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ResearchIn-Press PreviewBone biology Open Access | 10.1172/JCI180679
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Chen, R. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Zhang, X. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Li, B. in: JCI | PubMed | Google Scholar |
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Tonetti, M. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Yang, Y. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Liu, B. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Qian, S. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Gu, Y. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Wang, Q. in: JCI | PubMed | Google Scholar |
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Mao, K. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Cheng, H. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Lai, H. in: JCI | PubMed | Google Scholar
1Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant In, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China
4State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell, School of Life Sciences, Xiamen University, Xiamen, China
Find articles by Shi, J. in: JCI | PubMed | Google Scholar
Published November 7, 2024 - More info
Local immunoinflammatory events instruct skeletal stem cells (SSCs) to repair/regenerate bone after injury, but mechanisms are incompletely understood. We hypothesized that specialized Regulatory T (Treg) cells are necessary for bone repair and interact directly with SSCs through organ-specific messages. Both in human patients with bone fracture and mouse model of bone injury, we identified a bone injury-responding Treg subpopulation with bone-repair capacity marked by CCR8. Local production of CCL1 induced a massive migration of CCR8+ Treg cells from periphery to the injury site. Depending on secretion of progranulin (PGRN), a protein encoded by the granulin (Grn) gene, CCR8+ Treg cells supported the accumulation and osteogenic differentiation of SSCs, and thereby bone repair. Mechanistically, we revealed that CCL1 enhanced expression level of basic leucine zipper ATF-like transcription factor (BATF) in CCR8+ Treg cells, which bound to Grn promoter and increased Grn translational output and then PGRN secretion. Together, our work provides a new perspective in osteoimmunology and highlights possible ways of manipulating Treg cell signaling to enhance bone repair and regeneration.