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I. Sadaf Farooqi, … , Alex M. DePaoli, Stephen O’Rahilly
Published October 15, 2002
Citation Information: J Clin Invest. 2002;110(8):1093-1103. https://doi.org/10.1172/JCI15693.
Citation Information: J Clin Invest. 2002;110(8):1093-1103. https://doi.org/10.1172/JCI15693.
Abstract
Research Article
Authors
I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, Julia M. Keogh, Elizabeth Lawrence, Chizo Agwu, Veronica Sanna, Susan A. Jebb, Francesco Perna, Silvia Fontana, Robert I. Lechler, Alex M. DePaoli, Stephen O’Rahilly
Total citations by year
Citation information
Citations to this article (487)
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Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells
Y Chen, J Colello, W Jarjour, S Zheng |
Cells | 2019 |
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Leptin resistance: underlying mechanisms and diagnosis O Gruzdeva, D Borodkina, E Uchasova, Y Dyleva, O Barbarash |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | 2019 |
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GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans
AE Papathanasiou, E Nolen-Doerr, OM Farr, CS Mantzoros |
European Journal of Endocrinology | 2019 |
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Exploring immunomodulation by endocrine changes in Lady Windermere syndrome: Immunomodulation in Lady Windermere syndrome
MR Holt, JJ Miles, WJ Inder, RM Thomson |
Clinical & Experimental Immunology | 2019 |
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Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin
J Hebebrand, G Milos, M Wabitsch, M Teufel, D Führer, J Bühlmeier, L Libuda, C Ludwig, J Antel |
Frontiers in psychology | 2019 |
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Heterozygous rare genetic variants in non-syndromic early-onset obesity
C Serra-Juhé, GÁ Martos-Moreno, FB de Pieri, R Flores, JA Chowen, LA Pérez-Jurado, J Argente |
International Journal of Obesity | 2019 |
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The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease
Eder, Adler, Dobrowolska, KM, Witowski |
Cells | 2019 |
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The Impact of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Metabolic Peptides Regulating Appetite, Food Intake, Energy Homeostasis, and Systemic Inflammation: A Literature Review
S Mashaqi, MS Badr |
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | 2019 |
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An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China
J Jiang, X Qin, H Liu, S Meng, AS Abdullah, J Huang, C Qin, Y Liu, Y Huang, F Qin, J Huang, N Zang, B Liang, C Ning, Y Liao, H Liang, F Wu, L Ye |
Scientific Reports | 2019 |
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Fatty Liver and Autoimmune Hepatitis: Two Forms of Liver Involvement in Lipodystrophies
A Ribeiro, JR Brandão, E Cleto, M Santos, T Borges, ES Silva |
GE Portuguese Journal of Gastroenterology | 2019 |
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Cytokines and Abnormal Glucose and Lipid Metabolism
J Shi, J Fan, Q Su, Z Yang |
Frontiers in Endocrinology | 2019 |
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Leptin: Is It Thermogenic?
AW Fischer, B Cannon, J Nedergaard |
Endocrine reviews | 2019 |
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Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice
L Zheng, J Wu, J Mo, L Guo, X Wu, Y Bao |
BioMed Research International | 2019 |
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Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
JF Ziegler, C Böttcher, M Letizia, C Yerinde, H Wu, I Freise, Y Rodriguez-Sillke, AK Stoyanova, ME Kreis, P Asbach, D Kunkel, J Priller, I Anagnostopoulos, AA Kühl, K Miehle, M Stumvoll, F Tran, B Fredrich, M Forster, A Franke, C Bojarski, R Glauben, BS Löscher, B Siegmund, C Weidinger |
Nature Communications | 2019 |
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Statins decrease leptin expression in human white adipocytes
P Singh, Y Zhang, P Sharma, N Covassin, F Soucek, PA Friedman, VK Somers |
Physiological Reports | 2018 |
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Leptin Regulation of Core Body Temperature Involves Mechanisms Independent of the Thyroid Axis
JD Deem, K Muta, K Ogimoto, JT Nelson, KR Velasco, KJ Kaiyala, GJ Morton |
American journal of physiology. Endocrinology and metabolism | 2018 |
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Obesity, Fat Mass and Immune System: Role for Leptin
V Francisco, J Pino, V Campos-Cabaleiro, C Ruiz-Fernández, A Mera, MA Gonzalez-Gay, R Gómez, O Gualillo |
Frontiers in physiology | 2018 |
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Melanocortin-4 receptor pathway dysfunction in obesity: Patient stratification aimed at MC4R agonist treatment
KL Ayers, BS Glicksberg, AS Garfield, S Longerich, JA White, P Yang, L Du, TW Chittenden, JR Gulcher, S Roy, F Fiedorek, K Gottesdiener, S Cohen, KE North, EE Schadt, SD Li, R Chen, LH van der Ploeg |
The Journal of clinical endocrinology and metabolism | 2018 |
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Uncovering the molecular mechanisms behind disease-associated leptin variants
E Haglund, L Nguyen, NP Schafer, H Lammert, PA Jennings, JN Onuchic |
The Journal of biological chemistry | 2018 |
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Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone β-Subunit in Peripubertal Male Rats
P Argente-Arizón, D Castro-González, F Díaz, MJ Fernández-Gómez, MA Sánchez-Garrido, M Tena-Sempere, J Argente, JA Chowen |
Frontiers in Endocrinology | 2018 |
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Xylobiose Prevents High-Fat Diet Induced Mice Obesity by Suppressing Mesenteric Fat Deposition and Metabolic Dysregulation
S Lim, E Kim, JH Shin, P Seok, S Jung, SH Yoo, Y Kim |
Molecules (Basel, Switzerland) | 2018 |
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Emergence of Leptin in Infection and Immunity: Scope and Challenges in Vaccines Formulation
D Alti, C Sambamurthy, SK Kalangi |
Frontiers in Cellular and Infection Microbiology | 2018 |
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Intrauterine Malnutrition Reduced Long Leptin Receptor Isoform Expression and Proinflammatory Cytokine Production in Male Rat Pulmonary Endothelial Cells Stimulated by Lipopolysaccharide
AM Balbino, MM Silva, GA Azevedo, NL Gil, RR Ferreira, LA dos Santos, RM Gasparin, L Fernandes, MA Landgraf, RG Landgraf |
Mediators of Inflammation | 2018 |
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Hypogonadotropic Hypogonadism in Men With Diabesity
S Dhindsa, H Ghanim, M Batra, P Dandona |
Diabetes care | 2018 |
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Genetic identification of leptin neural circuits in energy and glucose homeostases
J Xu, CL Bartolome, CS Low, X Yi, CH Chien, P Wang, D Kong |
Nature | 2018 |
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Adipokines and inflammation: is it a question of weight?: Obesity and inflammatory diseases
V Francisco, J Pino, MA Gonzalez-Gay, A Mera, F Lago, R Gómez, A Mobasheri, O Gualillo |
British Journal of Pharmacology | 2018 |
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Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling:
C Angel, ZT Glovak, W Alami, S Mihalko, J Price, Y Jiang, HA Baghdoyan, R Lydic |
Anesthesiology | 2018 |
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Myeloid derived-suppressor cells: their role in cancer and obesity
S Ostrand-Rosenberg |
Current Opinion in Immunology | 2018 |
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Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis
A Katiyar, S Sharma, TP Singh, P Kaur |
Frontiers in Genetics | 2018 |
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Identifying behavioral phenotypes for childhood obesity
TV Kral, RH Moore, J Chittams, E Jones, L O'Malley, JO Fisher |
Appetite | 2018 |
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Severe Early Onset Obesity due to a Novel Missense Mutation in Exon 3 of the Leptin Gene in an Infant from Northwest India
D Dayal, K Seetharaman, I Panigrahi, B Muthuvel, A Agarwal |
Journal of clinical research in pediatric endocrinology | 2018 |
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Mutations in IRS4 are associated with central hypothyroidism
CA Heinen, EM de Vries, M Alders, H Bikker, N Zwaveling-Soonawala, EL van den Akker, B Bakker, G Hoorweg-Nijman, F Roelfsema, RC Hennekam, A Boelen, AS van Trotsenburg, E Fliers |
Journal of medical genetics | 2018 |
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Adipokines and Their Role in Intestinal Inflammation
C Weidinger, JF Ziegler, M Letizia, F Schmidt, B Siegmund |
Frontiers in immunology | 2018 |
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Salivary Leptin Level in Young Adult Males and its Association with Anthropometric Measurements, Fat Distribution and Muscle Mass
MM Abdalla, SS Choo |
2018 | |
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Phenotypic and Genetic Characteristics of Lipodystrophy: Pathophysiology, Metabolic Abnormalities, and Comorbidities
B Akinci, R Meral, EA Oral |
Current Diabetes Reports | 2018 |
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Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity
RK Niazi, AP Gjesing, M Hollensted, CT Have, N Grarup, O Pedersen, A Ullah, G Shahid, W Ahmad, A Gul, T Hansen |
BMC Medical Genetics | 2018 |
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Leptin Functions in Infectious Diseases
R Maurya, P Bhattacharya, R Dey, HL Nakhasi |
Frontiers in immunology | 2018 |
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Functional and phenotypic characteristics of human leptin receptor mutations
A Nunziata, JB Funcke, G Borck, J von Schnurbein, S Brandt, B Lennerz, B Moepps, P Gierschik, P Fischer-Posovszky, M Wabitsch |
Journal of the Endocrine Society | 2018 |
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Momordica cymbalaria fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice
Puttanarasaiah Mahesh Kumar, Marikunte V Venkataranganna, Kirangadur Manjunath, Gollapalle Lakshminarayanashastry Viswanatha, Godavarthi Ashok |
Iranian Journal of Basic Medical Sciences | 2018 |
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Epiregulin induces leptin secretion and energy expenditure in high-fat diet-fed mice
R Yasmeen, Q Shen, A Lee, JH Leung, D Kowdley, DJ DiSilvestro, L Xu, K Yang, A Maiseyeu, NC Bal, M Periasamy, P Fadda, O Ziouzenkova |
Journal of Endocrinology | 2018 |
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Animal models of obesity and diabetes mellitus
M Kleinert, C Clemmensen, SM Hofmann, MC Moore, S Renner, SC Woods, P Huypens, J Beckers, MH de Angelis, A Schürmann, M Bakhti, M Klingenspor, M Heiman, AD Cherrington, M Ristow, H Lickert, E Wolf, PJ Havel, TD Müller, MH Tschöp |
Nature Reviews Endocrinology | 2018 |
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KLB , encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism
C Xu, A Messina, E Somm, H Miraoui, T Kinnunen, J Acierno, NJ Niederländer, J Bouilly, AA Dwyer, Y Sidis, D Cassatella, GP Sykiotis, R Quinton, CD Geyter, M Dirlewanger, V Schwitzgebel, TR Cole, AA Toogood, JM Kirk, L Plummer, U Albrecht, WF Crowley, M Mohammadi, M TenaSempere, V Prevot, N Pitteloud |
EMBO Molecular Medicine | 2017 |
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Nutritional effects on T-cell immunometabolism: Highlights
S Cohen, K Danzaki, NJ MacIver |
European Journal of Immunology | 2017 |
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The role of leptin in health and disease
AM Ramos-Lobo, J Donato |
Temperature | 2017 |
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Leptin in inflammation and autoimmunity
AL Cava |
Cytokine | 2017 |
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The Leptin Receptor Complex: Heavier Than Expected?
