Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells
Robin Parihar, … , Yan Hu, William E. Carson
Robin Parihar, … , Yan Hu, William E. Carson
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):983-992. https://doi.org/10.1172/JCI15950.
View: Text | PDF
Article Oncology Article has an altmetric score of 12

IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells

  • Text
  • PDF
Abstract

Research Article

Authors

Robin Parihar, Julie Dierksheide, Yan Hu, William E. Carson

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2003 Total
Citations: 1 7 8 8 12 10 6 7 8 6 6 4 7 6 8 2 1 7 1 115
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (115)

Title and authors Publication Year
Natural killer cells: the immune frontline against circulating tumor cells
Masmoudi D, Villalba M, Alix-Panabières C
Journal of Experimental & Clinical Cancer Research : CR 2025
Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients
Lee NY, Hum M, Tan GP, Seah AC, Ong PY, Kin PT, Lim CW, Samol J, Tan NC, Law HY, Tan MH, Lee SC, Ang P, Lee AS
Clinical Epigenetics 2024
An Open-Label Study of Subcutaneous CpG Oligodeoxynucleotide (PF03512676) in Combination with Trastuzumab in Patients with Metastatic HER2+ Breast Cancer.
Quiroga D, Wesolowski R, Zelinskas S, Pinette A, Benner B, Schwarz E, Savardekar H, Johnson C, Stiff A, Yu L, Macrae E, Lustberg M, Mrozek E, Ramaswamy B, Carson WE 3rd
Cancer control : journal of the Moffitt Cancer Center 2024
Greater mechanistic understanding of the cutaneous pathogenesis of Stevens–Johnson syndrome/toxic epidermal necrolysis can shed light on novel therapeutic strategies: a comprehensive review
Ogiji ED, Aboheimed N, Ross K, Voller C, Siner R, Jensen RL, Jolly CE, Carr DF
Current Opinion in Allergy and Clinical Immunology 2024
Single-cell RNA Sequencing Identifies Natural Kill Cell-Related Transcription Factors Associated With Age-Related Macular Degeneration
Luo Y, Liu J, Feng W, Lin D, Chen M, Zheng H
Evolutionary Bioinformatics Online 2024
Evaluating Ovarian Cancer Chemotherapy Response Using Gene Expression Data and Machine Learning.
Amniouel S, Yalamanchili K, Sankararaman S, Jafri MS
BioMedInformatics 2024
Polymeric PD1/PDL1 bispecific antibody enhances immune checkpoint blockade therapy
Xue F, Ren X, Kong C, Wang J, Liu L, Hu J, Shen N, Tang Z
Materials Today Bio 2024
Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model.
Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F
International journal of nanomedicine 2024
Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells
Kim S, Park CI, Lee S, Choi HR, Kim CH
Frontiers in immunology 2023
Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses
Moran J, Mylod E, Kane LE, Marion C, Keenan E, Mekhaeil M, Lysaght J, Dev KK, O\u2019Sullivan J, Conroy MJ
Pharmaceutics 2023
Preclinical development of a first-in-class vaccine encoding HER2, Brachyury and CD40L for antibody enhanced tumor eradication.
Hinterberger M, Endt K, Bathke B, Habjan M, Heiseke A, Schweneker M, Von Rohrscheidt J, Atay C, Chaplin P, Kalla M, Hausmann J, Schmittwolf C, Lauterbach H, Volkmann A, Hochrein H, Medina-Echeverz J
Scientific Reports 2023
Phenotypic and functional analysis in HER2+ targeted therapy of human NK cell subpopulation according to the expression of FcεRIγ and NKG2C in breast cancer patients.
Bordignon MB, Pesce Viglietti AI, Juliá EP, Sanchez MB, Rölle A, Mandó P, Sabatini L, Ostinelli A, Rizzo MM, Barrio MM, Mordoh J, Fainboim L, Levy EM
Cancer Immunology, Immunotherapy 2023
Interaction between Radiation Therapy and Targeted Therapies in HER2-Positive Breast Cancer: Literature Review, Levels of Evidence for Safety and Recommendations for Optimal Treatment Sequence
Debbi K, Grellier N, Loganadane G, Boukhobza C, Mahé M, Cherif MA, Rida H, Gligorov J, Belkacemi Y
Cancers 2023
Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products
Kao CY, Mills JA, Burke CJ, Morse B, Marques BF
Biology 2023
Viral nanoparticle vaccines against S100A9 reduce lung tumor seeding and metastasis.
