JCI - Citations to The therapeutic potential of modulating the ceramide/sphingomyelin pathway

Citations to this article

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

Richard Kolesnick

Richard Kolesnick

Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):3-8. https://doi.org/10.1172/JCI16127.

View: Text | PDF

Total citations by year

Year:	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014	2013	2012	2011	2010	2009	2008	2007	2006	2005	2004	2003	2002	Total
Citations:	1	4	7	7	4	8	5	7	6	6	1	9	7	8	9	11	8	15	8	3	4	6	7	2	153

Citation information

Citations to this article (153)

Title and authors	Publication	Year
Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings Sharma D, Czarnota GJ	Cancer Metastasis Reviews	2025
Ceramide on the road to insulin resistance and immunometabolic disorders in transition dairy cows: driver or passenger? Zhao Y, Zhao H, Li L, Yu S, Liu M, Jiang L	Frontiers in immunology	2024
ReTimeML: a retention time predictor that supports the LC-MS/MS analysis of sphingolipids. Allwright M, Guennewig B, Hoffmann AE, Rohleder C, Jieu B, Chung LH, Jiang YC, Lemos Wimmer BF, Qi Y, Don AS, Leweke FM, Couttas TA	Scientific Reports	2024
Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD Lee AM, Xu Y, Hu J, Xiao R, Hooper SR, Hartung EA, Coresh J, Rhee EP, Vasan RS, Kimmel PL, Warady BA, Furth SL, Denburg MR	Clinical journal of the American Society of Nephrology : CJASN	2024
The Role of Vitamin E Isoforms and Metabolites in Cancer Prevention: Mechanistic Insights into Sphingolipid Metabolism Modulation Jang Y, Kim CY	Nutrients	2024
Ganglioside GM1 and the Central Nervous System Guo Z	International journal of molecular sciences	2023
Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy. Zhu H, Chen HJ, Wen HY, Wang ZG, Liu SL	Molecules (Basel, Switzerland)	2023
Radiotherapy in bone sarcoma: the quest for better treatment option. Locquet MA, Brahmi M, Blay JY, Dutour A	BMC Cancer	2023
Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands. Staquicini DI, Cardó-Vila M, Rotolo JA, Staquicini FI, Tang FHF, Smith TL, Ganju A, Schiavone C, Dogra P, Wang Z, Cristini V, Giordano RJ, Ozawa MG, Driessen WHP, Proneth B, Souza GR, Brinker LM, Noureddine A, Snider AJ, Canals D, Gelovani JG, Petrache I, Tuder RM, Obeid LM, Hannun YA, Kolesnick RN, Brinker CJ, Pasqualini R, Arap W	Proceedings of the National Academy of Sciences	2023
Radiation combined with ultrasound and microbubbles: A potential novel strategy for cancer treatment Sharma D, Xuan Leong K, Palhares D, Czarnota GJ	Zeitschrift für Medizinische Physik	2023
Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance Cui J, Christin JR, Reisz JA, Cendali FI, Sanawar R, Coutinho De Miranda M, D\u2019Alessandro A, Guo W	Science Advances	2023
Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase He X, Schuchman EH	Biomolecules	2023
Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology. Lee AM, Hu J, Xu Y, Abraham AG, Xiao R, Coresh J, Rebholz C, Chen J, Rhee EP, Feldman HI, Ramachandran VS, Kimmel PL, Warady BA, Furth SL, Denburg MR	Journal of the American Society of Nephrology : JASN	2022
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation. Arya SB, Chen S, Jordan-Javed F, Parent CA	Nature Cell Biology	2022
Plasma membrane effects of sphingolipid-synthesis inhibition by myriocin in CHO cells: a biophysical and lipidomic study. Monasterio BG, Jiménez-Rojo N, García-Arribas AB, Riezman H, Goñi FM, Alonso A	Scientific Reports	2022
Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy Sharma D, Czarnota GJ	International journal of molecular sciences	2022
Egg yolk lipids: separation, characterization, and utilization. Abeyrathne EDNS, Nam KC, Huang X, Ahn DU	Food Science and Biotechnology	2022