J Wauman, L Zabeau, J Tavernier |
Frontiers in Endocrinology | 2017 |
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Comparative Physiology of Energy Metabolism: Fishing for Endocrine Signals in the Early Vertebrate Pool
I de Pol, G Flik, M Gorissen |
Frontiers in Endocrinology | 2017 |
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A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila
DH Kim, M Shin, SH Jung, YJ Kim, WD Jones, A Gould |
PLoS Biology | 2017 |
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The concentrations of adipokines in goat milk: relation to plasma levels, inflammatory status, milk quality and composition
S GUZEL, A YIBAR, D BELENLI, I CETIN, M TANRIVERDI |
Journal of Veterinary Medical Science | 2017 |
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Assessing the Functional Role of Leptin in Energy Homeostasis and the Stress Response in Vertebrates
CA Deck, JL Honeycutt, E Cheung, HM Reynolds, RJ Borski |
Frontiers in Endocrinology | 2017 |
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Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants
C Serra-Juhé, GÁ Martos-Moreno, FB de Pieri, R Flores, JR González, B Rodríguez-Santiago, J Argente, LA Pérez-Jurado, X Estivill |
PLoS genetics | 2017 |
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Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life
EX Loo, A Goh, IB Aris, OH Teoh, LP Shek, BW Lee, YH Chan, MT Tint, SE Soh, SM Saw, P Gluckman, KM Godfrey, YS Chong, F Yap, MS Kramer, HV Bever, YS Lee |
BMC Pediatrics | 2017 |
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Association of adipokines, interleukin-6, and tumor necrosis factor-α concentrations with clinical characteristics and presence of spinal syndesmophytes in patients with ankylosing spondylitis: A cross-sectional study
L Gonzalez-Lopez, NS Fajardo-Robledo, AM Saldaña-Cruz, IV Moreno-Sandoval, D Bonilla-Lara, S Zavaleta-Muñiz, AH Nava-Zavala, P Hernandez-Cuervo, A Rocha-Muñoz, NA Rodriguez-Jimenez, ML Vazquez-Villegas, JF Muñoz-Valle, M Salazar-Paramo, EG Cardona-Muñoz, JI Gamez-Nava |
J INT MED RES | 2017 |
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Targeting Visceral Fat by Intraperitoneal Delivery of Novel AAV Serotype Vector Restricting Off-Target Transduction in Liver
W Huang, X Liu, NJ Queen, L Cao |
Molecular Therapy - Methods & Clinical Development | 2017 |
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Short-Term High-Fat Diet Increases Leptin Activation of CART Neurons and Advances Puberty in Female Mice
JC Venancio, LO Margatho, R Rorato, RR Rosales, LK Debarba, R Coletti, J Antunes-Rodrigues, CF Elias, LL Elias |
Endocrinology | 2017 |
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Estimated prevalence of potentially damaging variants in the leptin gene
A Nunziata, G Borck, JB Funcke, K Kohlsdorf, S Brandt, A Hinney, B Moepps, P Gierschik, KM Debatin, P Fischer-Posovszky, M Wabitsch |
Molecular and Cellular Pediatrics | 2017 |
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The genetics of obesity - Pathogenetic, clinical and diagnostic aspects
Barczyk A, Kutkowska-Kaźmierczak A, Castañeda J, Obersztyn E |
Developmental period medicine | 2017 |
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Obesity/overweight reduces the risk of active tuberculosis: a nationwide population-based cohort study in Taiwan.
Yen YF, Hu HY, Lee YL, Ku PW, Lin IF, Chu D, Lai YJ |
International Journal of Obesity | 2017 |
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Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.
Styne DM, Arslanian SA, Connor EL, Farooqi IS, Murad MH, Silverstein JH, Yanovski JA |
The Journal of clinical endocrinology and metabolism | 2017 |
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Leptin in the interplay of inflammation, metabolism and immune system disorders.
Abella V, Scotece M, Conde J, Pino J, Gonzalez-Gay MA, Gómez-Reino JJ, Mera A, Lago F, Gómez R, Gualillo O |
Nature reviews. Rheumatology | 2017 |
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Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity
Rubinstein M, Low MJ |
FEBS Letters | 2017 |
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Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity
Paiva ES, Andretta A, Batista ED, Lobo MM, de Miranda RC, Nisihara R, Schieferdecker ME, Boguszewski CL |
Archives of Endocrinology and Metabolism | 2017 |
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The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance
TH Collet, AA van der Klaauw, E Henning, JM Keogh, D Suddaby, SV Dachi, S Dunbar, S Kelway, SL Dickson, IS Farooqi, SM Schmid |
Sleep | 2016 |
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Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis
RJ Perry, KF Petersen, GI Shulman |
Diabetologia | 2016 |
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The role of adipokines in chronic inflammation
P Mancuso |
ImmunoTargets and Therapy | 2016 |
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Multiple Sclerosis and Obesity: Possible Roles of Adipokines
JJ Guerrero-García, L Carrera-Quintanar, RI López-Roa, AL Márquez-Aguirre, AE Rojas-Mayorquín, D Ortuño-Sahagún |
Mediators of Inflammation | 2016 |
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Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state
SJ Allen, D Garcia-Galiano, BC Borges, LL Burger, U Boehm, CF Elias |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2016 |
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Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients
AE Levenson, ME Haas, J Miao, RJ Brown, SD de Ferranti, R Muniyappa, SB Biddinger |
Endocrinology | 2016 |
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Kupffer cells facilitate the acute effects of leptin on hepatic lipid metabolism
A Metlakunta, W Huang, M Stefanovic-Racic, N Dedousis, I Sipula, RM ODoherty |
American journal of physiology. Endocrinology and metabolism | 2016 |
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Impact of Obesity and Metabolic Syndrome on Immunity
CJ Andersen, KE Murphy, ML Fernandez |
Advances in nutrition (Bethesda, Md.) | 2016 |
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Methanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates Insulin resistance by upregulating GLUT-4, PPAR- and #947;, adiponectin and leptin levels in vitro
P Kumar, M Venkataranganna, K Manjunath, G Viswanatha, G Ashok |
Journal of Intercultural Ethnopharmacology | 2016 |
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Electroacupuncture Reduces Weight Gain Induced by Rosiglitazone through PPAR γ and Leptin Receptor in CNS
X Jing, C Ou, H Chen, T Wang, B Xu, S Lu, BM Zhu |
Evidence-Based Complementary and Alternative Medicine | 2016 |
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Immune Dysfunction as a Cause and Consequence of Malnutrition
CD Bourke, JA Berkley, AJ Prendergast |
Trends in Immunology | 2016 |
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The Macronutrients, Appetite, and Energy Intake
AL Carreiro, J Dhillon, S Gordon, KA Higgins, AG Jacobs, BM McArthur, BW Redan, RL Rivera, LR Schmidt, RD Mattes |
Annual Review of Nutrition | 2016 |
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Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice
DJ DiSilvestro, E Melgar-Bermudez, R Yasmeen, P Fadda, LJ Lee, A Kalyanasundaram, CL Gilor, O Ziouzenkova, MB Aguila |
PloS one | 2016 |
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Differential Role of Leptin as an Immunomodulator in Controlling Visceral Leishmaniasis in Normal and Leptin-Deficient Mice
R Maurya, P Bhattacharya, N Ismail, PK Dagur, AB Joshi, K Razdan, JP McCoy, J Ascher, R Dey, HL Nakhasi |
The American journal of tropical medicine and hygiene | 2016 |
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Amylin/leptin synergy is absent in extreme obesity and not restored by calorie restriction-induced weight loss in rats: Amylin/leptin synergy set by pre-weight
JL Trevaskis, C Wittmer, J Athanacio, PS Griffin, DG Parkes, JD Roth |
Obesity Science & Practice | 2016 |
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Higher Time-Updated Body Mass Index: Association With Improved CD4+ Cell Recovery on HIV Treatment
JR Koethe, CA Jenkins, B Lau, BE Shepherd, W Wester, PF Rebeiro, MJ Silverberg, JE Thorne, J Gill, AM Mayor, A Willig, R Bosch, MA Horberg, AC Justice, TR Sterling, RD Moore |
Journal of acquired immune deficiency syndromes (1999) | 2016 |
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Higher maternal leptin levels at second trimester are associated with subsequent greater gestational weight gain in late pregnancy
M Lacroix, MC Battista, M Doyon, J Moreau, J Patenaude, L Guillemette, J Ménard, JL Ardilouze, P Perron, MF Hivert |
BMC pregnancy and childbirth | 2016 |
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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