Chung YH, Ortega-Rivera OA, Volckaert BA, Jung E, Zhao Z, Steinmetz NF
Proceedings of the National Academy of Sciences 2023
The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies
Rahimi A, Malakoutikhah Z, Rahimmanesh I, Ferns GA, Nedaeinia R, Ishaghi SM, Dana N, Haghjooy Javanmard S
Cancer Cell International 2023
Recent Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis
A Jangra, A Kothari, P Sarma, B Medhi, B Omar, K Kaushal
Cells 2022
A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells
C Cubitt, E McClain, M Becker-Hapak, J Foltz, P Wong, J Wagner, C Neal, N Marin, L Marsala, M Foster, T Schappe, P Soon-Shiong, J Lee, M Berrien-Elliott, T Fehniger
Molecular Therapy — Oncolytics 2022
Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives
Atallah-Yunes SA, Robertson MJ
Frontiers in immunology 2022
Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders
Hue SS, Ng SB, Wang S, Tan SY
Cancers 2022
Intratumoral delivery of dendritic cells plus anti-HER2 therapy triggers both robust systemic antitumor immunity and complete regression in HER2 mammary carcinoma
Ramamoorthi G, Kodumudi K, Snyder C, Grover P, Zhang H, Greene MI, Basu A, Gallen C, Wiener D, Costa RL, Han HS, Koski G, Czerniecki BJ
Journal for ImmunoTherapy of Cancer 2022
The balance of interleukin‐12 and interleukin‐23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection
Wang H, Nelson AG, Wang B, Zhao Z, Lim XY, Shi M, Meehan LJ, Jia X, Kedzierska K, Meehan BS, Eckle SB, Souter MN, Pediongco TJ, Mak JY, Fairlie DP, McCluskey J, Wang Z, Corbett AJ, Chen Z
Immunology and Cell Biology 2022
Antitumor Activities of Interleukin-12 in Melanoma
Gao W, Pan J, Pan J
Cancers 2022
TLR9 and Glioma: Friends or Foes?
Fehri E, Ennaifer E, Bel Haj Rhouma R, Ardhaoui M, Boubaker S
Cells 2022
Antibody Conjugation of Fluorescent Nanodiamonds for Targeted Innate Immune Cell Activation
LP Suarez-Kelly, SH Sun, C Ren, IV Rampersaud, D Albertson, MC Duggan, TC Noel, N Courtney, NJ Buteyn, C Moritz, L Yu, VO Yildiz, JP Butchar, S Tridandapani, AA Rampersaud, WE Carson
2021
Implications of a ‘Third Signal’ in NK Cells
M Khalil, D Wang, E Hashemi, SS Terhune, S Malarkannan
Cells 2021
The Role of Gut Microbiota in Overcoming Resistance to Checkpoint Inhibitors in Cancer Patients: Mechanisms and Challenges
Y Bouferraa, A Chedid, G Amhaz, AE Lakkiss, D Mukherji, S Temraz, A Shamseddine
International journal of molecular sciences 2021
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions
AM Altaie, T Venkatachalam, LP Samaranayake, SS Soliman, R Hamoudi
Frontiers in immunology 2021
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Therapeutic Opportunities and Clinical Challenges
AR Poh, M Ernst
Cancers 2021
Role of microRNAs in COVID-19 with implications for therapeutics
N Arghiani, T Nissan, MM Matin
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2021
Targeting ADCC: A different approach to HER2 breast cancer in the immunotherapy era
P Mandó, SG Rivero, MM Rizzo, M Pinkasz, EM Levy
Breast (Edinburgh, Scotland) 2021
Intranasal Administration of Codium fragile Polysaccharide Elicits Anti-Cancer Immunity against Lewis Lung Carcinoma
Y Wang, EK An, SJ Kim, SG You, JO Jin
International journal of molecular sciences 2021
Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments
CM Stewart, A Phan, Y Bo, ND LeBlond, TK Smith, G Laroche, PM Giguère, MD Fullerton, M Pelchat, D Kobasa, M Côté, JH Kuhn
PLoS pathogens 2021
Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy
Q Qiu, Y Lin, Y Ma, X Li, J Liang, Z Chen, K Liu, Y Huang, H Luo, R Huang, L Luo
