Differentiation | 2008 |
|
Novel somatic mutations of theVHL gene in an erythropoietin-producing renal carcinoma associated with secondary polycythemia and elevated circulating endothelial progenitor cells
FH Rad, A Ulusakarya, S Gad, M Sibony, F Juin, S Richard, D Machover, G Uzan |
American Journal of Hematology | 2008 |
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Evolution and Regulation of the Downstream Gene of Hypoxia-Inducible Factor-1α in Naked Carp (Gymnocypris przewalskii) from Lake Qinghai, China
YB Cao, XQ Chen, S Wang, YX Wang, JZ Du |
Journal of Molecular Evolution | 2008 |
|
STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination
JE Jung, HS Kim, CS Lee, YJ Shin, YN Kim, GH Kang, TY Kim, YS Juhnn, SJ Kim, JW Park, SK Ye, MH Chung |
Experimental & molecular medicine | 2008 |
|
An Oxygen Molecular Sensor, the HIF Prolyl 4-Hydroxylase, in the Marine Protist Perkinsus olseni
RB Leite, AB Brito, ML Cancela |
Protist | 2008 |
|
Mass spectrometric characterization of mitochondrial complex I NDUFA10 variants
J Muñoz, J Fernández-Irigoyen, E Santamaría, A Parbel, J Obeso, FJ Corrales |
PROTEOMICS | 2008 |
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Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors
M Frohn, V Viswanadhan, AJ Pickrell, JE Golden, KM Muller, RW Bürli, G Biddlecome, SC Yoder, N Rogers, JH Dao, R Hungate, JR Allen |
Bioorganic & Medicinal Chemistry Letters | 2008 |
|
Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation
CM Tegley, VN Viswanadhan, K Biswas, MJ Frohn, TA Peterkin, C Chang, RW Bürli, JH Dao, H Veith, N Rogers, SC Yoder, G Biddlecome, P Tagari, JR Allen, RW Hungate |
Bioorganic & Medicinal Chemistry Letters | 2008 |
|
Nur77 upregulates HIF-α by inhibiting pVHL-mediated degradation
BY Kim, H Kim, EJ Cho, HD Youn |
Experimental & molecular medicine | 2008 |
|
Gas phase reaction of substituted isoquinolines to carboxylic acids in ion trap and triple quadrupole mass spectrometers after electrospray ionization and collision-induced dissociation
M Thevis, M Kohler, N Schlörer, W Schänzer |
Journal of the American Society for Mass Spectrometry | 2008 |
|
Endothelial Cell Annexin A2 Regulates Polyubiquitination and Degradation of Its Binding Partner S100A10/p11
KL He, AB Deora, H Xiong, Q Ling, BB Weksler, R Niesvizky, KA Hajjar |
The Journal of biological chemistry | 2008 |
|
Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1
A Klein, D Flügel, T Kietzmann, WP Tansey |
Molecular biology of the cell | 2008 |
|
Expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in mouse squamous cell carcinoma subjected to photodynamic therapy
M Uehara, M Nonaka, Y Hayashi, I Asahina |
Oral Medicine & Pathology | 2008 |
|
Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1α- and basic FGF-dependent pathway in muscle cells
M Egger, W Schgoer, AG Beer, J Jeschke, J Leierer, M Theurl, S Frauscher, OM Tepper, A Niederwanger, A Ritsch, M Kearney, J Wanschitz, GC Gurtner, R Fischer-Colbrie, G Weiss, H Piza-Katzer, DW Losordo, JR Patsch, P Schratzberger, R Kirchmair |
The FASEB Journal | 2007 |
|
Cardiac metabolic adaptations in response to chronic hypoxia: Hypoxia-mediated cardiac metabolic remodelling
MF Essop |
The Journal of Physiology | 2007 |
|
Hypoxia Stabilizes Type 2 Deiodinase Activity in Rat Astrocytes
A Lamirand, G Mercier, M Ramaugé, M Pierre, F Courtin |
Endocrinology | 2007 |
|
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
TK Hunt, RS Aslam, S Beckert, S Wagner, QP Ghani, MZ Hussain, S Roy, CK Sen |
Antioxidants & Redox Signaling | 2007 |
|
Targeting VEGF-A to Treat Cancer and Age-Related Macular Degeneration
N Ferrara, RD Mass, C Campa, R Kim |
Annual Review of Medicine | 2007 |
|
Complex Interactions Between Hypoxia Inducible Factors, Insulin-Like Growth Factor-II and Oxygen in Early Murine Trophoblasts
KG Pringle, KL Kind, JG Thompson, CT Roberts |
Placenta | 2007 |
|
Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity
L Lu, Z Yang, B Zhu, S Fang, X Yang, W Cai, C Li, J Ma, G Gao |
Cancer Letters | 2007 |
|
Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1): A NEGATIVE FEEDBACK REGULATORY CIRCUIT IN HIF-1-MEDIATED SIGNALING IN HYPOXIC CELLS
