JCI - Citations to Stat proteins and oncogenesis

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Stat proteins and oncogenesis

Jacqueline Bromberg

Jacqueline Bromberg

Published May 1, 2002
Citation Information: J Clin Invest. 2002;109(9):1139-1142. https://doi.org/10.1172/JCI15617.

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Citations to this article (360)

Title and authors	Publication	Year
Association of Selected STAT Inhibitors with Prolactin-Induced Protein (PIP) in Breast Cancer Jabłońska K, Kmiecik A, Nowińska K, Piotrowska A, Suchański J, Ratajczak-Wielgomas K, Partyńska A, Romanowicz H, Smolarz B, Matkowski R, Dzięgiel P	International Journal of Molecular Sciences	2025
Protein tyrosine phosphatase receptor type kappa (PTPRK) revisited: evolving insights into structure, function, and pathology Zheng C, Liu T, Wang AQ, Chen XA, Zhang RZ, Wang XC, Lv CY, Pan RL, Wang OC, Lu XC	Journal of Translational Medicine	2025
Essential contribution of the JAK/STAT pathway to carcinogenesis, lytic infection of herpesviruses and pathogenesis of COVID‑19 (Review) Li W, Zhuang Y, Shao SJ, Trivedi P, Zheng B, Huang GL, He Z, Zhang X	Molecular medicine reports	2024
O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1 Zhang CC, Li Y, Jiang CY, Le QM, Liu X, Ma L, Wang FF	Acta Pharmacologica Sinica	2024
Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation Wang W, Lopez McDonald MC, Hariprasad R, Hamilton T, Frank DA	Cancers	2024
Potential therapeutic targets of the JAK2/STAT3 signaling pathway in triple-negative breast cancer Long L, Fei X, Chen L, Yao L, Lei X	Frontiers in Oncology	2024
Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma Abdullatif A, Abdelrahman AE, Bakry A, Gharieb SA, Ramadan MS, Wasfy MA, Abdelwanis AH, Fouad EM		2024
Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway Ma Z, Zhou F, Jin H, Wu X	Cells	2024
Epidermal Growth Factor Receptor Targeting in Colorectal Carcinoma: Antibodies and Patient-Derived Organoids as a Smart Model to Study Therapy Resistance Tardito S, Matis S, Zocchi MR, Benelli R, Poggi A	International journal of molecular sciences	2024
Potential of Natural Products in the Treatment of Glioma: Focus on Molecular Mechanisms. Sheida A, Farshadi M, Mirzaei A, Najjar Khalilabad S, Zarepour F, Taghavi SP, Hosseini Khabr MS, Ravaei F, Rafiei S, Mosadeghi K, Yazdani MS, Fakhraie A, Ghattan A, Zamani Fard MM, Shahyan M, Rafiei M, Rahimian N, Talaei Zavareh SA, Mirzaei H	Cell Biochemistry and Biophysics	2024
Investigating the Link between STAT4 Genetic Variants, STAT4 Protein Concentrations, and Laryngeal Squamous Cell Carcinoma: A Comprehensive Analysis of Clinical Manifestations Pileckaite E, Vilkeviciute A, Kriauciuniene L, Liutkevicius V, Liutkeviciene R	International Journal of Molecular Sciences	2024
Clinical implications of cytomegalovirus in glioblastoma progression and therapy Mercado NB, Real JN, Kaiserman J, Panagioti E, Cook CH, Lawler SE	NPJ Precision Oncology	2024
The Radiosensitizing Potentials of Silymarin/Silibinin in Cancer: A Systematic Review. Gupta J, Jalil AT, Riyad Muedii ZA, Aminov Z, Alsaikhan F, Ramírez-Coronel AA, Ramaiah P, Farhood B	Current medicinal chemistry	2024
STAT1 Promotes PD-L1 Activation and Tumor Growth in Lymphangioleiomyomatosis Olatoke T, Zhang EY, Wagner A, He Q, Li S, Astreinidis A, McCormack FX, Xu Y, Yu JJ	bioRxiv	2024
Expansion of B10 cells in vitro: Pathways, techniques and applications in transplantation (Review) Zhao D, Huai G, Yuan Y, Cui Y, Yuan Y, Zhao G	International Journal of Molecular Medicine	2024
Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells Wang M, Zhang Y, Liu M, Jia Y, He J, Xu X, Shi H, Zhang Y, Zhang J, Liu Y	Journal of Cancer	2023
STAT3/NF-κB decoy oligodeoxynucleotides inhibit atherosclerosis through regulation of the STAT/NF-κB signaling pathway in a mouse model of atherosclerosis An HJ, Gwon MG, Gu H, Bae S, Leem J, Lee JB, Park KK	International journal of molecular medicine	2023
Oncogenic metabolic reprogramming in breast cancer: focus on signaling pathways and mitochondrial genes. Malayil R, Chhichholiya Y, Vasudeva K, Singh HV, Singh T, Singh S, Munshi A	Medical Oncology	2023
Identification of RUNX1 and IFNGR2 as prognostic-related biomarkers correlated with immune infiltration and subtype differentiation of low-grade glioma Zhang X, Chu H, Cheng Y, Ren J, Wang W, Liu X, Yan X		2023
Canonical and non-canonical functions of STAT in germline stem cell maintenance Xing Y, Larson K, Li J, Li WX	Developmental dynamics : an official publication of the American Association of Anatomists	2023
Outline of Salivary Gland Pathogenesis of Sjögren's Syndrome and Current Therapeutic Approaches. Yura Y, Hamada M	International journal of molecular sciences	2023
Computational workflow for discovering small molecular binders for shallow binding sites by integrating molecular dynamics simulation, pharmacophore modeling, and machine learning: STAT3 as case study. Jaradat NJ, Hatmal M, Alqudah D, Taha MO	Journal of Computer-Aided Molecular Design	2023
Interplay between signal transducers and activators of transcription (STAT) proteins and cancer: involvement, therapeutic and prognostic perspective. Jill N, Bhootra S, Kannanthodi S, Shanmugam G, Rakshit S, Rajak R, Thakkar V, Sarkar K	Clinical and Experimental Medicine	2023
Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3 Wu Y, Chen L, Feng C, Wang T, He S, Zheng D, Lin L	BMC oral health	2023
STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness Arévalo J, Campoy I, Durán M, Nemours S, Areny A, Vall-Palomar M, Martínez C, Cantero-Recasens G, Meseguer A	Scientific Reports	2023
Bile Acid–Microbiome Interaction Promotes Gastric Carcinogenesis S Wang, J Kuang, H Zhang, W Chen, X Zheng, J Wang, F Huang, K Ge, M Li, M Zhao, C Rajani, J Zhu, A Zhao, W Jia	Advanced Science	2022
Structure-activity relationship studies on O-alkylamino-tethered salicylamide derivatives with various amino acid linkers as potent anticancer agents. Xu J, Kim H, Dong J, Chen H, Xu J, Ma R, Zhou M, Wang T, Shen Q, Zhou J	European Journal of Medicinal Chemistry	2022
A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities. Moutabian H, Majdaeen M, Ghahramani-Asl R, Yadollahi M, Gharepapagh E, Ataei G, Falahatpour Z, Bagheri H, Farhood B	Cancer Cell International	2022
Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis Chava S, Bugide S, Zhang X, Gupta R, Wajapeyee N	iScience	2022
DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer Casas G, Perche F, Midoux P, Pichon C, Malinge JM		2022
Comprehensive analysis of the prognostic and immunotherapeutic implications of STAT family members in human colorectal cancer Li D, Jiao Y, Gao W, Hu S, Li D, Zhao W, Chen P, Jin L, Zhao Y, Ma Z, Wu X, Yan Y, Sun W, Du X, Dong G	Frontiers in Genetics	2022
Ruxolitinib and exemestane for estrogen receptor positive, aromatase inhibitor resistant advanced breast cancer. Makhlin I, McAndrew NP, Wileyto EP, Clark AS, Holmes R, Bottalico LN, Mesaros C, Blair IA, Jeschke GR, Fox KR, Domchek SM, Matro JM, Bradbury AR, Feldman MD, Hexner EO, Bromberg JF, DeMichele A	npj Breast Cancer	2022
Early changes in gene expression profiles in AML patients during induction chemotherapy. Jakobsen I, Sundkvist M, Björn N, Gréen H, Lotfi K	BMC Genomics	2022
Multifaceted roles of MAGOH Proteins. Mitra R, Rehman A, Singh KK, Jaganathan BG	Molecular Biology Reports	2022
Effect of Soybean Isoflavones on Proliferation and Related Gene Expression of Sow Mammary Gland Cells In Vitro Ma X, Cui Y, Tian Z, Yu M		2022
The emerging role of regulatory cell-based therapy in autoimmune disease Ghobadinezhad F, Ebrahimi N, Mozaffari F, Moradi N, Beiranvand S, Pournazari M, Rezaei-Tazangi F, Khorram R, Afshinpour M, Robino RA, Aref AR, Ferreira LM	Frontiers in immunology	2022
Interactions of melatonin with various signaling pathways: implications for cancer therapy Mihanfar A, Yousefi B, Azizzadeh B, Majidinia M	Cancer Cell International	2022
Potent Antitumor Effects of Cell-Penetrating Peptides Targeting STAT3 axis Maryam Aftabizadeh, Yi-Jia Li, Qianqian Zhao, Chunyan Zhang, Nigus Ambaye, Jieun Song, Toshikage Nagao, Christoph Lahtz, Marwan Fakih, David Ann, Hua Yu, Andreas Herrmann	JCI Insight	2021
