Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome
Yasushi Hanakawa, … , Masayuki Amagai, John R. Stanley
Yasushi Hanakawa, … , Masayuki Amagai, John R. Stanley
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):53-60. https://doi.org/10.1172/JCI15766.
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Article Infectious disease

Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome

Abstract

Research Article

Authors

Yasushi Hanakawa, Norman M. Schechter, Chenyan Lin, Luis Garza, Hong Li, Takayuki Yamaguchi, Yasuyuki Fudaba, Koji Nishifuji, Motoyuki Sugai, Masayuki Amagai, John R. Stanley

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Figure 4

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Immunofluorescence colocalization of ETA Amu and Dsg1 in epidermis. Mous...
Immunofluorescence colocalization of ETA Amu and Dsg1 in epidermis. Mouse skin was incubated with ETA Amu with a V5 tag. Double immunofluorescence staining with antibodies against V5 tag (red fluorescence) and Dsg1 (green fluorescence) showed colocalization. Note that immunofluorescence localization of ETA Amu shows the typical pattern of Dsg1 localization, with less intense staining in the basal layer of the epidermis — a pattern opposite that of Dsg3, which is seen most intensely in the basal layer (36).