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ResearchIn-Press PreviewAgingCell biology Open Access | 10.1172/JCI165814
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Franco-Romero, A. in: JCI | PubMed | Google Scholar |
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Morbidoni, V. in: JCI | PubMed | Google Scholar |
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Milan, G. in: JCI | PubMed | Google Scholar |
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Sartori, R. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Wulff, J. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Romanello, V. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Armani, A. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Salviati, L. in: JCI | PubMed | Google Scholar |
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Conte, M. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Salvioli, S. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Franceschi, C. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Buonomo, V. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Swoboda, C. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Grumati, P. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Pannone, L. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Martinelli, S. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Jefferies, H. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Dikic, I. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by van der Laan, J. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
Find articles by Cabreiro, F. in: JCI | PubMed | Google Scholar
1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
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1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
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1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
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1Department of Biomedical Sciences, University of Padova, Padova, Italy
2Clinical Genetics Unit, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3Department of Cardiac Surgery, University Hospital Basel, Basel, Switzerland
4Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany
5Department of Medical and Surgical Science, University of Bologna, Bologna, Italy
6Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
7Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
8Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America
9Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
10Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, United Kingdom
11Institute of Biochemistry II, Goethe University of Frankfurt, Frankfurt, Germany
12CECAD Research Cluster, University of Cologne, Cologne, Germany
13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States of America
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Published June 13, 2024 - More info
The identification of genes that confer either extension of lifespan or accelerate age-related decline was a step forward in understanding the mechanisms of ageing and revealed that it is partially controlled by genetics and transcriptional programs. Here we discovered that the human DNA sequence C16ORF70 encoded for a protein, named MYTHO (Macroautophagy and YouTH Optimizer), which controls life- and health-span. MYTHO protein is conserved from C. elegans to humans and its mRNA was upregulated in aged mice and elderly people. Deletion of the ortholog myt-1 gene in C. elegans dramatically shortened lifespan and decreased animal survival upon exposure to oxidative stress. Mechanistically, MYTHO is required for autophagy likely because it acts as a scaffold that binds WIPI2 and BCAS3 to recruit and assemble the conjugation system at the phagophore, the nascent autophagosome. We conclude that MYTHO is a transcriptionally regulated initiator of autophagy that is central in promoting stress resistance and healthy ageing.