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The emerging importance of lymphatics in health and disease: an NIH workshop report
Babak J. Mehrara, … , Zorina S. Galis, Selen C. Muratoglu
Babak J. Mehrara, … , Zorina S. Galis, Selen C. Muratoglu
Published September 1, 2023
Citation Information: J Clin Invest. 2023;133(17):e171582. https://doi.org/10.1172/JCI171582.
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Review Article has an altmetric score of 9

The emerging importance of lymphatics in health and disease: an NIH workshop report

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Abstract

The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in the body. Abnormal development or malfunction of the LS has been shown to play a key role in the pathophysiology of many disease states. Thus, improved understanding of the anatomical and molecular characteristics of the LS may provide approaches for disease prevention or treatment. Recent advances harnessing single-cell technologies, clinical imaging, discovery of biomarkers, and computational tools have led to the development of strategies to study the LS. This Review summarizes the outcomes of the NIH workshop entitled “Yet to be Charted: Lymphatic System in Health and Disease,” held in September 2022, with emphasis on major areas for advancement. International experts showcased the current state of knowledge regarding the LS and highlighted remaining challenges and opportunities to advance the field.

Authors

Babak J. Mehrara, Andrea J. Radtke, Gwendalyn J. Randolph, Brianna T. Wachter, Patricia Greenwel, Ilsa I. Rovira, Zorina S. Galis, Selen C. Muratoglu

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Figure 3

Lymphatic diseases manifest across the human body.

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Lymphatic diseases manifest across the human body.
Changes in normal lym...
Changes in normal lymphatic function can alter multiple systems in the body and manifest as different and varied pathologies. There are many conditions related to lymphatic dysfunction within all body systems. Hematological malignancies were not included because the focus of the workshop was on understudied diseases of the lymphatic system. Various NIH Institutes or Centers that currently fund lymphatic research are indicated: NCATS, National Center for Advancing Translational Sciences; NCCIH, National Center for Complementary and Integrative Health; NCI, National Cancer Institute; NEI, National Eye Institute; NHLBI, National Heart, Lung, and Blood Institute; NIA, National Institute on Aging; NIAID, National Institute of Allergy and Infectious Diseases; NIAMS, National Institute of Arthritis and Musculoskeletal and Skin Diseases; NIDCD, National Institute on Deafness and Other Communication Disorders; NIDCR, National Institute of Dental and Craniofacial Research; NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases; NIGMS, National Institute of General Medical Sciences; NINDS, National Institute of Neurological Disorders and Stroke.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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