TO Kilpeläinen, JF Carli, AA Skowronski, Q Sun, J Kriebel, MF Feitosa, ÅK Hedman, AW Drong, JE Hayes, J Zhao, TH Pers, U Schick, N Grarup, Z Kutalik, S Trompet, M Mangino, K Kristiansson, M Beekman, LP Lyytikäinen, J Eriksson, P Henneman, J Lahti, T Tanaka, J Luan, FD M, D Pasko, F Renström, SM Willems, A Mahajan, LM Rose, X Guo, Y Liu, ME Kleber, L Pérusse, T Gaunt, TS Ahluwalia, YJ Sung, YF Ramos, N Amin, A Amuzu, I Barroso, C Bellis, J Blangero, BM Buckley, S Böhringer, YD Chen, AJ de Craen, DR Crosslin, CE Dale, Z Dastani, FR Day, J Deelen, GE Delgado, A Demirkan, FM Finucane, I Ford, ME Garcia, C Gieger, S Gustafsson, G Hallmans, SE Hankinson, AS Havulinna, C Herder, D Hernandez, AA Hicks, DJ Hunter, T Illig, E Ingelsson, A Ioan-Facsinay, JO Jansson, NS Jenny, ME Jørgensen, T Jørgensen, M Karlsson, W Koenig, P Kraft, J Kwekkeboom, T Laatikainen, KH Ladwig, CA LeDuc, G Lowe, Y Lu, P Marques-Vidal, C Meisinger, C Menni, AP Morris, RH Myers, S Männistö, MA Nalls, L Paternoster, A Peters, AD Pradhan, T Rankinen, LJ Rasmussen-Torvik, W Rathmann, TK Rice, JB Richards, PM Ridker, N Sattar, DB Savage, S Söderberg, NJ Timpson, L Vandenput, D Heemst, HW Uh, MC Vohl, M Walker, HE Wichmann, E Widén, AR Wood, J Yao, T Zeller, Y Zhang, I Meulenbelt, M Kloppenburg, A Astrup, TI Sørensen, MA Sarzynski, DC Rao, P Jousilahti, E Vartiainen, A Hofman, F Rivadeneira, AG Uitterlinden, E Kajantie, C Osmond, A Palotie, JG Eriksson, M Heliövaara, PB Knekt, S Koskinen, A Jula, M Perola, RK Huupponen, JS Viikari, M Kähönen, T Lehtimäki, OT Raitakari, D Mellström, M Lorentzon, JP Casas, S Bandinelli, W März, A Isaacs, KW van Dijk, CM van Duijn, TB Harris, C Bouchard, MA Allison, DI Chasman, C Ohlsson, L Lind, RA Scott, C Langenberg, NJ Wareham, L Ferrucci, TM Frayling, PP Pramstaller, IB Borecki, DM Waterworth, S Bergmann, G Waeber, P Vollenweider, H Vestergaard, T Hansen, O Pedersen, FB Hu, PE Slagboom, H Grallert, TD Spector, JW Jukema, RJ Klein, EE Schadt, PW Franks, CM Lindgren, RL Leibel, RJ Loos |
Nature Communications | 2016 |
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Renaissance of leptin for obesity therapy
C Quarta, MA Sánchez-Garrido, MH Tschöp, C Clemmensen |
Diabetologia | 2016 |
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Comparison of Serum Leptin Level in Women with Unexplained Infertility and Fertile Women in Iran
F Tafvizi, M Masomi |
The Journal of Obstetrics and Gynecology of India | 2016 |
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Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy
JL Chan, J Koda, JS Heilig, EK Cochran, P Gorden, EA Oral, RJ Brown |
Clinical Endocrinology | 2016 |
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Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis
MC Erlandsson, RD Medina, ST Silfverswärd, MI Bokarewa |
Mediators of Inflammation | 2016 |
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The Effects of Leptin Replacement on Neural Plasticity
GJ Paz-Filho |
Neural plasticity | 2016 |
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Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones
Y Liu, Y Wang, Y Zhang, T Liu, H Jia, H Zou, Q Fu, Y Zhang, L Lu, E Chao, H Parker, V Nguyen-Tran, W Shen, D Wang, PG Schultz, F Wang |
ACS chemical biology | 2016 |
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Harveian Oration 2016: Some observations on the causes and consequences of obesity
S O'Rahilly |
Clinical Medicine | 2016 |
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A Novel Homozygous Frameshift Mutation in Exon 2 of LEP Gene Associated with Severe Obesity: A Case Report
Ashwaq Shukri Altawil, Horia Ahmad Mawlawi, Khalid Ateeq Alghamdi, Faten Fohaid Almijmaj |
Clinical Medicine Insights: Pediatrics | 2016 |
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Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016
H Huvenne, B Dubern, K Clément, C Poitou |
Obesity facts | 2016 |
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The importance of gene-environment interactions in human obesity
H Reddon, JL Gueant, D Meyre |
Clinical Science | 2016 |
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An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation
J Xue, FY Ideraabdullah |
The Journal of Nutritional Biochemistry | 2015 |
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Obesity genetics in mouse and human: back and forth, and back again
FT Yazdi, SM Clee, D Meyre |
PeerJ | 2015 |
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Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice
M Razzoli, J McCallum, A Gurney, WC Engeland, A Bartolomucci |
Genes & Nutrition | 2015 |
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Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases
AO Shpakov, KV Derkach, LM Berstein |
Future Science OA | 2015 |
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The Intricate Network of Adipokines and Stroke
E Kantorová, Ľ Jesenská, D Čierny, K Zeleňák, Š Sivák, M Stančík, P Galajda, V Nosáľ, E Kurča |
International Journal of Endocrinology | 2015 |
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Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy
CA Meehan, E Cochran, A Kassai, RJ Brown, P Gorden |
Expert Review of Clinical Pharmacology | 2015 |
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Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity
YD Apalasamy, Z Mohamed |
Human Genetics | 2015 |
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Interrelationship between lymphocytes and leptin in fat depots of obese mice revealed by changes in nutritional status
K Lolmède, A Zakaroff-Girard, C Dray, ML Renoud, D Daviaud, R Burcelin, M Lafontan, J Galitzky, A Bouloumié |
Journal of Physiology and Biochemistry | 2015 |
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The role of leptin in regulating bone metabolism
J Upadhyay, OM Farr, CS Mantzoros |
Metabolism | 2015 |
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Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male Mice
F Hakim, Y Wang, A Carreras, C Hirotsu, J Zhang, E Peris, D Gozal |
Sleep | 2015 |
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Neuroendocrine control of the onset of puberty
TM Plant |
Frontiers in Neuroendocrinology | 2015 |
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Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010: BMI and early CD4 T-cell recovery on ART
JR Koethe, CA Jenkins, B Lau, BE Shepherd, MJ Silverberg, TT Brown, AJ Blashill, A Anema, A Willig, S Stinnette, S Napravnik, J Gill, HM Crane, TR Sterling |
HIV Medicine | 2015 |
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Nutrition and Metabolic Correlates of Obesity and Inflammation: Clinical Considerations
AR Johnson, L Makowski |
The Journal of nutrition | 2015 |
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Leptin and its cardiovascular effects: Focus on angiogenesis
M Khazaei, Z Tahergorabi |
Advanced Biomedical Research | 2015 |
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Lipopolysaccharide challenge significantly influences lipid metabolism and proteome of white adipose tissue in growing pigs
J Guo, Z Liu, H Sun, Y Huang, E Albrecht, R Zhao, X Yang |
Lipids in Health and Disease | 2015 |
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Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene
M Wabitsch, JB Funcke, J Schnurbein, F Denzer, G Lahr, I Mazen, M El-Gammal, C Denzer, A Moss, KM Debatin, P Gierschik, V Mistry, JM Keogh, IS Farooqi, B Moepps, P Fischer-Posovszky |
The Journal of clinical endocrinology and metabolism | 2015 |
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Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages
Y Zhou, X Yu, H Chen, S Sjöberg, J Roux, L Zhang, AH Ivoulsou, F Bensaid, CL Liu, J Liu, J Tordjman, K Clement, CH Lee, GS Hotamisligil, P Libby, GP Shi |
Cell Metabolism | 2015 |
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Endocrine and Metabolic Effects of Adipose Tissue in Children and Adolescents / Endokrina in Presnovna Funkcija Maščobnega Tkiva Pri Otrocih in Mladostnikih
P Kotnik, PF Posovszky, M Wabitsch |
Slovenian Journal of Public Health | 2015 |
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Obesity: impact of infections and response to vaccines
C Tagliabue, N Principi, C Giavoli, S Esposito |
European Journal of Clinical Microbiology & Infectious Diseases | 2015 |
|
Genetic Regulation of Puberty Timing in Humans
FR Day, JR Perry, KK Ong |
Neuroendocrinology | 2015 |
|
Effects of Recombinant Human Leptin (Metreleptin) on Nocturnal Luteinizing Hormone Secretion in Lipodystrophy Patients.
Abel BS, Muniyappa R, Stratton P, Skarulis MC, Gorden P, Brown RJ |
Neuroendocrinology | 2015 |
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Protective effects of L-arabinose in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats.
Hao L, Lu X, Sun M, Li K, Shen L, Wu T |
Food & Nutrition Research | 2015 |
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Leucine supplementation improves leptin sensitivity in high-fat diet fed rats.
Yuan XW, Han SF, Zhang JW, Xu JY, Qin LQ |
Food & Nutrition Research | 2015 |
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Leptin Does Not Mediate Hypertension Associated With Human Obesity.
