Usage Information
Citation Information: J Clin Invest. 2023;133(3):e166283. https://doi.org/10.1172/JCI166283.
Abstract
Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were discovered in 2006, but not initially linked to any viral disease. These two lines of clinical investigation converged in 2020, with the discovery that inherited and/or autoimmune deficiencies of type I IFN immunity accounted for approximately 15%–20% of cases of critical COVID-19 pneumonia in unvaccinated individuals. Thus, insufficient type I IFN immunity at the onset of SARS-CoV-2 infection may be a general determinant of life-threatening COVID-19. These findings illustrate the unpredictable, but considerable, contribution of the study of rare human genetic diseases to basic biology and public health.
Authors
Jean-Laurent Casanova, Mark S. Anderson
Usage data is cumulative from February 2024 through February 2025.
| Usage | JCI | PMC |
|---|---|---|
| Text version | 2,049 | 309 |
| 525 | 101 | |
| Figure | 173 | 3 |
| Table | 135 | 0 |
| Citation downloads | 110 | 0 |
| Totals | 2,992 | 413 |
| Total Views | 3,405 | |
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