Acid Sphingomyelinase Inhibitor, Imipramine, Reduces Hippocampal Neuronal Death after Traumatic Brain Injury Lee SH, Kho AR, Lee SH, Hong DK, Kang BS, Park MK, Lee CJ, Yang HW, Woo SY, Park SW, Kim DY, Choi BY, Suh SW	International journal of molecular sciences	2022
The Structural Diversity of Natural Glycosphingolipids (GSLs) Guo Z	Journal of Carbohydrate Chemistry	2022
Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease JH Song, GT Kim, KH Park, WJ Park, TS Park	Biomolecules and Therapeutics	2021
Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy I Giacomini, F Gianfanti, MA Desbats, G Orso, M Berretta, T Prayer-Galetti, E Ragazzi, V Cocetta	Frontiers in Oncology	2021
Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing AdipoR2 M Ruiz, M Henricsson, J Borén, M Pilon	Lipids in Health and Disease	2021
Ultrasound-Stimulated Microbubbles Inhibit Aggressive Phenotypes and Promotes Radiosensitivity of esophageal squamous cell carcinoma. Shi J, Fu C, Su X, Feng S, Wang S	Bioengineered	2021
Chemical Mechanisms of Nanoparticle Radiosensitization and Radioprotection: A Review of Structure-Function Relationships Influencing Reactive Oxygen Species D Howard, S Sebastian, QV Le, B Thierry, I Kempson	International journal of molecular sciences	2020
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases G Cutillo, AH Saariaho, S Meri	Cellular and Molecular Immunology	2020
Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics S Squillace, S Spiegel, D Salvemini	Trends in Pharmacological Sciences	2020
Secreted sphingomyelins modulate low mammary cancer incidence observed in certain mammals MM Ledet, RM Harman, JC Fan, E Schmitt-Matzen, ME Diaz-Rubio, S Zhang, GR de Walle	Scientific Reports	2020
mRNA profile provides novel insights into stress adaptation in mud crab megalopa, Scylla paramamosain after salinity stress Y Zhang, Q Wu, S Fang, S Li, H Zheng, Y Zhang, M Ikhwanuddin, H Ma	BMC Genomics	2020
Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1) JH Jung, K Taniguchi, HM Lee, MY Lee, R Bandu, K Komura, KY Lee, Y Akao, KP Kim	Scientific Reports	2020
C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes EJ González-Ramírez, AB García-Arribas, J Sot, FM Goñi, A Alonso	Scientific Reports	2020
Differential mechanisms underlying methotrexate-induced cell death and epithelial-mesenchymal transition in A549 cells T Ojima, M Kawami, R Yumoto, M Takano	Toxicological Research	2020
Development of a Label-Free LC-MS/MS-Based Glucosylceramide Synthase Assay and Its Application to Inhibitors Screening for Ceramide-Related Diseases Z Fu, SY Yun, JH Won, MJ Back, JM Jang, HC Ha, HK Lee, IC Shin, JY Kim, HS Kim, DK Kim	Biomolecules and Therapeutics	2019
Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course K Castro, A Ntranos, M Amatruda, M Petracca, P Kosa, EY Chen, J Morstein, D Trauner, CT Watson, MA Kiebish, B Bielekova, M Inglese, IK Sand, P Casaccia	EBioMedicine	2019
Ceramide Suppresses Influenza A Virus Replication In Vitro N Soudani, R Hage-Sleiman, W Karam, G Dbaibo, H Zaraket, BR Williams	Journal of virology	2019
The Role of Ceramides in Insulin Resistance E Sokolowska, A Blachnio-Zabielska	Frontiers in Endocrinology	2019
Cellular Stress Responses in Radiotherapy Kim, Lee, Seo, Kim, Kim, Kim, Kang, Seong, Youn, Youn	Cells	2019
Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells H Ahyayauch, AB García-Arribas, J Sot, EJ González-Ramírez, JV Busto, BG Monasterio, N Jiménez-Rojo, FX Contreras, A Rendón-Ramírez, C Martin, A Alonso, FM Goñi	Scientific Reports	2018
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells P Khiewkamrop, P Phunsomboon, L Richert, D Pekthong, P Srisawang	Cancer Cell International	2018
Low Serum Levels of (Dihydro-)Ceramides Reflect Liver Graft Dysfunction in a Real-World Cohort of Patients Post Liver Transplantation V Mücke, J Gerharz, K Jakobi, D Thomas, NF Bouzas, M Mücke, S Trötschler, N Weiler, MW Welker, S Zeuzem, J Pfeilschifter, G Grammatikos	International journal of molecular sciences	2018