Frontiers in immunology 2021
Nanotechnology-enhanced immunotherapy for metastatic cancer
P Zhang, J Meng, Y Li, C Yang, Y Hou, W Tang, KJ McHugh, L Jing
2021
Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function
P Trikha, J Moseman, A Thakkar, A Campbell, E Elmas, J Foltz, N Chakravarti, J Fitch, E Mardis, D Lee
Blood Advances 2021
Increased IL-2 and Reduced TGF-β Upon T-Cell Stimulation are Associated with GM-CSF Upregulation in Multiple Immune Cell Types in Multiple Sclerosis
J Aram, N Frakich, E Morandi, M Alrouji, A Samaraweera, D Onion, I Spendlove, SL Colombo, R Tanasescu, B Gran, CS Constantinescu
Biomedicines 2020
Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors
O Melaiu, V Lucarini, L Cifaldi, D Fruci
Frontiers in immunology 2020
High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model
RA Luchtel, T Bhagat, K Pradhan, WR Jacobs, M Levine, A Verma, N Shenoy
Proceedings of the National Academy of Sciences 2020
Clinical development of immunotherapies for HER2+ breast cancer: a review of HER2-directed monoclonal antibodies and beyond
RL Costa, BJ Czerniecki
npj Breast Cancer 2020
Mechanisms of Resistance to NK Cell Immunotherapy
C Sordo-Bahamonde, M Vitale, S Lorenzo-Herrero, A López-Soto, S Gonzalez
Cancers 2020
Gut Microbiome as a Potential Factor for Modulating Resistance to Cancer Immunotherapy
L Shui, , J Li, C Yi, Q Sun, H Zhu
Frontiers in immunology 2020
Oncolytic effects of the recombinant Newcastle disease virus, rAF-IL12, against colon cancer cells in vitro and in tumor-challenged NCr-Foxn1nu nude mice
SU Najmuddin, ZM Amin, SW Tan, SK Yeap, J Kalyanasundram, A Veerakumarasivam, SC Chan, SL Chia, K Yusoff, NB Alitheen
PeerJ 2020
Immunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse model
PT Kaumaya, L Guo, J Overholser, ML Penichet, T Bekaii-Saab
OncoImmunology 2020
Effect of interleukins (IL-2, IL-15, IL-18) on receptors activation and cytotoxic activity of natural killer cells in breast cancer cell
W Widowati, DK Jasaputra, SB Sumitro, MA Widodo, T Mozef, R Rizal, HS Kusuma, DR Laksmitawati, H Murti, I Bachtiar, A Faried
African health sciences 2020
CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axis
C Capuano, C Pighi, R Maggio, S Battella, S Morrone, G Palmieri, A Santoni, C Klein, R Galandrini
Cancer Immunology, Immunotherapy 2020
Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors
G Nayyar, Y Chu, MS Cairo
Frontiers in Oncology 2019
IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection
P Kumar, K Rajasekaran, A Nanbakhsh, J Gorski, MS Thakar, S Malarkannan
Scientific Reports 2019
Amino acid residues involved in the heparin-binding activity of murine IL-12 in the context of an antibody-cytokine fusion protein
R Luria-Pérez, PV Candelaria, TR Daniels-Wells, JA Rodríguez, G Helguera, ML Penichet
Cytokine 2019
Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function
TA Mace, MB Ware, SA King, S Loftus, MR Farren, E McMichael, S Scoville, C Geraghty, G Young, WE Carson, SK Clinton, GB Lesinski
Scientific Reports 2019
A Phase I/II Trial of Cetuximab in Combination with Interleukin-12 Administered to Patients with Unresectable Primary or Recurrent Head and Neck Squamous Cell Carcinoma
EL McMichael, B Benner, LS Atwal, NB Courtney, X Mo, ME Davis, AR Campbell, MC Duggan, K Williams, K Martin, K Levine, GN Salavaggione, T Noel, A Ganju, S Uppati, B Paul, T Olencki, TN Teknos, P Savvides, S Tridandapani, JC Byrd, MA Caligiuri, SV Liu, WE Carson
Clinical cancer research 2019
