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The lung mesenchyme in development, regeneration, and fibrosis
Elie El Agha, Victor J. Thannickal
Elie El Agha, Victor J. Thannickal
Published July 17, 2023
Citation Information: J Clin Invest. 2023;133(14):e170498. https://doi.org/10.1172/JCI170498.
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Review Series Article has an altmetric score of 23

The lung mesenchyme in development, regeneration, and fibrosis

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Abstract

Mesenchymal cells are uniquely located at the interface between the epithelial lining and the stroma, allowing them to act as a signaling hub among diverse cellular compartments of the lung. During embryonic and postnatal lung development, mesenchyme-derived signals instruct epithelial budding, branching morphogenesis, and subsequent structural and functional maturation. Later during adult life, the mesenchyme plays divergent roles wherein its balanced activation promotes epithelial repair after injury while its aberrant activation can lead to pathological remodeling and fibrosis that are associated with multiple chronic pulmonary diseases, including bronchopulmonary dysplasia, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease. In this Review, we discuss the involvement of the lung mesenchyme in various morphogenic, neomorphogenic, and dysmorphogenic aspects of lung biology and health, with special emphasis on lung fibroblast subsets and smooth muscle cells, intercellular communication, and intrinsic mesenchymal mechanisms that drive such physiological and pathophysiological events throughout development, homeostasis, injury repair, regeneration, and aging.

Authors

Elie El Agha, Victor J. Thannickal

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Figure 2

Mesenchymal-epithelial interactions in the alveolar and airway niches.

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Mesenchymal-epithelial interactions in the alveolar and airway niches.
(...
(A) AT2 and their so-far identified subclusters are shown. Among the identified niche cells are LIFs, MANCs, and LGR5+ cells. Cellular markers are also shown. (B) A WNT-FGF feedback loop mediates epithelial-mesenchymal communication during airway regeneration. AEP, alveolar epithelial progenitor; AMP, AXIN2+ myofibrogenic progenitor; ASMC, airway smooth muscle cell; AT2, alveolar epithelial type 2; BM, basement membrane; Epi, epithelium; IAAP, injury-activated alveolar progenitor; LGR5, leucine-rich repeat containing G protein–coupled receptor 5; LIF, lipofibroblast; MANC, mesenchymal alveolar niche cell; Mes, mesenchyme; RSMC, repair-supportive mesenchymal cell.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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