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Citations to this article

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Mitsutaka Yamamoto, … , Stephen F. Vatner, Junichi Sadoshima
Mitsutaka Yamamoto, … , Stephen F. Vatner, Junichi Sadoshima
Published November 1, 2003
Citation Information: J Clin Invest. 2003;112(9):1395-1406. https://doi.org/10.1172/JCI17700.
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Article Cardiology Article has an altmetric score of 12

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy

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Abstract

Thioredoxin 1 (Trx1) has redox-sensitive cysteine residues and acts as an antioxidant in cells. However, the extent of Trx1 contribution to overall antioxidant mechanisms is unknown in any organs. We generated transgenic mice with cardiac-specific overexpression of a dominant negative (DN) mutant (C32S/C35S) of Trx1 (Tg-DN-Trx1 mice), in which the activity of endogenous Trx was diminished. Markers of oxidative stress were significantly increased in hearts from Tg-DN-Trx1 mice compared with those from nontransgenic (NTg) mice. Tg-DN-Trx1 mice exhibited cardiac hypertrophy with maintained cardiac function at baseline. Intraperitoneal injection of N-2-mercaptopropionyl glycine, an antioxidant, normalized cardiac hypertrophy in Tg-DN-Trx1 mice. Thoracic aortic banding caused greater increases in myocardial oxidative stress and enhanced hypertrophy in Tg-DN-Trx1 compared with NTg mice. In contrast, transgenic mice with cardiac-specific overexpression of wild-type Trx1 did not show cardiac hypertrophy at baseline but exhibited reduced levels of hypertrophy and oxidative stress in response to pressure overload. These results demonstrate that endogenous Trx1 is an essential component of the cellular antioxidant mechanisms and plays a critical role in regulating oxidative stress in the heart in vivo. Furthermore, inhibition of endogenous Trx1 in the heart primarily stimulates hypertrophy, both under basal conditions and in response to pressure overload through redox-sensitive mechanisms.

Authors

Mitsutaka Yamamoto, Guiping Yang, Chull Hong, Jing Liu, Eric Holle, Xianzhong Yu, Thomas Wagner, Stephen F. Vatner, Junichi Sadoshima

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Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
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Matsuo I, Kawamura N, Ohnuki Y, Suita K, Ishikawa M, Matsubara T, Mototani Y, Ito A, Hayakawa Y, Nariyama M, Morii A, Kiyomoto K, Tsunoda M, Gomi K, Okumura S
PloS one 2022
The Role and Mechanism of Essential Selenoproteins for Homeostasis.
Ye R, Huang J, Wang Z, Chen Y, Dong Y
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SP Chelko, G Keceli, A Carpi, N Doti, J Agrimi, A Asimaki, CB Beti, M Miyamoto, N Amat-Codina, D Bedja, AC Wei, B Murray, C Tichnell, C Kwon, H Calkins, CA James, B ORourke, MK Halushka, E Melloni, JE Saffitz, DP Judge, M Ruvo, RN Kitsis, P Andersen, FD Lisa, N Paolocci
Science Translational Medicine 2021
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Y Nakayama, N Mukai, BF Wang, K Yang, P Patwari, RN Kitsis, J Yoshioka
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Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases
I Andreadou, P Efentakis, K Frenis, A Daiber, R Schulz
Basic Research in Cardiology 2021
The Impact of Selenium Deficiency on Cardiovascular Function
BK Shimada, N Alfulaij, LA Seale
International journal of molecular sciences 2021
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PP dos Santos, BP Rafacho, AF Gonçalves, VC Pires, MG Roscani, PS Azevedo, BF Polegato, MF Minicucci, AA Fernandes, SE Tanni, LA Zornoff, SA de Paiva
Arquivos brasileiros de cardiologia 2021
Thioredoxin 1 (TRX1) Overexpression Cancels the Slow Force Response (SFR) Development.
Zavala MR, Díaz RG, Villa-Abrille MC, Pérez NG
Frontiers in Cardiovascular Medicine 2021
Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China.
Shi Y, Yang W, Tang X, Yan Q, Cai X, Wu F
Frontiers in Pediatrics 2021
Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases.
Hossain MF, Bodnar Y, Klein C, Salas CO, Arnér ESJ, Gellert M, Lillig CH
Oxidative medicine and cellular longevity 2021
Effects of occlusal disharmony on susceptibility to atrial fibrillation in mice
K Suita, Y Yagisawa, Y Ohnuki, D Umeki, M Nariyama, A Ito, Y Hayakawa, I Matsuo, Y Mototani, Y Saeki, S Okumura
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Mitochondrial Ca2+, redox environment and ROS emission in heart failure: Two sides of the same coin?
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Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice
Y Yagisawa, K Suita, Y Ohnuki, M Ishikawa, Y Mototani, A Ito, I Matsuo, Y Hayakawa, M Nariyama, D Umeki, Y Saeki, Y Amitani, Y Nakamura, H Tomonari, S Okumura, T Sonobe
PloS one 2020
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Liu F, Su H, Liu B, Mei Y, Ke Q, Sun X, Tan W
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Cai M, Xu Z, Bo W, Wu F, Qi W, Tian Z
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A Sukumaran, JO Chang, M Han, S Mintri, BA Khaw, J Kim
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Cardiac Cell Senescence and Redox Signaling
D Cesselli, A Aleksova, S Sponga, C Cervellin, CD Loreto, G Tell, AP Beltrami
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Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes
S Oka, T Hirata, W Suzuki, D Naito, Y Chen, A Chin, H Yaginuma, T Saito, N Nagarajan, P Zhai, S Bhat, K Schesing, D Shao, Y Hirabayashi, J Yodoi, S Sciarretta, J Sadoshima
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Anti-cancer agents in medicinal chemistry 2011
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Y Wang
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Thioredoxin in the cardiovascular system
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