TGFβ1 Protein Trap AVID200 Beneficially Affects Hematopoiesis and Bone Marrow Fibrosis in Myelofibrosis Lilian Varricchio, Camelia Iancu-Rubin, Bhaskar Upadhyaya, Maria Zingariello, Fabrizio Martelli, Paola Verachi, Cara Clementelli, Jean-Francois Denis, Adeeb H Rahman, Gilles Tremblay, John Mascarenhas, Ruben Mesa, Maureen O'Connor-McCourt, Anna Rita Migliaccio, Ronald Hoffman	JCI Insight	2021
Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus LM Colli, L Jessop, TA Myers, SY Camp, MJ Machiela, J Choi, R Cunha, O Onabajo, GC Mills, V Schmid, SA Brodie, O Delattre, DR Mole, MP Purdue, K Yu, KM Brown, SJ Chanock	The American Journal of Human Genetics	2021
Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review AA Arabzadeh, T Mortezazadeh, T Aryafar, E Gharepapagh, M Majdaeen, B Farhood	Cancer Cell International	2021
Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy M Krishnamoorthy, L Gerhardt, SM Vareki	Cells	2021
m6A-Mediated Tumor Invasion and Methylation Modification in Breast Cancer Microenvironment F Liu, X Yu, G He, J Wang	Journal of Oncology	2021
Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer JJ McGuire, JS Frieling, CH Lo, T Li, A Muhammad, HR Lawrence, NJ Lawrence, LM Cook, CC Lynch	Nature Communications	2021
The role of Src homology region 2 domain-containing phosphatase-1 hypermethylation in the classification of patients with myelodysplastic syndromes and its association with signal transducer and activator of transcription 3 phosphorylation in skm-1 cells Y Han, J Zhang, Y Pang, Y Wang, X Zhang, H Zhang	J INT MED RES	2021
Upregulation of ARNTL2 is associated with poor survival and immune infiltration in clear cell renal cell carcinoma S Wang, X Ma, Y Ying, J Sun, Z Yang, J Li, K Jin, X Wang, B Xie, X Zheng, B Liu, L Xie	Cancer Cell International	2021
STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma ZY Zheng, PL Yang, W Luo, SX Yu, HY Xu, Y Huang, RY Li, Y Chen, XE Xu, LD Liao, SH Wang, HC Huang, EM Li, LY Xu	Cancers	2021
Mathematical model of STAT signalling pathways in cancer development and optimal control approaches J Lee, D Lee, Y Kim	Royal Society Open Science	2021
B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors P Rasic, M Jovanovic-Tucovic, M Jeremic, SM Djuricic, ZV Vasiljevic, M Milickovic, D Savic	World journal of gastrointestinal oncology	2021
Napabucasin Induces Mouse Bone Loss by Impairing Bone Formation via STAT3 X Huang, A Jin, X Wang, X Gao, H Xu, M Chung, Q Dai, Y Yang, L Jiang	Frontiers in Cell and Developmental Biology	2021
Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells A Coker-Gurkan, E Can, S Sahin, P Obakan-Yerlikaya, ED Arisan	Molecular Biology Reports	2021
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses F Boehi, P Manetsch, MO Hottiger	Cell Discovery	2021
AntagomiR-19a Induced Better Responsiveness to Bortezomib in Myeloma Cell Lines Azam Kazemi, Saeid Abroun, Masoud Soleimani	Cell Journal (Yakhteh)	2021
NFAT as a Biomarker and Therapeutic Target in Non-Small Cell Lung Cancer-Related Brain Metastasis. Peng L, Tao Y, Wu R, Su J, Sun M, Cheng Y, Xie Z, Mao J, Zhan X, Liu G	Frontiers in Oncology	2021
Therapeutic effects of an innovative BS-HH-002 drug on pancreatic cancer cells via induction of complete MCL-1 degradation Wang AM, Qiu R, Zhang D, Zhao XY	Translational oncology	2021
STAT3: Versatile Functions in Non-Small Cell Lung Cancer J Mohrherr, IZ Uras, HP Moll, E Casanova	Cancers	2020
TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance Z Ding, JM Kloss, S Tuncali, NL Tran, JC Loftus	Neoplasia (New York, N.Y.)	2020
Involvement of STAT5 in Oncogenesis CE Halim, S Deng, MS Ong, CT Yap	Biomedicines	2020
Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors MB Minus, H Wang, JO Munoz, AM Stevens, AE Mangubat-Medina, MJ Krueger, W Liu, MM Kasembeli, JC Cooper, MI Kolosov, DJ Tweardy, MS Redell, ZT Ball	Organic & Biomolecular Chemistry	2020
Feng-Liao-Chang-Wei-Kang Combined with 5-Fluorouracil Synergistically Suppresses Colitis-Associated Colorectal Cancer via the IL-6/STAT3 Signalling Pathway L Zhong, F Yang, L Gan, Z Yang, S Tian, M Huang, C Lv, L Huang, B Romano	Evidence-Based Complementary and Alternative Medicine	2020
Bone marrow-derived mesenchymal stem cells promote healing of rabbit tibial fractures via JAK-STAT signaling pathway P Wang, Z Zhang	Experimental and therapeutic medicine	2020
The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer M Dehhaghi, HK Panahi, B Heng, GJ Guillemin	Frontiers in Cell and Developmental Biology	2020
Activation of STAT transcription factors by the Rho-family GTPases J Corry, HR Mott, D Owen	Biochemical Society Transactions	2020
MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking HY Peng, JR Hsiao, ST Chou, YM Hsu, GH Wu, YS Shieh, SG Shiah	Neoplasia (New York, N.Y.)	2020
Novel Nanocomplexes Targeting STAT3 Demonstrate Promising Anti-Ovarian Cancer Effects in vivo X Zhang, T Lu, Y Ma, R Li, Y Pang, H Mao, P Liu	OncoTargets and therapy	2020
Icariin prevents oestrogen deficiency–induced alveolar bone loss through promoting osteogenesis via STAT3 H Xu, S Zhou, R Qu, Y Yang, X Gong, Y Hong, A Jin, X Huang, Q Dai, L Jiang	Cell Proliferation	2020
STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs FO Oladipupo, CR Yu, E Olumuyide, Y Jittaysothorn, JK Choi, CE Egwuagu	Scientific Reports	2020
Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors RA Cerulli, L Shehaj, I Tosic, K Jiang, J Wang, DA Frank, JA Kritzer	Bioorganic & Medicinal Chemistry	2020
Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3 X Qi, M Li, X Zhang, X Dai, J Cui, D Li, Q Gu, Z Lv, J Li	Molecules (Basel, Switzerland)	2020
The polymorphisms of IL-6/STAT3 signaling pathway may contribute to cutaneous T-cell lymphomas susceptibility B Olszewska, J Gleń, M Zabłotna, RJ Nowicki, M Sokołowska-Wojdyło	Archives of Dermatological Research	2020
The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies N Sarodaya, J Karapurkar, KS Kim, SH Hong, S Ramakrishna	Cancers	2020
Modeling Adaptive Resistance of KRAS Mutant Colorectal Cancer to MAPK Pathway Inhibitors with a Three-Dimensional Tumor Model PS Thakuri, A Lamichhane, S Singh, M Gupta, GD Luker, H Tavana		2020
Molecular mechanism of gossypol mediating CCL2 and IL‑8 attenuation in triple‑negative breast cancer cells S Messeha, N Zarmouh, P Mendonca, C Cotton, K Soliman	Molecular medicine reports	2020
Phosphorylated STAT3 expression linked to SOCS3 methylation is associated with proliferative ability of gastric mucosa in patients with early gastric cancer H Fukui, J Watari, X Zhang, Y Ran, T Tomita, T Oshima, S Hirota, H Miwa	Oncology Letters	2020
Eupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway C Lou, Y Chen, J Zhang, B Yang, H Zhao	Frontiers in pharmacology	2019
Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy J Wei, L Ma, YH Lai, R Zhang, H Li, C Li, J Lin	Journal of Experimental & Clinical Cancer Research	2019
Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology C Recio, B Guerra, M Guerra-Rodríguez, H Aranda-Tavío, P Martín-Rodríguez, M de Mirecki-Garrido, Y Brito-Casillas, JM García-Castellano, A Estévez-Braun, L Fernández-Pérez	Oncogene	2019
Hypoxia-induced pulmonary hypertension and chronic lung disease: caveolin-1 dysfunction an important underlying feature J Huang, M Frid, MH Gewitz, JT Fallon, D Brown, G Krafsur, K Stenmark, R Mathew	Pulmonary circulation	2019
Ponatinib Inhibits Proliferation and Induces Apoptosis of Liver Cancer Cells, but Its Efficacy Is Compromised by Its Activation on PDK1/Akt/mTOR Signaling C Liu, X Mu, X Wang, C Zhang, L Zhang, B Yu, G Sun	Molecules (Basel, Switzerland)	2019
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia M Soutto, Z Chen, AA Bhat, L Wang, S Zhu, A Gomaa, A Bates, NS Bhat, D Peng, A Belkhiri, MB Piazuelo, MK Washington, , R Peek, W El-Rifai	Nature Communications	2019
Downregulation of TfR1 promotes progression of colorectal cancer via the JAK/STAT pathway C Cui, X Cheng, L Yan, H Ding, X Guan, W Zhang, X Tian, C Hao	Cancer management and research	2019
Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway H Hu, S Wang, D Shi, B Zhong, X Huang, C Shi, Z Shao	OncoTargets and therapy	2019
Formononetin: A Review of Its Anticancer Potentials and Mechanisms KC Tay, LT Tan, CK Chan, SL Hong, KG Chan, WH Yap, P Pusparajah, LH Lee, BH Goh	Frontiers in pharmacology	2019
Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma X Wang, X Liao, T Yu, Y Gong, L Zhang, J Huang, C Yang, C Han, L Yu, G Zhu, W Qin, Z Liu, X Zhou, J Liu, Q Han, T Peng	International journal of oncology	2019
The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer Yang, Wu, Yen, Liu, Hwang, Stern, Chiu	Cells	2019
The role of p-Stat3 Y705 immunohistochemistry in glioblastoma prognosis S Susman, R Pîrlog, D Leucuța, AO Mitre, VA Padurean, C Melincovici, I Moldovan, D Crișan, SI Florian	Diagnostic Pathology	2019
Balancing STAT Activity as a Therapeutic Strategy Polak, Chernosky, Smigiel, Tamagno, Jackson	Cancers	2019
Second-line treatment of EGFR T790M-negative non-small cell lung cancer patients BC Liao, S Griesing, JC Yang	Therapeutic advances in medical oncology	2019
Companion Animals as Models for Inhibition of STAT3 and STAT5 M Kieslinger, A Swoboda, N Kramer, B Pratscher, B Wolfesberger, IA Burgener	Cancers	2019
TYK2: An Upstream Kinase of STATs in Cancer K Wöss, N Simonović, B Strobl, S Macho-Maschler, M Müller	Cancers	2019
Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance W Zhou, W Sun, MM Yung, S Dai, Y Cai, CW Chen, Y Meng, JB Lee, JC Braisted, Y Xu, NT Southall, P Shinn, X Huang, Z Song, X Chen, Y Kai, X Cai, Z Li, Q Hao, AN Cheung, HY Ngan, SS Liu, S Barak, J Hao, Z Dai, A Tzatsos, W Peng, H Pei, Z Han, DW Chan, W Zheng, W Zhu	Oncogene	2018
Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy PM Dantonio, MO Klein, MR Freire, CN Araujo, AC Chiacetti, RG Correa	Bioscience Reports	2018
Survivin-Based Treatment Strategies for Squamous Cell Carcinoma A Santarelli, M Mascitti, LL Russo, D Sartini, G Troiano, M Emanuelli, LL Muzio	International journal of molecular sciences	2018
Management of primary Sjögren’s syndrome: recent developments and new classification criteria ND Papa, C Vitali	Therapeutic Advances in Musculoskeletal Diseases	2018
STAT3/PIAS3 levels serve as "early signature" genes in the development of high-grade serous carcinoma from the fallopian tube U Saini, AA Suarez, S Naidu, JJ Wallbillich, K Bixel, R Wanner, J Bice, RD Kladney, J Lester, BY Karlan, PJ Goodfellow, DE Cohn, K Selvendiran	Cancer research	2018
Targeting the IL-6/JAK/STAT3 signalling axis in cancer DE Johnson, RA O'Keefe, JR Grandis	Nature Reviews Clinical Oncology	2018
STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells P Guha, J Gardell, J Darpolor, M Cunetta, M Lima, G Miller, NJ Espat, RP Junghans, SC Katz	Oncogene	2018
Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling M Kim, L Morales, IS Jang, YY Cho, D Kim	International journal of molecular sciences	2018
Therapeutic Potency of Nanoformulations of siRNAs and shRNAs in Animal Models of Cancers Karim, K Tha, I Othman, MB Uddin, E Chowdhury	Pharmaceutics	2018
Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide L Lu, J Dong, L Wang, Q Xia, D Zhang, H Kim, T Yin, S Fan, Q Shen	Oncogene	2018
Antitumor Efficacy of Huqizhengxiao (HQZX) Decoction Based on Inhibition of Telomerase Activity in Nude Mice of Hepatocarcinoma Xenograft XX Yu, XJ Lin, S Wang, XH Liu, WH Li, BX Kou, MY Chai, DX Chen, XN Liu, XJ Wang	Integrative Cancer Therapies	2018
Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs P Vogel, M Moschref, Q Li, T Merkle, KD Selvasaravanan, JB Li, T Stafforst	Nature Methods	2018
Mechanism of metastasis suppression by luteolin in breast cancer MT Cook	Breast cancer : targets and therapy	2018
Differential Modulation of Transcription Factors and Cytoskeletal Proteins in Prostate Carcinoma Cells by a Bacterial Lactone SR Kumar, JN Bryan, AM Eaton, KL Robinson, S Gajagowni	BioMed Research International	2018
Extracellular Vesicles in Bladder Cancer: Biomarkers and Beyond YR Liu, C Ortiz-Bonilla, YF Lee	International journal of molecular sciences	2018
Phenotypic and Functional Diversities of Myeloid-Derived Suppressor Cells in Autoimmune Diseases H Ma, CQ Xia	Mediators of Inflammation	2018
Long Noncoding RNA FEZF1-AS1 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer by Activation of JAK-STAT3 Pathway X Zhao, Z Cheng, J Wang	Medical science monitor : international medical journal of experimental and clinical research	2018
p38 Expression and Modulation of STAT3 Signaling in Oral Cancer I Gkouveris, N Nikitakis, A Sklavounou	Pathology & Oncology Research	2018
A Phase 1/2 Trial of Ruxolitinib and Erlotinib in Patients with EGFR-Mutant Lung Adenocarcinomas with Acquired Resistance to Erlotinib HA Yu, L Perez, Q Chang, SP Gao, MG Kris, GJ Riely, J Bromberg	Journal of Thoracic Oncology	2017
MicroRNA-199a-5p promotes tumour growth by dual-targeting PIAS3 and p27 in human osteosarcoma C Wang, X Ba, Y Guo, D Sun, H Jiang, W Li, Z Huang, G Zhou, S Wu, J Zhang, J Chen	Scientific Reports	2017
TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3 C Zhang, S Mukherjee, C Tucker-Burden, JL Ross, MJ Chau, J Kong, DJ Brat	Molecular Oncology	2017
An integrated method for the identification of novel genes related to oral cancer L Chen, J Yang, Z Xing, F Yuan, Y Shu, YH Zhang, XY Kong, T Huang, HP Li, YD Cai, Q Zou	PloS one	2017
Quantitative specificity of STAT1 and several variants B Roy, Z Zuo, GD Stormo	Nucleic Acids Research	2017
Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer RJ Morrow, N Etemadi, B Yeo, M Ernst	Mediators of Inflammation	2017
Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma C Musolino, A Allegra, V Innao, AG Allegra, G Pioggia, S Gangemi	Mediators of Inflammation	2017
Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes A Tsurumi, C Zhao, WX Li	BMC Genomics	2017
Stellettin B induces apoptosis in human chronic myeloid leukemia cells via targeting PI3K and Stat5 Y Chen, Q Zhou, L Zhang, Y Zhong, G Fan, Z Zhang, R Wang, M Jin, Y Qiu, D Kong	Oncotarget	2017
Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation V Leidgens, J Proske, L Rauer, S Moeckel, K Renner, U Bogdahn, MJ Riemenschneider, M Proescholdt, A Vollmann-Zwerenz, P Hau, C Seliger	Oncotarget	2017
SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes YK Choi, SG Cho, YJ Choi, YJ Yun, KM Lee, K Lee, HH Yoo, YC Shin, SG Ko	Oncotarget	2017
UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation M Kim, LD Morales, M Baek, TJ Slaga, J DiGiovanni, DJ Kim	Oncotarget	2017
Angiogenic factors: role in esophageal cancer, a brief review K Ladeira, F Macedo, A Longatto-Filho, SF Martins	Esophagus	2017
STAT5B: A Differential Regulator of the Life and Death of CD4 + Effector Memory T Cells SS Majri, JM Fritz, AV Villarino, L Zheng, C Kanellopoulou, B Chaigne-Delalande, J Grönholm, JE Niemela, B Afzali, M Biancalana, S Pittaluga, A Sun, JL Cohen, SM Holland, JJ OShea, G Uzel, MJ Lenardo	Journal of immunology (Baltimore, Md. : 1950)	2017
The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury L Campana, PJ Lewis, A Pellicoro, RL Aucott, J Man, E ODuibhir, SE Mok, S Ferreira-Gonzalez, E Livingstone, SN Greenhalgh, KL Hull, TJ Kendall, D Vernimmen, NC Henderson, L Boulter, CD Gregory, Y Feng, SM Anderton, SJ Forbes, JP Iredale	Journal of immunology (Baltimore, Md. : 1950)	2017
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma: KELLER et al A Keller, B Wingelhofer, B Peter, K Bauer, D Berger, S Gamperl, M Reifinger, S Cerny-Reiterer, R Moriggl, M Willmann, P Valent, E Hadzijusufovic	Veterinary and Comparative Oncology	2017
CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity S Vallath, EK Sage, KK Kolluri, SN Lourenco, VS Teixeira, S Chimalapati, PJ George, SM Janes, A Giangreco	Scientific Reports	2016
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation R Romagnoli, PG Baraldi, F Prencipe, C Lopez-Cara, R Rondanin, D Simoni, E Hamel, S Grimaudo, RM Pipitone, M Meli, M Tolomeo	European Journal of Medicinal Chemistry	2016
Reciprocal activation between STAT3 and miR-181b regulates the proliferation of esophageal cancer stem-like cells via the CYLD pathway D Xu, P Zhou, Y Wang, L Zhang, W Fu, B Ruan, H Xu, C Hu, L Tian, J Qin, S Wang, X Wang, Y Li, Q Liu, Z Ren, R Zhang, Y Wang	Molecular Cancer	2016
Significance of Interleukin-6/STAT Pathway for the Gene Expression of REG Iα, a New Autoantigen in Sjögren’s Syndrome Patients, in Salivary Duct Epithelial Cells T Fujimura, T Fujimoto, A Itaya-Hironaka, T Miyaoka, K Yoshimoto, S Sakuramoto-Tsuchida, A Yamauchi, M Takeda, H Tsujinaka, Y Tanaka, S Takasawa	Clinical Reviews in Allergy & Immunology	2016