Synergistic cancer immunotherapy combines MVA-CD40L induced innate and adaptive immunity with tumor targeting antibodies
J Medina-Echeverz, M Hinterberger, M Testori, M Geiger, R Giessel, B Bathke, R Kassub, F Gräbnitz, G Fiore, ST Wennier, P Chaplin, M Suter, H Hochrein, H Lauterbach
Nature Communications 2019
Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function
A Stiff, P Trikha, B Mundy-Bosse, E McMichael, TA Mace, B Benner, K Kendra, A Campbell, S Gautam, D Abood, I Landi, V Hsu, M Duggan, R Wesolowski, M Old, JH Howard, L Yu, N Stasik, T Olencki, N Muthusamy, S Tridandapani, JC Byrd, M Caligiuri, WE Carson
Clinical cancer research 2018
FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety
NS Alakhras, J Qiu, GV Rocha, DR Witcher, A Koester, J You, DA Schaer, RB Holmgaard, K Driscoll, JA Willy, LP Malherbe
mAbs 2018
Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8 + T cells
K Jung, JH Ha, JE Kim, JA Kim, YJ Kim, CH Kim, YS Kim
OncoImmunology 2018
IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production
HR Wagstaffe, CM Nielsen, EM Riley, MR Goodier
Journal of immunology (Baltimore, Md. : 1950) 2018
Avelumab, an IgG1 anti-PD-L1 Immune Checkpoint Inhibitor, Triggers NK Cell-Mediated Cytotoxicity and Cytokine Production Against Triple Negative Breast Cancer Cells
EP Juliá, A Amante, MB Pampena, J Mordoh, EM Levy
Frontiers in immunology 2018
IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages
M Zhang, B Wen, OM Anton, Z Yao, S Dubois, W Ju, N Sato, DJ DiLillo, RN Bamford, JV Ravetch, TA Waldmann
Proceedings of the National Academy of Sciences 2018
Genomic and transcriptional Profiling of tumor infiltrated CD8 + T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma
Z Li, G Chen, Z Cai, X Dong, L Qiu, H Xu, Y Zeng, X Liu, J Liu
OncoImmunology 2018
MICA-Expressing Monocytes Enhance Natural Killer Cell Fc Receptor-Mediated Antitumor Functions
AR Campbell, MC Duggan, LP Suarez-Kelly, N Bhave, KS Opheim, EL McMichael, P Trikha, R Parihar, E Luedke, A Lewis, B Yung, R Lee, D Raulet, S Tridandapani, V Groh, L Yu, V Yildiz, JC Byrd, MA Caligiuri, WE Carson
Cancer immunology research 2017
Natural Killer Cells - Their Role in Tumour Immunosurveillance
P Sharma
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2017
Tocilizumab (Anti-IL-6R) Suppressed TNFα Production by Human Monocytes in an In Vitro Model of Anti-HLA Antibody-Induced Antibody-Dependent Cellular Cytotoxicity:
BH Shin, S Ge, J Mirocha, SC Jordan, M Toyoda
Transplantation Direct 2017
Activation of the FcgammaReceptorIIIa on human natural killer cells leads to increased expression of functional interleukin-21 receptor
EL McMichael, NB Courtney, MC Duggan, R Wesolowski, D Quiroga, SV Kondadasula, LS Atwal, N Bhave, E Luedke, AC Jaime-Ramirez, AR Campbell, X Mo, JC Byrd, WE Carson
OncoImmunology 2017
Patient’s Natural Killer Cells in the Era of Targeted Therapies: Role for Tumor Killers
M Messaoudene, A Frazao, PJ Gavlovsky, A Toubert, N Dulphy, A Caignard
Frontiers in immunology 2017
Co-stimulation of the Fc receptor and Interleukin-12 receptor on human natural killer cells leads to increased expression of CD25
MC Duggan, AR Campbell, EL McMichael, KS Opheim, KM Levine, N Bhave, MC Culbertson, T Noel, L Yu, WE Carson
OncoImmunology 2017
Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy
A Muntasell, M Cabo, S Servitja, I Tusquets, M Martínez-García, A Rovira, F Rojo, J Albanell, M López-Botet
Frontiers in immunology 2017
Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production
