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Citations to this article

Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
Paul J. Egan, … , Warren S. Alexander, Ian P. Wicks
Paul J. Egan, … , Warren S. Alexander, Ian P. Wicks
Published March 15, 2003
Citation Information: J Clin Invest. 2003;111(6):915-924. https://doi.org/10.1172/JCI16156.
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Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation

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Abstract

Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of cytokine signaling. To investigate the role of SOCS-1 in regulating inflammatory and immune responses in disease, acute inflammatory arthritis was induced in mice lacking SOCS-1. Expression of SOCS-1 protein was detected within synovial granulomas and pannus tissue of WT mice by day 7 following induction of acute arthritis. The severity of synovial inflammation and joint destruction at the peak of disease was greater in the absence of SOCS-1, although disease resolution occurred normally. There was an increased percentage of myeloid cells infiltrating the synovium in mice lacking SOCS-1, and SOCS-1 promoter activity was present in synovial macrophages, lymphocytes, and fibroblasts, but not granulocytes. The T cell response in draining LNs was also dysregulated, as popliteal LNs from mice lacking SOCS-1 contained approximately fivefold more cells at the peak of acute arthritis. These cells were hyperproliferative on exposure to antigen in vitro, and purified splenic CD4+ T cells from mice lacking SOCS-1 proliferated more strongly in response to stimulation with anti-CD3. Reporter gene expression was detected in CD4+ T cells bearing the activation markers CD25, CD44, and CD69. SOCS-1 is therefore expressed in hematopoietic and nonhematopoietic cell types in vivo and is an important regulator of acute inflammatory arthritis and of CD4+ T cell activation.

Authors

Paul J. Egan, Kate E. Lawlor, Warren S. Alexander, Ian P. Wicks

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Total citations by year

Year: 2025 2024 2021 2020 2019 2016 2015 2014 2013 2012 2010 2009 2008 2007 2006 2005 2003 Total
Citations: 1 1 1 1 1 1 4 1 3 1 4 2 4 1 1 6 2 35
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (4)

Title and authors Publication Year
The role of cytokines in Guillain–Barré syndrome
MO Lu, J Zhu
Journal of Neurology 2010
Suppressors of Cytokine Signaling Abrogate Diabetic Nephropathy
G Ortiz-Munoz, V Lopez-Parra, O Lopez-Franco, P Fernandez-Vizarra, B Mallavia, C Flores, A Sanz, J Blanco, S Mezzano, A Ortiz, J Egido, C Gomez-Guerrero
Journal of the American Society of Nephrology : JASN 2010
Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve
EI Girolami, D Bouhy, M Haber, H Johnson, S David
Experimental Neurology 2010
Increased expression of suppressor of cytokine signaling 1 mRNA in patients with rheumatoid arthritis.
Chan HC, Ke LY, Liu CC, Chang LL, Tsai WC, Liu HW, Yen JH
The Kaohsiung journal of medical sciences 2010

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