A lysosome–plasma membrane–sphingolipid axis linking lysosomal storage to cell growth arrest M Samarani, N Loberto, G Soldà, L Straniero, R Asselta, S Duga, G Lunghi, FA Zucca, L Mauri, MG Ciampa, D Schiumarini, R Bassi, P Giussani, E Chiricozzi, A Prinetti, M Aureli, S Sonnino	The FASEB Journal	2018
Tumor Necrosis Factor-α in Heart Failure: an Updated Review SM Schumacher, SV Prasad	Current Cardiology Reports	2018
Effect of ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells V Perla, M Nadimi, R Reddy, GR Hankins, P Nimmakayala, RT Harris, J Valluri, C Sirbu, UK Reddy, A Ahmad	PloS one	2018
Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome HE Kong, J Lim, F Zhang, L Huang, Y Gu, DL Nelson, EG Allen, P Jin	Human Molecular Genetics	2018
Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity J Maldonado-Hernández, GE Saldaña-Dávila, MI Piña-Aguero, BA Núñez-García, MG López-Alarcón	Canadian journal of gastroenterology & hepatology	2017
Proinflammatory Cytokines Mediate GPCR Dysfunction: ML Mohan, NT Vasudevan, SV Prasad	Journal of Cardiovascular Pharmacology	2017
Plasma sphingolipids and depressive symptoms in coronary artery disease A Dinoff, M Saleem, N Herrmann, MM Mielke, PI Oh, SL Venkata, NJ Haughey, KL Lanctôt	Brain and Behavior	2017
Spatial Mapping and Profiling of Metabolite Distributions during Germination AD Feenstra, LE Alexander, Z Song, AR Korte, MD Yandeau-Nelson, BJ Nikolau, YJ Lee	Plant physiology	2017
Changes in ceramide metabolism are essential in Madin-Darby canine kidney cell differentiation LG Pescio, BJ Santacreu, VG Lopez, CH Paván, DJ Romero, NO Favale, NB Sterin-Speziale	Journal of lipid research	2017
Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells mobilization. Maeng HJ, Song JH, Kim GT, Song YJ, Lee K, Kim JY, Park TS	BMB Reports	2017
Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues To Regulate Skeletal Muscle Maturation and Vascularization JH Tsui, K Janebodin, N Ieronimakis, DM Yama, HS Yang, R Chavanachat, AL Hays, H Lee, M Reyes, DH Kim	ACS Nano	2016
Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization P Maier, L Hartmann, F Wenz, C Herskind	International journal of molecular sciences	2016
Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells D Vejselova, HM Kutlu, G Kuş	Cytotechnology	2016
Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development J Li, G Manickam, S Ray, C Oh, H Yasuda, P Moffatt, M Murshed	Molecular and cellular biology	2016
The paradox role of caspase cascade in ionizing radiation therapy N Rahmanian, SJ Hosseinimehr, A Khalaj	Journal of Biomedical Science	2016
Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma. Stefanovic M, Tutusaus A, Martinez-Nieto GA, Bárcena C, de Gregorio E, Moutinho C, Barbero-Camps E, Villanueva A, Colell A, Marí M, García-Ruiz C, Fernandez-Checa JC, Morales A	Oncotarget	2016
The traditional Tibetan medicine Yukyung Karne exhibits a potent anti-metastatic activity by inhibiting the epithelial to mesenchymal transition and cell migration T Choedon, G Mathan, V Kumar	BMC complementary and alternative medicine	2015
Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status J Liu, P Sun, Y Sun, A Liu, D You, F Jiang, Y Sun	Diagnostic Pathology	2014
Neuropathic cancer pain: What we are dealing with? How to manage it? E Esin, S Yalcin	OncoTargets and therapy	2014
Ceramide–lipid interactions studied by MD simulations and solid-state NMR B Dutagaci, J Becker-Baldus, JD Faraldo-Gómez, C Glaubitz	Biochimica et Biophysica Acta (BBA) - Biomembranes	2014
On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging EE Jones, S Dworski, D Canals, J Casas, G Fabrias, D Schoenling, T Levade, C Denlinger, YA Hannun, JA Medin, RR Drake	Analytical Chemistry	2014
