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Citations to this article

The rise of viperin: the emerging role of viperin in cancer progression
Alyssa G. Weinstein, … , Inês Godet, Daniele M. Gilkes
Alyssa G. Weinstein, … , Inês Godet, Daniele M. Gilkes
Published December 15, 2022
Citation Information: J Clin Invest. 2022;132(24):e165907. https://doi.org/10.1172/JCI165907.
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The rise of viperin: the emerging role of viperin in cancer progression

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Abstract

Viperin, an IFN-regulated gene product, is known to inhibit fatty acid β-oxidation in the mitochondria, which enhances glycolysis and lipogenesis during viral infections. Yet, its role in altering the phenotype of cancer cells has not been established. In this issue of the JCI, Choi, Kim, and co-authors report on a role of viperin in regulating metabolic alterations in cancer cells. The authors showed a correlation between clinical outcomes and viperin expression levels in multiple cancer tissues and proposed that viperin expression was upregulated in the tumor microenvironment via the JAK/STAT and PI3K/AKT/mTOR/HIF-1α pathways. Functionally, viperin increased lipogenesis and glycolysis in cancer cells by inhibiting fatty acid β-oxidation. Viperin expression also enhanced cancer stem cell properties, ultimately promoting tumor initiation in murine models. This study proposes a protumorigenic role for viperin and identifies HIF-1α as a transcription factor that increases viperin expression under serum starvation and hypoxia.

Authors

Alyssa G. Weinstein, Inês Godet, Daniele M. Gilkes

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Total citations by year

Year: 2025 2024 2023 2009 Total
Citations: 3 2 2 1 8
Citation information
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Citations to this article (8)

Title and authors Publication Year
Enhancement of adipose stem cell quality via Cu‐MON: Transcriptome and bioinformatics analysis of normal and diabetic stem cells
Pang R, Liu K, Liu B, Yang J
FASEB BioAdvances 2025
Viperin expression leads to downregulation of mitochondrial genes through misincorporation of ddhCTP by mitochondrial RNA polymerase
Majhi S, Roy P, Jo M, Liu J, Hurto R, Freddolino L, Marsh EN
The Journal of Biological Chemistry 2025
Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis
Cui Q, Miao Y, Li M, Zheng H, Yuan Y
Pathogens 2025
Interpretable Machine Learning Algorithms Identify Inetetamab‐Mediated Metabolic Signatures and Biomarkers in Treating Breast Cancer
Xie N, Liao D, Liu B, Zhang J, Liu L, Huang G, Ouyang Q
Journal of Clinical Laboratory Analysis 2024
TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma
Tian M, Yang L, Zhao Z, Li J, Wang L, Yin Q, Hu W, Lou Y, Du J, Zhao P
eLife 2024
Host cell restriction factors of equine infectious anemia virus.
Wang XF, Zhang X, Ma W, Li J, Wang X
Virologica Sinica 2023
Identification of a basement membrane-related genes signature to predict prognosis, immune landscape and guide therapy in gastric cancer
Liu ZY, Xin L
Medicine 2023
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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