Brown RJ, Meehan CA, Gorden P |
Cell | 2015 |
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Leptin’s metabolic and immune functions can be uncoupled at the ligand/receptor interaction level
L Zabeau, CJ Jensen, S Seeuws, K Venken, A Verhee, D Catteeuw, G Loo, H Chen, K Walder, J Hollis, S Foote, MJ Morris, JV der Heyden, F Peelman, BJ Oldfield, JP Rubio, D Elewaut, J Tavernier |
Cellular and Molecular Life Sciences | 2014 |
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Comparative endocrinology of leptin: Assessing function in a phylogenetic context
RL Londraville, Y Macotela, RJ Duff, MR Easterling, Q Liu, EJ Crespi |
General and Comparative Endocrinology | 2014 |
|
Defining the neural basis of appetite and obesity: from genes to behaviour
IS Farooqi |
Clinical Medicine | 2014 |
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Targeting adipose tissue via systemic gene therapy
SM O'Neill, C Hinkle, SJ Chen, A Sandhu, R Hovhannisyan, S Stephan, WR Lagor, RS Ahima, JC Johnston, MP Reilly |
Gene Therapy | 2014 |
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Thyroid Hormone and Leptin in the Testis
CF Ramos, A Zamoner |
Frontiers in Endocrinology | 2014 |
|
Central Regulation of Hypothalamic-Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions
C Fekete, RM Lechan |
Endocrine reviews | 2014 |
|
Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3
DM Lateef, G Abreu-Vieira, C Xiao, ML Reitman |
American journal of physiology. Endocrinology and metabolism | 2014 |
|
Chemical Identity of Hypothalamic Neurons Engaged by Leptin in Reproductive Control
DV Ratra, CF Elias |
Journal of Chemical Neuroanatomy | 2014 |
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Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity
G Lartigue, CC Ronveaux, HE Raybould |
Molecular Metabolism | 2014 |
|
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
HK Park, RS Ahima |
Metabolism | 2014 |
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Recombinant human leptin treatment in genetic lipodystrophic syndromes: the long-term Spanish experience
D Araujo-Vilar, S Sánchez-Iglesias, C Guillín-Amarelle, A Castro, M Lage, M Pazos, JM Rial, J Blasco, E Guillén-Navarro, R Domingo-Jiménez, MR Campo, B González-Méndez, FF Casanueva |
Endocrine | 2014 |
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Bone Mineral Content in Patients With Congenital Generalized Lipodystrophy Is Unaffected by Metreleptin Replacement Therapy
JD Christensen, AO Lungu, E Cochran, MT Collins, RI Gafni, JC Reynolds, KI Rother, P Gorden, RJ Brown |
The Journal of clinical endocrinology and metabolism | 2014 |
|
Adipokines - removing road blocks to obesity and diabetes therapy
M Blüher |
Molecular Metabolism | 2014 |
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Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth
J Rojas, M Chávez, L Olivar, M Rojas, J Morillo, J Mejías, M Calvo, V Bermúdez |
International Journal of Reproductive Medicine | 2014 |
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FTO Is a Relevant Factor for the Development of the Metabolic Syndrome in Mice
K Ikels, S Kuschel, J Fischer, W Kaisers, D Eberhard, U Rüther |
PloS one | 2014 |
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Monogenic forms of childhood obesity due to mutations in the leptin gene
JB Funcke, J Schnurbein, B Lennerz, G Lahr, KM Debatin, P Fischer-Posovszky, M Wabitsch |
Molecular and Cellular Pediatrics | 2014 |
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Leptin deficiency in vivo enhances the ability of splenic dendritic cells to activate T cells
O Ramirez, KM Garza |
International Immunology | 2014 |
|
Genetic strategies to understand physiological pathways regulating body weight
S Farooqi |
Mammalian Genome | 2014 |
|
Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats
JC Cavalcante, JC Bittencourt, CF Elias |
Brain Research | 2014 |
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Adiponectin levels are reduced while markers of systemic inflammation and aortic remodelling are increased in intrauterine growth restricted mother-child couple
S Visentin, A Lapolla, AP Londero, C Cosma, M Dalfrà, M Camerin, D Faggian, M Plebani, E Cosmi |
BioMed Research International | 2014 |
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Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice
M Ito, S Fukuda, S Sakata, H Morinaga, T Ohta |
Journal of Diabetes Research | 2014 |
|
20 YEARS OF LEPTIN: Connecting leptin signaling to biological function
MB Allison, MG Myers |
Journal of Endocrinology | 2014 |
|
20 YEARS OF LEPTIN: Role of leptin in energy homeostasis in humans
M Rosenbaum, RL Leibel |
Journal of Endocrinology | 2014 |
|
Soluble Mediators Regulating Immunity in Early Life
MA Pettengill, SD van Haren, O Levy |
2014 | |
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New Pharmacological Perspectives for the Leptin Receptor in the Treatment of Obesity
C Roujeau, R Jockers, J Dam |
Frontiers in Endocrinology | 2014 |
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A novel mutation in the leptin gene (W121X) in an Egyptian family
I Mazen, K Amr, S Tantawy, IS Farooqi, ME Gammal |
Molecular Genetics and Metabolism Reports | 2014 |
|
Energy balancing by fat Pik3ca
VL Nelson, LM Ballou, RZ Lin |
Adipocyte | 2014 |
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Leptin Mediates the Increase in Blood Pressure Associated with Obesity
SE Simonds, JT Pryor, E Ravussin, FL Greenway, R Dileone, AM Allen, J Bassi, JK Elmquist, JM Keogh, E Henning, MG Myers, J Licinio, RD Brown, PJ Enriori, S O’Rahilly, SM Sternson, KL Grove, DC Spanswick, IS Farooqi, MA Cowley |
Cell | 2014 |
|
Obesity-dependent dysregulation of glucose homeostasis in kinase suppressor of ras 2-/- mice
MD Henry, DL Costanzo-Garvey, PJ Klutho, RE Lewis |
Physiological Reports | 2014 |
|
Increasing Adiposity Is Associated With Higher Adipokine Levels and Lower Bone Mineral Density in Obese Older Adults
L Aguirre, N Napoli, D Waters, C Qualls, DT Villareal, R Armamento-Villareal |
The Journal of clinical endocrinology and metabolism | 2014 |
|
Editorial: Molecular Obesity Research: Lessons Learned?
RS Ahima |
Molecular Endocrinology | 2014 |
|
Fluticasone furoate maintains epithelial homeostasis via leptin/leptin receptor pathway in nasal cells.
Bruno A, Gerbino S, Ferraro M, Siena L, Bonura A, Colombo P, La Grutta S, Gallina S, Ballacchino A, Giammanco M, Gjomarkaj M, Pace E |
Molecular and Cellular Biochemistry | 2014 |
|
Heritability: The family roots of obesity.
Willyard C |
Nature | 2014 |
|
Randomized double-blind placebo-controlled study of leptin administration after gastric bypass
J Korner, R Conroy, G Febres, DJ McMahon, I Conwell, W Karmally, LJ Aronne |
Obesity | 2013 |
|
Adipokines: A link between obesity and cardiovascular disease
K Nakamura, JJ Fuster, K Walsh |
Journal of Cardiology | 2013 |
|
From obesity genetics to the future of personalized obesity therapy
JS Moustafa, P Froguel |
Nature Reviews Endocrinology | 2013 |
|
Leptin signaling and leptin resistance
Y Zhou, L Rui |
Frontiers of Medicine | 2013 |
|
The role of leptin in the control of insulin-glucose axis
M Amitani, A Asakawa, H Amitani, A Inui |
Frontiers in neuroscience | 2013 |
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Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors
VA Cortes, KM Cautivo, S Rong, A Garg, JD Horton, AK Agarwal |
Journal of lipid research | 2013 |
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Metreleptin Improves Blood Glucose in Patients With Insulin Receptor Mutations
RJ Brown, E Cochran, P Gorden |
The Journal of clinical endocrinology and metabolism | 2013 |
|
Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals
HS Moon, M Dalamaga, SY Kim, SA Polyzos, OP Hamnvik, F Magkos, J Paruthi, CS Mantzoros |
Endocrine reviews | 2013 |
|
Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia
G Matarese, CL Rocca, HS Moon, JY Huh, MT Brinkoetter, S Chou, F Perna, D Greco, HP Kilim, C Gao, K Arampatzi, Z Wang, CS Mantzoros |
Proceedings of the National Academy of Sciences | 2013 |
|
Leptin-based adjuvants: An innovative approach to improve vaccine response
SJ White, MJ Taylor, RT Hurt, MD Jensen, GA Poland |
Vaccine | 2013 |
|
Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels
C Abbenhardt, A McTiernan, CM Alfano, MH Wener, KL Campbell, C Duggan, KE Foster-Schubert, A Kong, AT Toriola, JD Potter, C Mason, L Xiao, GL Blackburn, C Bain, CM Ulrich |
Journal of Internal Medicine | 2013 |
|
Controlling complexity: the clinical relevance of mouse complex genetics
K Schughart, C Libert, MJ Kas |
European Journal of Human Genetics | 2013 |
|
The Emerging Role of Leptin Antagonist as Potential Therapeutic Option for Inflammatory Bowel Disease
UP Singh, NP Singh, H Guan, B Busbee, RL Price, DD Taub, MK Mishra, R Fayad, M Nagarkatti, PS Nagarkatti |
International Reviews of Immunology | 2013 |
|
Obesity and asthma: physiological perspective
B Brashier, S Salvi |
Journal of allergy | 2013 |
|
The neuropathology of obesity: insights from human disease
EB Lee, MP Mattson |
Acta Neuropathologica | 2013 |
|
Variation in plasma leptin levels in young Iranian children with cystic fibrosis
M Monajemzadeh, MT Ashtiani, E Sadrian, S Shams, F Motamed, MN Sani, SS Banihosseini, A Abbasi |
Archives of Medical Science : AMS | 2013 |
|
Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects
S Saeed, PR Bech, T Hafeez, R Alam, M Falchi, MA Ghatei, SR Bloom, M Arslan, P Froguel |
Endocrine | 2013 |
|
Human NK cell subset functions are differentially affected by adipokines
L Huebner, S Engeli, CD Wrann, L Goudeva, T Laue, H Kielstein |
PloS one | 2013 |
|
Gender-specific metabolomic profiling of obesity in leptin-deficient ob/ob mice by 1H NMR spectroscopy
EY Won, MK Yoon, SW Kim, Y Jung, HW Bae, D Lee, SG Park, CH Lee, GS Hwang, SW Chi |
PloS one | 2013 |
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Molecular genetic aspects of weight regulation
J Hebebrand, A Hinney, N Knoll, AL Volckmar, A Scherag |
Deutsches Ärzteblatt international | 2013 |
|
The genetics of childhood obesity and interaction with dietary macronutrients
WS Garver, SB Newman, DM Gonzales-Pacheco, JJ Castillo, D Jelinek, RA Heidenreich, RA Orlando |
Genes & Nutrition | 2013 |
|
Metabolic regulation of T lymphocytes
NJ MacIver, RD Michalek, JC Rathmell |
Annual Review of Immunology | 2013 |
|
Nutrition and the biology of human ageing: Cognitive decline/food intake & caloric restriction
JL Coutre, MP Mattson, A Dillin, J Friedman, B Bistrian |
The journal of nutrition, health & aging | 2013 |
|
Obesity and infection: two sides of one coin
G Genoni, F Prodam, A Marolda, E Giglione, I Demarchi, S Bellone, G Bona |
European Journal of Pediatrics | 2013 |
|
Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity
DC Saucillo, VA Gerriets, J Sheng, JC Rathmell, NJ MacIver |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
Body Mass Index, Immune Status, and Virological Control in HIV-Infected Men Who Have Sex with Men
AJ Blashill, KH Mayer, HM Crane, C Grasso, SA Safren |
Journal of the International Association of Providers of AIDS Care | 2013 |
|
Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
F Cahill, P Amini, D Wadden, S Khalili, E Randell, S Vasdev, W Gulliver, G Sun, RM Luque |
PloS one | 2013 |
|
Longitudinal Changes in the Physical Activity of Adolescents with Anorexia Nervosa and Their Influence on Body Composition and Leptin Serum Levels after Recovery
E Kostrzewa, AA van Elburg, N Sanders, L Sternheim, RA Adan, MJ Kas, Z Andrews |
PloS one | 2013 |
|
Long-Term Stabilization Effects of Leptin on Brain Functions in a Leptin-Deficient Patient
S Frank, M Heni, A Moss, J Schnurbein, S Farooqi, HU Häring, A Fritsche, H Preissl, M Wabitsch, JA Calbet |
PloS one | 2013 |
|
Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
W Hinkle, M Cordell, R Leibel, M Rosenbaum, J Hirsch, A Bruce |
PloS one | 2013 |
|
Obesity pharmacotherapy: current perspectives and future directions.
