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Citations to this article

Beyond adaptive immunity: induction of trained immunity by COVID-19 adenoviral vaccines
Mihai G. Netea, Leo A.B. Joosten
Mihai G. Netea, Leo A.B. Joosten
Published January 17, 2023
Citation Information: J Clin Invest. 2023;133(2):e166467. https://doi.org/10.1172/JCI166467.
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Commentary Article has an altmetric score of 2

Beyond adaptive immunity: induction of trained immunity by COVID-19 adenoviral vaccines

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Abstract

The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has resulted in much human suffering and societal disruption. The ChAdOx1 nCoV-19 vaccine against COVID-19 has had a crucial role in the fight against the pandemic. While ChAdOx1 nCoV-19 has been shown to induce adaptive B and T cell responses, which protect against COVID-19, in this issue of the JCI, Murphy et al. show that this vaccine also induces trained innate immunity. This finding contributes to a better understanding of the complex immunological effects of adenoviral-based vaccines, provides the possibility of clinically relevant heterologous effects of these vaccines, and suggests that other adenoviral-based vaccines may induce trained immunity.

Authors

Mihai G. Netea, Leo A.B. Joosten

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Total citations by year

Year: 2025 2023 Total
Citations: 1 2 3
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (3)

Title and authors Publication Year
Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review
Hou G, Wang J, Liu S, Gao D, Xu Y, Zhuang Y, Dong W, Yue Y, Bai J, Li S, Ma J, Li M, Wang W, Wang Y, Li S, Cao Z
International Journal of Biological Sciences 2025
Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
Gonzalez-Perez M, Baranda J, Berges-Buxeda MJ, Conde P, Pérez-Olmeda M, Lozano-Ojalvo D, Cámara C, del Rosario Llópez-Carratalá M, Gonzalez-Parra E, Portolés P, Ortiz A, Portoles J, Ochando J
Pharmaceuticals 2023
No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines
Stevens NE, Ryan FJ, Messina NL, Blake SJ, Norton TS, Germano S, James J, Eden GL, Tee YC, Lynn MA, Botten R, Barry SE, Curtis N, Lynn DJ
Journal of Clinical Investigation 2023

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ISSN: 0021-9738 (print), 1558-8238 (online)

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