JCI - Citations to Osteoclasts are essential for TNF-α–mediated joint destruction

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Osteoclasts are essential for TNF-α–mediated joint destruction

Kurt Redlich, … , Erwin F. Wagner, Georg Schett

Kurt Redlich, … , Erwin F. Wagner, Georg Schett

Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1419-1427. https://doi.org/10.1172/JCI15582.

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Article Immunology

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Citations to this article (185)

Title and authors	Publication	Year
Osteoporosis and Rheumatoid Arthritis: Mechanisms Underlying Osteoclast Differentiation and Activation or Factors Associated with Hip Fractures Miyamoto T	Journal of Clinical Medicine	2025
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L-arginine metabolism inhibits arthritis and inflammatory bone loss. Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A	Annals of the rheumatic diseases	2024
Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets Zheng H, Liu Y, Deng Y, Li Y, Liu S, Yang Y, Qiu Y, Li B, Sheng W, Liu J, Peng C, Wang W, Yu H	Molecular Medicine	2024
Osteoimmunology: The Crosstalk between T Cells, B Cells, and Osteoclasts in Rheumatoid Arthritis Yang M, Zhu L	International journal of molecular sciences	2024
Vigeo attenuates cartilage and bone destruction in a collagen‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines. Cheon YH, Lee CH, Eun SY, Park GD, Chung CH, Kim JY, Lee MS	Experimental and therapeutic medicine	2024
Screening of Diagnostic Biomarkers and Immune Infiltration Characteristics Linking Rheumatoid Arthritis and Rosacea Based on Bioinformatics Analysis. Wang Y, Chen J, Shen ZY, Zhang J, Zhu YJ, Xia XQ	Journal of inflammation research	2024
Inflammatory diseases causing joint and bone destruction: rheumatoid arthritis and hemophilic arthropathy. Terashima A, Ono K, Omata Y, Tanaka S, Saito T	Journal of bone and mineral metabolism	2024
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RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts Bae S, Kim K, Kang K, Kim H, Lee M, Oh B, Kaneko K, Ma S, Choi JH, Kwak H, Lee EY, Park SH, Park-Min KH	Cellular and Molecular Immunology	2022
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Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis S Wäldele, C Koers-Wunrau, D Beckmann, A Korb-Pap, C Wehmeyer, T Pap, B Dankbar	Arthritis Research & Therapy	2015
Muramyl Dipeptide Enhances Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption through Increased RANKL Expression in Stromal Cells M Ishida, H Kitaura, K Kimura, H Sugisawa, T Aonuma, H Takada, T Takano-Yamamoto	Journal of Immunology Research	2015
Using a Novel MicroRNA Delivery System to Inhibit Osteoclastogenesis Y Yao, T Jia, Y Pan, H Gou, Y Li, Y Sun, R Zhang, K Zhang, G Lin, J Xie, J Li, L Wang	International journal of molecular sciences	2015
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Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-κB Signaling Li A, Yang L, Geng X, Peng X, Lu T, Deng Y, Dong Y	Molecules and Cells	2015
The phosphoinositide-3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption D Győri, D Csete, S Benkő, S Kulkarni, P Mandl, C Dobó-Nagy, B Vanhaesebroeck, L Stephens, PT Hawkins, A Mócsai	Arthritis & Rheumatism	2014
Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB B Yu, J Chang, Y Liu, J Li, K Kevork, K Al-Hezaimi, DT Graves, NH Park, CY Wang	Nature Medicine	2014
SH3BP2 Gain-Of-Function Mutation Exacerbates Inflammation and Bone Loss in a Murine Collagen-Induced Arthritis Model T Mukai, R Gallant, S Ishida, T Yoshitaka, M Kittaka, K Nishida, DA Fox, Y Morita, Y Ueki	PloS one	2014
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TNF-α induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-κB activation in osteoblast-like MC3T3-E1 cells CL Tsai, WC Chen, HL Hsieh, PL Chi, LD Hsiao, CM Yang	Journal of Biomedical Science	2014
The Study of Mechanisms of Protective Effect of Rg1 against Arthritis by Inhibiting Osteoclast Differentiation and Maturation in CIA Mice Y Gu, W Fan, G Yin	Mediators of Inflammation	2014