Misra M |
Current cardiology reviews | 2013 |
|
Obesity and Appetite Control
K Suzuki, CN Jayasena, SR Bloom |
Experimental Diabetes Research | 2012 |
|
Leptin revisited: its mechanism of action and potential for treating diabetes
R Coppari, C Bjørbæk |
Nature Reviews Drug Discovery | 2012 |
|
Defining Clinical Leptin Resistance - Challenges and Opportunities
MG Myers, SB Heymsfield, C Haft, BB Kahn, M Laughlin, RL Leibel, MH Tschöp, JA Yanovski |
Cell Metabolism | 2012 |
|
Central Leptin Regulation of Obesity and Fertility
Q Tong, Y Xu |
Current Obesity Reports | 2012 |
|
Energy metabolism and the skeleton: Reciprocal interplay
P D'Amelio, A Panico, E Spertino, GC Isaia |
World Journal of Orthopedics | 2012 |
|
The role of leptin in glucose homeostasis
HC Denroche, FK Huynh, TJ Kieffer |
Journal of Diabetes Investigation | 2012 |
|
Syndromic Insulin Resistance: Models for the Therapeutic Basis of the Metabolic Syndrome and Other Targets of Insulin Resistance
P Gorden, ES Zadeh, E Cochran, RJ Brown |
Endocrine Practice | 2012 |
|
Consequences of stopping and restarting leptin in an adolescent with lipodystrophy
F Kamran, KI Rother, E Cochran, ES Zadeh, P Gorden, RJ Brown |
Hormone Research in Pædiatrics | 2012 |
|
Early Alterations of the Immune Transcriptome in Cultured Progenitor Cells From Obese African-American Women
PE Pemu, L Anderson, BE Gee, EO Ofili, S Ghosh |
Obesity | 2012 |
|
Laboratory animals as surrogate models of human obesity
C Nilsson, K Raun, F Yan, MO Larsen, M Tang-Christensen |
Acta Pharmacologica Sinica | 2012 |
|
The impact of obesity on the immune response to infection
JJ Milner, MA Beck |
Proceedings of the Nutrition Society | 2012 |
|
Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy
J Tang, H Yan, S Zhuang |
International Journal of Nephrology | 2012 |
|
Immunological complications of obesity
TD Kanneganti, VD Dixit |
Nature Immunology | 2012 |
|
Leptin as a Modulator of Neuroendocrine Function in Humans
SM Khan, OP Hamnvik, M Brinkoetter, CS Mantzoros |
Yonsei Medical Journal | 2012 |
|
The Changes They are A-Timed: Metabolism, Endogenous Clocks, and the Timing of Puberty
KP Tolson, PE Chappell |
Frontiers in Endocrinology | 2012 |
|
Leptin and mucosal immunity
NM Mackey-Lawrence, WA Petri |
Mucosal Immunology | 2012 |
|
Pharmacotherapy for childhood obesity: present and future prospects
R Sherafat-Kazemzadeh, SZ Yanovski, JA Yanovski |
International Journal of Obesity | 2012 |
|
Adipoquinas en el niño sano y con obesidad
GA Martos-Moreno, JJ Kopchick, J Argente |
Anales de Pediatría | 2012 |
|
Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome
H Ye, GC Hamri, K Zwicky, M Christen, M Folcher, M Fussenegger |
Proceedings of the National Academy of Sciences | 2012 |
|
Leptin reverses declines in satiation in weight-reduced obese humans
HR Kissileff, JC Thornton, MI Torres, K Pavlovich, LS Mayer, V Kalari, RL Leibel, M Rosenbaum |
The American journal of clinical nutrition | 2012 |
|
Appetite control: worm's-eye-view
YJ You, L Avery |
Animal Cells and Systems | 2012 |
|
Body composition and skeletal health: too heavy? Too thin?
A Faje, A Klibanski |
Current Osteoporosis Reports | 2012 |
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Leptin in pediatrics: A hormone from adipocyte that wheels several functions in children
AT Soliman, M Yasin, A Kassem |
Indian journal of endocrinology and metabolism | 2012 |
|
A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals
SD Bianco |
Frontiers in Endocrinology | 2012 |
|
Leptin in the Liver: A Toxic or Beneficial Mix?
ML Reitman |
Cell Metabolism | 2012 |
|
Pregnancy in a Woman With Congenital Generalized Lipodystrophy: Leptinʼs Vital Role in Reproduction
M Maguire, A Lungu, P Gorden, E Cochran, P Stratton |
Obstetrics & Gynecology | 2012 |
|
Review on the impact of pregnancy and obesity on influenza virus infection: Obesity, pregnancy, and influenza
EA Karlsson, G Marcelin, RJ Webby, S Schultz-Cherry |
Influenza and Other Respiratory Viruses | 2012 |
|
Alterations in Mouse Hypothalamic Adipokine Gene Expression and Leptin Signaling following Chronic Spinal Cord Injury and with Advanced Age
GE Bigford, VC Bracchi-Ricard, MS Nash, JR Bethea, H Reddy |
PloS one | 2012 |
|
Cord Blood Leptin Levels of Healthy Neonates Are Associated with IFN-γ Production by Cord Blood T-Cells
A Mouzaki, I Panagoulias, G Raptis, E Farri-Kostopoulou, N Gay |
PloS one | 2012 |
|
A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis
JR Speakman, KR Westerterp |
Disease models & mechanisms | 2012 |
|
Leptin as an Adolescent: An Update on Leptin Regulation of Energy Balance
Laurent Gautron, Joel Elmquist |
Journal of Clinical Investigation | 2011 |
|
Genetic approaches to understanding human obesity
Sadaf Farooqi, Shwetha Ramachandrappa |
Journal of Clinical Investigation | 2011 |
|
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
|
Pediatric Obesity: Etiology and Treatment^
MK Crocker, JA Yanovski |
Pediatric Clinics of North America | 2011 |
|
An overview of mongenic and syndromic obesities in humans
WK Chung |
Pediatric Blood & Cancer | 2011 |
|
AMPK as Target for Intervention in Childhood and Adolescent Obesity
J Rojas, N Arraiz, M Aguirre, M Velasco, V Bermúdez |
Journal of Obesity | 2011 |
|
Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women
M Brinkoetter, F Magkos, M Vamvini, CS Mantzoros |
American journal of physiology. Endocrinology and metabolism | 2011 |
|
Energy Deprivation Alters in a Leptin- and Cortisol-Independent Manner Circulating Levels of Activin A and Follistatin But Not Myostatin in Healthy Males
MT Vamvini, KN Aronis, JP Chamberland, CS Mantzoros |
The Journal of clinical endocrinology and metabolism | 2011 |
|
Altered hypothalamic function in diet-induced obesity
LA Velloso, MW Schwartz |
International Journal of Obesity | 2011 |
|
Leptin action in pubertal development: recent advances and unanswered questions
CF Elias |
Trends in Endocrinology and Metabolism | 2011 |
|
Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network
KW Williams, MM Scott, JK Elmquist |
European Journal of Pharmacology | 2011 |
|
Novel strategy for the use of leptin for obesity therapy
CS Tam, V Lecoultre, E Ravussin |
Expert Opinion on Biological Therapy | 2011 |
|
Leptin in human physiology and pathophysiology
CS Mantzoros, F Magkos, M Brinkoetter, E Sienkiewicz, TA Dardeno, SY Kim, OP Hamnvik, A Koniaris |
American journal of physiology. Endocrinology and metabolism | 2011 |
|
Adipokines in inflammation and metabolic disease
N Ouchi, JL Parker, JJ Lugus, K Walsh |
Nature Reviews Immunology | 2011 |
|
Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism
T Scherer, C Buettner |
Reviews in Endocrine and Metabolic Disorders | 2011 |
|
The central effects of thyroid hormones on appetite
A Amin, WS Dhillo, KG Murphy |
Journal of Thyroid Research | 2011 |
|
Inflammatory concepts of obesity
VZ Rocha, EJ Folco |
International Journal of Inflammation | 2011 |
|
Breast milk hormones and regulation of glucose homeostasis
F Savino, SA Liguori, M Sorrenti, MF Fissore, R Oggero |
International journal of pediatrics | 2011 |
|
Extraluminal factors contributing to inflammatory bowel disease
A Batra, T Stroh, B Siegmund |
World journal of gastroenterology : WJG | 2011 |
|
Leptin in immuno-rheumatological diseases
M Vadacca, DP Margiotta, L Navarini, A Afeltra |
Cellular and Molecular Immunology | 2011 |
|
Etiology and Treatment of Hypogonadism in Adolescents
V Viswanathan, EA Eugster |
Pediatric Clinics of North America | 2011 |
|
The Acute Effects of Leptin Require PI3K Signaling in the Hypothalamic Ventral Premammillary Nucleus
KW Williams, JW Sohn, J Donato, CE Lee, JJ Zhao, JK Elmquist, CF Elias |
Journal of Neuroscience | 2011 |
|
Leptin administration to overweight and obese subjects for six months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet
GK Shetty, G Matarese, F Magkos, HS Moon, X Liu, AM Brennan, G Mylvaganam, D Sykoutri, AM Depaoli, CS Mantzoros |
European Journal of Endocrinology | 2011 |
|
Leptin is an effective treatment for hypothalamic amenorrhea
SH Chou, JP Chamberland, X Liu, G Matarese, C Gao, R Stefanakis, MT Brinkoetter, H Gong, K Arampatzi, CS Mantzoros |
Proceedings of the National Academy of Sciences | 2011 |
|
Repositioning leptin as a therapy for Alzheimer's disease
JM Johnston, SJ Greco, A Hamzelou, JW Ashford, N Tezapsidis |
Therapy | 2011 |
|
Genetics of Obesity: What have we Learned?
