New weapons against inflammation: dual inhibitors of phospholipase A2 and transglutaminase
Lucio Miele
Lucio Miele
Published January 1, 2003
Citation Information: J Clin Invest. 2003;111(1):19-21. https://doi.org/10.1172/JCI17506.
View: Text | PDF
Commentary

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
sPLA2s hydrolyze the ester bond at the sn-2 position of membrane glycero...
sPLA2s hydrolyze the ester bond at the sn-2 position of membrane glycerophospholipids, generating free arachidonic acid. This acid is metabolized in a complex series of reactions involving COX or lipoxigenases (LOX), generating pro-inflammatory eicosanoids. TGase-catalyzed post-translational modifications activate sPLA2, potentially increasing eicosanoid production during acute inflammation. The new recombinant peptides contain a pro-elafin sequence that inhibits TGase and an antiflammin sequence that inhibits sPLA2. Thus they prevent TGase-induced sPLA2 activation.