Exploring the link between ceramide and ionizing radiation M Aureli, V Murdica, N Loberto, M Samarani, A Prinetti, R Bassi, S Sonnino	Glycoconjugate Journal	2014
Analysis of the phospholipid profile of metaphase II mouse oocytes undergoing vitrification J Jung, H Shin, S Bang, HJ Mok, CS Suh, KP Kim, HJ Lim	PloS one	2014
Ceramide Signaling in the Coronary Microcirculation: A Double-Edged Sword? BR Weil, JM Canty	Circulation research	2014
Direct Inhibition of Choline Kinase by a Near-Infrared Fluorescent Carbocyanine SP Arlauckas, AV Popov, EJ Delikatny	Molecular cancer therapeutics	2014
Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II F Cingolani, M Casasampere, P Sanllehi, J Casas, J Bujons, G Fabrias	Journal of lipid research	2014
Systemic ceramide accumulation leads to severe and varied pathological consequences AM Alayoubi, JC Wang, BC Au, S Carpentier, V Garcia, S Dworski, S El-Ghamrasni, KN Kirouac, MJ Exertier, ZJ Xiong, GG Privé, CM Simonaro, J Casas, G Fabrias, EH Schuchman, PV Turner, R Hakem, T Levade, JA Medin	EMBO Molecular Medicine	2013
Sphingolipids in Disease E Gulbins, I Petrache		2013
Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders H Chen, AY Chan, DU Stone, NA Mandal	Survey of Ophthalmology	2013
Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles C Peetla, S Vijayaraghavalu, V Labhasetwar	Advanced Drug Delivery Reviews	2013
Sphingolipid metabolic pathway: an overview of major roles played in human diseases RP Rao, N Vaidyanathan, M Rengasamy, AM Oommen, N Somaiya, MR Jagannath	Journal of Lipids	2013
Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer R Savić, X He, I Fiel, EH Schuchman, A Arlt	PloS one	2013
Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases LM Halasiddappa, H Koefeler, AH Futerman, A Hermetter, PK Datta	PloS one	2013
Ceramide-orchestrated signalling in cancer cells SA Morad, MC Cabot	Nature Reviews Cancer	2012
Ceramide function in the brain: when a slight tilt is enough C Mencarelli, P Martinez–Martinez	Cellular and Molecular Life Sciences	2012
Function and Regulation of Lipid Biology in Caenorhabditis elegans Aging NS Hou, S Taubert	Frontiers in physiology	2012
Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine S Preuß, FD Omam, J Scheiermann, S Stadelmann, S Winoto-Morbach, P Bismarck, S Adam-Klages, F Knerlich-Lukoschus, D Lex, D Wesch, J Held-Feindt, S Uhlig, S Schütze, MF Krause	Journal of Cellular and Molecular Medicine	2012
Examining the role of lipid mediators in diabetic retinopathy JV Busik, WJ Esselman, GE Reid	Clinical Lipidology	2012
Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression W Ruangsiriluk, SE Grosskurth, D Ziemek, M Kuhn, SG Etages, OL Francone	Journal of lipid research	2012
Mixing properties of sphingomyelin ceramide bilayers: a simulation study R Metcalf, SA Pandit	The Journal of Physical Chemistry B	2012
Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression NC Lucki, S Bandyopadhyay, E Wang, AH Merrill, MB Sewer	Molecular Endocrinology	2012
Clinical Utility of Serum Autoantibodies Detected by Protein Microarray in Melanoma MS Sabel, Y Liu, KA Griffith, J He, X Xie, DM Lubman	International Journal of Proteomics	2011
Free Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Reduces Retinal Vascular Permeability in Association with a Reduction of Acid Sphingomyelinase (ASMase) JL Kielczewski, SL Calzi, LC Shaw, J Cai, X Qi, Q Ruan, L Wu, L Liu, P Hu, T Chan-Ling, RN Mames, S Firth, RC Baxter, P Turowski, JV Busik, ME Boulton, MB Grant	Investigative ophthalmology & visual science	2011
Roles of Reactive Oxygen and Nitrogen Species in Pain D Salvemini, JW Little, T Doyle, WL Neumann	Free radical biology & medicine	2011
Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain R Tidhar, S Ben-Dor, E Wang, S Kelly, AH Merrill, AH Futerman	The Journal of biological chemistry	2011
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage S Lépine, JC Allegood, Y Edmonds, S Milstien, S Spiegel	The Journal of biological chemistry	2011
AP-1 binding transcriptionally regulates human neutral ceramidase SM O’Neill, KL Houck, JK Yun, TE Fox, M Kester	Archives of Biochemistry and Biophysics	2011
Transcriptional regulation of the human neutral ceramidase gene SM O’Neill, JK Yun, TE Fox, M Kester	Archives of Biochemistry and Biophysics	2011
Identification of Novel Functional Inhibitors of Acid Sphingomyelinase J Kornhuber, M Muehlbacher, S Trapp, S Pechmann, A Friedl, M Reichel, C Mühle, L Terfloth, TW Groemer, GM Spitzer, KR Liedl, E Gulbins, P Tripal, H Riezman	PloS one	2011
Alpha particles induce apoptosis through the sphingomyelin pathway. Seideman JH, Stancevic B, Rotolo JA, McDevitt MR, Howell RW, Kolesnick RN, Scheinberg DA	Radiation Research	2011
Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid M Opreanu, TA Lydic, GE Reid, KM McSorley, WJ Esselman, JV Busik	Investigative ophthalmology & visual science	2010
Ceramide and ceramide 1-phosphate in health and disease L Arana, P Gangoiti, A Ouro, M Trueba, A Gómez-Muñoz	Lipids in Health and Disease	2010
Ceramide-rich platforms in transmembrane signaling B Stancevic, R Kolesnick	FEBS Letters	2010
Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials TH Beckham, S Elojeimy, JC Cheng, LS Turner, SR Hoffman, JS Norris, X Liu	Expert Opinion on Therapeutic Targets	2010
The interplay between bioactive sphingolipids and steroid hormones NC Lucki, MB Sewer	Steroids	2010
Perspective on plasma membrane cholesterol efflux and spermatozoal function DS Sheriff, EF Ali	Journal of human reproductive sciences	2010
Ceramide modulates HERG potassium channel gating by translocation into lipid rafts SB Ganapathi, TE Fox, M Kester, KS Elmslie	American journal of physiology. Cell physiology	2010
Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems LE van Vlerken, Z Duan, SR Little, MV Seiden, MM Amiji	The AAPS Journal	2010
Mammalian ceramide synthases M Levy, AH Futerman	IUBMB Life	2010
Effect of Irradiation on Microvascular Endothelial Cells of Parotid Glands in the Miniature Pig J Xu, X Yan, R Gao, L Mao, AP Cotrim, C Zheng, C Zhang, BJ Baum, S Wang	International journal of radiation oncology, biology, physics	2010
Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells YJ Kim, EA Kim, UD Sohn, CB Yim, C Im	The Korean Journal of Physiology & Pharmacology	2010
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Never say die: survival signaling in large granular lymphocyte leukemia MV Shah, R Zhang, TP Loughran	Clinical Lymphoma & Myeloma	2009
Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance L Bryant, T Doyle, Z Chen, S Cuzzocrea, E Masini, MC Vinci, E Esposito, E Mazzon, DN Petrusca, I Petrache, D Salvemini	Neuroscience Letters	2009
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy S Pattingre, C Bauvy, S Carpentier, T Levade, B Levine, P Codogno	The Journal of biological chemistry	2009
Ceramide acyl chain length markedly influences miscibility with palmitoyl sphingomyelin in bilayer membranes B Westerlund, PM Grandell, YJ Isaksson, JP Slotte	European Biophysics Journal	2009
The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia: DMS inhibits neointimal formation RA McDonald, S Pyne, NJ Pyne, A Grant, CL Wainwright, RM Wadsworth	British Journal of Pharmacology	2009
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms M Athar, JH Back, L Kopelovich, DR Bickers, AL Kim	Archives of Biochemistry and Biophysics	2009
Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo V Juric, CC Chen, LF Lau	Molecular and cellular biology	2009
