The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has resulted in much human suffering and societal disruption. The ChAdOx1 nCoV-19 vaccine against COVID-19 has had a crucial role in the fight against the pandemic. While ChAdOx1 nCoV-19 has been shown to induce adaptive B and T cell responses, which protect against COVID-19, in this issue of the JCI, Murphy et al. show that this vaccine also induces trained innate immunity. This finding contributes to a better understanding of the complex immunological effects of adenoviral-based vaccines, provides the possibility of clinically relevant heterologous effects of these vaccines, and suggests that other adenoviral-based vaccines may induce trained immunity.
Mihai G. Netea, Leo A.B. Joosten
Title and authors | Publication | Year |
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Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review
Hou G, Wang J, Liu S, Gao D, Xu Y, Zhuang Y, Dong W, Yue Y, Bai J, Li S, Ma J, Li M, Wang W, Wang Y, Li S, Cao Z |
International Journal of Biological Sciences | 2025 |
Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
Gonzalez-Perez M, Baranda J, Berges-Buxeda MJ, Conde P, Pérez-Olmeda M, Lozano-Ojalvo D, Cámara C, del Rosario Llópez-Carratalá M, Gonzalez-Parra E, Portolés P, Ortiz A, Portoles J, Ochando J |
Pharmaceuticals | 2023 |
No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines
Stevens NE, Ryan FJ, Messina NL, Blake SJ, Norton TS, Germano S, James J, Eden GL, Tee YC, Lynn MA, Botten R, Barry SE, Curtis N, Lynn DJ |
Journal of Clinical Investigation | 2023 |