Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
Colleen E. Clancy, … , Michihiro Tateyama, Robert S. Kass
Colleen E. Clancy, … , Michihiro Tateyama, Robert S. Kass
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1251-1262. https://doi.org/10.1172/JCI15928.
View: Text | PDF
Article Cardiology

Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

  • Text
  • PDF
Abstract

Research Article

Authors

Colleen E. Clancy, Michihiro Tateyama, Robert S. Kass

×

Figure 4

Options: View larger image (or click on image) Download as PowerPoint
Background gating properties of WT and Y1795C mutant channels. (a) Exper...
Background gating properties of WT and Y1795C mutant channels. (a) Experimentally observed WT (left) and Y1795C (right) single channels in the background mode. (b) MOTs of experimentally measured (top) and simulated (bottom) channels in the background mode (i.e., non-burst mode) at –30 mV. Histograms (bin size = 200 microseconds) were generated from all events (500–1,000 sweeps) for each construct. Only patches containing fewer than three channels were used to generate histograms. MOT was determined by single exponential fits to the experimental data. The time constants extracted from the fits were: Y1795C, 0.97 ± 0.05 milliseconds, n = 6; WT, 0.50 ± 0.05 milliseconds, n = 7. The computation (lower panel) accurately simulates mutation-induced prolongation of MOT (Y1795C, 1.01 milliseconds; WT, 0.50 milliseconds). The MOT is determined theoretically by the single exponential function e–t/τ where τ = 1/sum of transition rates out of the open state. τ, time constant.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts