Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner
Dimitri Lodygin, … , Antje Menssen, Heiko Hermeking
Dimitri Lodygin, … , Antje Menssen, Heiko Hermeking
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1717-1727. https://doi.org/10.1172/JCI16588.
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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

Abstract

Research Article

Authors

Dimitri Lodygin, Antje Menssen, Heiko Hermeking

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Effects of LY on epithelial cancer cells. (a) Growth curves of MCF7, A-3...
Effects of LY on epithelial cancer cells. (a) Growth curves of MCF7, A-375, HCT116, and DLD1 cells. Cells were trypsinized at the indicated time points and cell numbers were determined. (b) Induction of p21 protein after treatment with LY. HCT116 colorectal cancer cells were treated with 1.5 μM LY for the indicated periods. Cell lysates were prepared and subjected to Western blot analysis. For details, see the Methods.