The Obesity-Breast Cancer Conundrum: An Analysis of the Issues S Matthews, H Thompson	International journal of molecular sciences	2016
MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma HY Peng, YC Cheng, YM Hsu, GH Wu, CC Kuo, JP Liou, JY Chang, SL Jin, SG Shiah, JW Lee	PloS one	2016
JNK1/2 expression and modulation of STAT3 signaling in oral cancer I Gkouveris, N Nikitakis, M Karanikou, G Rassidakis, A Sklavounou	Oncology Letters	2016
Tudor staphylococcal nuclease: biochemistry and functions E Gutierrez-Beltran, TV Denisenko, B Zhivotovsky, PV Bozhkov	Cell Death and Differentiation	2016
Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis G Dalagiorgou, C Piperi, C Adamopoulos, U Georgopoulou, AN Gargalionis, A Spyropoulou, I Zoi, M Nokhbehsaim, A Damanaki, J Deschner, EK Basdra, AG Papavassiliou	Cellular and Molecular Life Sciences	2016
Antagonizing STAT5B dimerization with an osmium complex LJ Liu, W Wang, TS Kang, JX Liang, C Liu, DW Kwong, VK Wong, DL Ma, CH Leung	Scientific Reports	2016
A sensible approach to targeting STAT3-mediated transcription NE Bhola, DE Johnson, JR Grandis	Annals of translational medicine	2016
Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer ZA Sobani, A Sawant, M Jafri, AK Correa, IH Sahin	World journal of clinical oncology	2016
The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling X Song, J Hao, J Wang, C Guo, Y Wang, Q He, H Tang, X Qin, Y Li, Y Zhang, Y Yin	Oncogene	2016
Cyclin D1 expression in peripheral T-cell lymphomas JY Song, L Song, AF Herrera, G Venkataraman, JL Murata-Collins, VH Bedell, YY Chen, YS Kim, R Tadros, BN Nathwani, DD Weisenburger, AL Feldman	Modern Pathology	2016
A Phase II Trial of a Histone Deacetylase Inhibitor Panobinostat in Patients With Low-Grade Neuroendocrine Tumors N Jin, SJ Lubner, DL Mulkerin, S Rajguru, L Carmichael, H Chen, KD Holen, NK LoConte	The oncologist	2016
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response D Heim, I Gil-Ibanez, J Herden, AC Parplys, K Borgmann, D Schmidt-Arras, AW Lohse, S Rose-John, H Wege	Oncotarget	2016
STAT3 induces growth hormone: targeting strategy for pituitary somatotroph adenomas Cuiqi Zhou, Yonghui Jiao, Renzhi Wang, Song-Guang Ren, Kolja Wawrowsky, Shlomo Melmed	Journal of Clinical Investigation	2015
The role of STAT3 in autophagy L You, Z Wang, H Li, J Shou, Z Jing, J Xie, X Sui, H Pan, W Han	Autophagy	2015
An SH2 domain model of STAT5 in complex with phospho-peptides define “STAT5 Binding Signatures” E Gianti, RJ Zauhar	Journal of Computer-Aided Molecular Design	2015
Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells H Zhang, S Kuang, Y Wang, X Sun, Y Gu, L Hu, Q Yu	Acta Pharmacologica Sinica	2015
Immunohistological Analysis of the Jun Family and the Signal Transducers and Activators of Transcription in Thymus A Papoudou-Bai, A Barbouti, V Galani, K Stefanaki, P Kanavaros	Anatomy Research International	2015
Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies C Raggi, HS Mousa, M Correnti, A Sica, P Invernizzi	Oncogene	2015
Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation A Schütz, K Röser, J Klitzsch, F Lieder, F Aberger, W Gruber, KM Mueller, A Pupyshev, R Moriggl, K Friedrich	Translational oncology	2015
Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer N Uddin, RK Kim, KC Yoo, YH Kim, YH Cui, IG Kim, Y Suh, SJ Lee	Cancer Science	2015
Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Iα, a new auto-antigen in Sjögren׳s syndrome patients, in salivary duct epithelial cells T Fujimura, T Fujimoto, A Itaya-Hironaka, T Miyaoka, K Yoshimoto, A Yamauchi, S Sakuramoto-Tsuchida, S Kondo, M Takeda, H Tsujinaka, M Azuma, Y Tanaka, S Takasawa	Biochemistry and Biophysics Reports	2015
Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 X Yu, L He, P Cao, Q Yu, IV Lebedeva	PloS one	2015
HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL R Carson, B Celtikci, C Fenning, A Javadi, N Crawford, L Perez-Carbonell, M Lawler, DB Longley, PG Johnston, SV Schaeybroeck	Clinical cancer research	2015
Inflammation and cancer: advances and new agents SM Crusz, FR Balkwill	Nature Reviews Clinical Oncology	2015
G6PD downregulation triggered growth inhibition and induced apoptosis by regulating STAT3 signaling pathway in esophageal squamous cell carcinoma X Wang, H Liu, X Zhang, X Li, H Gu, H Zhang, R Fan	Tumor Biology	2015
Interleukin-10 production by myeloid-derived suppressor cells contributes to bacterial persistence during Staphylococcus aureus orthopedic biofilm infection CE Heim, D Vidlak, T Kielian	Journal of leukocyte biology	2015
MAPK/ERK signaling pathway-induced hyper-O-GlcNAcylation enhances cancer malignancy X Zhang, L Ma, J Qi, H Shan, W Yu, Y Gu	Molecular and Cellular Biochemistry	2015
Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity T Hu, JE Yeh, L Pinello, J Jacob, S Chakravarthy, GC Yuan, R Chopra, DA Frank	Molecular and cellular biology	2015
Novel 2-Carbonylbenzo[ b ]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway P Ji, X Xu, S Ma, J Fan, Q Zhou, X Mao, C Qiao	ACS Medicinal Chemistry Letters	2015
Interleukin‑6 as a potential molecular target in esophageal squamous cell carcinoma ZF Zhao, JX Li, R Ye, X Wu, LL Gao, BL Niu	Oncology Letters	2015
Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Lee HT, Xue J, Chou PC, Zhou A, Yang P, Conrad CA, Aldape KD, Priebe W, Patterson C, Sawaya R, Xie K, Huang S	Oncotarget	2015
STATs: An Old Story, Yet Mesmerizing. Abroun S, Saki N, Ahmadvand M, Asghari F, Salari F, Rahim F		2015
STAT3 in Cancer—Friend or Foe? Hai-Feng Zhang, Raymond Lai	Cancers	2014
Role of STAT3 in lung cancer P Dutta, N Sabri, J Li, WX Li	JAK-STAT	2014
STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy M Spitzner, R Ebner, H Wolff, B Ghadimi, J Wienands, M Grade	Cancers	2014
XPO1 (CRM1) Inhibition Represses STAT3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer Y Cheng, MP Holloway, K Nguyen, D McCauley, Y Landesman, MG Kauffman, S Shacham, RA Altura	Molecular cancer therapeutics	2014
Adult Neurogenesis and Glial Oncogenesis: When the Process Fails CM Batista, ED Mariano, BJ Barbosa, M Morgalla, SK Marie, MJ Teixeira, G Lepski	BioMed Research International	2014
Bortezomib induces apoptosis by interacting with JAK/STAT pathway in K562 leukemic cells N Selvi, BT Kaymaz, C Gündüz, Ç Aktan, HD Kiper, F Şahin, M Cömert, AF Selvi, B Kosova, G Saydam	Tumor Biology	2014
Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance E Putz, M Hoelzl, J Baeck, Z Bago-Horvath, C Schuster, B Reichholf, D Kern, F Aberger, V Sexl, A Hoelbl-Kovacic	Cancers	2014
Signal transducer and activator of transcription 1 (STAT1) acts like an oncogene in malignant pleural mesothelioma L Arzt, H Kothmaier, I Halbwedl, F Quehenberger, HH Popper	Virchows Archiv	2014
A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling: STAT1 IN CHRYSAROBIN-MEDIATED TUMOR PROMOTION R Bozeman, EL Abel, E Macias, T Cheng, L Beltran, J DiGiovanni	Molecular Carcinogenesis	2014
Rho GTPases modulate malignant transformation of tumor cells JL Orgaz, C Herraiz, V Sanz-Moreno	Small GTPases	2014
Discovery of Potent Anticancer Agent HJC0416, an Orally Bioavailable Small Molecule Inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3) H Chen, Z Yang, C Ding, A Xiong, C Wild, L Wang, N Ye, G Cai, RM Flores, Y Ding, Q Shen, J Zhou	European Journal of Medicinal Chemistry	2014
Knockdown of PKCε Expression Inhibits Growth, Induces Apoptosis and Decreases Invasiveness of Human Glioma Cells Partially Through Stat3 Y Xu, Z Li, C Zhang, S Zhang, Y Ji, F Chen	Journal of Molecular Neuroscience	2014
AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers A Katsha, J Arras, M Soutto, A Belkhiri, W El-Rifai	Molecular Oncology	2014
Microenvironment, Oncoantigens, and Antitumor Vaccination: Lessons Learned from BALB-neuT Mice L Conti, R Ruiu, G Barutello, M Macagno, S Bandini, F Cavallo, S Lanzardo	BioMed Research International	2014
Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma V Pandey, ZS Wu, M Zhang, R Li, J Zhang, T Zhu, PE Lobie	Breast Cancer Research	2014