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation MM Ndengele, S Cuzzocrea, E Masini, MC Vinci, E Esposito, C Muscoli, DN Petrusca, V Mollace, E Mazzon, D Li, I Petrache, GM Matuschak, D Salvemini	The Journal of pharmacology and experimental therapeutics	2008
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes MV Shah, R Zhang, R Irby, R Kothapalli, X Liu, T Arrington, B Frank, NH Lee, TP Loughran	Blood	2008
Lipids in Health and Disease PJ Quinn, X Wang	Lipids in Health and Disease	2008
Enhancement in Anti-proliferative Effects of Paclitaxel in Aortic Smooth Muscle Cells upon Co-administration with Ceramide using Biodegradable Polymeric Nanoparticles D Deshpande, H Devalapally, M Amiji	Pharmaceutical Research	2008
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism WL Holland, SA Summers	Endocrine reviews	2008
Structure and function of glycosphingolipids and sphingolipids: recollections and future trends S Hakomori	Biochimica et Biophysica Acta	2008
The role of skeletal muscle sphingolipids in the development of insulin resistance M Straczkowski, I Kowalska	The review of diabetic studies : RDS	2008
Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair S Markovic-Plese, AK Singh, I Singh	Future Neurology	2008
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer AE Mahdy, JC Cheng, J Li, S Elojeimy, WD Meacham, LS Turner, A Bai, CR Gault, AS McPherson, N Garcia, TH Beckham, A Saad, A Bielawska, J Bielawski, YA Hannun, TE Keane, MI Taha, HM Hammouda, JS Norris, X Liu	Molecular Therapy	2008
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity CG Ng, I Coppens, D Govindarajan, J Pisciotta, V Shulaev, DE Griffin	Proceedings of the National Academy of Sciences	2008
Statins’ immunomodulatory potential against Th17 cell-mediated autoimmune response X Zhang, S Markovic-Plese	Immunologic Research	2008
Apoptotic Effects of Dietary and Synthetic Sphingolipids in Androgen-Independent (PC-3) Prostate Cancer Cells KD Kent, EA Clubbs, WJ Harper, JA Bomser	Lipids	2008
All-trans-retinoic acid induces apoptosis in Leydig cells via activation of the mitochondrial death pathway and antioxidant enzyme regulation P Tucci, E Cione, M Perri, G Genchi	Journal of Bioenergetics and Biomembranes	2008
Albumin-Associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal FR Garcia-Gonzalo, JC Belmonte, S Rutherford	PloS one	2008
Dietary terpenoids and prostate cancer chemoprevention. Rabi T, Gupta S	Frontiers in bioscience : a journal and virtual library	2008
Disturbance in Activated Sphingolipid Metabolism Causes Maternally-Derived Pregnancy Loss Kiyomi Mizugishi, Cuiling Li, Ana Olivera, Jacek Bielawski, Alicja Bielawska, Chu-Xia Deng, Richard L. Proia	Journal of Clinical Investigation	2007
Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes M Straczkowski, I Kowalska, M Baranowski, A Nikolajuk, E Otziomek, P Zabielski, A Adamska, A Blachnio, J Gorski, M Gorska	Diabetologia	2007
Sphingolipid therapy in myocardial ischemia-reperfusion injury S Gundewar, DJ Lefer	Biochimica et Biophysica Acta	2007
The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells H Chandru, V Boggaram	Gene	2007
Steroidogenic factor-1 is a sphingolipid binding protein AN Urs, E Dammer, S Kelly, E Wang, AH Merrill, MB Sewer	Molecular and Cellular Endocrinology	2007
Neuronal Conduction of Excitation without Action Potentials Based on Ceramide Production C Fasano, F Tercé, JP Niel, HT Nguyen, A Hiol, J Bertrand-Michel, N Mallet, X Collet, JP Miolan, B Brembs	PloS one	2007
Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization Z Li, TK Hailemariam, H Zhou, Y Li, DC Duckworth, DA Peake, Y Zhang, MS Kuo, G Cao, XC Jiang	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2007
Cyclodextrins Inhibit Replication of Scrapie Prion Protein in Cell Culture M Prior, S Lehmann, MS Sy, B Molloy, HE McMahon	Journal of virology	2007