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Ligation of TLR5 Promotes Myeloid Cell Infiltration and Differentiation into Mature Osteoclasts in Rheumatoid Arthritis and Experimental Arthritis S Kim, Z Chen, ND Chamberlain, AB Essani, MV Volin, MA Amin, S Volkov, EM Gravallese, S Arami, W Swedler, NE Lane, A Mehta, N Sweiss, S Shahrara	Journal of immunology (Baltimore, Md. : 1950)	2014
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Mycobacterium tuberculosis promotes arthritis development through Toll-like receptor 2. Kanagawa H, Niki Y, Kobayashi T, Sato Y, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Watanabe R, Morita M, Morioka H, Matsumoto M, Toyama Y, Miyamoto T	Journal of Bone and Mineral Metabolism	2014
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Impact of Inflammation on the Osteoblast in Rheumatic Diseases R Baum, EM Gravallese	Current Osteoporosis Reports	2013
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Inflammatory bone loss: pathogenesis and therapeutic intervention K Redlich, JS Smolen	Nature Reviews Drug Discovery	2012
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Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal Cells in Joints N Komatsu, H Takayanagi	Frontiers in immunology	2012
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Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells KA Oduro, F Liu, Q Tan, CK Kim, O Lubman, D Fremont, JC Mills, K Choi	Blood	2012
Atorvastatin inhibits osteoclastogenesis by decreasing the expression of RANKL in the synoviocytes of rheumatoid arthritis JY Kim, EY Lee, EB Lee, YJ Lee, HJ Yoo, J Choi, YW Song	Arthritis Research & Therapy	2012
Staphylococcus aureus Protein A Plays a Critical Role in Mediating Bone Destruction and Bone Loss in Osteomyelitis A Widaa, T Claro, TJ Foster, FJ OBrien, SW Kerrigan, M Rottman	PloS one	2012
A Dynamic Real Time In Vivo and Static Ex Vivo Analysis of Granulomonocytic Cell Migration in the Collagen-Induced Arthritis Model R Byrne, E Rath, A Hladik, B Niederreiter, M Bonelli, S Frantal, JS Smolen, C Scheinecker, JC Alves-Filho	PloS one	2012
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer and infection Dallas Jones, Laurie Glimcher, Antonios Aliprantis	Journal of Clinical Investigation	2011
Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway MM Matzelle, MA Gallant, KW Condon, NC Walsh, CA Manning, GS Stein, JB Lian, DB Burr, EM Gravallese	Arthritis & Rheumatism	2011
Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction JS Smolen, JC Avila, D Aletaha	Annals of the rheumatic diseases	2011
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Type 17 T-helper cells might be a promising therapeutic target for osteoporosis FL Yuan, X Li, WG Lu, YQ Zhao, CW Li, JP Li, JM Sun, RS Xu	Molecular Biology Reports	2011
Systemic bone effects of biologic therapies in rheumatoid arthritis and ankylosing spondylitis CB Confavreux, RD Chapurlat	Osteoporosis International	2010
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Supplementation of diet with krill oil protects against experimental rheumatoid arthritis M Ierna, A Kerr, H Scales, K Berge, M Griinari	BMC musculoskeletal disorders	2010
Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice S Toyama, N Tamura, K Haruta, T Karakida, S Mori, T Watanabe, T Yamori, Y Takasaki	Arthritis Research & Therapy	2010
Genetic deficiency of Syk protects mice from autoantibody-induced arthritis Z Jakus, E Simon, B Balázs, A Mócsai	Arthritis & Rheumatism	2010
Fracture-Associated Hospitalizations in Patients with Inflammatory Bowel Disease AN Ananthakrishnan, EL McGinley, DG Binion, K Saeian	Digestive Diseases and Sciences	2010
Green tea polyphenol epigallocatechi3-gallate: Inflammation and arthritis R Singh, N Akhtar, TM Haqqi	Life Sciences	2010
NF-kappaB2p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism Zhenqiang Yao, Lianping Xing, Brendan Boyce	Journal of Clinical Investigation	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Osteoimmunology and the effects of the immune system on bone H Takayanagi	Nature Reviews Rheumatology	2009
Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis K Nozawa, M Fujishiro, M Kawasaki, H Kaneko, K Iwabuchi, M Yanagida, F Suzuki, K Miyazawa, Y Takasaki, H Ogawa, K Takamori, I Sekigawa	Arthritis Research & Therapy	2009
Osteoimmunology in rheumatic diseases G Schett	Arthritis Research & Therapy	2009
Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years D van der Heijde, D Salonen, BN Weissman, R Landewé, WP Maksymowych, H Kupper, S Ballal, E Gibson, R Wong	Arthritis Research & Therapy	2009
Lessons from animal models of arthritis over the past decade WB van Berg	Arthritis Research & Therapy	2009
Entheses and Bones in Spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN) RA Colbert, AA Deodhar, DA Fox, EM Gravallese, MA Khan, DE McGONAGLE, JD Reveille, G Schett, M Weisman, DO Clegg	The Journal of rheumatology	2009
Osteoclasts and the immune system T Nakashima, H Takayanagi	Journal of Bone and Mineral Metabolism	2009
Osteoimmunology: Crosstalk Between the Immune and Bone Systems T Nakashima, H Takayanagi	Journal of Clinical Immunology	2009
Garden of therapeutic delights: new targets in rheumatic diseases JM Waldburger, GS Firestein	Arthritis Research & Therapy	2009
Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradation VR Konda, A Desai, G Darland, JS Bland, ML Tripp	Journal of inflammation (London, England)	2009
A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis BL Goff, E Soltner, C Charrier, Y Maugars, F Rédini, D Heymann, JM Berthelot	Arthritis Research & Therapy	2009
Osteoporosis in inflammatory bowel disease T Ali, D Lam, MS Bronze, MB Humphrey	The American Journal of Medicine	2009
Developments in the clinical understanding of rheumatoid arthritis JS Smolen, D Aletaha	Arthritis Research & Therapy	2009
NFATc1 represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism Antonios O. Aliprantis, Yasuyoshi Ueki, Rosalyn Sulyanto, Arnold Park, Kirsten S. Sigrist, Sudarshana M. Sharma, Michael C. Ostrowski, Bjorn R. Olsen, and Laurie H. Glimcher	Journal of Clinical Investigation	2008
Mechanisms modulating inflammatory osteolysis: A review with insights into therapeutic targets S Wei, GP Siegal	Pathology - Research and Practice	2008
The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? JS Smolen, D Aletaha, J Grisar, K Redlich, G Steiner, O Wagner	Arthritis Research & Therapy	2008
The Development of Novel Therapies for Rheumatoid Arthritis LD Quan, GM Thiele, J Tian, D Wang	Expert Opinion on Therapeutic Patents	2008
Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis M Koufany, D Moulin, A Bianchi, M Muresan, S Sebillaud, P Netter, G Weryha, JY Jouzeau	Arthritis Research & Therapy	2008
Adalimumab therapy reduces hand bone loss in early rheumatoid arthritis: explorative analyses from the PREMIER study M Hoff, TK Kvien, J Kälvesten, A Elden, G Haugeberg	Annals of the rheumatic diseases	2008
Prevention of bone mineral density loss in patients with rheumatoid arthritis treated with anti-TNFalpha therapy. Marotte H, Miossec P	Biologics : targets & therapy	2008
Pathological role of osteoclast costimulation in arthritis-induced bone loss S Ochi, M Shinohara, K Sato, HJ Gober, T Koga, T Kodama, T Takai, N Miyasaka, H Takayanagi	Proceedings of the National Academy of Sciences	2007
Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease AE Kearns, S Khosla, PJ Kostenuik	Endocrine reviews	2007
An extensive phenotypic characterization of the hTNFalpha transgenic mice MD Hayward, BK Jones, A Saparov, HS Hain, AC Trillat, MM Bunzel, A Corona, B Li-Wang, B Strenkowski, C Giordano, H Shen, E Arcamone, J Weidlick, M Vilensky, M Tugusheva, RH Felkner, W Campbell, Y Rao, DS Grass, O Buiakova	BMC Physiology	2007
Erosive arthritis G Schett	Arthritis Research & Therapy	2007
Aspects of early arthritis. Biological therapy in early arthritis--overtreatment or the way to go? K Ikeda, S Cox, P Emery	Arthritis Research & Therapy	2007
Cells of the synovium in rheumatoid arthritis. Osteoclasts G Schett	Arthritis Research & Therapy	2007
The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis G Schett, J Zwerina, G Firestein	Annals of the rheumatic diseases	2007
Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography ST Proulx, E Kwok, Z You, MO Papuga, CA Beck, DJ Shealy, CT Ritchlin, HA Awad, BF Boyce, L Xing, EM Schwarz	Arthritis & Rheumatism	2007
NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor T Kubota, M Hoshino, K Aoki, K Ohya, Y Komano, T Nanki, N Miyasaka, K Umezawa	Arthritis Research & Therapy	2007