R Tsuji, K Ikado, D Fujiwara
International journal of molecular sciences 2017
NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
AC Jaime-Ramirez, EL McMichael, S Kondadasula, CC Skinner, BL Mundy-Bosse, E Luedke, NB Jones, A Mani, J Roda, V Karpa, H Li, J Li, S Elavazhagan, KM la Perle, AC Schmitt, Y Lu, X Zhang, X Pan, H Mao, M Davis, D Jarjoura, JP Butchar, M Poi, M Phelps, S Tridandapani, JC Byrd, MA Caligiuri, RJ Lee, WE Carson
Cancer immunology research 2016
Folate-conjugated immunoglobulin targets melanoma tumor cells for NK cell effector functions:
CC Skinner, EL McMichael, AC Jaime-Ramirez, ZB Abrams, RJ Lee, WE Carson
Melanoma Research 2016
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
T Li, H Cheng, H Yuan, Q Xu, C Shu, Y Zhang, P Xu, J Tan, Y Rui, P Li, X Tan
Scientific Reports 2016
Fluorescent nanodiamonds engage innate immune effector cells: A potential vehicle for targeted anti-tumor immunotherapy
LP Suarez-Kelly, AR Campbell, IV Rampersaud, A Bumb, MS Wang, JP Butchar, S Tridandapani, L Yu, AA Rampersaud, WE Carson
Nanomedicine: Nanotechnology, Biology and Medicine 2016
IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells
EL McMichael, AC Jaime-Ramirez, KD Guenterberg, E Luedke, LS Atwal, AR Campbell, Z Hu, AS Tatum, SV Kondadasula, X Mo, S Tridandapani, M Bloomston, EC Ellison, TM Williams, T Bekaii-Saab, WE Carson
Clinical cancer research 2016
A Phase I Trial to Evaluate Antibody-Dependent Cellular Cytotoxicity of Cetuximab and Lenalidomide in Advanced Colorectal and Head and Neck Cancer
EM Bertino, EL McMichael, X Mo, P Trikha, M Davis, B Paul, M Grever, WE Carson, GA Otterson
Molecular cancer therapeutics 2016
Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection
TR Fouts, K Bagley, IJ Prado, KL Bobb, JA Schwartz, R Xu, RJ Zagursky, MA Egan, JH Eldridge, CC LaBranche, DC Montefiori, HL Buanec, D Zagury, R Pal, GN Pavlakis, BK Felber, G Franchini, S Gordon, M Vaccari, GK Lewis, AL DeVico, RC Gallo
Proceedings of the National Academy of Sciences 2015
An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions
M Kinder, AR Greenplate, WR Strohl, RE Jordan, RJ Brezski
mAbs 2015
Adjuvant cellular immunotherapy in patients with resected primary non-small cell lung cancer
QZ Pan, Y Tang, QJ Wang, YQ Li, L Zhang, XD Li, JJ Zhao, DS Weng, Q Liu, LX Huang, J He, SP Chen, ML Ke, YX Zeng, JC Xia
OncoImmunology 2015
The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells
SE Campo, KM Levine, BL Mundy-Bosse, VP Grignol, ET Fairchild, AR Campbell, P Trikha, TA Mace, BK Paul, AC Jaime-Ramirez, J Markowitz, SV Kondadasula, KD Guenterberg, S McClory, VI Karpa, X Pan, TE Olencki, JP Monk, A Mortazavi, S Tridandapani, GB Lesinski, JC Byrd, MA Caligiuri, MH Shah, WE Carson
Journal of immunology (Baltimore, Md. : 1950) 2015
Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines
S Boero, A Morabito, B Banelli, B Cardinali, B Dozin, G Lunardi, P Piccioli, S Lastraioli, R Carosio, S Salvi, A Levaggi, F Poggio, A DAlonzo, M Romani, LD Mastro, A Poggi, MP Pistillo
Journal of Translational Medicine 2015
Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12
AR Campbell, K Regan, N Bhave, A Pattanayak, R Parihar, AR Stiff, P Trikha, SD Scoville, S Liyanarachchi, SV Kondadasula, O Lele, R Davuluri, PR Payne, WE Carson
BMC Medical Genomics 2015
Clinical utility of natural killer cells in cancer therapy and transplantation
DA Knorr, V Bachanova, MR Verneris, JS Miller
Seminars in Immunology 2014
Interleukin 12: still a promising candidate for tumor immunotherapy?