Signal transducer and activator of transcription 5b drives malignant progression in a PDGFB-dependent proneural glioma model by suppressing apoptosis: STAT5b Suppresses Apoptosis in Proneural Glioma LV Gressot, TA Doucette, Y Yang, GN Fuller, AB Heimberger, O Bögler, A Rao, K Latha, G Rao	International Journal of Cancer	2014
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells JH Lim	The Korean Journal of Physiology & Pharmacology	2014
Role of the staphylococcal nuclease and tudor domain containing 1 in oncogenesis (Review) N Jariwala, D Rajasekaran, J Srivastava, R Gredler, M Akiel, C Robertson, L Emdad, P Fisher, D Sarkar	International journal of oncology	2014
Activation of T-cell Protein-tyrosine Phosphatase Suppresses Keratinocyte Survival and Proliferation following UVB Irradiation H Lee, LD Morales, TJ Slaga, DJ Kim	The Journal of biological chemistry	2014
Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinoma in Vitro and in Vivo CD Mohan, H Bharathkumar, KC Bulusu, V Pandey, S Rangappa, JE Fuchs, MK Shanmugam, X Dai, F Li, A Deivasigamani, KM Hui, AP Kumar, PE Lobie, A Bender, Basappa, G Sethi, KS Rangappa	The Journal of biological chemistry	2014
Mechanisms of Jak/STAT Signaling in Immunity and Disease AV Villarino, Y Kanno, JR Ferdinand, JJ O'Shea	Journal of immunology (Baltimore, Md. : 1950)	2014
Increased STAT1 Signaling in Endocrine-Resistant Breast Cancer R Huang, D Faratian, AH Sims, D Wilson, JS Thomas, DJ Harrison, SP Langdon, V Cheriyath	PloS one	2014
Acylglycerol Kinase (AGK) Promotes the Stem Cell-Like Phenotype through Activating JAK2-STAT3 Signaling in Human Esophageal Squamous Cell Carcinoma Xiuting Chen, Zhe Ying, Xi Lin, Huanxin Lin, Jueheng Wu, Mengfeng Li, Libing Song	Journal of Clinical Investigation	2013
Lrig1 controls corneal maintenance through the Stat3-dependent inflammatory pathway Takahiro Nakamura, Junji Hamuro, Mikiro Takaishi, Szandor Simmons, Kazuichi Maruyama, Andrea Zaffalon, Adam J. Bentley, Satoshi Kawasaki, Maho Nagata-Takaoka, Nigel J. Fullwood, Satoshi Itami, Shigetoshi Sano, Masaru Ishii, Yann Barrandon, Shigeru Kinoshita	Journal of Clinical Investigation	2013
MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis W Wu, M Takanashi, N Borjigin, S Ohno, K Fujita, S Hoshino, Y Osaka, A Tsuchida, M Kuroda	British Journal of Cancer	2013
Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer S You, R Li, D Park, M Xie, GL Sica, Y Cao, ZQ Xiao, X Deng	Molecular cancer therapeutics	2013
Scoparone Exerts Anti-Tumor Activity against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity JK Kim, JY Kim, HJ Kim, KG Park, RA Harris, WJ Cho, JT Lee, IK Lee, M Muders	PloS one	2013
Caveolin-1 as a promoter of tumour spreading: when, how, where and why R Senetta, G Stella, E Pozzi, N Sturli, D Massi, P Cassoni	Journal of Cellular and Molecular Medicine	2013
JAKs and STATs in Immunity, Immunodeficiency, and Cancer JJ O'Shea, SM Holland, LM Staudt	New England Journal of Medicine	2013
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy P Godwin, AM Baird, S Heavey, MP Barr, KJ O'Byrne, K Gately	Frontiers in Oncology	2013
JAK-STAT and bone metabolism J Li	JAK-STAT	2013
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis A Berger, A Hoelbl-Kovacic, J Bourgeais, L Hoefling, W Warsch, E Grundschober, IZ Uras, I Menzl, EM Putz, G Hoermann, C Schuster, S Fajmann, E Leitner, S Kubicek, R Moriggl, F Gouilleux, V Sexl	Leukemia	2013
Innovative Therapeutic Strategies in the Treatment of Brain Metastases M Caffo, V Barresi, G Caruso, M Cutugno, GL Fata, M Venza, C Alafaci, F Tomasello	International journal of molecular sciences	2013
Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid Malignancies A Grassadonia, P Cioffi, F Simiele, L Iezzi, M Zilli, C Natoli	Cancers	2013
Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications Z Wang, X Si, A Xu, X Meng, S Gao, Y Qi, L Zhu, T Li, W Li, L Dong	PloS one	2013
Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure K Panagopoulos, S Cross-Knorr, C Dillard, D Pantazatos, MD Tatto, D Mills, L Goldstein, J Renzulli, P Quesenberry, D Chatterjee	Molecular Cancer	2013
The tumor suppressor function of STAT1 in breast cancer AE Koromilas, V Sexl	JAK-STAT	2013
A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3) C Hogstrand, P Kille, ML Ackland, S Hiscox, KM Taylor	Biochemical Journal	2013
Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer HB da Silva, EP Amaral, EL Nolasco, NC de Victo, R Atique, CC Jank, V Anschau, LF Zerbini, RG Correa	Prostate Cancer	2013
Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model T Hu, C Zhang, Q Tang, Y Su, B Li, L Chen, Z Zhang, T Cai, Y Zhu	BMC Cancer	2013
IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus MF Chen, PT Chen, MS Lu, PY Lin, WC Chen, KD Lee	Molecular Cancer	2013
Expression of STAT3 and IGF2 in adrenocortical carcinoma and its relationship with angiogenesis Y Zhu, Y Xu, D Chen, C Zhang, W Rui, J Zhao, Q Zhu, Y Wu, Z Shen, W Wang, G Ning, X Wang	Clinical and Translational Oncology	2013
Targeting the tumor microenvironment E Bournazou, J Bromberg	JAK-STAT	2013
Detection of Deregulated Modules Using Deregulatory Linked Path Y Hu, L Gao, K Shi, DK Chiu, P Csermely	PloS one	2013
Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition M Ai, K Liang, Y Lu, S Qiu, Z Fan	Cancer biology & therapy	2013
Tumor self-seeding by circulating tumor cells in nude mouse models of human osteosarcoma and a preliminary study of its mechanisms Y Zhang, Q Ma, T Liu, S Ke, K Jiang, Y Wen, B Ma, Y Zhou, Q Fan, X Qiu	Journal of Cancer Research and Clinical Oncology	2013
STAT3 as a new autophagy regulator B Jonchère, A Bélanger, C Guette, B Barré, O Coqueret	JAK-STAT	2013
Co-expression of receptors of the HER family correlates with clinical outcome in non-small cell lung cancer (NSCLC) G Bellezza, RD Sordo, R Colella, V Ludovini, M Ragusa, F Bianconi, I Ferri, F Borri, R Chiari, F Puma, L Crinò, A Sidoni	Virchows Archiv	2013
Bortezomib enhances antigen-specific cytotoxic T cell responses against immune-resistant cancer cells generated by STAT3-ablated dendritic cells JE Kim, DH Jin, WJ Lee, D Hur, TC Wu, D Kim	Pharmacological Research	2013
Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy H Chen, Z Yang, C Ding, L Chu, Y Zhang, K Terry, H Liu, Q Shen, J Zhou	European Journal of Medicinal Chemistry	2013
Discovery of O -Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents H Chen, Z Yang, C Ding, L Chu, Y Zhang, K Terry, H Liu, Q Shen, J Zhou	ACS Medicinal Chemistry Letters	2013
Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis F Arihara, E Mizukoshi, M Kitahara, Y Takata, K Arai, T Yamashita, Y Nakamoto, S Kaneko	Cancer Immunology, Immunotherapy	2013
WT1 Promotes Cell Proliferation in Non-Small Cell Lung Cancer Cell Lines through Up-Regulating Cyclin D1 and p-pRb In Vitro and In Vivo C Xu, C Wu, Y Xia, Z Zhong, X Liu, J Xu, F Cui, B Chen, OD Røe, A Li, Y Chen, SP Chellappan	PloS one	2013
IL-6 Expression Regulates Tumorigenicity and Correlates with Prognosis in Bladder Cancer MF Chen, PY Lin, CF Wu, WC Chen, CT Wu, P Canoll	PloS one	2013
Cucurbitacins – A Promising Target for Cancer Therapy Alghasham AA	International journal of health sciences	2013
Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells CJ Chang, CH Chiang, WS Song, SK Tsai, LC Woung, CH Chang, SY Jeng, CY Tsai, CC Hsu, HF Lee, CS Huang, MC Yung, JH Liu, KH Lu	Child's Nervous System	2012
STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis Y Dunkel, A Ong, D Notani, Y Mittal, M Lam, X Mi, P Ghosh	The Journal of biological chemistry	2012
The Sin3a repressor complex is a master regulator of STAT transcriptional activity L Icardi, R Mori, V Gesellchen, S Eyckerman, LD Cauwer, J Verhelst, K Vercauteren, X Saelens, P Meuleman, G Leroux-Roels, KD Bosscher, M Boutros, J Tavernier	Proceedings of the National Academy of Sciences	2012
Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines MA Bill, C Nicholas, TA Mace, JP Etter, C Li, EB Schwartz, JR Fuchs, GS Young, L Lin, J Lin, L He, M Phelps, PK Li, GB Lesinski	PloS one	2012
A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line I Souissi, P Ladam, JA Cognet, SL Coquil, N Varin-Blank, F Baran-Marszak, V Metelev, R Fagard	Molecular Cancer	2012
Glioma revisited: from neurogenesis and cancer stem cells to the epigenetic regulation of the niche FA Sassi, AL Brunetto, G Schwartsmann, R Roesler, AL Abujamra	Journal of Oncology	2012