Hand bone loss as an outcome measure in established rheumatoid arthritis: 2-year observational study comparing cortical and total bone loss M Hoff, G Haugeberg, TK Kvien	Arthritis Research & Therapy	2007
Interaction between the immune system and bone metabolism: an emerging field of osteoimmunology. Takayanagi H	Proceedings of the Japan Academy. Series B, Physical and biological sciences	2007
Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts Y Komano, T Nanki, K Hayashida, K Taniguchi, N Miyasaka	Arthritis Research & Therapy	2006
Modulation of osteoclastogenesis induced by nucleoside reverse transcriptase inhibitors G Pan, M Kilby, JM McDonald	AIDS Research and Human Retroviruses	2006
A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis N Simard, G Boire, AJ de Brum-Fernandes, Y St-Pierre	Arthritis Research & Therapy	2006
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction K Sato, A Suematsu, K Okamoto, A Yamaguchi, Y Morishita, Y Kadono, S Tanaka, T Kodama, S Akira, Y Iwakura, DJ Cua, H Takayanagi	Journal of Experimental Medicine	2006
Interleukin-1 mediates tumor necrosis factor-induced osteoclastogenesis Shi Wei, Hideki Kitaura, Ping Zhou, F. Patrick Ross and Steven L. Teitelbaum	Journal of Clinical Investigation	2005
NIK controls lymphocyte and osteoclast activities in inflammatory arthritis Kunihiko Aya, Muhammad Alhawagri, Amanda Hagen-Stapleton, HIdeki Kitaura, Osami Kanagawa, and Deborah Veis Novack	Journal of Clinical Investigation	2005
M-CSF mediates TNF-induced inflammatory osteolysis Hideki Kitaura, Ping Zhou, Deborah V. Novack, F. Patrick Ross, Steven L. Teitelbaum	Journal of Clinical Investigation	2005
IKK{beta} as a target for treatment of inflammation induced bone loss MG Ruocco, M Karin	Annals of the rheumatic diseases	2005
Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis J Zwerina, B Tuerk, K Redlich, JS Smolen, G Schett	Arthritis Research & Therapy	2005
THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis T Tomita, Y Kakiuchi, PS Tsao	Arthritis Research & Therapy	2005
Benefit of pregnancy in inflammatory arthritis RH Straub, F Buttgereit, M Cutolo	Annals of the rheumatic diseases	2005
CD44 is a determinant of inflammatory bone loss S Hayer, G Steiner, B Görtz, E Reiter, M Tohidast-Akrad, M Amling, O Hoffmann, K Redlich, J Zwerina, K Skriner, F Hilberg, EF Wagner, JS Smolen, G Schett	Journal of Experimental Medicine	2005
Pro-inflammatory cytokines in rheumatoid arthritis: pathogenetic and therapeutic aspects. Smolen JS, Redlich K, Zwerina J, Aletaha D, Steiner G, Schett G	Clinical Reviews in Allergy & Immunology	2005
Experimental arthritis in CC chemokine receptor 2 null mice closely mimics severe human rheumatoid arthritis Marlon P. Quinones, Sunil K. Ahuja, Fabio Jimenez, Jason Schaefer, Edgar Garavito, Arun Rao, George Chenaux, Robert L. Reddick, William A. Kuziel, Seema S. Ahuja	Journal of Clinical Investigation	2004
Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis K Redlich, B Görtz, S Hayer, J Zwerina, N Doerr, P Kostenuik, H Bergmeister, G Kollias, G Steiner, JS Smolen, G Schett	The American Journal of Pathology	2004
Interleukin-4 Cellular Gene Therapy and Osteoprotegerin Decrease Inflammation-Associated Bone Resorption in Collagen-Induced Arthritis N Saidenberg-Kermanac'h, N Bessis, D Lemeiter, MC de Vernejoul, MC Boissier, M Cohen-Solal	Journal of Clinical Immunology	2004
JNK1 is not essential for TNF-mediated joint disease M Köller, S Hayer, K Redlich, R Ricci, JP David, G Steiner, JS Smolen, EF Wagner, G Schett	Arthritis Research & Therapy	2004
Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells KS Nandakumar, J Bäcklund, M Vestberg, R Holmdahl	Arthritis Research & Therapy	2004
Long term high intensity exercise and damage of small joints in rheumatoid arthritis Z Jong, M Munneke, AH Zwinderman, HM Kroon, KH Ronday, WF Lems, BA Dijkmans, FC Breedveld, TP Vlieland, JM Hazes, TW Huizinga	Annals of the rheumatic diseases	2004
Lower limb arterial incompressibility and obstruction in rheumatoid arthritis I Rincón, RW Haas, S Pogosian, A Escalante	Annals of the rheumatic diseases	2004
The role of osteoprotegerin in arthritis. Schett G, Redlich K, Smolen JS	Arthritis Research & Therapy	2003

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