W Lasek, R Zagożdżon, M Jakobisiak
Cancer Immunology, Immunotherapy 2014
Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer
R Romee, JW Leong, TA Fehniger
Scientifica 2014
Genkwadaphnin Induces IFN-γ via PKD1/NF-κB/STAT1 Dependent Pathway in NK-92 Cells
HB Kang, KS Ahn, SR Oh, JW Kim, QJ Wang
PloS one 2014
Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients
RM Srivastava, SC Lee, PA Filho, CA Lord, HB Jie, HC Davidson, A López-Albaitero, SP Gibson, WE Gooding, S Ferrone, RL Ferris
Clinical cancer research 2013
Toll-like receptor 2 ligands regulate monocyte Fcγ receptor expression and function
P Shah, K Fatehchand, H Patel, H Fang, SE Justiniano, X Mo, D Jarjoura, S Tridandapani, JP Butchar
The Journal of biological chemistry 2013
Gene Expression Meta-Analysis Identifies Cytokine Pathways and 5q Aberrations Involved in Metastasis of ERBB2 Amplified and Basal Breast Cancer
M Thomassen, Q Tan, M Burton, TA Kruse
Cancer informatics 2013
Effects of interleukin-18 on natural killer cells: costimulation of activation through Fc receptors for immunoglobulin
S Srivastava, D Pelloso, H Feng, L Voiles, D Lewis, Z Haskova, M Whitacre, S Trulli, YJ Chen, J Toso, ZL Jonak, HC Chang, MJ Robertson
Cancer Immunology, Immunotherapy 2013
NK cell-based immunotherapy for malignant diseases
M Cheng, Y Chen, W Xiao, R Sun, Z Tian
Cellular and Molecular Immunology 2013
The marginating-pulmonary immune compartment in mice exhibits increased NK cytotoxicity and unique cellular characteristics
M Benish, R Melamed, E Rosenne, E Neeman, L Sorski, B Levi, L Shaashua, P Matzner, S Ben-Eliyahu
Immunologic Research 2013
The use of lentinan for treating gastric cancer.
Ina K, Kataoka T, Ando T
Anti-cancer agents in medicinal chemistry 2013
Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins
AC Brown, IM Dobbie, JM Alakoskela, I Davis, DM Davis
Blood 2012
Monoclonal antibody therapy of pancreatic cancer with cetuximab: potential for immune modulation
E Luedke, AC Jaime-Ramirez, N Bhave, WE 3rd
Journal of immunotherapy (Hagerstown, Md. : 1997) 2012
Combination strategies to enhance antitumor ADCC
HE Kohrt, R Houot, A Marabelle, HJ Cho, K Osman, M Goldstein, R Levy, J Brody
Immunotherapy 2012
Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production
MK Gleason, MR Verneris, DA Todhunter, B Zhang, V McCullar, SX Zhou, A Panoskaltsis-Mortari, LM Weiner, DA Vallera, JS Miller
Molecular cancer therapeutics 2012
miR-155 regulates IFN-γ production in natural killer cells
R Trotta, L Chen, D Ciarlariello, S Josyula, C Mao, S Costinean, L Yu, JP Butchar, S Tridandapani, CM Croce, MA Caligiuri
Blood 2012
Cetuximab therapy in head and neck cancer: Immune modulation with interleukin-12 and other natural killer cell–activating cytokines
E Luedke, AC Jaime-Ramirez, N Bhave, J Roda, MM Choudhary, B Kumar, TN Teknos, WE Carson
Surgery 2012
Anti-cancer immune response mechanisms in neoadjuvant and targeted therapy
C Denkert, S Darb-Esfahani, S Loibl, I Anagnostopoulos, K Jöhrens
Seminars in Immunopathology 2011
Clinical cancer therapy by NK cells via antibody-dependent cell-mediated cytotoxicity
KL Alderson, PM Sondel
Journal of biomedicine & biotechnology 2011
T-bet expression in intratumoral lymphoid structures after neoadjuvant trastuzumab plus docetaxel for HER2-overexpressing breast carcinoma predicts survival