H Choquet, D Meyre |
Current genomics | 2011 |
|
Leptin Administration Does Not Prevent the Bone Mineral Metabolism Changes Induced by Weight Loss
R Conroy, M Girotra, E Shane, DJ McMahon, KH Pavlovich, RL Leibel, M Rosenbaum, J Korner |
Metabolism: clinical and experimental | 2011 |
|
Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines
LG Bermúdez-Humarán, P Kharrat, JM Chatel, P Langella |
Microbial cell factories | 2011 |
|
A comparison between metabolic syndrome post-hematopoietic stem cell transplantation and spontaneously occurring metabolic syndrome
L Airaghi, P Usardi, S Forti, A Orsatti, M Baldini, C Annaloro, GL Deliliers |
Journal of Endocrinological Investigation | 2011 |
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Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin
KN Aronis, H Kilim, JP Chamberland, A Breggia, C Rosen, CS Mantzoros |
The Journal of clinical endocrinology and metabolism | 2011 |
|
Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation
AE Dixon, RE Pratley, PM Forgione, DA Kaminsky, LA Whittaker-Leclair, LA Griffes, J Garudathri, D Raymond, ME Poynter, JY Bunn, CG Irvin |
Journal of Allergy and Clinical Immunology | 2011 |
|
Eating Disturbance in Behavioural-Variant Frontotemporal Dementia
O Piguet |
Journal of Molecular Neuroscience | 2011 |
|
Body Mass Index and CD4+ T-Lymphocyte Recovery in HIV-Infected Men with Viral Suppression on Antiretroviral Therapy
B Palermo, RJ Bosch, K Bennett, JM Jacobson |
HIV clinical trials | 2011 |
|
Contrasting Effects of Leptin on Food Anticipatory and Total Locomotor Activity
AC Ribeiro, G Ceccarini, C Dupré, JM Friedman, DW Pfaff, AL Mark, S Yamazaki |
PloS one | 2011 |
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Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
JR Speakman, DA Levitsky, DB Allison, MS Bray, JM de Castro, DJ Clegg, JC Clapham, AG Dulloo, L Gruer, S Haw, J Hebebrand, MM Hetherington, S Higgs, SA Jebb, RJ Loos, S Luckman, A Luke, V Mohammed-Ali, S ORahilly, M Pereira, L Perusse, TN Robinson, B Rolls, ME Symonds, MS Westerterp-Plantenga |
Disease models & mechanisms | 2011 |
|
Once fat was fat and that was that: our changing perspectives on adipose tissue.
Ferris WF, Crowther NJ |
CardioVascular Journal of Africa | 2011 |
|
Raised Energy Expenditure, Muscle Mitochondrial Uncoupling and Hyperphagia in Resistance to Thyroid Hormone
Catherine Mitchell, David Savage, Sylvie Dufour, Nadia Schoenmakers, Peter Murgatroyd, Douglas Befroy, David Halsall, Samantha Northcott, Philippa Raymond-Barker, Suzanne Curran, Elena Henning, Julia Keogh, Penny Owen, John Lazarus, Douglas L. Rothman, Sadaf Farooqi, Gerald Shulman, Krishna Chatterjee, Kitt Falk Petersen |
Journal of Clinical Investigation | 2010 |
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Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
Jose Donato, Roberta Cravo, Renata Frazao, Laurent Gautron, michael scott, Jennifer Lachey, Inar Castro, Lisandra Margatho, Syann Lee, charlotte lee, James Richardson, Jeffrey Friedman, Streamson Chua, Roberto Coppari, Jeffey Zigman, Joel Elmquist, Carol Elias |
Journal of Clinical Investigation | 2010 |
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Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level
M Perello, I Cakir, NE Cyr, A Romero, RC Stuart, F Chiappini, AN Hollenberg, EA Nillni |
American journal of physiology. Endocrinology and metabolism | 2010 |
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Regulation of the hypothalamic Thyrotropin Releasing Hormone (TRH) neuron by neuronal and peripheral inputs
EA Nillni |
Frontiers in Neuroendocrinology | 2010 |
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Adipocytokines: The pied pipers
H Gandhi, A Upaganlawar, R Balaraman |
Journal of pharmacology & pharmacotherapeutics | 2010 |
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Relevance of serum leptin and leptin-receptor concentrations in critically ill patients
A Koch, R Weiskirchen, HW Zimmermann, E Sanson, C Trautwein, F Tacke |
Mediators of Inflammation | 2010 |
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Leptin Induces Phosphorylation of Neuronal Nitric Oxide Synthase in Defined Hypothalamic Neurons
J Donato, R Frazão, M Fukuda, CR Vianna, CF Elias |
Endocrinology | 2010 |
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Narrative review: the role of leptin in human physiology: emerging clinical applications
T Kelesidis, I Kelesidis, S Chou, CS Mantzoros |
Annals of internal medicine | 2010 |
|
Leptin in human physiology and therapeutics
TA Dardeno, SH Chou, HS Moon, JP Chamberland, CG Fiorenza, CS Mantzoros |
Frontiers in Neuroendocrinology | 2010 |
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CNS leptin action modulates immune response and survival in sepsis
J Tschöp, R Nogueiras, S Haas-Lockie, KR Kasten, TR Castañeda, N Huber, K Guanciale, D Perez-Tilve, K Habegger, N Ottaway, SC Woods, B Oldfield, I Clarke, S Chua, IS Farooqi, S O'Rahilly, CC Caldwell, MH Tschöp |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2010 |
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Thymic fatness and approaches to enhance thymopoietic fitness in aging
VD Dixit |
Current Opinion in Immunology | 2010 |
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Role of leptin in the activation of immune cells
P Fernández-Riejos, S Najib, J Santos-Alvarez, C Martín-Romero, A Pérez-Pérez, C González-Yanes, V Sánchez-Margalet |
Mediators of Inflammation | 2010 |
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Mechanism of attenuation of leptin signaling under chronic ligand stimulation
H Knobelspies, J Zeidler, P Hekerman, S Bamberg-Lemper, W Becker |
BMC Biochemistry | 2010 |
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From monogenic to polygenic obesity: recent advances
A Hinney, CI Vogel, J Hebebrand |
European Child & Adolescent Psychiatry | 2010 |
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Inflammation, a link between obesity and cardiovascular disease
Z Wang, T Nakayama |
Mediators of Inflammation | 2010 |
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Does leptin predict incident hypertension in older adults?
CK Kramer, D Mühlen, E Barrett-Connor |
Clinical Endocrinology | 2010 |
|
Leptin as a metabolic link to multiple sclerosis
G Matarese, PB Carrieri, S Montella, VD Rosa, AL Cava |
Nature Reviews Neurology | 2010 |
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Energy Intake in Weight-Reduced Humans
M Rosenbaum, HR Kissileff, LE Mayer, J Hirsch, RL Leibel |
Brain Research | 2010 |
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Hypothalamic Sites of Leptin Action Linking Metabolism and Reproduction
J Donato, RM Cravo, R Frazão, CF Elias |
Neuroendocrinology | 2010 |
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Prediabetes Is not All About Obesity: Association between Plasma Leptin and Prediabetes in Lean Rural Chinese Adults
G Wang, X Liu, KK Christoffel, S Zhang, B Wang, R Liu, Z Li, X Liu, WJ Brickman, D Zimmerman, X Xu, X Wang |
European Journal of Endocrinology | 2010 |
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The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone
MB Glier, P Pissios, SL Babich, ML Macdonald, MR Hayden, E Maratos-Flier, WT Gibson |
Peptides | 2010 |
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Leptin Replacement Prevents Weight Loss-Induced Metabolic Adaptation in Congenital Leptin-Deficient Patients
JE Galgani, FL Greenway, S Caglayan, ML Wong, J Licinio, E Ravussin |
The Journal of clinical endocrinology and metabolism | 2010 |
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Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy.