Y Makino, R Uenishi, K Okamoto, T Isoe, O Hosono, H Tanaka, A Kanopka, L Poellinger, M Haneda, C Morimoto |
The Journal of biological chemistry | 2007 |
|
JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism
KL Wu, H Miao, S Khan |
American journal of physiology. Renal physiology | 2007 |
|
Suppression of the Hypoxia-Inducible Factor-1 Response in Cervical Carcinoma Xenografts by Proteasome Inhibitors
DC Birle, DW Hedley |
Cancer research | 2007 |
|
Cell-Permeating α-Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells
ED MacKenzie, MA Selak, DA Tennant, LJ Payne, S Crosby, CM Frederiksen, DG Watson, E Gottlieb |
Molecular and cellular biology | 2007 |
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Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia
EL Bell, TA Klimova, J Eisenbart, PT Schumacker, NS Chandel |
Molecular and cellular biology | 2007 |
|
Protein Kinase C-Mediated Modulation of FIH-1 Expression by the Homeodomain Protein CDP/Cut/Cux
J Li, E Wang, S Dutta, JS Lau, S Jiang, K Datta, D Mukhopadhyay |
Molecular and cellular biology | 2007 |
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p53-expressing conditionally replicative adenovirus CNHK500-p53 against hepatocellular carcinoma in vitro.
Zhao HC, Zhang Q, Yang Y, Lu MQ, Li H, Xu C, Chen GH |
World Journal of Gastroenterology | 2007 |
|
Antimicrobial Peptides and Human Disease
WM Shafer |
2006 | |
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Mitochondrial disorders in renal tumors
E Hervouet, C Godinot |
Mitochondrion | 2006 |
|
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase
BL Petrella, CE Brinckerhoff |
Molecular Cancer | 2006 |
|
Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1)
DG Nagle, YD Zhou |
Current pharmaceutical design | 2006 |
|
Therapeutic options to target angiogenesis in human malignancies
RS Herbst |
Expert Opinion on Emerging Drugs | 2006 |
|
Antivascular Endothelial Growth Factor Agents and Their Development: Therapeutic Implications in Ocular Diseases
PK Kaiser |
American Journal of Ophthalmology | 2006 |
|
The role of hypoxia inducible factor-1 in cell metabolism - a possible target in cancer therapy
RS Aiba, EY Dimova, A Gorlach, T Kietzmann |
Expert Opinion on Therapeutic Targets | 2006 |
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Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation
F Nguyen-Khac, VD Valle, RG Lopez, E Ravet, M Mauchauffé, AD Friedman, LE Huang, S Fichelson, J Ghysdael, OA Bernard |
Oncogene | 2006 |
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Role of Peritubular Capillary Loss and Hypoxia in Progressive Tubulointerstitial Fibrosis in a Rat Model of Aristolochic Acid Nephropathy
D Sun, J Feng, C Dai, L Sun, T Jin, J Ma, L Wang |
American Journal of Nephrology | 2006 |
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Gene therapy of the ischemic lower limb — Therapeutic angiogenesis
V Bobek, O Taltynov, D Pinterova, K Kolostova |
Vascular Pharmacology | 2006 |
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DEVELOPMENT OF RANIBIZUMAB, AN ANTI???VASCULAR ENDOTHELIAL GROWTH FACTOR ANTIGEN BINDING FRAGMENT, AS THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION:
N Ferrara, L Damico, N Shams, H Lowman, R Kim |
Retina | 2006 |
|
Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors
NC Warshakoon, S Wu, A Boyer, R Kawamoto, J Sheville, RT Bhatt, S Renock, K Xu, M Pokross, S Zhou, R Walter, M Mekel, AG Evdokimov, S East |
Bioorganic & Medicinal Chemistry Letters | 2006 |
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A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors
NC Warshakoon, S Wu, A Boyer, R Kawamoto, J Sheville, S Renock, K Xu, M Pokross, AG Evdokimov, R Walter, M Mekel |
Bioorganic & Medicinal Chemistry Letters | 2006 |
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Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors
NC Warshakoon, S Wu, A Boyer, R Kawamoto, S Renock, K Xu, M Pokross, AG Evdokimov, S Zhou, C Winter, R Walter, M Mekel |
Bioorganic & Medicinal Chemistry Letters | 2006 |
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Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors
NC Warshakoon, S Wu, A Boyer, R Kawamoto, J Sheville, S Renock, K Xu, M Pokross, S Zhou, C Winter, R Walter, M Mekel, AG Evdokimov |
Bioorganic & Medicinal Chemistry Letters | 2006 |
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Vascular endothelial growth factor (VEGF) inhibitorsin cancer therapy: an update
J Homsi, LC Kim, PN Munster, C Chodkiewicz, A Daud |
The Women's Oncology Review | 2006 |
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Mucin 1 Oncoprotein Blocks Hypoxia-inducible Factor 1α Activation in a Survival Response to Hypoxia
L Yin, S Kharbanda, D Kufe |
The Journal of biological chemistry | 2006 |
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Hypoxia and Exercise
RC Roach, PD Wagner, PH Hackett |
2006 | |
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The Vascular Endothelium II
S Moncada, A Higgs |
2006 | |
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Oxygen- and Glucose-Dependent Expression of Trhxt1 , a Putative Glucose Transporter Gene of Trichoderma reesei,
AS Ramos, FS Chambergo, ED Bonaccorsi, AJ Ferreira, N Cella, AK Gombert, A Tonso, H El-Dorry |
Biochemistry | 2006 |
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Hepcidins in amphibians and fishes: Antimicrobial peptides or iron-regulatory hormones?
J Shi, AC Camus |
Developmental and comparative immunology | 2005 |
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Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
S Aleffi, I Petrai, C Bertolani, M Parola, S Colombatto, E Novo, F Vizzutti, FA Anania, S Milani, K Rombouts, G Laffi, M Pinzani, F Marra |
Hepatology | 2005 |
|
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
N Ferrara, KJ Hillan, W Novotny |
Biochemical and Biophysical Research Communications | 2005 |
|
Inconsistent effects of acidosis on HIF-α protein and its target genes
C Willam, C Warnecke, JC Schefold, J Kügler, P Koehne, U Frei, M Wiesener, KU Eckardt |
Pflügers Archiv - European Journal of Physiology | 2005 |
|
Angiogenesis as a therapeutic target
N Ferrara, RS Kerbel |
Nature | 2005 |
|
A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas
M Ogura, T Shibata, J Yi, J Liu, R Qu, H Harada, M Hiraoka |
Cancer Science | 2005 |
|
Mdm2 and HIF-1α interaction in tumor cells during hypoxia
AL Nieminen, S Qanungo, EA Schneider, BH Jiang, FH Agani |
Journal of Cellular Physiology | 2005 |
|
Role of impaired peritubular capillary and hypoxia in progressive interstitial fibrosis after 56 subtotal nephrectomy of rats
B Zhang, X Liang, W Shi, Z Ye, C He, X Hu, S Liu |
Nephrology | 2005 |
|
The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids
B Banerji, A Conejo-Garcia, LA McNeill, MA McDonough, MR Buck, KS Hewitson, NJ Oldham, CJ Schofield |
Chemical Communications | 2005 |
|
Mitochondrial tumour suppressors: a genetic and biochemical update
E Gottlieb, IP Tomlinson |
Nature Reviews Cancer | 2005 |
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Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
LA McNeill, E Flashman, MR Buck, KS Hewitson, IJ Clifton, G Jeschke, TD Claridge, D Ehrismann, NJ Oldham, CJ Schofield |
Molecular BioSystems | 2005 |
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Krebs cycle enzymes as tumor suppressors
BE Baysal |
Drug Discovery Today: Disease Mechanisms | 2005 |
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Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications
C Brahimi-Horn, N Mazure, J Pouysségur |
Cellular Signalling | 2005 |
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Hypoxia-induced tumor angiogenic pathway in head and neck cancer: an in vivo study
PA Kyzas, D Stefanou, A Batistatou, NJ Agnantis |
Cancer Letters | 2005 |
|
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
MA Selak, SM Armour, ED MacKenzie, H Boulahbel, DG Watson, KD Mansfield, Y Pan, MC Simon, CB Thompson, E Gottlieb |
Cancer Cell | 2005 |
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Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition
M Abu-Farha, J Niles, WG Willmore |
Biochemistry and Cell Biology | 2005 |
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Oxygen and reactive oxygen species in cartilage degradation: friends or foes?
Y Henrotin, B Kurz, T Aigner |
Osteoarthritis and Cartilage | 2005 |
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The Skp1 Prolyl Hydroxylase from Dictyostelium Is Related to the Hypoxia-inducible Factor-α Class of Animal Prolyl 4-Hydroxylases
H der Wel, A Ercan, CM West |
The Journal of biological chemistry | 2005 |
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Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase
E Temes, S Martín-Puig, B Acosta-Iborra, MC Castellanos, M Feijoo-Cuaresma, G Olmos, J Aragonés, MO Landazuri |
The Journal of biological chemistry | 2005 |
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Role of Arginine 220 in the Oxygen Sensor FixL from Bradyrhizobium japonicum
V Balland, L Bouzhir-Sima, L Kiger, MC Marden, MH Vos, U Liebl, TA Mattioli |
The Journal of biological chemistry | 2005 |
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Mechanism of hypertensive nephropathy in the Dahl/Rapp rat: a primary disorder of vascular smooth muscle
PX Wang, PW Sanders |
American journal of physiology. Renal physiology | 2005 |
|
Zinc Finger Proteins
S Iuchi, N Kuldell |
2005 | |
|
Evidence for the Presence of a Guanine Quadruplex Forming Region within a Polypurine Tract of the Hypoxia Inducible Factor 1α Promoter
RD Armond, S Wood, D Sun, LH Hurley, SW Ebbinghaus |
Biochemistry | 2005 |
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Selective Inhibition of Factor Inhibiting Hypoxia-Inducible Factor
MA McDonough, LA McNeill, M Tilliet, CA Papamicaël, QY Chen, B Banerji, KS Hewitson, CJ Schofield |
Journal of the American Chemical Society | 2005 |
|
Inhibition of NGF deprivation–induced death by low oxygen involves suppression of BIMEL and activation of HIF-1
L Xie, RS Johnson, RS Freeman |
The Journal of Cell Biology | 2005 |
|
Adaptive Myogenesis under Hypoxia
Z Yun, Q Lin, AJ Giaccia |
Molecular and cellular biology | 2005 |
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A tumor‐specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas
Ogura M, Shibata T, Yi J, Liu J, Qu R, Harada H, Hiraoka M |
Cancer Science | 2005 |
|
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
N Ferrara |
Endocrine reviews | 2004 |
|
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface
K Red-Horse, Y Zhou, O Genbacev, A Prakobphol, R Foulk, M McMaster, SJ Fisher |
Journal of Clinical Investigation | 2004 |
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Maternal Adaptation to High-altitude Pregnancy: An Experiment of Nature—A Review
LG Moore, M Shriver, L Bemis, B Hickler, M Wilson, T Brutsaert, E Parra, E Vargas |
Placenta | 2004 |
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Mouse Models of Human Cancer
R Benezra, S Rafii, D Lyden |
Mouse Models of Human Cancer | 2004 |
|
Angiogenic growth factors and hypertension
DC Sane, L Anton, KB Brosnihan |
Angiogenesis | 2004 |
|
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
JH Reiling, E Hafen |
Genes & development | 2004 |
|
Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis
B Glaunsinger, D Ganem |
Journal of Experimental Medicine | 2004 |
|
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity
DE Lancaster, LA McNeill, MA McDonough, RT Aplin, KS Hewitson, CW Pugh, PJ Ratcliffe, CJ Schofield |
Biochemical Journal | 2004 |
|
Case history: Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
N Ferrara, KJ Hillan, HP Gerber, W Novotny |
Nature Reviews Drug Discovery | 2004 |
|
Metabolic Regulation of Potassium Channels
XD Tang, LC Santarelli, SH Heinemann, T Hoshi |
Annual Review of Physiology | 2004 |
|
Anti-angiogenic effects of SN38 (active metabolite of irinotecan): inhibition of hypoxia-inducible factor 1 alpha (HIF-1?)/vascular endothelial growth factor (VEGF) expression of glioma and growth of endothelial cells
H Kamiyama, S Takano, K Tsuboi, A Matsumura |
Journal of Cancer Research and Clinical Oncology | 2004 |
|