S Ladoire, L Arnould, G Mignot, L Apetoh, C Rébé, F Martin, P Fumoleau, B Coudert, F Ghiringhelli
British Journal of Cancer 2011
TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy
H Lu, Y Yang, E Gad, C Inatsuka, CA Wenner, ML Disis, LJ Standish
Clinical cancer research 2011
Use of a nanoporous biodegradable miniature device to regulate cytokine release for cancer treatment
H He, V Grignol, V Karpa, C Yen, K LaPerle, X Zhang, NB Jones, MI Liang, GB Lesinski, WS Ho, WE Carson, LJ Lee
Journal of Controlled Release 2011
Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells:
JL Wong, RB Mailliard, SJ Moschos, H Edington, MT Lotze, JM Kirkwood, P Kalinski
Journal of immunotherapy (Hagerstown, Md. : 1997) 2011
IL-12 Enhances the Antitumor Actions of Trastuzumab via NK Cell IFN-γ Production
AC Jaime-Ramirez, BL Mundy-Bosse, SV Kondadasula, NB Jones, JM Roda, A Mani, R Parihar, V Karpa, TL Papenfuss, KM LaPerle, E Biller, A Lehman, AR Chaudhury, D Jarjoura, RW Burry, WE Carson
Journal of immunology (Baltimore, Md. : 1950) 2011
Immune therapy for breast cancer in 2010—hype or hope?
Florescu A, Amir E, Bouganim N, Clemons M
Current Oncology 2011
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody
FT Awan, R Lapalombella, R Trotta, JP Butchar, B Yu, DM Benson, JM Roda, C Cheney, X Mo, A Lehman, J Jones, J Flynn, D Jarjoura, JR Desjarlais, S Tridandapani, MA Caligiuri, N Muthusamy, JC Byrd
Blood 2010
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12
DJ Klinke
Molecular Cancer 2010
Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines
MA Bill, C Bakan, DM Benson, J Fuchs, G Young, GB Lesinski
Molecular cancer therapeutics 2009
Gene expression profiling reveals similarities between the in vitro and in vivo responses of immune effector cells to IFN-alpha
JM Zimmerer, GB Lesinski, AS Ruppert, MD Radmacher, C Noble, K Kendra, MJ Walker, WE 3rd
Clinical cancer research 2008
Human natural killer cells
MA Caligiuri
Blood 2008
Rafting with the IL-12 receptor
DW McVicar
Blood 2008
Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration
AC Boullart, EH Aarntzen, P Verdijk, JF Jacobs, DH Schuurhuis, D Benitez-Ribas, G Schreibelt, MW van de Rakt, NM Scharenborg, A Boer, M Kramer, CG Figdor, CJ Punt, GJ Adema, IJ de Vries
Cancer Immunology, Immunotherapy 2008
Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma
SV Kondadasula, JM Roda, R Parihar, J Yu, A Lehman, MA Caligiuri, S Tridandapani, RW Burry, WE 3rd
Blood 2008
A phase II trial of trastuzumab in combination with low-dose interleukin-2 (IL-2) in patients (PTS) with metastatic breast cancer (MBC) who have previously failed trastuzumab
A Mani, J Roda, D Young, MA Caligiuri, GF Fleming, P Kaufman, A Brufsky, S Ottman, WE Carson, CL Shapiro
Breast Cancer Research and Treatment 2008
TGF-β Utilizes SMAD3 to Inhibit CD16-Mediated IFN-γ Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells
Trotta R, Col JD, Yu J, Ciarlariello D, Thomas B, Zhang X, Allard J II, Wei M, Mao H, Byrd JC, Perrotti D, Caligiuri MA
Journal of immunology (Baltimore, Md. : 1950) 2008
Biology and clinical impact of human natural killer cells
SS Farag, JB VanDeusen, TA Fehniger, MA Caligiuri
International Journal of Hematology 2003

← Previous 1 2 3 4 5 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 10 patents
43 readers on Mendeley
See more details