Normal and neoplastic urothelial stem cells: getting to the root of the problem PL Ho, A Kurtova, KS Chan	Nature Reviews Urology	2012
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3 H Yue, K Tanaka, T Furukawa, SS Karnik, W Li	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2012
The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain JS McMurray, PK Mandal, WS Liao, J Klostergaard, FM Robertson	JAK-STAT	2012
STAT3 mediates resistance of CD44(+)CD24(-/low) breast cancer stem cells to tamoxifen in vitro X Wang, G Wang, Y Zhao, X Liu, Q Ding, J Shi, Y Ding, S Wang	Journal of Biomedical Research	2012
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling J Sommer, T Effenberger, E Volpi, GH Waetzig, M Bernhardt, J Suthaus, C Garbers, S Rose-John, DM Floss, J Scheller	The Journal of biological chemistry	2012
Emerging strategies for the early detection and prevention of head and neck squamous cell cancer S Dasgupta, R Dash, SK Das, D Sarkar, PB Fisher	Journal of Cellular Physiology	2012
Hypermethylation of SHP-1 promoter in patient with high-risk myelodysplastic syndrome and it predicts poor prognosis Y Zhang, D Zhao, H Zhao, X Wu, W Zhao, Y Wang, B Xia, W Da	Medical Oncology	2012
The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma SW Lee, YY Ahn, YS Kim, SB Kang, SW Nam, DS Lee, HY Jeong, JM Kim	Gut and Liver	2012
Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway K Sai, S Wang, V Balasubramaniyan, C Conrad, FF Lang, K Aldape, S Szymanski, I Fokt, A Dasgupta, T Madden, S Guan, Z Chen, WK Yung, W Priebe, H Colman	Journal of Neuro-Oncology	2012
YB-1 suppression induces STAT3 proteolysis and sensitizes renal cancer to interferon-α A Takeuchi, M Shiota, K Tatsugami, A Yokomizo, K Kuroiwa, T Dejima, S Tanaka, M Itsumi, M Eto, S Naito	Cancer Immunology, Immunotherapy	2012
Plant HDAC inhibitor chrysin arrest cell growth and induce p21 WAF1 by altering chromatin of STAT response element in A375 cells M Pal-Bhadra, MJ Ramaiah, TL Reddy, A Krishnan, SN Pushpavalli, KS Babu, AK Tiwari, JM Rao, JS Yadav, U Bhadra	BMC Cancer	2012
STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma BD Looyenga, D Hutchings, I Cherni, C Kingsley, GJ Weiss, JP MacKeigan, JG Gelovani	PloS one	2012
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling Simon Jones, Jürgen Scheller, Stefan Rose-John	Journal of Clinical Investigation	2011
A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB I Souissi, I Najjar, L Ah-Koon, PO Schischmanoff, D Lesage, SL Coquil, C Roger, I Dusanter-Fourt, N Varin-Blank, A Cao, V Metelev, F Baran-Marszak, R Fagard	BMC cell biology	2011
An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population W Yoo, HY Jung, S Lim, JS Sung, KH Park, JS Ryu, SW Shin, JS Kim, JH Seo, YH Kim	Cancer research and treatment : official journal of Korean Cancer Association	2011
HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop ZA Syed, W Yin, K Hughes, JN Gill, R Shi, JL Clifford	BMC Cancer	2011
Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors T Hornakova, L Springuel, J Devreux, A Dusa, SN Constantinescu, L Knoops, JC Renauld	Haematologica	2011
Stat3 Mediates Expression of Autotaxin in Breast Cancer J Azare, A Doane, K Leslie, Q Chang, M Berishaj, J Nnoli, K Mark, H Al-Ahmadie, W Gerald, M Hassimi, A Viale, M Stracke, D Lyden, J Bromberg	PloS one	2011
Sca-1+ Cardiac Stem Cells Mediate Acute Cardioprotection via Paracrine Factor SDF-1 following Myocardial Ischemia/Reperfusion C Huang, H Gu, Q Yu, MC Manukyan, JA Poynter, M Wang	PloS one	2011
Non-Receptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3 OA Guryanova, Q Wu, L Cheng, JD Lathia, Z Huang, J Yang, J MacSwords, CE Eyler, RE McLendon, JM Heddleston, W Shou, D Hambardzumyan, J Lee, AB Hjelmeland, AE Sloan, M Bredel, GR Stark, JN Rich, S Bao	Cancer Cell	2011
Significance of CXCR4, phosphorylated STAT3 and VEGF-A expression in resected non-small cell lung cancer M Wang, GY Chen, HT Song, X Hong, ZY Yang, GJ Sui	Experimental and therapeutic medicine	2011
CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling WN Zhang, L Wang, Q Wang, X Luo, DF Fang, Y Chen, X Pan, JH Man, Q Xia, BF Jin, WH Li, T Li, B Liang, L Chen, WL Gong, M Yu, AL Li, T Zhou, HY Li	The Journal of biological chemistry	2011
Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition J Tisserand, K Khetchoumian, C Thibault, D Dembélé, P Chambon, R Losson	The Journal of biological chemistry	2011
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain BD Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, JL Wrana, S Trudel, AD Schimmer, J Turkson, PT Gunning	Bioorganic & Medicinal Chemistry Letters	2011
Positive outcomes of oil palm phenolics on degenerative diseases in animal models R Sambanthamurthi, YA Tan, K Sundram, KC Hayes, M Abeywardena, SS Leow, SD Sekaran, TG Sambandan, CK Rha, AJ Sinskey, K Subramaniam, S Fairus, MB Wahid	British Journal of Nutrition	2011
Caveolin-1 Upregulation Mediates Suppression of Primary Breast Tumor Growth and Brain Metastases by Stat3 Inhibition WT Chiu, HT Lee, FJ Huang, KD Aldape, J Yao, PS Steeg, CY Chou, Z Lu, K Xie, S Huang	Cancer research	2011
Disruption of the Mouse Protein Tyrosine Kinase 6 Gene Prevents STAT3 Activation and Confers Resistance to Azoxymethane J Gierut, Y Zheng, W Bie, RE Carroll, S Ball-Kell, A Haegebarth, AL Tyner	Gastroenterology	2011
STAT1 mediates cellular senescence induced by angiotensin II and H2O2 in human glomerular mesangial cells S Jiao, F Meng, J Zhang, X Yang, X Zheng, L Wang	Molecular and Cellular Biochemistry	2011
Ideal Experimental Rat Models for Liver Diseases SW Lee, SH Kim, SO Min, KS Kim	Korean Journal of Hepato-Biliary-Pancreatic Surgery	2011
Galiellalactone Inhibits Stem Cell-Like ALDH-Positive Prostate Cancer Cells R Hellsten, M Johansson, A Dahlman, O Sterner, A Bjartell, D Gullberg	PloS one	2011
Negative Cross Talk between NFAT1 and Stat5 Signaling in Breast Cancer J Zheng, F Fang, X Zeng, TR Medler, AA Fiorillo, CV Clevenger	Molecular Endocrinology	2011
Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas W G Kim, H-J Choi, W B Kim, E Y Kim, J H Yim, T Y Kim, G Gong, S Y Kim, N Chung, Y K Shong	Journal of Endocrinological Investigation	2011
Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling? A Jarnicki, T Putoczki, M Ernst	Cell division	2010
Challenges in clinical design of immunotherapy trials for malignant glioma CE Rolle, S Sengupta, MS Lesniak	Neurosurgery Clinics of North America	2010
Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1) LJ Buro, E Chipumuro, MA Henriksen	Epigenetics & chromatin	2010
Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase N Stefanou, V Papanikolaou, Y Furukawa, Y Nakamura, A Tsezou	BMC Cancer	2010
Identification of a structural motif in the tumor-suppressive protein GRIM-19 required for its antitumor activity SC Nallar, S Kalakonda, P Sun, Y Ohmori, M Hiroi, K Mori, DJ Lindner, DV Kalvakolanu	The American Journal of Pathology	2010
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity MA Bill, JR Fuchs, C Li, J Yui, C Bakan, DM Benson, EB Schwartz, D Abdelhamid, J Lin, DG Hoyt, SL Fossey, GS Young, WE 3rd, PK Li, GB Lesinski	Molecular Cancer	2010
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation DJ Kim, ML Tremblay, J Digiovanni	PloS one	2010
Immunobiological characterization of cancer stem cells isolated from glioblastoma patients TD Tomaso, S Mazzoleni, E Wang, G Sovena, D Clavenna, A Franzin, P Mortini, S Ferrone, C Doglioni, FM Marincola, R Galli, G Parmiani, C Maccalli	Clinical cancer research	2010
Unexpected Repertoire of Metazoan Transcription Factors in the Unicellular Holozoan Capsaspora owczarzaki A Sebe-Pedros, A Mendoza, BF Lang, BM Degnan, I Ruiz-Trillo	Molecular Biology and Evolution	2010
Inhibition of STAT3 reverses drug resistance acquired in temozolomide-resistant human glioma cells ES Lee, KK Ko, YA Joe, SG Kang, YK Hong	Oncology Letters	2010
Regulation of Translocator Protein 18 kDa (TSPO) Expression in Health and Disease States A Batarseh, V Papadopoulos	Molecular and Cellular Endocrinology	2010
Structure-Function Correlation of G6, a Novel Small Molecule Inhibitor of Jak2 A Majumder, L Govindasamy, A Magis, R Kiss, T Polgár, R Baskin, RW Allan, M Agbandje-McKenna, GW Reuther, GM Keseru, KS Bisht, PP Sayeski	The Journal of biological chemistry	2010
