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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
Gaël Nicolas, … , Axel Kahn, Sophie Vaulont
Gaël Nicolas, … , Axel Kahn, Sophie Vaulont
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):1037-1044. https://doi.org/10.1172/JCI15686.
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Article Inflammation Article has an altmetric score of 14

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

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Abstract

Research Article

Authors

Gaël Nicolas, Caroline Chauvet, Lydie Viatte, Jean Louis Danan, Xavier Bigard, Isabelle Devaux, Carole Beaumont, Axel Kahn, Sophie Vaulont

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Effect of PHZ treatment in control mice and experimentally iron-overload...
Effect of PHZ treatment in control mice and experimentally iron-overloaded animals. (a) Hepcidin mRNA content in liver of control mice, mice treated with PHZ, mice experimentally iron overloaded, and mice iron overloaded and treated with PHZ (see Methods) as determined by Northern blot analysis. Twenty micrograms of total liver RNAs were electrophoresed, blotted, and hybridized with both hepcidin and 18S-labeled probes (as described in Methods). Id, iron dextran. (b) Relative changes in hepcidin. mRNA level (18S normalized, arbitrary units) as calculated using a STORM850 PhosphoImager and ImageQuant 5.0. Results are expressed as mean ± SD for n animals, and statistical analysis was performed using the Student t test (unpaired, two-tailed). *P < 0.001 as compared with iron-overloaded mice.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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