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Isoprenoids as mediators of the biological effects of statins
James K. Liao
James K. Liao
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):285-288. https://doi.org/10.1172/JCI16421.
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Isoprenoids as mediators of the biological effects of statins

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James K. Liao

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Figure 1

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Biological actions of isoprenoids and cholesterol. This diagram of the c...
Biological actions of isoprenoids and cholesterol. This diagram of the cholesterol biosynthesis pathway shows the effects of inhibition of HMG-CoA reductase by statins. Decrease in isoprenylation of signaling molecules such as Ras, Rho, and Rac leads to modulation of various signaling pathways. BMP-2, bone morphogenetic protein-2; eNOS, endothelial nitric oxide synthase; t-PA, tissue-type plasminogen activator; ET-1, endothelin-1; PAI-1, plasminogen activator inhibitor-1.

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