Vascular endothelial growth factor and the nervous system
A Brockington, C Lewis, S Wharton, PJ Shaw |
Neuropathology and Applied Neurobiology | 2004 |
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Antiangiogenic therapy and tumor progression
MV Blagosklonny |
Cancer Cell | 2004 |
|
Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia
K Nakayama, IJ Frew, M Hagensen, M Skals, H Habelhah, A Bhoumik, T Kadoya, H Erdjument-Bromage, P Tempst, PB Frappell, DD Bowtell, Z Ronai |
Cell | 2004 |
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Angiotensin II Induces Hypoxia-Inducible Factor-1α in PC 12 Cells through a Posttranscriptional Mechanism: Role of AT2 Receptors
G Wolf, R Schroeder, RA Stahl |
American Journal of Nephrology | 2004 |
|
Regulation of ferrochelatase gene expression by hypoxia
YL Liu, SO Ang, DA Weigent, JT Prchal, JR Bloomer |
Life Sciences | 2004 |
|
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol
T Hagen, G D’Amico, M Quintero, M Palacios-Callender, V Hollis, F Lam, S Moncada |
Biochemical and Biophysical Research Communications | 2004 |
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Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter
N Erez, P Stambolsky, I Shats, M Milyavsky, T Kachko, V Rotter |
FEBS Letters | 2004 |
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HIF-1: master and commander of the hypoxic world
NM Mazure, MC Brahimi-Horn, MA Berta, E Benizri, RL Bilton, F Dayan, A Ginouvès, E Berra, J Pouysségur |
Biochemical Pharmacology | 2004 |
|
Hypoxic stabilization and proteolytic degradation of erythroid-specific 5-aminolevulinate synthase
M Abu-Farha, WG Willmore |
International Congress Series | 2004 |
|
VEGF and Cancer
JH Harmey |
2004 | |
|
Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
VR Gordeuk, AI Sergueeva, GY Miasnikova, D Okhotin, Y Voloshin, PL Choyke, JA Butman, K Jedlickova, JT Prchal, LA Polyakova |
Blood | 2004 |
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The worldwide distribution of the VHL 598C>T mutation indicates a single founding event
E Liu, MJ Percy, CI Amos, Y Guan, S Shete, DW Stockton, MF McMullin, LA Polyakova, SO Ang, YD Pastore, K Jedlickova, TR Lappin, V Gordeuk, JT Prchal |
Blood | 2003 |
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Series Introduction: The expanding network of redox signaling: new observations, complexities, and perspectives
RJ Soberman |
Journal of Clinical Investigation | 2003 |
|
The biology of VEGF and its receptors
N Ferrara, HP Gerber, J LeCouter |
Nature Medicine | 2003 |
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Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing: Pro-amyloidogenic effects of hypoxia
IF Smith, JP Boyle, KN Green, HA Pearson, C Peers |
Journal of Neurochemistry | 2003 |
|
Peritubular Capillary Loss after Mouse Acute Nephrotoxicity Correlates with Down-Regulation of Vascular Endothelial Growth Factor-A and Hypoxia-Inducible Factor-1α
HT Yuan, XZ Li, JE Pitera, DA Long, AS Woolf |
The American Journal of Pathology | 2003 |
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Role of Iron (II)-2-Oxoglutarate-dependent Dioxygenases in the Generation of Hypoxia-induced Phosphatidic Acid through HIF-1/2 and von Hippel-Lindau-independent Mechanisms
S Martín-Puig, E Temes, G Olmos, DR Jones, J Aragonés, MO Landázuri |
The Journal of biological chemistry | 2003 |
|
A Mechanism of Oxygen Sensing in Yeast: MULTIPLE OXYGEN-RESPONSIVE STEPS IN THE HEME BIOSYNTHETIC PATHWAY AFFECT Hap1 ACTIVITY
T Hon, A Dodd, R Dirmeier, N Gorman, PR Sinclair, L Zhang, RO Poyton |
The Journal of biological chemistry | 2003 |
|
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
T Hagen, CT Taylor, F Lam, S Moncada |
Science | 2003 |
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Tumor Angiogenesis
M Detmar |
Journal of Investigative Dermatology Symposium Proceedings | 2000 |
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