NF-kappaB and STAT3 signaling in glioma: targets for future therapies GP Atkinson, SE Nozell, ET Benveniste	Expert Review of Neurotherapeutics	2010
The role of deubiquitinating enzymes in apoptosis S Ramakrishna, B Suresh, KH Baek	Cellular and Molecular Life Sciences	2010
Stat5 is indispensable for the maintenance of bcr/abl -positive leukaemia: Stat5 in leukaemia maintenance A Hoelbl, C Schuster, B Kovacic, B Zhu, M Wickre, MA Hoelzl, S Fajmann, F Grebien, W Warsch, G Stengl, L Hennighausen, V Poli, H Beug, R Moriggl, V Sexl	EMBO Molecular Medicine	2010
Immunohistochemical detection of phosphorylated JAK-2 and STAT-5 proteins and correlation with erythropoietin receptor (EpoR) expression status in human brain tumors M Kondyli, G Gatzounis, A Kyritsis, J Varakis, M Assimakopoulou	Journal of Neuro-Oncology	2010
Down-Regulation of Stat3 Decreases Invasion Activity and Induces Apoptosis of Human Glioma Cells F Chen, Y Xu, Y Luo, D Zheng, Y Song, K Yu, H Li, L Zhang, W Zhong, Y Ji	Journal of Molecular Neuroscience	2010
Distinct Patterns of DNA Damage Response and Apoptosis Correlate with Jak/Stat and PI3Kinase Response Profiles in Human Acute Myelogenous Leukemia DB Rosen, S Putta, T Covey, YW Huang, GP Nolan, A Cesano, MD Minden, WJ Fantl, RE Means	PloS one	2010
Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation K Leslie, SP Gao, M Berishaj, K Podsypanina, H Ho, L Ivashkiv, J Bromberg	Breast Cancer Research	2010
IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer L Wang, T Yi, W Zhang, DM Pardoll, H Yu	Cancer research	2010
Forced Homo- and Heterodimerization of All gp130-Type Receptor Complexes Leads to Constitutive Ligand-independent Signaling and Cytokine-independent Growth J Suthaus, A Tillmann, I Lorenzen, E Bulanova, S Rose-John, J Scheller, J Chernoff	Molecular biology of the cell	2010
[Advances of the correlation between JAK-STAT3 signaling pathway and the biological behavior of non-small cell lung cancer] Yang Yu, Zhou Wang	Zhongguo fei ai za zhi = Chinese journal of lung cancer	2010
Kaposi's Sarcoma-Associated Herpesvirus Inhibits Interleukin-4-Mediated STAT6 Phosphorylation To Regulate Apoptosis and Maintain Latency Q Cai, SC Verma, JY Choi, M Ma, ES Robertson	Journal of virology	2010
Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium L Zhang, D Wang, W Jiang, D Edwards, W Qiu, LM Barroilhet, J Rho, L Jin, V Seethappan, A Vitonis, J Wang, SC Mok, C Crum, DW Cramer, B Ye	Reproductive Biology and Endocrinology	2010
The cdk5 Kinase Regulates the STAT3 Transcription Factor to Prevent DNA Damage upon Topoisomerase I Inhibition S Courapied, H Sellier, S de Carné Trécesson, A Vigneron, AC Bernard, E Gamelin, B Barré, O Coqueret	The Journal of biological chemistry	2010
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Dysregulated molecular networks in head and neck carcinogenesis AA Molinolo, P Amornphimoltham, CH Squarize, RM Castilho, V Patel, JS Gutkind	Oral Oncology	2009
ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside J Zhou, BC Goh, DH Albert, CS Chen	Journal of Hematology & Oncology	2009
Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma S Takemoto, K Ushijima, K Kawano, T Yamaguchi, A Terada, N Fujiyoshi, S Nishio, N Tsuda, M Ijichi, T Kakuma, M Kage, D Hori, T Kamura	British Journal of Cancer	2009
Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3 K Selvendiran, A Bratasz, ML Kuppusamy, MF Tazi, BK Rivera, P Kuppusamy	International Journal of Cancer	2009
Myeloid-derived suppressor cells as regulators of the immune system DI Gabrilovich, S Nagaraj	Nature reviews. Immunology	2009
Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis DJ Kim, JM Angel, S Sano, J DiGiovanni	Oncogene	2009
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation DJ Kim, K Kataoka, D Rao, K Kiguchi, G Cotsarelis, J Digiovanni	Cancer research	2009
Transcriptional toxicity of the Yangtze River source water on mouse (Mus musculus) detected by cDNA microarray B Wu, S Cheng, Y Li, J Kong, D Zhao, Y Zhang, X Zhang	Ecotoxicology	2009
Heavy ion irradiation increases apoptosis and STAT-3 expression, led to the cells arrested at G2/M phase in human hepatoma SMMC-7721 cells J Ma, L Ye, M Da, X Wang	Molecular and Cellular Biochemistry	2009
Interleukin-6 Promotes Carcinogenesis Through Multiple Signal Pathways: Comment on: Clinical Significance of Interleukin-6 Gene Polymorphism and IL-6 Serum Level in Pancreatic Adenocarcinoma and Chronic Pancreatitis J Chen, XF Huang	Digestive Diseases and Sciences	2009
STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells MM Sherry, A Reeves, JK Wu, BH Cochran	Stem Cells	2009
Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion M Wang, Y Wang, A Abarbanell, J Tan, B Weil, J Herrmann, DR Meldrum	Surgery	2009
Prediction and Experimental Validation of Novel STAT3 Target Genes in Human Cancer Cells YM Oh, JK Kim, Y Choi, S Choi, JY Yoo, S Hannenhalli	PloS one	2009
Conformationally Constrained Peptidomimetic Inhibitors of Signal Transducer and Activator of Transcription 3: Evaluation and Molecular Modeling PK Mandal, D Limbrick, DR Coleman, GA Dyer, Z Ren, JS Birtwistle, C Xiong, X Chen, JM Briggs, JS McMurray	Journal of Medicinal Chemistry	2009
12-O-Tetradecanoylphorbol-13-acetate Inhibits Melanoma Growth by Inactivation of STAT3 through Protein Kinase C-activated Tyrosine Phosphatase(s) M Oka, N Sumita, M Sakaguchi, T Iwasaki, T Bito, T Kageshita, K Sato, Y Fukami, C Nishigori	The Journal of biological chemistry	2009
STAT3 regulation of glioblastoma pathogenesis. de la Iglesia N, Puram SV, Bonni A	Current molecular medicine	2009
Stat3 and Stat1 mediate IL-11-dependent and inflammation-associated gastric toumorigenesis in gp130 receptor mutant mice Matthias Ernst, Meri Najdovska, Dianne Grail, Therese Lundgren-May, Michael Buchert, Hazel Tye, Vance B. Matthews, Jane Armes, Prithi S. Bhathal, Norman R. Hughes, Eric G. Marcusson, James G. Karras, Songqing Na, Jonathon D. Sedgwick, Paul J. Hertzog and Brendan J. Jenkins.	Journal of Clinical Investigation	2008
What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis Juanita L. Merchant	Journal of Clinical Investigation	2008
FOLLOWING THE CYTOKINE SIGNALING PATHWAY TO LEUKEMOGENESIS: A CHRONOLOGY Kendall A. Smith1 and James D. Griffin2	Journal of Clinical Investigation	2008
Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis K Kataoka, DJ Kim, S Carbajal, JL Clifford, J DiGiovanni	Carcinogenesis	2008
Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells J Xu, R Sylvester, AP Tighe, S Chen, LJ Gudas	Journal of Molecular Biology	2008
Paxgenes in embryogenesis and oncogenesis Q Wang, WH Fang, J Krupinski, S Kumar, M Slevin, P Kumar	Journal of Cellular and Molecular Medicine	2008
Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1 S Wang, JF Raven, JE Durbin, AE Koromilas	PloS one	2008
Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability S Shi, K Larson, D Guo, SJ Lim, P Dutta, SJ Yan, WX Li	Nature Cell Biology	2008
The epidermal growth factor receptor family: biology driving targeted therapeutics MJ Wieduwilt, MM Moasser	Cellular and molecular life sciences : CMLS	2008
Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells Y Fan, YL Zhang, Y Wu, W Zhang, YH Wang, ZM Cheng, H Li	World journal of gastroenterology : WJG	2008
Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression EC Brantley, LB Nabors, GY Gillespie, YH Choi, CA Palmer, K Harrison, K Roarty, EN Benveniste	Clinical cancer research	2008
Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas EC Brantley, EN Benveniste	Molecular cancer research : MCR	2008
Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas MD Johnson, M O’Connell, F Vito, RS Bakos	Journal of Neuro-Oncology	2008
Epidermal growth factor receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon cancer cell lines T Yamatodani, L Ekblad, E Kjellén, A Johnsson, H Mineta, J Wennerberg	Journal of Cancer Research and Clinical Oncology	2008
Canonical and non-canonical JAK–STAT signaling WX Li	Trends in Cell Biology	2008
Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells Q Yuan, PD Li, BH Li, XZ Yang, SB Xu, XH Liu, FX Zhou, WJ Zhang	Journal of Cancer Research and Clinical Oncology	2008