Paz-Filho G, Mastronardi C, Delibasi T, Wong ML, Licinio J |
Arquivos brasileiros de endocrinologia e metabologia | 2010 |
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Leaping for leptin: the 2010 Albert Lasker Basic Medical Research Award goes to Douglas Coleman and Jeffrey M. Friedman
Neill US |
Journal of Clinical Investigation | 2010 |
|
Narrative review: the role of leptin in human physiology: emerging clinical applications.
Kelesidis T, Kelesidis I, Chou S, Mantzoros CS |
Annals of internal medicine | 2010 |
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Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin
Jovanovic Z, Loraine Tung YC, Lam BY, O\u2019Rahilly S, Yeo GS |
Journal of neuroendocrinology | 2010 |
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Obesity accelerates thymic aging
H Yang, YH Youm, B Vandanmagsar, J Rood, KG Kumar, AA Butler, VD Dixit |
Blood | 2009 |
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Hematopoietic stem cell origin of adipocytes
Y Sera, AC LaRue, O Moussa, M Mehrotra, JD Duncan, CR Williams, E Nishimoto, BA Schulte, PM Watson, DK Watson, M Ogawa |
Experimental Hematology | 2009 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Pediatric obesity: etiology and treatment
MK Crocker, JA Yanovski |
Endocrinology and metabolism clinics of North America | 2009 |
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Leptin at 14 y of age: an ongoing story
JM Friedman |
The American journal of clinical nutrition | 2009 |
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Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls
M Russell, J Stark, S Nayak, KK Miller, DB Herzog, A Klibanski, M Misra |
Bone | 2009 |
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Three questions about leptin and immunity
G Fantuzzi |
Brain, Behavior, and Immunity | 2009 |
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PET Imaging of Leptin Biodistribution and Metabolism in Rodents and Primates
G Ceccarini, RR Flavell, ER Butelman, M Synan, TE Willnow, M Bar-Dagan, SJ Goldsmith, MJ Kreek, P Kothari, S Vallabhajosula, TW Muir, JM Friedman |
Cell Metabolism | 2009 |
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Energy Homoeostasis: The Roles of Adipose Tissue-Derived Hormones, Peptide YY and Ghrelin
J Hall, R Roberts, N Vora |
Obesity facts | 2009 |
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Efficacy of leptin therapy in the different forms of human lipodystrophy
AY Chong, BC Lupsa, EK Cochran, P Gorden |
Diabetologia | 2009 |
|
Leptin therapy in lipodystrophy
DB Savage, S ORahilly |
Diabetologia | 2009 |
|
Hormonal Regulators of Appetite
J Austin, D Marks |
International Journal of Pediatric Endocrinology | 2009 |
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Etiology and Treatment of Hypogonadism in Adolescents
V Viswanathan, EA Eugster |
Endocrinology & Metabolism Clinics of North America | 2009 |
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Serum adiponectin as a predictor of childhood non-Hodgkin's lymphoma: a nationwide case-control study
ET Petridou, TN Sergentanis, N Dessypris, IT Vlachantoni, S Tseleni-Balafouta, A Pourtsidis, M Moschovi, S Polychronopoulou, F Athanasiadou-Piperopoulou, M Kalmanti, CS Mantzoros |
Journal of Clinical Oncology | 2009 |
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Metabolic characterization of a mouse deficient in all known leptin receptor isoforms
O Osborn, M Sanchez-Alavez, SE Brownell, B Ross, J Klaus, J Dubins, B Beutler, B Conti, T Bartfai |
Cellular and Molecular Neurobiology | 2009 |
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Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy
RG Burwell, RK Aujla, MP Grevitt, PH Dangerfield, A Moulton, TL Randell, SI Anderson |
Scoliosis | 2009 |
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Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis
L Strandberg, M Verdrengh, M Enge, N Andersson, S Amu, K Onnheim, A Benrick, M Brisslert, J Bylund, M Bokarewa, S Nilsson, JO Jansson |
PloS one | 2009 |
|
Congenital leptin deficiency and thyroid function
G Paz-Filho, T Delibasi, HK Erol, ML Wong, J Licinio |
Thyroid Research | 2009 |
|
Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy
E Ravussin, SR Smith, JA Mitchell, R Shringarpure, K Shan, H Maier, JE Koda, C Weyer |
Obesity (Silver Spring, Md.) | 2009 |
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The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion
J Donato, RJ Silva, LV Sita, S Lee, C Lee, S Lacchini, JC Bittencourt, CR Franci, NS Canteras, CF Elias |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2009 |
|
Leptin in humans: lessons from translational research
S Blüher, CS Mantzoros |
The American journal of clinical nutrition | 2009 |
|
Adipose tissue lymphocytes: types and roles
S Caspar-Bauguil, B Cousin, S Bour, L Castiella, L Penicaud, C Carpéné |
Journal of Physiology and Biochemistry | 2009 |
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A 12-week regimen of caloric restriction improves levels of adipokines and pro-inflammatory cytokines in Korean women with BMIs greater than 23 kg/m2
IS Lee, G Shin, R Choue |
Inflammation Research | 2009 |
|
Fyn Mediates Leptin Actions in the Thymus of Rodents
A Girasol, GG Albuquerque, E Mansour, EP Araújo, G Degasperi, RG Denis, JB Carvalheira, MJ Saad, LA Velloso, ST Ferreira |
PloS one | 2009 |
|
Leptin Deficiency: Clinical Implications and Opportunities for Therapeutic Interventions
S Blüher, S Shah, CS Mantzoros |
Journal of Investigative Medicine | 2009 |
|
Human genetics illuminates the paths to metabolic disease
S ORahilly |
Nature | 2009 |
|
Molecular signatures of obstructive sleep apnea in adults: a review and perspective.
Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI |
Sleep | 2009 |
|
Weight-loss induces leptin-reversible changes in regional neural activity responses to visual food stimuli
Michael Rosenbaum, M.D., Melissa Sy, B.A., Katherine Pavlovich, B.A., Rudolph L. Leibel, M.D., Joy Hirsch, Ph.D. |
Journal of Clinical Investigation | 2008 |
|
Revisiting leptin’s role in obesity and weight loss
Rexford S. Ahima |
Journal of Clinical Investigation | 2008 |
|
Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation
A Johnston, S Arnadottir, JE Gudjonsson, A Aphale, AA Sigmarsdottir, SI Gunnarsson, JT Steinsson, JT Elder, H Valdimarsson |
The British journal of dermatology | 2008 |
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Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice
NS Singhal, RT Patel, Y Qi, YS Lee, RS Ahima |
American journal of physiology. Endocrinology and metabolism | 2008 |
|
Adipocytokines and the metabolic complications of obesity
N Rasouli, PA Kern |
The Journal of clinical endocrinology and metabolism | 2008 |
|
Leptin Resistance
SS Martin, A Qasim, MP Reilly |
Journal of the American College of Cardiology | 2008 |
|
Adipokines and the peripheral and neural control of energy balance
RS Ahima, MA Lazar |
Molecular Endocrinology | 2008 |
|
Leptin regulates peripheral lipid metabolism primarily through central effects on food intake
X Prieur, YC Tung, JL Griffin, IS Farooqi, S O'Rahilly, AP Coll |
Endocrinology | 2008 |
|
Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
G Paz-Filho, K Esposito, B Hurwitz, A Sharma, C Dong, V Andreev, T Delibasi, H Erol, A Ayala, ML Wong, J Licinio |
American journal of physiology. Endocrinology and metabolism | 2008 |
|
Serum leptin in systemic lupus erythematosus
M Wisłowska, M Rok, K Stępień, A Kuklo-Kowalska |
Rheumatology International | 2008 |
|
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span
VD Dixit |
Journal of leukocyte biology | 2008 |
|
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
NJ Maciver, SR Jacobs, HL Wieman, JA Wofford, JL Coloff, JC Rathmell |
Journal of leukocyte biology | 2008 |
|
Leptin and Inflammation
N Iikuni, QL Lam, L Lu, G Matarese, AL Cava |
Current immunology reviews | 2008 |
|
Leptin replacement improves cognitive development
GJ Paz-Filho, T Babikian, R Asarnow, T Delibasi, K Esposito, HK Erol, ML Wong, J Licinio |
PloS one | 2008 |
|
Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase
P Fernández-Riejos, R Goberna, V Sánchez-Margalet |
Clinical & Experimental Immunology | 2008 |
|
Functional consequences of the human leptin receptor (LEPR) Q223R transversion
G Stratigopoulos, CA LeDuc, N Matsuoka, R Gutman, R Rausch, SA Robertson, MG Myers, WK Chung, SC Chua, RL Leibel |
Obesity (Silver Spring, Md.) | 2008 |
|
Feeding our immune system: impact on metabolism
I Wolowczuk, C Verwaerde, O Viltart, A Delanoye, M Delacre, B Pot, C Grangette |
Clinical & developmental immunology | 2008 |
|
CNTF: a target therapeutic for obesity-related metabolic disease?
VB Matthews, MA Febbraio |
Journal of Molecular Medicine | 2008 |
|
Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions
S O'Rahilly, IS Farooqi |
Diabetes | 2008 |
|
Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?