Acid Sphingomyelinase Deficiency Increases Susceptibility to Fatal Alphavirus Encephalomyelitis CG Ng, DE Griffin	Journal of virology	2006
Diabetes Alters Sphingolipid Metabolism in the Retina: A Potential Mechanism of Cell Death in Diabetic Retinopathy TE Fox, X Han, S Kelly, AH Merrill, RE Martin, RE Anderson, TW Gardner, M Kester	Diabetes	2006
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat SK Ryu, DS Ahn, YE Cho, SK Choi, YH Kim, KG Morgan, YH Lee	Naunyn-Schmiedeberg's Archives of Pharmacology	2006
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice I Petrache, V Natarajan, L Zhen, TR Medler, AT Richter, C Cho, WC Hubbard, EV Berdyshev, RM Tuder	Nature Medicine	2005
Ceramide alters endothelial cell permeability by a nonapoptotic mechanism K Lindner, U Uhlig, S Uhlig	British Journal of Pharmacology	2005
The 3-Hydroxy Group and 4,5-trans Double Bond of Sphingomyelin Are Essential for Modulation of Galactosylceramide Transmembrane Asymmetry B Malewicz, JT Valiyaveettil, K Jacob, HS Byun, P Mattjus, WJ Baumann, R Bittman, RE Brown	Biophysical Journal	2005
Inhibitory effect of dietary monoglucosylceramide 1‐O‐β‐glucosyl‐N‐2′‐hydroxyarachidoyl‐4,8‐sphingadienine on two different categories of colon preneoplastic lesions induced by 1,2‐dimethylhydrazine in F344 rats Inamine M, Suzui M, Morioka T, Kinjo T, Kaneshiro T, Sugishita T, Okada T, Yoshimi N	Cancer Science	2005
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1a contributing to tumor necrosis factor induced lethal hepatitis Monserrat Mari, Anna Colell, Albert Morales, Covadonga Paneda, Isabel Varela-Nieto, Jose C Fernandez-Checa	Journal of Clinical Investigation	2004
Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites AE Alewijnse, SL Peters, MC Michel	British Journal of Pharmacology	2004
Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells AS Jaiswal, S Narayan	Journal of Cancer Research and Clinical Oncology	2004
Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert E Suzuki, K Handa, MS Toledo, S Hakomori	Proceedings of the National Academy of Sciences	2004
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis Q Jiang, J Wong, H Fyrst, JD Saba, BN Ames	Proceedings of the National Academy of Sciences	2004
Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis C Gajate, ED Canto-Jañez, AU Acuña, F Amat-Guerri, E Geijo, AM Santos-Beneit, RJ Veldman, F Mollinedo	Journal of Experimental Medicine	2004
Defective tumor necrosis factor-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice Carmen García-Ruiz, Anna Colell, Montserrat Marí, Albert Morales, María Calvo, Carles Enrich, José C. Fernández-Checa.	Journal of Clinical Investigation	2003
Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes PG Ribaux, PB Iynedjian	Biochemical Journal	2003
Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism DJ Powell, E Hajduch, G Kular, HS Hundal	Molecular and cellular biology	2003
Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP S Basu, R Ma, B Mikulla, M Bradley, C Moulton, M Basu, S Banerjee, J Inokuchi	Glycoconjugate Journal	2003
Glycosphingolipids and cell death M Bektas, S Spiegel	Glycoconjugate Journal	2003
DIFFERENTIAL SENSITIVITY TO SHORT-CHAIN CERAMIDE ANALOGUES OF HUMAN INTESTINAL CARCINOMA CELLS GROWN IN TUMOR SPHEROIDS VERSUS MONOLAYER CULTURE EL Lowthers, CL Richard, J Blay	In vitro cellular & developmental biology. Animal	2003
Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model Y Tazuke, RA Drongowski, DH Teitelbaum, AG Coran	Pediatric Surgery International	2003
Cholesterol, lipid rafts and disease Kai Simons, Robert Ehehalt	Journal of Clinical Investigation	2002
The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatazoa Alexander Travis, Gregory Kopf	Journal of Clinical Investigation	2002

Advertisement