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Citations to this article

Rheumatic fever–associated Streptococcus pyogenes isolates aggregate collagen
Katrin Dinkla, … , Gursharan S. Chhatwal, Susanne R. Talay
Katrin Dinkla, … , Gursharan S. Chhatwal, Susanne R. Talay
Published June 15, 2003
Citation Information: J Clin Invest. 2003;111(12):1905-1912. https://doi.org/10.1172/JCI17247.
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Article Infectious disease Article has an altmetric score of 5

Rheumatic fever–associated Streptococcus pyogenes isolates aggregate collagen

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Abstract

Acute rheumatic fever is a serious autoimmune sequel of Streptococcus pyogenes infection. This study shows that serotype M3 and M18 S. pyogenes isolated during outbreaks of rheumatic fever have the unique capability to bind and aggregate human basement membrane collagen type IV. M3 protein is identified as collagen-binding factor of M3 streptococci, whereas M18 isolates bind collagen through a hyaluronic acid capsule, revealing a novel function for M3 protein and capsule. Following in vivo mouse passage, conversion of a nonencapsulated and collagen-binding negative M1 S. pyogenes into an encapsulated, collagen-binding strain further supports the crucial role of capsule in mediating collagen binding. Collagen binding represents a novel colonization mechanism, as it is demonstrated that S. pyogenes bind to collagen matrix in vitro and in vivo. Moreover, immunization of mice with purified recombinant M3 protein led to the generation of anti–collagen type IV antibodies. Finally, sera from acute rheumatic fever patients had significantly increased titers of anti–collagen type IV antibodies as compared with healthy controls. These findings may suggest a link between the potential of rheumatogenic S. pyogenes isolates to bind collagen, and the presence of collagen-reactive autoantibodies in the serum of rheumatic fever patients, which may form a basis for post-streptococcal rheumatic disease. These anti-collagen antibodies may form a basis for poststreptococcal rheumatic disease.

Authors

Katrin Dinkla, Manfred Rohde, Wouter T.M. Jansen, Edward L. Kaplan, Gursharan S. Chhatwal, Susanne R. Talay

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Total citations by year

Year: 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 2007 2005 2004 Total
Citations: 2 5 4 1 2 2 3 1 2 6 2 4 2 1 1 1 1 1 41
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Citations to this article (41)

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Human vaccines 2024
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Fan J, Toth I, Stephenson RJ
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Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.
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Circulation 2022
Recent Advances in the Rheumatic Fever and Rheumatic Heart Disease Continuum.
Rwebembera J, Nascimento BR, Minja NW, de Loizaga S, Aliku T, Dos Santos LPA, Galdino BF, Corte LS, Silva VR, Chang AY, Dutra WO, Nunes MCP, Beaton AZ
2022
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections.
Jahagirdar S, Morris L, Benis N, Oppegaard O, Svenson M, Hyldegaard O, Skrede S, Norrby-Teglund A, Martins Dos Santos VAP, Saccenti E
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