P Calabrò, E Golia, V Maddaloni, M Malvezzi, B Casillo, C Marotta, R Calabrò, P Golino |
Internal and Emergency Medicine | 2008 |
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Adipose Tissue: The New Endocrine Organ? A Review Article
SE Wozniak, LL Gee, MS Wachtel, EE Frezza |
Digestive Diseases and Sciences | 2008 |
|
Lessons from Extreme Human Obesity: Monogenic Disorders
SA Ranadive, C Vaisse |
Endocrinology and metabolism clinics of North America | 2008 |
|
Prevention and Treatment of Pediatric Obesity: An Endocrine Society Clinical Practice Guideline Based on Expert Opinion
GP August, S Caprio, I Fennoy, M Freemark, FR Kaufman, RH Lustig, JH Silverstein, PW Speiser, DM Styne, VM Montori |
The Journal of clinical endocrinology and metabolism | 2008 |
|
Adipokines and Insulin Resistance
K Rabe, M Lehrke, KG Parhofer, UC Broedl |
Molecular Medicine | 2008 |
|
Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity.
Chan JL, Wong SL, Mantzoros CS |
Clinical Pharmacokinetics | 2008 |
|
The endocrinopathies of anorexia nervosa.
Usdan LS, Khaodhiar L, Apovian CM |
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists | 2008 |
|
Obesity and the beta cell: Lessons from leptin
Kevin D. Niswender1 and Mark A. Magnuson2 |
Journal of Clinical Investigation | 2007 |
|
gp130 receptor ligands: potential therapeutic targets for obesity
Mark A. Febbraio |
Journal of Clinical Investigation | 2007 |
|
The role of leptin in the regulation of neuroendocrine function and CNS development
GW Louis, MG Myers |
Reviews in Endocrine and Metabolic Disorders | 2007 |
|
Leptin: At the crossroads of energy balance and systemic inflammation
AA Steiner, AA Romanovsky |
Progress in Lipid Research | 2007 |
|
Leptin levels in various manifestations of pulmonary tuberculosis
H Buyukoglan, I Gulmez, F Kelestimur, L Kart, FS Oymak, R Demir, M Ozesmi |
Mediators of Inflammation | 2007 |
|
Leptin replacement alters brain response to food cues in genetically leptin-deficient adults
K Baicy, ED London, J Monterosso, ML Wong, T Delibasi, A Sharma, J Licinio |
Proceedings of the National Academy of Sciences | 2007 |
|
Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice
JL Trevaskis, EA Meyer, JE Galgani, AA Butler |
Endocrinology | 2007 |
|
In search of fat profits
G Watts |
BMJ (Clinical research ed.) | 2007 |
|
The hormonal control of food intake
AP Coll, IS Farooqi, S O'Rahilly |
Cell | 2007 |
|
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
IS Farooqi, T Wangensteen, S Collins, W Kimber, G Matarese, JM Keogh, E Lank, B Bottomley, J Lopez-Fernandez, I Ferraz-Amaro, MT Dattani, O Ercan, AG Myhre, L Retterstol, R Stanhope, JA Edge, S McKenzie, N Lessan, M Ghodsi, VD Rosa, F Perna, S Fontana, I Barroso, DE Undlien, S O'Rahilly |
The New England journal of medicine | 2007 |
|
Serum leptin in rheumatoid arthritis
M Wisłowska, M Rok, B Jaszczyk, K Stępień, M Cicha |
Rheumatology International | 2007 |
|
Anorexia, bulimia, and the athletic triad: Evaluation and management
RM Fenichel, MP Warren |
Current Osteoporosis Reports | 2007 |
|
Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: a prospective cohort study
AM Brennan, TY Li, I Kelesidis, A Gavrila, FB Hu, CS Mantzoros |
Diabetologia | 2007 |
|
Leptin and adiponectin: Their role in diabetes
AM Brennan, CS Mantzoros |
Current Diabetes Reports | 2007 |
|
Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight
J Licinio, M Milane, S Thakur, F Whelan, BO Yildiz, T Delibasi, PB de Miranda, M Ozata, E Bolu, A DePaoli, ML Wong |
Appetite | 2007 |
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Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3gene in extremely obese children and adolescents
K Hölter, AK Wermter, A Scherag, W Siegfried, H Goldschmidt, J Hebebrand, A Hinney |
BMC Medical Genetics | 2007 |
|
Relationship of Obesity with Osteoporosis
LJ Zhao, YJ Liu, PY Liu, J Hamilton, RR Recker, HW Deng |
The Journal of clinical endocrinology and metabolism | 2007 |
|
Effects of Intranasal Administration of a Leptin-Secreting Lactococcus lactis Recombinant on Food Intake, Body Weight, and Immune Response of Mice
LG Bermúdez-Humarán, S Nouaille, V Zilberfarb, G Corthier, A Gruss, P Langella, T Issad |
Applied and environmental microbiology | 2007 |
|
Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease.
Qureshi K, Abrams GA |
World Journal of Gastroenterology | 2007 |
|
Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons.
Ortega E, Pannacciulli N, Bogardus C, Krakoff J |
The American journal of clinical nutrition | 2007 |
|
Nutrigenomics, beta-cell function and type 2 diabetes.
Nino-Fong R, Collins T, Chan C |
Current genomics | 2007 |
|
Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans
JL Chan, G Matarese, GK Shetty, P Raciti, I Kelesidis, D Aufiero, VD Rosa, F Perna, S Fontana, CS Mantzoros |
Proceedings of the National Academy of Sciences | 2006 |
|
Unraveling the genetics of human obesity
DM Mutch, K Clément |
PLoS genetics | 2006 |
|
The role of leptin in innate and adaptive immune responses
E Bernotiene, G Palmer, C Gabay |
Arthritis Research & Therapy | 2006 |
|
Leptin and Its Emerging Role in Children and Adolescents
I Kelesidis, CS Mantzoros |
Clinical Pediatric Endocrinology | 2006 |
|
Genes involved in obesity: Adipocytes, brain and microflora
L Macia, O Viltart, C Verwaerde, M Delacre, A Delanoye, C Grangette, I Wolowczuk |
Genes & Nutrition | 2006 |
|
Appetite and energy balance signals from adipocytes
P Trayhurn, C Bing |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2006 |
|
Adipocytes as regulators of energy balance and glucose homeostasis
ED Rosen, BM Spiegelman |
Nature | 2006 |
|
Obesity and its therapy: from genes to community action
JA Skelton, L DeMattia, L Miller, M Olivier |
Pediatric Clinics of North America | 2006 |
|
Genetics of obesity
S O'Rahilly, IS Farooqi |
Philosophical transactions of the Royal Society of London. Series B, Biological sciences | 2006 |
|
Intra-follicular leptin concentration as a predictive factor for in vitro oocyte fertilization in assisted reproductive techniques.
De Placido G, Alviggi C, Clarizia R, Mollo A, Alviggi E, Strina I, Fiore E, Wilding M, Pagano T, Matarese G |
Journal of Endocrinological Investigation | 2006 |
|
Low dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
Michael Rosenbaum, Rochelle Goldsmith, Daniel Bloomfield, Anthony Magnano, Louis Weimer, Steven Heymsfield, Dympna Gallagher, Laurel Mayer, Ellen Murphy, and Rudolph L. Leibel |
Journal of Clinical Investigation | 2005 |
|
Pediatric Endocrine Disorders of Energy Balance
RH Lustig |
Reviews in Endocrine and Metabolic Disorders | 2005 |
|
Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection.
Liu ZW, Zhang N, Han QY, Zeng JT, Chu YL, Qiu JM, Wang YW, Ma LT, Wang XQ |
World Journal of Gastroenterology | 2005 |
|
Inflammation, stress, and diabetes.
Wellen KE, Hotamisligil GS |
Journal of Clinical Investigation | 2005 |
|
Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency
JR McDuffie, PA Riggs, KA Calis, RJ Freedman, EA Oral, AM DePaoli, JA Yanovski |
The Journal of clinical endocrinology and metabolism | 2004 |
|
The role of leptin?STAT3 signaling in neuroendocrine function: an integrative perspective
SH Bates, MG Myers |
Journal of Molecular Medicine | 2004 |
|
Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice
E Bernotiene, G Palmer, D Talabot-Ayer, I Szalay-Quinodoz, ML Aubert, C Gabay |
Arthritis Research & Therapy | 2004 |
|
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
Y Lee, RH Naseem, L Duplomb, BH Park, DJ Garry, JA Richardson, JE Schaffer, RH Unger |
Proceedings of the National Academy of Sciences | 2004 |
|
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
EE Zhang, E Chapeau, K Hagihara, GS Feng |
Proceedings of the National Academy of Sciences | 2004 |
|
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
J Licinio, S Caglayan, M Ozata, BO Yildiz, PB de Miranda, F O'Kirwan, R Whitby, L Liang, P Cohen, S Bhasin, RM Krauss, JD Veldhuis, AJ Wagner, AM DePaoli, SM McCann, ML Wong |
Proceedings of the National Academy of Sciences | 2004 |
|
Exceptional matters
K Peters |
Lancet | 2004 |
|
Unraveling the multiple roles of leptin in inflammation and autoimmunity
AL Cava, C Alviggi, G Matarese |
Journal of Molecular Medicine | 2004 |
|
From gene function to improved health: genome research in the United Kingdom.
Radda GK, Viney I |
Journal of Molecular Medicine | 2004 |
|
The role of falling leptin in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
Jean L. Chan, M.D., Kathleen Heist, Alex M. DePaoli, M.D., Johannes D. Veldhuis, M.D., Christos S. Mantzoros, M.D., D.Sc. |
Journal of Clinical Investigation | 2003 |
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Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV-infected patients
C Sánchez-Pozo, J Rodriguez-Baño, A Domínguez-Castellano, MA Muniain, R Goberna, V Sánchez-Margalet |
Clinical & Experimental Immunology | 2003 |
|
A role for leptin in rheumatic diseases?
G Palmer, C Gabay |
Annals of the rheumatic diseases | 2003 |
|
Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action
V Sánchez-Margalet, C Martín-Romero, J Santos-Alvarez, R Goberna, S Najib, C Gonzalez-Yanes |
Clinical & Experimental Immunology | 2003 |
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