Targeting Protein-Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small-Molecule, Nonpeptidic SH2 Domain Binders PT Gunning, MP Glenn, KA Siddiquee, WP Katt, E Masson, SM Sebti, J Turkson, AD Hamilton	ChemBioChem	2008
Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21 JM Escandell, P Kaler, MC Recio, T Sasazuki, S Shirasawa, L Augenlicht, JL Ríos, L Klampfer	Biochemical Pharmacology	2008
Tris (Dibenzylideneacetone) Dipalladium, a N-Myristoyltransferase-1 Inhibitor, Is Effective against Melanoma Growth In vitro and In vivo SS Bhandarkar, J Bromberg, C Carrillo, P Selvakumar, RK Sharma, BN Perry, B Govindarajan, L Fried, A Sohn, K Reddy, JL Arbiser	Clinical cancer research	2008
Molecular Basis for the Critical Role of Suppressor of Cytokine Signaling-1 in Melanoma Brain Metastasis FJ Huang, PS Steeg, JE Price, WT Chiu, PC Chou, K Xie, R Sawaya, S Huang	Cancer research	2008
EGFR kinase domain mutations mediates IL-6 production activating the gp130/Jak/Stat3 pathway in lung adenocarcinomas Sizhi Paul Gao, Kevin G. Mark, Kenneth Leslie, William Pao, Noriko Motoi, William L. Gerald, William D. Travis, William Bornmann, Darren Veach, Bayard Clarkson and Jacqueline F. Bromberg*	Journal of Clinical Investigation	2007
Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice X Zhang, J Zhang, L Wang, H Wei, Z Tian	BMC Cancer	2007
Understanding signaling cascades in melanoma P Lopez-Bergami, B Fitchman, Z Ronai	Photochemistry and Photobiology	2007
Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer M Berishaj, SP Gao, S Ahmed, K Leslie, H Al-Ahmadie, WL Gerald, W Bornmann, JF Bromberg	Breast Cancer Research	2007
Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes B Cox, T Kislinger, DA Wigle, A Kannan, K Brown, T Okubo, B Hogan, I Jurisica, B Frey, J Rossant, A Emili	Molecular Systems Biology	2007
STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation S Lassmann, I Schuster, A Walch, H Göbel, U Jütting, F Makowiec, U Hopt, M Werner	Journal of clinical pathology	2007
Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context JH Gutzman, DE Rugowski, SE Nikolai, LA Schuler	Oncogene	2007
Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics PK Mandal, PA Heard, Z Ren, X Chen, JS McMurray	Bioorganic & Medicinal Chemistry Letters	2007
Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling A Quaglino, C Schere-Levy, L Romorini, RP Meiss, EC Kordon	Breast Cancer Research	2007
Persistent Activation of STAT3 by Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells AS Punjabi, PA Carroll, L Chen, M Lagunoff	Journal of virology	2007
Intracellular Tat of Human Immunodeficiency Virus Type 1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus: Role of JAK/STAT Signaling Y Zeng, X Zhang, Z Huang, L Cheng, S Yao, D Qin, X Chen, Q Tang, Z Lv, L Zhang, C Lu	Journal of virology	2007
Signaling Pathways in Cancer and Embryonic Stem Cells O Dreesen, AH Brivanlou	Stem Cell Reviews and Reports	2007
Signal Transducer and Activator of Transcription 3 Activation Promotes Invasive Growth of Colon Carcinomas through Matrix Metalloproteinase Induction Tsareva SA, Moriggl R, Corvinus FM, Wiederanders B, Schütz A, Kovacic B, Friedrich K	Neoplasia (New York, N.Y.)	2007
Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions W Yin, S Cheepala, JN Roberts, K Syson-Chan, J DiGiovanni, JL Clifford	Molecular Cancer	2006
Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer J Dien, HM Amin, N Chiu, W Wong, C Frantz, B Chiu, JR Mackey, R Lai	The American Journal of Pathology	2006
Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin DC Ng, BH Lin, CP Lim, G Huang, T Zhang, V Poli, X Cao	The Journal of Cell Biology	2006
Identification of Drosophila genes modulating Janus kinase/signal transducer and activator of transcription signal transduction T Mukherjee, U Schäfer, MP Zeidler	Genetics	2006
Cell Type Specific Signalling by Hematopoietic Growth Factors in Neural Cells N Byts, A Samoylenko, H Woldt, H Ehrenreich, AL Sirén	Neurochemical Research	2006
Interleukin-6 and its receptor: from bench to bedside J Scheller, S Rose-John	Medical Microbiology and Immunology	2006
The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt OO Ogunwobi, IL Beales	International Journal of Colorectal Disease	2006
Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells C Stuhlmann-Laeisz, S Lang, A Chalaris, P Krzysztof, S Enge, J Eichler, U Klingmüller, M Samuel, M Ernst, S Rose-John, J Scheller, CH Heldin	Molecular biology of the cell	2006
Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation A Hoelbl, B Kovacic, MA Kerenyi, O Simma, W Warsch, Y Cui, H Beug, L Hennighausen, R Moriggl, V Sexl	Blood	2006
Overexpression of PIAS3 Suppresses Cell Growth and Restores the Drug Sensitivity of Human Lung Cancer Cells in Association with PI3-K/Akt Inactivation Ogata Y, Osaki T, Naka T, Iwahori K, Furukawa M, Nagatomo I, Kijima T, Kumagai T, Yoshida M, Tachibana I, Kawase I	Neoplasia (New York, N.Y.)	2006
Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells HF Huang, TF Murphy, P Shu, AB Barton, BE Barton	Molecular Cancer	2005
Suppressors of cytokine signaling in health and disease JC Tan, R Rabkin	Pediatric Nephrology	2005
STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3 L Liu, KM McBride, NC Reich	Proceedings of the National Academy of Sciences	2005
Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas TJ Mitchell, S John	Immunology	2005
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors T Kusaba, T Nakayama, K Yamazumi, Y Yakata, A Yoshizaki, T Nagayasu, I Sekine	Journal of clinical pathology	2005
Role of immature myeloid cells in mechanisms of immune evasion in cancer S Kusmartsev, DI Gabrilovich	Cancer Immunology, Immunotherapy	2005
Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3 K Schlessinger, DE Levy	Cancer research	2005
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Corvinus FM, Orth C, Moriggl R, Tsareva SA, Wagner S, Pfitzner EB, Baus D, Kaufmann R, Huber LA, Zatloukal K, Beug H, Ohlschläger P, Schütz A, Halbhuber KJ, Friedrich K	Neoplasia (New York, N.Y.)	2005
Dominant‐negative Stat5 inhibits growth and induces apoptosis in T47D‐derived tumors in nude mice Yamashita H, Nishio M, Fujii Y, Iwase H	Cancer Science	2005
Disruption of Stat3 reveals a critical role in both the initiation and promotion stages of epithelial carcinogenesis Keith Syson Chan, Shigetoshi Sano, Kaoru Kiguchi, Joanne Anders, Nobuyasu Komazawa, Junji Takeda, John DiGiovanni	Journal of Clinical Investigation	2004
Interferon-gamma induced medulloblastoma in the developing cerebellum W Lin, A Kemper, KD McCarthy, P Pytel, JP Wang, IL Campbell, MF Utset, B Popko	The Journal of neuroscience : the official journal of the Society for Neuroscience	2004
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C TN Dechow, L Pedranzini, A Leitch, K Leslie, WL Gerald, I Linkov, JF Bromberg	Proceedings of the National Academy of Sciences	2004
Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells H Siavash, NG Nikitakis, JJ Sauk	British Journal of Cancer	2004
Stat3 is required for the development of skin cancer L Pedranzini, A Leitch, J Bromberg	Journal of Clinical Investigation	2004
Transcriptional Control of the Cell Cycle in Mammary Gland Development and Tumorigenesis RD Coletta, P Jedlicka, A Gutierrez-Hartmann, HL Ford	Journal of Mammary Gland Biology and Neoplasia	2004
Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M	World Journal of Gastroenterology	2004
Dysregulated sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain Jianping Wang, Ngan Pham-Mitchell, Christian Schindler and Iain L. Campbell	Journal of Clinical Investigation	2003
Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells L Konnikova, M Kotecki, MM Kruger, BH Cochran	BMC Cancer	2003
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3 J Zhang, J Yang, SK Roy, S Tininini, J Hu, JF Bromberg, V Poli, GR Stark, DV Kalvakolanu	Proceedings of the National Academy of Sciences	2003
Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Li J, Xia F, Li WX	Developmental Cell	2003
JAK-STAT signaling in human disease Christian Schindler	Journal of Clinical Investigation	2002
What does STAT3 do? David Levy, Chien-kuo Lee	Journal of Clinical Investigation	2002

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